This week, listen as the US debates covid-19, play a struggling survivor of an earthquake-torn city and discover how the planet gains from human progress slowing down

Russell Howard, Nish Kumar, Jon Richardson and others help 'landlady' Kiri Pritchard-Mclean host 'The Big Comedy Quiz at The Covid Arms' and break a Guinness World Record.

From a bunch of radishes to a sleeping cat, Parisian Agnes Goyet has turned to her life indoors for inspiration as France's coronavirus lockdown frees her up to pursue her hobby - art.

A London bus stop has been transformed into a children's art gallery by a local resident who wanted to brighten the drudgery of lockdown life, creating a colourful community hub amid the anxiety and isolation of the COVID-19 pandemic.

Cuba's artists are rising to the occasion during the coronavirus lockdown, taking to rooftops and balconies to create music or dance.

The head of the International Monetary Fund on Friday signaled a possible downward revision of global economic forecasts, and warned the United States and China against rekindling a trade war that could weaken a recovery from the coronavirus pandemic.

Mexican President Andres Manuel Lopez Obrador said on Friday he aims to present plans next week to reopen the economy, as key sectors like carmaking look to begin business again after over a month of quarantine measures to curb the coronavirus outbreak.

Two Humboldt penguins, Nacho and Goat, went on a field trip in the forest accompanied by their keepers at Oregon Zoo on Friday (May 1) in Portland, United States.

Russell Howard, Nish Kumar, Jon Richardson and others help 'landlady' Kiri Pritchard-Mclean host 'The Big Comedy Quiz at The Covid Arms' and break a Guinness World Record.

While most film and TV production around the world has shut down, one UK network has made a new drama series "Isolation Stories" about life under lockdown. Edward Baran reports.

Kate, Britain's Duchess of Cambridge, launched a project on Thursday to encourage Britons to submit pictures of their daily lives during lockdown. Edward Baran reports.

Dutch King Willem-Alexander urged all people in the Netherlands to stay at home on Monday, instead of flocking onto the streets clad in orange as they normally do for the annual celebration of Kingsday.

Kate, Britain's Duchess of Cambridge, launched a project on Thursday to encourage Britons to submit pictures of their current daily lives and the work of "Helpers and Heroes" to capture a snapshot of the nation in coronavirus lockdown.

Priest Don Giuseppe Castelvecchio hasn't been able to conduct services in his San Fiorano church for two months. In the town where restrictions are easing, his sermons delivered from a loud speaker in a car are a welcome relief. Joe Davies reports.

Syria's government allowed mosques to open on Friday for worshipers willing to perform prayers. The mosque had remained closed as part of the measures taken to contain the spread of coronavirus.

Russia marked 75 years since the Soviet victory over Nazi Germany in World War Two on Saturday, but the coronavirus outbreak forced it to scale back celebrations. Olivia Chan reports.

The coronavirus pandemic is making life feel slower than ever, but observing timescales across the universe can bring us some comfort, writes Chanda Prescod-Weinstein

Many people are turning to virtual therapy and mental health apps to cope with the stress of the coronavirus pandemic, but they may not be as helpful as talking face to face

People in lockdown are no longer trying to use technology to get their old lives back and that's a good thing, says Annalee Newitz

The S&P 500 and the Dow fell on Wednesday but the Nasdaq ended higher. The indexes pulled back late in the session after U.S. President Donald Trump said China may or may not keep a trade deal between the two countries. Fred Katayama reports.

Title: Asthma Sufferers Win When Coal Plants Shut Down
Category: Health News
Created: 4/16/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

Title: Study Downplays Risk of CT Scans
Category: Health News
Created: 5/1/2012 10:05:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: Nearby Lightning Shut Down a Woman's Brain Implant
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Title: FDA Cracks Down on Dangerous E-Cig Liquids That Resemble Cookies, Candy
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: Love in the Time of Coronavirus: Couples Feel the Strain of Lockdown
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM

Title: To Cut Down on Boozing, Offer Other Choices: Study
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

Title: Baby Boom After Pandemic Lockdowns? Maybe Not
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Researchers conducted nearly 1,500 online interviews and found that nearly 82% of those surveyed said they didn't plan to conceive during the coronavirus pandemic.

A large-scale update of the file names used for articles available via the PMC FTP service for bulk download was undertaken in early January 2017. The new file naming convention is PMCID-based (e.g., PMC4855680.tar.gz) rather than being built from article citation data (i.e., journal abbreviation_pub date_volume_issue_page). This update was made following user reports that the previous naming convention was resulting in missing contents in cases where citation data was duplicated across multiple articles. The new convention will ensure that file names are unique and that the corpus available via the FTP service is complete.

