mas Mask Versus Nasal Tube for Stabilization of Preterm Infants at Birth: A Randomized Controlled Trial By pediatrics.aappublications.org Published On :: 2013-07-29T00:07:10-07:00 Effective ventilation is fundamental to successful resuscitation of newborns, but face mask leak and airway obstruction are common during manual positive-pressure ventilation in the delivery room, which may compromise resuscitation.Compared with a soft, round silicone face mask, using a nasal tube to provide respiratory support in the delivery room does not reduce the rate of intubation but may be a suitable alternative with equivocal efficacy. (Read the full article) Full Article
mas A Randomized Trial of Nasal Prong or Face Mask for Respiratory Support for Preterm Newborns By pediatrics.aappublications.org Published On :: 2013-07-29T00:07:08-07:00 Respiratory support is commonly given to newborn infants via a face mask in the delivery room. Respiratory support given to preterm infants via a single nasal prong may be more effective.Compared with a face mask, using a single nasal prong to deliver respiratory support to preterm newborns did not result in less intubation and ventilation in the delivery room. (Read the full article) Full Article
mas Screening for Behavioral Health Issues in Children Enrolled in Massachusetts Medicaid By pediatrics.aappublications.org Published On :: 2013-12-02T00:06:05-08:00 Use of behavioral health (BH) screens in pediatrics have increased identification of children with BH issues. Screening rates increased in Massachusetts after it was mandated, as did the volume of some mental health services.This is the first study of children after Massachusetts mandated behavioral screening began. Almost 40% of children who screened positive were newly identified. Being male, having a BH history, and being in foster care predicted a positive screen. (Read the full article) Full Article
mas Attention Deficit Disorder, Stimulant Use, and Childhood Body Mass Index Trajectory By pediatrics.aappublications.org Published On :: 2014-03-17T00:06:40-07:00 Childhood attention-deficit/hyperactivity disorder has been associated with both childhood and adult obesity, whereas treatment with stimulants has been associated with delayed child growth. No longitudinal studies with details about dates of diagnosis, treatment, and duration of stimulant use have been published.Using electronic health record data, this was the first study to evaluate the independent associations of attention-deficit/hyperactivity disorder diagnosis, stimulant treatment, age at first stimulant use, and duration of stimulant use on longitudinal BMI trajectories throughout childhood and adolescence. (Read the full article) Full Article
mas Massachusetts Health Reform and Access for Children With Special Health Care Needs By pediatrics.aappublications.org Published On :: 2014-07-07T05:07:01-07:00 Massachusetts implemented a major health reform in 2006 to reduce uninsurance, improve access to care, and increase financial protection for its citizens, but little is known about its effect on privately and publicly insured children with special health care needs.Massachusetts health reform improved access to specialists for privately insured children with special health care needs but did not reduce uninsurance, increase access to primary care, or improve financial protection. National reform may produce similarly modest outcomes for these children. (Read the full article) Full Article
mas Behavioral Health Services Following Implementation of Screening in Massachusetts Medicaid Children By pediatrics.aappublications.org Published On :: 2014-09-15T00:06:27-07:00 Behavioral health (BH) screening is known to increase identification of children with BH issues, but in small-scale studies, rates of follow-up after screening have been reported to be low.This study examines the relationship between BH screening and the receipt of BH services in Massachusetts Medicaid children. Nearly 60% of children identified with BH problems received BH services, but only 30% of newly identified children received BH services. (Read the full article) Full Article
mas Changes in Body Mass Index Associated With Head Start Participation By pediatrics.aappublications.org Published On :: 2015-01-12T00:05:27-08:00 Head Start, a federally funded preschool program for low-income US children, has been reported to have beneficial effects on developmental outcomes. The association of Head Start participation with changes in children’s BMI has not been examined.Preschool-aged children with an unhealthy weight status who participated in Head Start had a significantly healthier BMI by kindergarten entry age than comparison children in a primary care health system (both those receiving and those not receiving Medicaid). (Read the full article) Full Article
