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Appeals Court Revives Mississippi Suit Asserting Federal Right to Education

The court revived a lawsuit claiming that Mississippi's lack of a "uniform" education system violates the 1868 federal law that readmitted the state to the Union.




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Tennessee soccer earns fourth straight NCAA Tournament berth, will face No. 7 seed Virginia Tech

Tennessee soccer earned an NCAA Tournament berth for the fourth straight season and will face No. 7 seed Virginia Tech in the first round Friday




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A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3{alpha} Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses

α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the elaborate extracellular sequences of α-neurexins contribute to synapse function is poorly understood. We recently characterized the presynaptic gain-of-function phenotype caused by a missense mutation in an evolutionarily conserved extracellular sequence of neurexin-3α (A687T) that we identified in a patient diagnosed with profound intellectual disability and epilepsy. The striking A687T gain-of-function mutation on neurexin-3α prompted us to systematically test using mutants whether the presynaptic gain-of-function phenotype is a consequence of the addition of side-chain bulk (i.e., A687V) or polar/hydrophilic properties (i.e., A687S). We used multidisciplinary approaches in mixed-sex primary hippocampal cultures to assess the impact of the neurexin-3αA687 residue on synapse morphology, function and ligand binding. Unexpectedly, neither A687V nor A687S recapitulated the neurexin-3α A687T phenotype. Instead, distinct from A687T, molecular replacement with A687S significantly enhanced postsynaptic properties exclusively at excitatory synapses and selectively increased binding to neuroligin-1 and neuroligin-3 without changing binding to neuroligin-2 or LRRTM2. Importantly, we provide the first experimental evidence supporting the notion that the position A687 of neurexin-3α and the N-terminal sequences of neuroligins may contribute to the stability of α-neurexin–neuroligin-1 trans-synaptic interactions and that these interactions may specifically regulate the postsynaptic strength of excitatory synapses.




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FAO at your fingertips

As part of its efforts  to create awareness on the fight against hunger and malnutrition, FAO launched today a free mobile application that showcases the main sections [...]




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FAO - Globally Important Agricultural Heritage Systems Programme call for experts

Rome - The FAO - Globally Important Agricultural Heritage Systems Programme opens the process of establishing a new Scientific Advisory Groupfor the 2021-2022 term.  The Programme is seeking for [...]




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The global fertilizer market: taking stock of a tightening market situation

International fertilizer benchmark prices have risen throughout 2021.




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FAO in review: Building and deploying professional and practical expertise

Read the seriesFull Article



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FAO's GIAHS Programme seeks new experts for the Scientific Advisory Group

Rome - The Food and Agriculture Organization (FAO) is currently seeking applications from experts to join the Scientific Advisory Group (SAG) of its Globally Important Agricultural Heritage Systems [...]




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Transitions: Photographs by Robert Creamer

Transitions: Photographs by Robert Creamer




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Gene Therapy Experts Look Ahead in Treating Blindness

Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN)




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The Man Who Stopped the Desert – D.C. Environmental Film Festival Trailer

Yacouba Sawadogo, a farmer from Burkina Faso, has become a pioneer in the fight against desertification – succeeding where many international agencies have failed




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Stephen Colbert Congratulates OK Go | Smithsonian American Ingenuity Awards

"OK Go made music videos relevant again." – Stephen Colbert OK Go​, Damian Kulash Jr. and Trish Sie​ won the Smithsonian magazine​ American Ingenuity Award for Visual Arts for pushing the music-video envelope with their zero-gravity video for "Upside Down & Inside Out." Read more about their work and see the video here: http://smithmag.co/HZ8vzr The Smithsonian has been celebrating innovation in American culture for more than 150 years, and following in this tradition, Smithsonian magazine presents the American Ingenuity Awards, honoring revolutionary breakthroughs in the arts and sciences, education and social progress. http://smithmag.co/R7hyRO




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Albert Einstein Lives On

Through the science of robotics, researchers in California have created a lifelike bust of Albert Einstein to teach others, and themselves, about the breakthroughs made with robots




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Inside Photographer Robert Frank's The Americans

The National Gallery of Art organized a comprehensive exhibit of Robert Frank's work (Images courtesy of: National Gallery of Art; Produced by: Diane Bolz and Brian Wolly)




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What 'Bridgerton' Gets Right About the Regency Era

From gender roles to etiquette to fashion, step back in time to learn more about the real lives of the Regency women who inspired 'Bridgerton.' --- To read more about the Regency era - and 'Bridgerton' - check out these articles from Smithsonian Magazine: What 'Bridgerton' Gets Wrong About Corsets: https://www.smithsonianmag.com/history/what-bridgerton-gets-wrong-about-corsets-180976691/ The Real History Behind 'Queen Charlotte: A Bridgerton Story' https://www.smithsonianmag.com/smart-news/the-real-history-behind-queen-charlotte-a-bridgerton-story-180982130/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Producer: Nicki Marko Video Editor: Sierra Theobald




