A shaping machine system including a shaping device and a computer is provided. The shaping device includes at least one jig mount body configured for mounting a jig; a shaping tool support body configured for supporting a shaping tool; a first drive device configured for rotating the shaping tool; and a second drive device configured for driving the shaping tool support body or the at least one jig mount body or changing a posture of the shaping tool relative to the workpiece. The computer is configured for controlling the first and second drive devices according to predetermined shaping data. The computer includes a jig position measuring unit configured for measuring a position of the jig; a position error detecting unit configured for detecting a position error of the jig, and a shaping data correcting unit configured for correcting the predetermined shaping data according to a jig position error.

A tool handling device for machine tools, comprising a tool magazine having a transfer position for the transfer of the tools, including a tool changer movable between the transfer position and an exchange position, which has a rotatable double gripper, and a supporting structure movable on a foundation, on which the tool changer is mounted. In order to achieve fast tool changes in tight spaces on the machine, the supporting structure has an upper slide and a lower slide which can both be displaced by means of spindle drives in the same direction on a foundation, wherein a single drive motor is provided for driving the two spindle drives.

Method for a memory including a first, second, third and fourth cells include applying a read, program, or erase voltage, the first and second cells coupled to a first top interconnect, the third and fourth cells coupled to a second top interconnect, the first and third cells coupled to a first bottom interconnect, the second and fourth cells are to a second bottom interconnect, each cell includes a switching material overlying a non-linear element (NLE), the resistive switching material is associated with a first conductive threshold voltage, the NLE is associated with a lower, second conductive threshold voltage, comprising applying the read voltage between the first top and the first bottom electrode to switch the NLE of the first cell to conductive, while the NLEs of the second, third, and the fourth cells remain non-conductive, and detecting a read current across the first cell in response to the read voltage.

A horizontal machining center includes: a table driven in first and second directions (directions indicated by arrows 530p and 530q, respectively) allowing the table to approach and move away from a spindle, respectively; a magazine having a plurality of tool gripping claws; and a coupling mechanism for coupling the table and the magazine together and moving the magazine in one of the first and second directions when the table is driven in the other of the first and second directions. When a tool attached to the spindle is removed from the spindle, the table is driven in the first direction, and when a tool accommodated by the magazine is attached to the spindle, the table is driven in the second direction. A horizontal machining center having a simple structure and prevented from having a bulky structure can thus be accomplished.

A machine tool having a turning function and a milling function includes a spindle, a spindle housing supporting the spindle in a rotatable manner, a main clamp provided at the spindle, an auxiliary clamp provided at the spindle housing, and a double arm with a first gripper and a second gripper. The auxiliary clamp clamps a tool holder together with the main clamp during fixing a fixed tool. The double arm exchanges a tool holder grasped at the first gripper for another tool holder grasped at the second gripper by rotating and sliding movements. The auxiliary clamp is arranged at a position not interfering with the double arm that moves during exchanging tool holders. By such a configuration, a machine tool achieving a clamping force sufficient to withstand the load during a turning process, and that allows tool exchange in a short period of time, and a tool holder employed in such a machine tool, can be provided.

The invention relates to a machine tool (1), comprising a plurality of fixed tool spindles (3) and such that can optionally be displaced from a retracted idle position to an extended working position and can be positioned at different positions in a frame-like rack (2), and a workpiece carrier (4) with at least one workpiece holder (5), with the workpiece (4) carrier being movable at least in several axes in a translational manner and preferably also in a rotational manner. In order to provide advantageous constructional conditions it is proposed that at least one of the tool spindles (3) is associated with a tool magazine (7) plus tool changer (8).

There is provided a component mounting apparatus, which includes: a nozzle which sucks a component; a nozzle supporting member, on which the nozzle is installed, which moves in a vertical direction with respect to an upper surface of a substrate on which the component sucked at the nozzle is mounted; an optical system which captures an image of a leading edge portion of the nozzle where the component is sucked in a component mounting operation, from a side direction, such that an optical axis of the optical system is inclined at a predetermined angle with respect to a sucking surface of the nozzle; and an analyzer which analyzes the image of the leading edge portion to determine whether a sucking state of the component sucked by the nozzle is normal or abnormal.

Device for managing the electrodes for electrical discharge machining EDM machine tools comprises at least one magazine (1) that has a series of individual housings (33) designed to accept and hold exchangeable elements (5) consisting of electrodes (6, 22) mounted on an electrode holder (11a, 11b), and a changer device (2) equipped with a gripper (2) intended to move the exchangeable elements (5) from the individual housings (33) towards the machine and vice versa. A first adapter piece (21) is associated with each of the exchangeable elements (5). This adapter piece (21) surrounds the electrode holder (11a, 11b) and is gripped around its periphery by the gripper (9) of the changer (2) so as to guarantee that the exchangeable element (5) is held precisely. The device further comprises a second adapter piece (32) associated with each of the individual housings (33) of the magazine (1) that are likely to be used.

A section member drilling or milling machine comprises a machine bed for supporting a workpiece to be drilled, the machine bed including guides for controllably sliding thereon a support comprising precision vertical guides thereon a platform is engaged, the platform comprising parallel horizontal guides slidably supporting a carriage, in turn supporting a cantilever arm, including a driving motor for controllably driving a drilling and milling tool along parallel guides of the cantilever arm.