mas Continuous Positive Airway Pressure With Helmet Versus Mask in Infants With Bronchiolitis: An RCT By pediatrics.aappublications.org Published On :: 2015-03-16T00:05:28-07:00 In a previous short-term physiologic randomized controlled trial, continuous positive airway pressure by helmet was feasible and efficient in improving gas exchange in pediatric acute respiratory failure due to bronchiolitis.Continuous positive airway pressure administered by helmet reduces the rate of noninvasive respiratory support failure and provides longer application time with less sedation than a facial mask. In addition, it is safe to use and free from adverse events. (Read the full article) Full Article
mas Point-of-Care Child Psychiatry Expertise: The Massachusetts Child Psychiatry Access Project By pediatrics.aappublications.org Published On :: 2015-04-20T00:05:23-07:00 A program to support pediatric primary care providers in mental health care using point-of-care, telephone-based advice from specialists has been available since 2005 in Massachusetts. Other US states are implementing similar models. Little is known about how providers use this service.There is wide variability in adoption and use of this program. Patterns are associated with panel size, enrollment timing, and assignment to the program team at the pilot site. Findings will help new programs establish expectations and design implementation interventions. (Read the full article) Full Article
mas Maternal Prepregnancy Body Mass Index and Child Psychosocial Development at 6 Years of Age By pediatrics.aappublications.org Published On :: 2015-04-27T00:05:21-07:00 Both obesity and developmental disabilities have increased in recent decades; however, the full long-term effects of prepregnancy obesity on a child’s psychosocial development remain unknown. Limited studies suggest associations between maternal prepregnancy obesity and child psychosocial development.This study in 6-year-old children provides evidence that severe prepregnancy obesity is associated with adverse child psychosocial outcomes, including attention-deficit/hyperactivity disorder. These findings were not explained by many pregnancy and postpartum factors related to maternal obesity or child development. (Read the full article) Full Article
mas Grammy-winning, genre-smashing quartet to visit Williamsport By news.psu.edu Published On :: Tue, 10 Mar 2020 16:01 -0400 Groundbreaking, Grammy-winning quartet Béla Fleck & The Flecktones is celebrating its 30th anniversary with an extended tour that will stop by the Community Arts Center on Tuesday, March 24, at 7:30 p.m. Full Article
mas Latvia's tactical masterclass By www.uefa.com Published On :: Mon, 19 Mar 2012 08:32:00 GMT We analyse how Latvia secured a point against Germany at UEFA EURO 2004. Full Article
mas Fin24.com | OPINION | Beer for health workers, fashion face masks: How businesses innovate during Covid-19 By www.fin24.com Published On :: Mon, 04 May 2020 17:44:02 +0200 Where businesses are fighting to survive, agility is the name of the game, says Mignon Reynecke. Full Article
mas Fin24.com | Herman Mashaba | Our economy is in deep, deep trouble By www.fin24.com Published On :: Fri, 08 May 2020 06:02:28 +0200 Our economy is in deep trouble, from whichever perspective you look at it. The economic battering taken by economically strong countries is frightening, leaving us in South Africa to fear the worst. Full Article
mas Biochemical Characterization of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo-Beta-Lactamases [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-03-09T08:34:13-07:00 QPX7728 is a new ultra-broad-spectrum inhibitor of serine and metallo beta-lactamases from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhibits class A ESBLs (IC50 range 1-3 nM) and carbapenemases such as KPC (IC50 2.9±0.4 nM) as well as class C P99 (IC50 of 22±8 nM) with a potency that is comparable or higher than recently FDA approved BLIs avibactam, relebactam and vaborbactam. Unlike those other BLIs, QPX7728 is also a potent inhibitor of class D carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from A. baumannii (OXA-23/24/58, IC50 range 1-2 nM) as well as MBLs such as NDM-1 (IC50 55±25 nM), VIM-1 (IC50 14±4 nM) and IMP-1 (IC50 610±70 nM). Inhibition of serine enzymes by QPX7728 is associated with progressive inactivation with a high efficiency k2/K ranging from of 6.3 x 104 (for P99) to 9.9 x 105 M-1 s-1 (for OXA-23). This inhibition is reversible with variable stability of the QPX7728-beta-lactamase complexes with target residence time ranging from minutes to several hours: 5-20 minutes for OXA carbapenemases from A. baumanii, ~50 minutes for OXA-48 and 2-3 hours for KPC and CTX-M-15. QPX7728 inhibited all tested serine enzymes at 1:1 molar ratio. Metallo-beta-lactamases NDM, VIM, and IMP were inhibited by a competitive mechanism with fast-on-fast-off kinetics, with Kis of 7.5±2.1 nM, 32±14 nM and 240±30 nM for VIM-1, NDM-1 and IMP-1, respectively. QPX7728 ultra-broad-spectrum of BLI inhibition combined with its high potency enables combinations with multiple different beta-lactam antibiotics. Full Article