Title: Broiling in a Heat Wave? Wet T-shirt Can Safely Cool You Down
Category: Health News
Created: 4/13/2020 12:00:00 AM
Last Editorial Review: 4/14/2020 12:00:00 AM

ABSTRACT

Human immunodeficiency virus type 1 (HIV-1) establishes lifelong infections in humans, a process that relies on its ability to thwart innate and adaptive immune defenses of the host. Recently, we reported that HIV-1 infection results in a dramatic reduction of the cellular peroxisome pool. Peroxisomes are metabolic organelles that also function as signaling platforms in the innate immune response. Here, we show that the HIV-1 accessory protein Vpu is necessary and sufficient for the depletion of cellular peroxisomes during infection. Vpu induces the expression of four microRNAs that target mRNAs encoding proteins required for peroxisome formation and metabolic function. The ability of Vpu to downregulate peroxisomes was found to be dependent upon the Wnt/β-catenin signaling pathway. Given the importance of peroxisomes in innate immune signaling and central nervous system function, the roles of Vpu in dampening antiviral signaling appear to be more diverse than previously realized. Finally, our findings highlight a potential role for Wnt/β-catenin signaling in peroxisome homeostasis through modulating the production of biogenesis factors.

IMPORTANCE People living with HIV can experience accelerated aging and the development of neurological disorders. Recently, we reported that HIV-1 infection results in a dramatic loss of peroxisomes in macrophages and brain tissue. This is significant because (i) peroxisomes are important for the innate immune response and (ii) loss of peroxisome function is associated with cellular aging and neurodegeneration. Accordingly, understanding how HIV-1 infection causes peroxisome depletion may provide clues regarding how the virus establishes persistent infections and, potentially, the development of neurological disorders. Here, we show that the accessory protein Vpu is necessary and sufficient for the induction of microRNAs that target peroxisome biogenesis factors. The ability of Vpu to downregulate peroxisome formation depends on the Wnt/β-catenin pathway. Thus, in addition to revealing a novel mechanism by which HIV-1 uses intracellular signaling pathways to target antiviral signaling platforms (peroxisomes), we have uncovered a previously unknown link between the Wnt/β-catenin pathway and peroxisome homeostasis.

ABSTRACT

Reversible repression of HIV-1 5' long terminal repeat (5'-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency. Identification of host factors that modulate LTR activity and viral latency may help develop new antiretroviral therapies. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are known to regulate gene expression and possess multiple physiological functions. hnRNP family members have recently been identified as the sensors for viral nucleic acids to induce antiviral responses, highlighting the crucial roles of hnRNPs in regulating viral infection. A member of the hnRNP family, X-linked RNA-binding motif protein (RBMX), has been identified in this study as a novel HIV-1 restriction factor that modulates HIV-1 5'-LTR-driven transcription of viral genome in CD4⁺ T cells. Mechanistically, RBMX binds to HIV-1 proviral DNA at the LTR downstream region and maintains the repressive trimethylation of histone H3 lysine 9 (H3K9me3), leading to a blockage of the recruitment of the positive transcription factor phosphorylated RNA polymerase II (RNA pol II) and consequential impediment of transcription elongation. This RBMX-mediated modulation of HIV-1 transcription maintains viral latency by inhibiting viral reactivation from an integrated proviral DNA. Our findings provide a new understanding of how host factors modulate HIV-1 infection and latency and suggest a potential new target for the development of HIV-1 therapies.

IMPORTANCE HIV-1 latency featuring silence of transcription from HIV-1 proviral DNA represents a major obstacle for HIV-1 eradication. Reversible repression of HIV-1 5'-LTR-mediated transcription represents the main mechanism for HIV-1 to maintain latency. The 5'-LTR-driven HIV gene transcription can be modulated by multiple host factors and mechanisms. The hnRNPs are known to regulate gene expression. A member of the hnRNP family, RBMX, has been identified in this study as a novel HIV-1 restriction factor that modulates HIV-1 5'-LTR-driven transcription of viral genome in CD4⁺ T cells and maintains viral latency. These findings provide a new understanding of how host factors modulate HIV-1 infection and latency and suggest a potential new target for the development of HIV-1 therapies.

Recently, abundant evidence has clarified that long noncoding RNAs (lncRNAs) play an oncogenic or anticancer role in the tumorigenesis and development of diverse human cancers. Described as a crucial regulator in some cancers, MIR22HG has not yet been studied in laryngocarcinoma and therefore the underlying regulatory role of MIR22HG in laryngocarcinoma is worth detecting. In this study, MIR22HG expression in laryngocarcinoma cells was confirmed to be downregulated, and upregulated MIR22HG expression led to suppressive effects on laryngocarcinoma cell proliferation and migration. Molecular mechanism assays revealed that MIR22HG sponges miR-5000-3p in laryngocarcinoma cells. Besides, decreased expression of miR-5000-3p suppressed laryngocarcinoma cell proliferation and migration. Moreover, the FBXW7 gene was reported to be a downstream target gene of miR-5000-3p in laryngocarcinoma cells. More importantly, rescue assays verified that FBXW7 depletion or miR-5000-3p upregulation countervailed the repressive effects of MIR22HG overexpression on laryngocarcinoma progression. In addition, E2F6 was proved to be capable of inhibiting MIR22HG transcription in laryngocarcinoma cells. To sum up, E2F6-induced downregulation of MIR22HG promotes laryngocarcinoma progression through the miR-5000-3p/FBXW7 axis.

Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus. As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was comparable to 3 days of DAP plus ceftriaxone against all bacteria and to 3 days of DAP plus gentamicin against E. faecalis OG1RF.

Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multiple mouse models of cancer cachexia. Loss of Myoc alone was sufficient to induce phenotypes identified in mouse models of cancer cachexia, including muscle fiber atrophy, sarcolemmal fragility, and impaired muscle regeneration. By 18 months of age, mice deficient in Myoc showed significant skeletal muscle remodeling, characterized by increased fat and collagen deposition compared with wild-type mice, thus also supporting Myoc as a regulator of muscle quality. In cancer cachexia models, maintaining skeletal muscle expression of Myoc significantly attenuated muscle loss, while mice lacking Myoc showed enhanced muscle wasting. Furthermore, we identified the myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain of function significantly deterred cancer-induced muscle wasting and dysfunction in a preclinical model of pancreatic ductal adenocarcinoma (PDAC). Finally, compared with noncancer control patients, MYOC was significantly reduced in skeletal muscle of patients with PDAC defined as cachectic and correlated with MEF2c. These data therefore identify disruptions in MEF2c-dependent transcription of Myoc as a novel mechanism of cancer-associated muscle wasting that is similarly disrupted in muscle of patients with cachectic cancer.Significance:This work identifies a novel transcriptional mechanism that mediates skeletal muscle wasting in murine models of cancer cachexia that is disrupted in skeletal muscle of patients with cancer exhibiting cachexia.

In the third quarter of 2019, condotel and resort villa market saw both supply and consumption falling by double digits since the ‘Ghost month’ made investors hesitate.

The Vietnam’s real estate market has clearly seen signs of a downturn in many segments since the beginning of 2018. So how to gain profit from your realty investment?

गुजरात से 1200 श्रमिकों को लेकर स्पेशल ट्रेन पहुंची कासगंज

भारतीय सिनेमा में बाहर से जितनी चकाचौंध दिखती है, अंदर जाकर उतना ही अंधेरा है। यहां पर स्टार किड्स के लिए रास्ता तो बहुत आसान है लेकिन जिनका इस इंडस्ट्री से कोई लेना देना नहीं रहा है

कोरोना वायरस की वजह से पूरे भारत में लॉकडाउन लागू है। इसके चलते लोगों को परेशानियां तो हो ही रही हैं। जो लोग अपने घर हैं और आसपास का माहौल कुछ हद तक ठीक है, वे तो फिर भी ठीक हैं। लेकिन, बाहर फंसे लोगों के लिए तो ये मुश्किलों भरा वक्त है।

कोरोना वायरस के चलते पूरे देश में जारी लॉकडाउन की वजह से 25 मार्च से बंद पड़े रेस्टोरेंट, क्लब और बार आदि को कर्नाटक सरकार ने राज्य में शराब की थोक कीमत पर बिक्री करने की अनुमति दे दी है।

श्रम मंत्री हरक सिंह का कहना है कि 15 दिन के अंदर ही यह धनराशि श्रमिकों के खातों में पहुंच जाएगी

बिहार सरकार से डाकघर में खुले खाते में आर्थिक मदद की आस लगाए श्रमिक पोस्ट ऑफिस में इंडियन पोस्ट पेमेंट बैंकिंग (आईपीपीबी) का खाता खुलवाने पहुंच रहे हैं।

उत्तराखंड बोर्ड की परीक्षाएं इसी महीने हो सकती हैं। वहीं बोर्ड का रिजल्ट भी 10 जून से पहले घोषित किया जा सकता है।

कोरोना लॉकडाउन के दौरान पैदा हुई मुश्किलों को आसान करने के लिए देहरादून के युवाओं ने कुछ अलग किया है।

अस्थि विर्सजन से रोक हटने से कई लोगों ने राहत की सास ली है। वे अब श्मशान घाटों में रखीं परिजनों की अस्थियों को गंगा में विर्सजित कर सकेंगे।

उत्तराखंड में पूर्व सैनिकों के लिए अब सेना की कैंटीनों में शराब उपलब्ध कराई जाएगी।

प्रदेश के ऐसे लोग जो दूसरे राज्य में नौकरी या अन्य काम करते हैं और निजी वाहन से जाना चाहते हैं, वह http://smartcitydehradun.uk.gov.in/e-pass पर आवेदन कर ई-पास बनवा सकते हैं।

अन्य राज्यों में फंसे प्रवासियों को उत्तराखंड लाने के लिए अब 10 मई से स्पेशल ट्रेनें नहीं चलेगी। ये ट्रेन कब से चलेंगी अभी यह तारीख तय नहीं है।