A tool changing device for a cutting head of a machine for cutting flat glass sheets, the tool changing device comprising: a bridge; a carriage for supporting the cutting head, the carriage being slidingly attached to the bridge for translation along the bridge; an electric motor that provides for translational motion of the carriage with respect to the bridge; and a tool supporting slider, which is configured to support a plurality of tools such that the tools can be automatically exchanged between the tool supporting slider and the cutting head, the tool supporting slider coupled, by way of reversible fixing elements to the cutting head supporting carriage during work by the cutting head, and wherein the tool supporting slider is uncoupled from the cutting head supporting carriage during tool changing operations.

A tool radius adjusting device executes an operation for adjusting the tool radius of a boring holder in parallel with execution of a machining program for executing an operation of a spindle head and an operation of a tool changer. A carrier control unit determines whether the tool changer is executing a tool changing process. When the tool changing process is not being executed, the carrier control unit allows the carrier device to execute an operation for picking the boring holder out from the tool magazine and an operation for returning the boring holder, of which the tool radius has been adjusted, to the tool magazine.

Loads that act on all the bearings that support a main spindle are derived from a variation in the state of the main spindle and, in addition, raceway surface contact pressures of the respective bearings are analyzed, so it is possible to accurately keep track of the state of each bearing. Then, when the raceway surface contact pressure exceeds a corresponding threshold, a machining condition is changed to execute control such that the raceway surface contact pressure does not exceed the corresponding threshold, and, furthermore, when the raceway surface contact pressure exceeds the corresponding threshold even when the machining condition is changed, the main spindle is controlled to stop, so it is possible to prevent a seizure of each bearing. Thus, it is possible to improve machining accuracy by controlling the main spindle with high accuracy.

In a multitasking machine tool, a first tool post including a tool spindle configured to allow a tool to be detachably attached thereto is configured to be slidable in predetermined directions, while a second tool post is configured to allow a tool to be detachably attached thereto. A tool-change part includes at least one gripper configured to hold a tool to be attached to the second tool post. An automatic tool changer is configured to detachably attach the tool-change part (as well as to change the tool installed) to the tool spindle of the first tool post positioned in a first tool-change region. Change of the tool attached to the second tool post is carried out by a motion (sliding and/or rotation of the tool spindle) of the first tool post (with the tool-change part attached to the tool spindle thereof) located in a second tool-change region.

In a combination machining lathe, a workpiece holding device holds a workpiece in a manner that permits the workpiece to rotate around an axis parallel to a direction of a horizontal Z axis. A tool post holds a tool that comprises a holder and a bit. The tool held by the tool post is indexed to a position in which the longitudinal axis of the holder is parallel to an X axis direction. The bit of the tool held by the tool post is angled such that a longitudinal axis of the bit is disposed in a position tilted away from the X axis direction closer to a horizontal axis in a plane containing the X axis and the Y axis. A turning operation is performed while the tool and/or the workpiece are moved relative to each other in a direction of the longitudinal axis of the bit.

Methods and systems for decoding a signal include compensating for impairments in a received signal using at least carrier phase estimation, where residual phase error remains after compensation; calculating symbol log-likelihood ratios (LLRs) for symbols in the compensated signal using Monte Carlo integration; demapping the symbols in the compensated signal using the symbol LLRs and extrinsic information from signal decoding to produce one or more estimated codewords; and decoding each estimated codeword with a decoder that generates a decoded codeword and extrinsic information.

The invention provides optical interconnects of data-processing cores of multicore chips by means of digital planar holographic microchips. The method comprises delivering “N” laser lights to “N” data-processing cores on the host chip, coding the obtained optical signals by modulating them with the core-generated data, and then delivering the modulated and coded optical signals to a holographic microchip formed on the same substrate of the host chip as the data-processing cores, splitting the modulated and coded optical signals into (N−1)N modulated optical copy signals, delivering the copy signals to all data-processing cores except the one that generates the copy signals, and decoding the data obtained from the output signals delivered to the processing cores by the receivers. The method is efficient in that it allows replacing electrical interconnects between the cores with optical interconnects and can be matched to current semiconductor production technology.

Milling cutter and method of operating same, and other machine tools, and an adjustment mechanism therefor. A cutting insert is adjusted by moving a resilient web with an adjusting screw.

A cutting insert of the present invention includes an upper surface; a lower surface; a side surface; a cutting edge which is located along an intersection of the upper surface and the side surface, and comprises a major cutting edge, a flat cutting edge, and a minor cutting edge located between the major cutting edge and the flat cutting edge; and a land part located along the cutting edge on the upper surface. The land part includes a minor cutting edge land portion located correspondingly to the minor cutting edge. The minor cutting edge land portion is inclined downward toward a central part of the upper surface. The present invention also provides a cutting tool including the cutting insert, and a method of manufacturing a machined product by using the cutting tool.