mas ZN148 - a modular synthetic metallo-{beta}-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivo [Experimental Therapeutics] By aac.asm.org Published On :: 2020-03-16T08:17:37-07:00 Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo β-lactamase (MBL) families. The recent introduction of SBL carbapenemase-inhibitors has provided alternative therapeutic options. Unfortunately, there are no approved inhibitors of MBL-mediated carbapenem-resistance and treatment options for infections caused by MBL-producing Gram-negatives are limited. Here, we present ZN148, a zinc-chelating MBL-inhibitor capable of restoring the bactericidal effect of meropenem and in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains (n=234). Moreover, ZN148 was able to potentiate the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model. ZN148 showed no inhibition of the human zinc-containing enzyme glyoxylase II at 500 μM and no acute toxicity was observed in an in vivo mouse model with cumulative dosages up to 128 mg/kg. Biochemical analysis showed a time-dependent inhibition of MBLs by ZN148 and removal of zinc ions from the active site. Addition of exogenous zinc after ZN148 exposure only restored MBL activity by ~30%, suggesting an irreversible mechanism of inhibition. Mass-spectrometry and molecular modelling indicated potential oxidation of the active site Cys221 residue. Overall, these results demonstrate the therapeutic potential of a ZN148-carbapenem combination against MBL-producing Gram-negative pathogens and that ZN148 is a highly promising MBL inhibitor, capable of operating in a functional space not presently filled by any clinically approved compound. Full Article
mas Structure and molecular recognition mechanism of IMP-13 metallo-{beta}-lactamase [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-03-23T08:47:35-07:00 Multi-drug resistance among Gram-negative bacteria is a major global public health threat. Metallo-β-lactamases (MBLs) target the most widely-used antibiotic class, the β-lactams, including the most recent-generation carbapenems. Interspecies spread renders these enzymes a serious clinical threat and there are no clinically-available inhibitors. We present crystal structures of IMP-13, a structurally-uncharacterized MBL from Gram-negative Pseudomonas aerugionasa found in clinical outbreaks globally, and characterize the binding using solution NMR-spectroscopy and molecular-dynamics simulations. Crystal structures of apo IMP-13 and bound to four clinically-relevant carbapenem antibiotics (doripenem, ertapenem, imipenem and meropenem) are presented. Active site plasticity and the active-site loop, where a tryptophan residue stabilizes the antibiotic core scaffold, are essential to the substrate-binding mechanism. The conserved carbapenem scaffold plays the most significant role in IMP-13 binding, explaining the broad substrate specificity. The observed plasticity and substrate-locking mechanism provide opportunities for rational drug design of novel metallo-β-lactamase inhibitors, essential in the fight against antibiotic resistance. Full Article
mas Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics Against Isogenic Strains Expressing Single {beta} By aac.asm.org Published On :: 2020-03-30T10:04:32-07:00 QPX7728 is an ultra-broad-spectrum boronic acid beta-lactamase inhibitor with potent inhibition of key serine and metallo beta-lactamases observed in biochemical assays. Microbiological studies using characterized strains were used to provide a comprehensive characterization of the spectrum of beta-lactamase inhibition by QPX7728. The MIC of multiple IV only (ceftazidime, piperacillin, cefepime, ceftolozane and meropenem) and orally bioavailable (ceftibuten, cefpodoxime, tebipenem) antibiotics alone and in combination with QPX7728 (4 μg/ml), as well as comparator agents, were determined against the panels of laboratory strains of P. aeruginosa and K. pneumoniae expressing over 55 diverse serine and metallo beta-lactamases. QPX7728 significantly enhanced the potency of antibiotics against the strains expressing Class A extended spectrum beta-lactamases (CTX-M, SHV, TEM, VEB, PER) and carbapenemases (KPC, SME, NMC-A, BKC-1), consistent with beta-lactamase inhibition demonstrated in biochemical assays. It also inhibits both plasmidic (CMY, FOX, MIR, DHA) and chromosomally encoded (P99, PDC, ADC) Class C beta-lactamases and Class D enzymes including carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from Acinetobacter baumannii (OXA-23/24/72/58). QPX7728 is also a potent inhibitor of many class B metallo beta-lactamases (NDM, VIM, CcrA1, IMP, GIM but not SPM or L1). Addition of QPX7728 (4 μg/ml) reduced the MICs in a majority of strains to the level observed for the vector alone control, indicative of complete beta-lactamase inhibition. The ultra-broad-spectrum beta-lactamase inhibition profile makes QPX7728 a viable candidate for further development. Full Article
mas The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. [Mechanisms of Resis By aac.asm.org Published On :: 2020-03-30T10:04:32-07:00 QPX7728 is an ultra-broad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo beta-lactamases at a nano molar range in biochemical assays with purified enzymes. The broad-spectrum inhibitory activity of QPX7728 observed in biochemical experiments translates into enhancement of the potency of many beta-lactams against strains of target pathogens producing beta-lactamases. The impact of bacterial efflux and permeability on inhibitory potency were determined using isogenic panels of KPC-3 producing isogenic strains of K. pneumoniae and P. aeruginosa and OXA-23-producing strains of A. baumannii with various combinations of efflux and porin mutations. QPX7728 was minimally affected by multi-drug resistance efflux pumps in either Enterobacteriaceae, or in non-fermenters such as P. aeruginosa or A. baumannii. In P. aeruginosa, the potency of QPX7728 was further enhanced when the outer membrane is permeabilized. The potency of QPX7728 in P. aeruginosa is not affected by inactivation of the carbapenem porin OprD. While changes in OmpK36 (but not OmpK35) reduced the potency of QPX7728 (8-16-fold), QPX7728 (4 μg/ml) nevertheless completely reversed KPC-mediated meropenem resistance in strains with porin mutations, consistent with a lesser effect of these mutations on the potency of QPX7728 compared to other agents. The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate QPX7728 is a useful inhibitor for use with multiple beta-lactam antibiotics. Full Article
mas Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum Beta Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia caused by ESBL-Producing Klebsiella pneumoniae [Pharmacology] By aac.asm.org Published On :: 2020-04-06T08:49:25-07:00 Klebsiella pneumoniae that produce extended spectrum beta lactamases (ESBLs) are a persistent public health threat. There are relatively few therapeutic options and there is undue reliance on carbapenems. Alternative therapeutic options are urgently required. A combination of cefepime and the novel beta lactamase inhibitor enmetazobactam is being developed for treatment of serious infections caused by ESBL-producing organisms. The pharmacokinetics-pharmacodynamics (PK-PD) of cefepime-enmetazobactam against ESBL-producing K. pneumoniae was studied in a neutropenic murine pneumonia model. Dose ranging studies were performed. Dose fractionation studies were performed to define the relevant PD index for the inhibitor. The partitioning of cefepime and enmetazobactam into the lung was determined by comparing area under the concentration time curve (AUC) in plasma and epithelial lining fluid. The magnitude of drug exposure for cefepime-enmetazobactam required for logarithmic killing in the lung was defined using 3 ESBL-producing strains. Cefepime 100 mg/kg q8h i.v. had minimal antimicrobial effect. When this background regimen of cefepime was combined with enmetazobactam half-maximal effect was induced with enmetazobactam 4.71 mg/kg q8h i.v. The dose fractionation study suggest both fT>threshold and fAUC:MIC are potentially relevant PD indices. The AUCELF:AUCplasma for cefepime and enmetazobactam was 73.4% and 61.5%, respectively. A ≥2-log kill in the lung was achieved with a plasma and ELF cefepime fT>MIC of ≥20% and enmetazobactam fT>2 mg/L of ≥20% of the dosing interval. These data and analyses provide the underpinning evidence for the combined use of cefepime and enmetazobactam for nosocomial pneumonia. Full Article