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What Will Happen to Puerto Maldonado

A local fisherman talks about the uncertain future facing locals when the new bridge connecting Peru and Brazil is completed




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What Roberto Clemente Meant to Baseball

Biographer David Maraniss says that in order to truly understand Clemente's importance to the sport, you have to look beyond his spectacular numbers




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Off-Road Drivers Are Destroying Ancient Artworks Stretching Across Chile's Deserts

As hundreds of motorists take to the desert, their tracks damage the massive geoglyphs made by Indigenous groups in northern Chile




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Workers Just Started Building the World's First 3D-Printed Hotel in the Texas Desert

In the dusty landscape surrounding the city of Marfa, a huge 3D printer is constructing 43 new rooms and 18 residential homes as part of an expansion of El Cosmico




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Human Lifespan Might Be About to Hit a Ceiling, Experts Say

In the ’90s, many scientists disputed an epidemiologist’s warning that the fast-paced life extension of the 20th century would plateau. Now, a new study suggests he was right




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Experts Don't Know How This Mysterious White Fox Ended Up in Oregon, More Than 1,000 Miles Away From Home

Identified as an Arctic fox, the animal is believed to have been kept in captivity far from its native habitat in the tundra. Now, it's receiving care from wildlife officials




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He Escaped Slavery and Became a Civil War Hero. Now, Robert Smalls Is Getting a Statue in South Carolina

A special committee has until January 15 to finalize the design, location and funding for a monument that will be erected on the lawn of the South Carolina State House




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Amplification and Identification of Vertebrate Host Cytochrome c Oxidase Subunit I (COI) DNA Barcoding Templates from Mosquito Blood Meals

Mosquitoes take blood meals from a diverse range of host animals and their host associations vary by species. Characterizing these associations is an important element of the transmission dynamics of mosquito-vectored pathogens. To characterize mosquito host associations, various molecular techniques have been developed, which are collectively referred to as blood meal analysis. DNA barcoding has diverse biological applications and is well-suited to mosquito blood meal analysis. The standard DNA barcoding marker for animals is a 5' fragment of the cytochrome c oxidase I (COI) gene. A major advantage of this marker is its taxonomic coverage in DNA sequence reference databases, making it feasible to identify a wider range of mosquito host species than with any other gene. However, the COI gene contains high sequence variation at potential priming sites between vertebrate orders. Coupled with the need for primer sequences to be mismatched with mosquito priming sites so that annealing to mosquito DNA is inhibited, it can be difficult to design primers suitable for blood meal analysis applications. Several primers are available that perform well in mosquito blood meal analysis, annealing to priming sites for most vertebrate host taxa, but not to those of mosquitoes. Because priming site sequence variation among vertebrate taxa can cause amplification to fail, a hierarchical approach to DNA barcoding-based blood meal analysis can be applied. In such an approach, no single primer set is expected to be effective for 100% of potential host species. If amplification fails in the initial reaction, a subsequent reaction is attempted with primers that anneal to different priming sites, and so on, until amplification is successful.




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Former mayor accused of property encroachment violations in Dawson City files his defence against town

Former Dawson City Mayor Bill Kendrick has filed his defence against the town's encroachment violation lawsuit.



  • News/Canada/North

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“Invertir mi tiempo en esta tierra, en lugar de desperdiciarlo”

Para Roberto Ramírez de Costa Rica, servir a Dios en misiones ha sido un paso de fe tras otro. Perdió su trabajo, su estabilidad financiera e incluso a su prometida, pero ganó mucho más.




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'It is urgent': Alberta military reservists eager to join Canadian Forces in Latvia

At 2,700 square kilometres, CFB Suffield is the largest military training area in Canada. It has been the site of military training in southern Alberta since 1972.



  • News/Canada/Calgary

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Legacy of Indigenous soldiers now being preserved in northwestern Alberta

A researcher in Grande Prairie, Alta., has undertaken a project to ensure past Indigenous soldiers and veterans are recognized for their sacrifices in both world wars.



  • News/Canada/Edmonton

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'Financially desperate' Winnipeg business swindled out of 2 properties, lawsuit alleges

A Winnipeg business owner is suing a man she alleges swindled her out of ownership of two properties after promising financial help — the latest in a string of court proceedings against the man, whom a judge previously described as showing the signs of a "predator" who seeks out financially vulnerable clients.