mas Ceftazidime-avibactam resistance mediated by the N346Y substitution in various AmpC {beta}-lactamases [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-04-06T08:49:26-07:00 Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid residue Asn346 of AmpC cephalosporinases directly interacts with the avibactam sulfonate. Disruption of this interaction caused by the N346Y amino acid substitution in Citrobacter freundii AmpC was previously shown to confer resistance to the ceftazidime-avibactam combination (CAZ-AVI). The aim of this study was to phenotypically and biochemically characterize the consequences of the N346Y substitution in various AmpC backgrounds. Introduction of N346Y into Enterobacter cloacae AmpC (AmpCcloacae), plasmid-mediated DHA-1, and P. aeruginosa PDC-5, led to 270-, 12,000-, and 79-fold decreases in the inhibitory efficacy (k2/Ki) of avibactam, respectively. The kinetic parameters of AmpCcloacaeand DHA-1 for ceftazidime hydrolysis were moderately affected by the substitution. Accordingly, AmpCcloacaeand DHA-1 harboring N346Y conferred CAZ-AVI resistance (MIC of ceftazidime of 16 µg/ml in the presence of 4 µg/ml of avibactam). In contrast, production of PDC-5 N346Y was associated with a lower MIC (4 µg/ml) since this β-lactamase retained a higher inactivation efficacy by avibactam in comparison to AmpCcloacaeN346Y. For FOX-3, the I346Y substitution did not reduce the inactivation efficacy of avibactam and the substitution was highly deleterious for β-lactam hydrolysis, including ceftazidime, preventing CAZ-AVI resistance. Since AmpCcloacaeand DHA-1 display substantial sequence diversity, our results suggest that loss of hydrogen interaction between Asn346 and avibactam could be a common mechanism of acquisition of CAZ-AVI resistance. Full Article
mas Safety, Pharmacokinetics, and Drug:Drug Interaction Potential of Intravenous Durlobactam, a {beta}-lactamase Inhibitor, in Healthy Subjects [Pharmacology] By aac.asm.org Published On :: 2020-04-13T08:15:30-07:00 Durlobactam (DUR, also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii. The safety and pharmacokinetics (PK) of DUR alone and with SUL and/or imipenem/cilastatin (IMI/CIL) were evaluated in healthy subjects. This was a randomized, placebo-controlled study. In Part A, subjects including an elderly cohort (DUR 1 g) received single ascending doses of DUR 0.25-8 g. In Part B, multiple ascending dose of DUR 0.25-2 g were administered every 6 hours (q6h) for 29 doses. In Parts C and D, the drug-drug interaction (DDI) potential, including safety, of DUR (1 g) with SUL (1 g) and/or IMI/CIL (0.5/0.5 g) was investigated after single and multiple doses. Plasma and urine concentrations of DUR, SUL, and IMI/CIL were determined. Among 124 subjects, DUR was generally safe and well tolerated either alone or in combination with SUL and/or IMI/CIL. After single and multiple doses, DUR demonstrated linear dose proportional exposure across the studied dose ranges. Renal excretion was a predominant clearance mechanism. No drug:drug interaction potential was identified between DUR and SUL and/or IMI/CIL. SUL-DUR, 1 g (of each component) administered q6h with a 3 hour IV infusion, is under development for the treatment of serious infections due to A. baumannii. Full Article
mas A genotype-phenotype correlation study of SHV {beta}-lactamases - new insight into SHV resistance profiles [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-04-13T08:15:31-07:00 The SHV β-lactamases (BLs) have undergone strong allele diversification that changed their substrate specificities. Based on 147 NCBI entries for SHV alleles, in silico mathematical models predicted five positions as relevant for the β-lactamase inhibitor (BLI) resistant (2br) phenotype, 12 as relevant for the extended-spectrum BL (ESBL) (2be) phenotype, and two positions were related to solely the narrow spectrum (2b) phenotype. These positions and additional 6 positions described in other studies (including one promoter mutation), were systematically substituted and investigated for their substrate specificities in a BL-free E. coli background, representing, to our knowledge, the most comprehensive substrate and substitution analysis for SHV alleles to date. An in vitro analysis confirmed the essentiality of the positions 238 and 179 for the 2be phenotype and 69 for the 2br phenotype. The substitutions E240K and E240R, which do not occur alone in known 2br SHV variants, led to a 2br phenotype, indicating a latent BLI-resistance potential of these substitutions. The substitutions M129V, A234G, S271I and R292Q conferred latent resistance to cefotaxime. In addition, 7 positions that were found to be not always associated with the ESBL phenotype resulted in increased resistance to ceftaroline. We also observed that coupling of a strong promoter (IS26) to a A146V mutant with the 2b phenotype resulted in a highly increased resistance to BLIs, cefepime and ceftaroline but not to 3rd generation cephalosporins, indicating that SHV enzymes represent an underestimated risk for empirical therapies that use piperacillin/tazobactam or cefepime to treat different infectious diseases caused by gram-negatives. Full Article