  • News/Canada/Manitoba

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Trump's return to White House spells uncertainty for U.S.-China relationship

The impact of Donald Trump's election win on Nov. 5 will be felt globally, especially in China — one of the world's emerging superpowers and one of the United States' biggest trading partners. The relationship could also affect Canada.




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Motorcyclist dead after collision with SUV in Mount Albert, Ont.

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.



  • News/Canada/Toronto

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Alberta hiring to restore land where fireguards were created in 2023 wildfire season

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.



  • News/Canada/Edmonton

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Laura Walker makes game-winning draw to win Alberta playdown, book Scotties ticket

Laura Walker made a game-winning draw Sunday afternoon to win the Alberta women's curling playdowns and secure a berth in the upcoming national championship.



  • Sports/Olympics/Winter Sports/Curling

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Homan selection for Beijing gives Team Hollie Duncan the Ontario berth at Scotties

Rachel Homan and John Morris weren't the only ones celebrating after their selection to wear the Maple Leaf in mixed doubles curling competition at the Beijing Olympics. The nomination also cleared the path for Team Hollie Duncan to represent Ontario at the national championship.



  • Sports/Olympics/Winter Sports/Curling

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SOLIDWORKS releases first 3D CAD industry product to be certified for Windows Vista

SOLIDWORKS Edition for Windows Vista delivers enhanced user experience plus advanced search, preview, and content distribution




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SOLIDWORKS unveils new certification to gauge students' 3D CAD abilities

Test enables teachers, potential employers to evaluate students' modeling skills as well as their grasp of engineering principles




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Bertrand Sicot Named CEO of Dassault Systèmes SolidWorks Corp.

Previous CEO, Jeff Ray, Promoted to Dassault Systèmes Executive Team




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SolidWorks Software Helps Non-Engineer Design and Test “SuperTruck”

User Group Community Continues to Innovate and Elevate Jeremy Singley’s Design to the Next Level




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SolidWorks Certifications Exceed 50,000 Users

Industry-Recognized Achievement Provides Workers and Employers With Competitive Advantage




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Travertson Motorcycles Revs Engines with SOLIDWORKS

Luxury Bike Shop Eliminates Prototypes Using SOLIDWORKS Simulation Software




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Day2Night Uses SOLIDWORKS Software to Bring Convertible Heels to Market

FISHER/UNITECH Provides Innovative Shoe Company with Tools to Design a Single Shoe with Multiple Heel Heights




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Product Modification Summary: Expansion of the Listing Schedule for Certain Commodity Index Futures, Options, and Swaps Contracts - Effective November 18, 2024




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iPhone 18 Pro rumored to gain a variable aperture wide-angle lens

In a major update to the camera system, analyst Ming-Chi Kuo says the iPhone 18 Pro's wide angle lens will be upgraded to have a variable aperture.


Apple may update the iPhone's wide-angle lens to give it a variable aperture

Rumors concerning the cameras in the forthcoming iPhone 17 range and later have previously varied from saying they will get better bokeh, to how the front camera's resolution will double to 24MP. Now analyst Ming-Chi Kuo claims to have specific information that the iPhone 18 Pro will gain this variable aperture update.

In a blog post that he says is based on his own industry sources, Kuo says that this update will "significantly improve the user's photography experience."


Rumor Score: ???? Possible


Continue Reading on AppleInsider | Discuss on our Forums




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New friendships in the desert

Missionaries share the gospel and bring freedom in a little farming village.




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News24 Business | MONEY CLINIC | I can't afford to pay for debt clearance certificate. What are my options?

A News24 Business reader has to pay R500 to receive a debt clearance certificate but is currently unemployed.




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A hope-filled desert town

Valverde Vega Sarchí is filled with sadness after suffering a 7.9 earthquake in September, but even amidst the sadness are a few smiles.




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The 8 Things Teachers Know for Certain When Schools Reopen

There are some serious questions that still need answers, but there are a few certainties that teachers can hold onto, writes Casey M. Bethel.




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Teaching in the U.S. Should Be More 'Intellectually Attractive,' Global Expert Says

A panel of experts—including a national teacher's union president and an official from the Department of Education—discussed how to make teaching a more attractive profession.




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This Tool Can Help Identify 'STEM Deserts.' But It Needs Your Feedback

The National Math and Science Initiative's new tool aims to help the field look for patterns in STEM data, so educators and policy folks can fill in holes.




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Fighting Bible poverty

No method is infallible when trying to reduce Bible poverty among the least reached, an OM worker discovers as he distributed Bibles.




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Penn State mathematician Paul Baum named Atherton Professor

Paul Frank Baum, Evan Pugh University Professor of Mathematics at Penn State, has been honored by Penn State with the title of Atherton Professor. The University created the Atherton Professorship to recognize the continuing high level of scholarly or creative activity Evan Pugh Professors may pursue after their retirement.