mas Epidemiological study on prevalence, serovar diversity, multi-drug resistance and CTX-M-type extended-spectrum {beta}-lactamases of Salmonella spp. from patients with diarrhea, food of animal origin, and pets in several provinces of China [Epidemiology an By aac.asm.org Published On :: 2020-04-20T08:36:46-07:00 A total of 2,283 Salmonella spp. isolates were recovered from 18,334 samples including patients with diarrhea, food of animal origin and pets across 5 provinces of China. The highest prevalence of Salmonella spp. was detected in chicken meats (39.3%, 486/1,237). Fifteen serogroups and 66 serovars were identified, with Typhimurium and Enteritidis being the most dominant. Most (85.5%, 1,952/2,283) isolates exhibited resistant to ≥ 1 antimicrobial and 56.4% were multi-drug resistant (MDR). A total of 222 isolates harbored extended-spectrum β-lactamases (ESBLs), 200 of which were CTX-M-type that were mostly detected from chicken meat and turtle fecal. Overall, eight blaCTX-M genes were identified, with blaCTX-M-65, blaCTX-M-123, blaCTX-M-14, blaCTX-M-79, and blaCTX-M-130 being the most prevalent. Totally, 166 of the 222 ESBL-producing isolates had amino acid substitutions in GyrA (S83Y, S83F, D87G, D87N, and D87Y) and ParC (and S80I), whilst the PMQR-encoding genes oqxA/B, qepA, and qnrB/S were detected in almost all isolates. Of the fifteen sequence types (STs) identified in the 222 ESBLs, ST17, ST11, ST34, and ST26 ranked among the top 5 in the number of isolates. Our study revealed considerable serovars diversity, high prevalence of co-occurrence of MDR determinants, including CTX-M-type ESBLs, QRDRs mutations and PMQR genes. This is the first report of CTX-M-130 Salmonella spp. from patients with diarrhea and QRDRs mutations from turtle fecal samples. Our study emphasizes the importance of actions, both in the health care settings and in the veterinary medicine sector, to control the dissemination of MDR, especially the CTX-M Salmonella spp. isolates. Full Article
mas Berks faculty member coordinates mask donation from Reading Chinese Association By news.psu.edu Published On :: Thu, 23 Apr 2020 09:49 -0400 Hongyan “Red” Yuan, an instructional designer at Penn State Berks and member of the board of the Reading Chinese Association (RCA), recently helped to coordinate the donation of 1,500 surgical masks to Penn State Health St. Joseph. Full Article
mas Canadian archbishop offers prayers after mass shooting By feedproxy.google.com Published On :: Tue, 21 Apr 2020 11:00:00 -0600 CNA Staff, Apr 21, 2020 / 11:00 am (CNA).- The Archbishop of Halifax-Yarmouth in Canada has offered prayers for the victims of a weekend shooting rampage in a small town in Nova Scotia, including a member of the country’s Royal Canadian Mounted Police. In a letter addressed to the commissioner of the Royal Canadian Mounted Police (RCMP) dated April 20, Archbishop Anthony Mancini of Halifax-Yarmouth expressed condolences for the death of Constable Heidi Stevenson, a 23-year veteran of the force. “I wish to express on my behalf, as Archbishop of Halifax-Yarmouth, and in the name of Catholic faithful, our sincere condolences on the loss of life of Constable Heidi Stevenson,” said Mancini. “Her death in the line of duty indicates the highest sacrifice that one can make on behalf of the citizens she served,” he added. The archbishop said that he would be praying for her family, and for the officers of the RCMP who are mourning her life. In a video message posted on Tuesday, April 21, Mancini offered condolences, prayers, and assurances to the people of his archdiocese after, according to police, denture-fitter Gabriel Wortman went on a 14-hour shooting attack which spread across Saturday and Sunday. “These last few days have been a shock, as we have all been affected by the useless and premature death of so many of our fellow citizens,” he said. “Try as we will to understand this tragedy, it remains incomprehensible. We are experiencing a great sense of loss, frustration, and even anger,” he added. As of Monday morning, 18 people have been confirmed to have been killed by the shooter, making it the deadliest mass shooting in Canadian history, stunning a province which typically sees fewer than 15 homicides total per year. Authorities have not yet determined a motive for why the 51-year-old denture fitter committed the attack. The suspect is now deceased, although it has not yet been determined how he died. Mancini acknowledged that the existing circumstances related to the ongoing COVID-19 pandemic has made the grieving process more complicated. “This loss of life comes upon us at a time when we are already weighed down by the threat of the coronavirus. In this time of mourning, we ought to be able to come together to experience the comfort of community care and its support. Yet here we are, in isolation in order to stay safe, making the present circumstances even more tragic,” he said. The archbishop encouraged people to use “technological means” to offer support to each other throughout the grieving process, and reminded Nova Scotians that “love is greater than tragedy and death.” “I wish to extend to all the families and friends of those who have died our prayers and our expression of solidarity,” he said. “In this time, when we celebrate the resurrection, it is good to recall that death is not the last word.” Mancini also suggested that his flock pray for “the growing number of COVID-19 victims” and “for those on the front lines doing all they can to protect us--the doctors, the nurses, and of course, the police.” Full Article Americas
mas Brandywine alumna offers free face masks to help slow the spread of coronavirus By news.psu.edu Published On :: Fri, 17 Apr 2020 08:25 -0400 Meaghan Paige, a women’s fashion brand started by a Penn State Brandywine alumna, is supporting the local community by offering free, handmade cloth face masks during the novel coronavirus pandemic. Full Article
mas 'Gargantuan' hail in Argentina may have smashed world record By news.psu.edu Published On :: Wed, 29 Apr 2020 10:17 -0400 A supercell thunderstorm pelted a city center in Argentina a few years ago with hailstones so large scientists suggested a new category to describe them — gargantuan hail. Full Article
mas Men arrested in killing of Family Dollar security guard after face mask dispute By abcnews.go.com Published On :: Sat, 09 May 2020 09:23:32 -0400 The U.S. coronavirus death toll has surpassed 77,000. Full Article US
mas Court halts ban on mass gatherings at Kentucky churches By abcnews.go.com Published On :: Sat, 09 May 2020 09:58:42 -0400 The ruling clears the way for Sunday church services in Kentucky. Full Article Health
mas Uluslararası Kriz Grubu Türkiye'deki PKK çatışmasının insani maliyeti ile ilgili bir rapor yayınladı. By www.crisisgroup.org Published On :: Thu, 17 Mar 2016 17:30:00 GMT Türkiye devleti ile uluslararası alanda terör örgütü olarak kabul edilen PKK arasındaki çözüm sürecinin çökmesi, Temmuz 2015’te çatışmaların yeniden başlaması ve daha sonra derinleşen şiddet sarmalı, yeni bir çözüm sürecinin inşasını hiç olmadığı kadar gerekli kılıyor. Full Article
mas Unorthodox Parenteral {beta}-Lactam and {beta}-Lactamase Inhibitor Combinations: Flouting Antimicrobial Stewardship and Compromising Patient Care [Commentary] By feedproxy.google.com Published On :: 2020-04-21T08:01:09-07:00 In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development. Full Article
mas Education professor designs kid-friendly face masks By news.psu.edu Published On :: Thu, 07 May 2020 11:04 -0400 An education professor at Penn State is utilizing her understanding of child psychology — as well as her sewing skills — to help protect children in her community by appealing to their imaginations. Full Article
mas Jimmy Kimmel’s Quarantine Monologue – Trump Won’t Wear Masks & Jane's Pancake Stand-off By www.youtube.com Published On :: Thu, 07 May 2020 03:49:26 GMT Source: www.youtube.com - Wednesday, May 06, 2020All Related Full Article
mas When and why should I wear a cloth mask? | Ask CIDD By news.psu.edu Published On :: Wed, 06 May 2020 12:30 -0400 Full Article
mas Cooler Master Blames Parents for Thermal Paste Tube Redesign By www.pcmag.com Published On :: It no longer looks like a syringe, so parents can stop being suspicious their kid is doing drugs. Full Article
mas Not just for Christmas By feedproxy.google.com Published On :: Wed, 01 Apr 2015 13:50:02 +0000 New believers in the village of Sunkapur have started meeting together regularly to study God's Word. Full Article
mas Master the Ball: Free promotional futsal flier By www.uefa.com Published On :: Tue, 07 Oct 2014 15:46:00 GMT UEFA has produced a free to download flier 'Master the Ball' in 11 languages explaining the benefits and laws of futsal with testimonies from the likes of Lionel Messi. Full Article general
mas Fin24.com | Dis-Chem hiked mask prices before costs escalated, says Commission By www.fin24.com Published On :: Wed, 06 May 2020 14:30:32 +0200 The pharmaceutical retailer says it was forced to increase prices of surgical masks because of suppliers' inflated quotes and to match competitors, while the commission says retailers could have been following Dis-Chem's lead. Full Article
mas Hugging grandmas and businessmen By feedproxy.google.com Published On :: Thu, 08 Dec 2011 16:19:10 +0000 OM Chile's Intensive Training participants spend a morning sharing the gospel in a local plaza in Santiago. Full Article
mas Quality time with water slides, dramas and pizzas By feedproxy.google.com Published On :: Mon, 06 Feb 2012 16:57:56 +0000 OM Chile celebrates Christmas with the boys and girls of two children's homes in Santiago. Full Article
mas Racketeering Judgment Against Massage Parlor Owner; Murder Conviction in 2012 Cold Case By news.delaware.gov Published On :: Fri, 01 Nov 2019 18:32:53 +0000 Prison time for other defendants on murder, weapons, racketeering, drug, and sexual abuse charges The operator of a criminal enterprise run out of several massage parlors he owned throughout the state, was found liable of 3 violations of the Racketeer Influenced and Corrupt Organizations (R.I.C.O.) statute. The State alleged that Da Zhong Wang, 55, formerly […] Full Article Criminal Division Department of Justice Department of Justice Press Releases Attorney General Kathy Jennings Delaware Department of Justice superior court
mas Debating Independence: Delaware’s John Dickinson Squares Off with Thomas Jefferson LIVE in Dover By news.delaware.gov Published On :: Tue, 14 Nov 2017 16:03:55 +0000 On Sunday, Nov. 19, The Old State House will host an engaging historical dramatic production, John Dickinson and Thomas Jefferson Debate Independence: “We have called by different names brethren of the same principle,” presented by the American Historical Theatre of Philadelphia. Full Article Department of State Historical and Cultural Affairs Delaware history John Dickinson John Dickinson Plantation old state house
mas The Mezzanine Gallery to Exhibit “Established Color” a Painting Exhibit by Thomas Del Porte By news.delaware.gov Published On :: Tue, 28 Aug 2018 14:00:09 +0000 On view from September 7-28, 2018 Free opening reception on Friday, September 7 at 5 p.m. Wilmington, Del. (August 28, 2018) – Established Color, an exhibition of paintings by Thomas Del Porte, will be on view in the Mezzanine Gallery from September 7-28, 2018. Del Porte received a 2018 Fellowship Visual Arts: Painting. The artist […] Full Article Delaware Division of the Arts Department of State Kent County New Castle County Sussex County art exhibition artist Mezzanine Gallery painting Thomas del Porte
mas Secretary of State Announces Massage Therapy License Suspension By news.delaware.gov Published On :: Thu, 29 Nov 2018 15:55:58 +0000 Secretary of State Jeffrey Bullock has suspended the Delaware massage therapy license of Christopher D. Dorman in light of allegations of sexual assault made by several female clients. Full Article Department of State "Secretary of State" Division of Professional Regulation license suspension
mas Fiat Chrysler Automobiles To Make 3 Million Face Masks A Month In China By www.carandbike.com Published On :: Sat, 09 May 2020 15:31:24 +0530 Following the start of production in April, capacity has been increased with a target to produce 3 million masks per month across two lines, with over 1 million masks manufactured in the first 10 days... Full Article News
mas Mercedes-Benz Produces Hand Crafted Face Masks For Employees At Sindelfingen Plant By www.carandbike.com Published On :: Sat, 09 May 2020 18:30:09 +0530 During the COVID-19 pandemic, however, the daily work routine for tailors and apprentices looks a bit different than usual: for several weeks, they have been producing hand-crafted masks for use of... Full Article News
mas BIG FM CEO Abraham Thomas shares his wanderlust, life’s inspiration and favourite movie By www.financialexpress.com Published On :: 2019-11-01T10:26:25+05:30 The Godfather, of course. It is a cult classic. Another movie that I would like to watch again is Andhadhun for its unpredictable storyline and performances. Full Article Brand Wagon
mas 20 Hidden WhatsApp iPhone Tricks That Everyone Can Master By gadgets.ndtv.com Published On :: Sat, 09 May 2020 18:59:21 +0530 WhatsApp tricks 2020 for iPhone includes some advanced tips such as how to schedule WhatsApp messages, how to hide online status, and how to send WhatsApp message without adding a contact. Full Article How to
mas Did Congress' karsewa led to demolition of Babri Masjid? | Seedha Sawal (04.11.2019) By Published On :: Mon, 04 Nov 2019 20:18:01 GMT Madhav Godbole's statement has caused a political stir. He said, "Rajiv Gandhi went to the extent of opening locks of Babri Masjid." This statement is in his book which has talked about Ram Mandir and Babri Masjid dispute in a detailed manner.<br />In today's Seedha Sawal, we raise the Full Article seedha-sawaal