A cutting insert has at least first and second side surfaces, with a chip-control arrangement. The chip-control arrangement includes at least one projection disposed at an intersection of a corner of the cutting insert. When the chip-control arrangement includes two projections they can be disposed symmetrically on both sides of the intersection. Each of the at least one projections is elongated and extends longitudinally along an associated side surface.

A cutting tool includes a polygonal cutter body and an end cutting insert for chipforming machining mounted in a serrated seat disposed at an axial end of the cutter body. A bottom surface of the insert has a plurality of parallel serrations meshing with corresponding serrations of the seat. The serrations extend transversely relative to the longitudinal axis for resisting axially rearward cutting forces applied to the insert. The seat is formed directly by the cutter body, or by a shim disposed beneath the insert. The shim is provided with a downward lip to transfer axial forces to the cutter body. The insert can be square or triangular, wherein the serrations are in the form of a plurality of sets of parallel serrations disposed adjacent respective cutting edges.

A cutting insert includes an upper surface; a lower surface; a side surface which is connected to each of the upper surface and the lower surface and includes a first side surface, a second side surface and a third side surface being adjacent to each other in order; an upper cutting edge including an upper major cutting edge located at an intersection of the upper surface and the first side surface, and an upper flat cutting edge located closer to the upper major cutting edge in an intersection of the upper surface and the second side surface; and a lower cutting edge including a lower major cutting edge located at an intersection of the lower surface and the third side surface, and a lower flat cutting edge located closer to the lower major cutting edge in an intersection of the lower surface and the second side surface. The second side surface comprises an upper flank surface connected to the upper flat cutting edge, and a lower flank surface connected to the lower flat cutting edge. As going from the upper surface to the lower surface, the upper flank surface is closer to a central axis extending between the upper surface and the lower surface and the lower flank surface is separated from the central axis in a side sectional view. A cutting tool including the cutting insert, and a method of manufacturing a machined product by using the cutting tool are also provided.

In a cutting tool for chip removing machining a holder for a cutter has a body received therein and movable with surfaces to bear against the cutter for defining the position of the cutter in the direction of an intended axis of rotation of the holder as well as a screw which may be screwed in a threaded bore in the holder. Spring members are arranged to act between the holder and the body for biasing the body against said screw portions.

A cutting insert having excellent chip discharge performance is provided. The cutting insert (1) according to an embodiment of the present invention includes an upper surface (2), a lower surface (3), a side surface (4) connected to the upper surface (2) and the lower surface (3), and a cutting edge (5) which is located at an intersection of the upper surface (2) and the side surface (4), and includes a major cutting edge (51) and a flat cutting edge (52). The major cutting edge (51) includes a major cutting section (512) which has a concave shape and is inclined downward as a straight line connecting both ends thereof is away from the flat cutting edge (52) in a side view. A cutting tool (11) according to an embodiment of the present invention includes the cutting insert (1) and a holder (10) configured to attach the cutting insert (1) thereto.

A cutting insert according to an embodiment of the present invention includes an upper surface; a lower surface; a side surface located between the upper surface and the lower surface; at least one concave part extending in a thickness direction in the side surface, and having one end thereof located at the upper surface; and a cutting edge which is located at an intersection region of the upper surface and the side surface, and is divided into a plurality of divided cutting edges with the at least one concave part interposed therebetween. The upper surface includes a first raised part located inwardly of the at least one concave part, and a plurality of second raised parts respectively located inwardly of the plurality of divided cutting edges. The plurality of the second raised parts are located inward compared to one end of the first raised part close to the cutting edge in a top view. A cutting tool including the cutting insert, and a method of manufacturing a machined product using the cutting tool are also provided.

A cutting insert according to an embodiment of the invention includes: an upper surface; a lower surface; a side surface which is connected to each of the upper surface and the lower surface, and includes a first side surface and a second side surface adjacent to each other; and a cutting edge including a major cutting edge located at an intersection of the upper surface and the first side surface, and a minor cutting edge located at an intersection of the upper surface and the second side surface. The upper surface includes a rake surface which is located along the major cutting edge, and is inclined downward as the upper surface separates from the major cutting edge. The second side surface includes a second upper constraining surface and a second lower constraining surface in order as the second side surface goes from the upper surface to the lower surface. The second upper constraining surface is inclined inward at an inclination angle α1 with reference to a central axis extending between the upper surface and the lower surface. The second lower constraining surface is continuous with the second upper constraining surface, and is inclined outward at an inclination angle α2 with reference to the central axis. A cutting tool with the cutting inserts, and a method of manufacturing a machined product by using the cutting tool are also provided.

A rotary cutting tool, such as a milling cutter (10) includes a central hub (12), a cutting rim (14) and a plurality of spokes (22) connecting the central hub (12) to the cutting rim (14). Each spoke (22) is separated by an opening (32) and polygonal in cross-sectional shape formed by two side walls (22a, 22b), two front walls (22c, 22d) and a rear wall (22e). One of the side walls (22a) of each spoke (22) is formed at a pitch angle (42) with respect to a central axis (11) of the cutting tool (10) that is sufficient to cause lift of chips through the opening (32), thereby providing effective chip evacuation during a material removal operation.

A roughing end mill comprises an end mill body and plural inserts which are placed on an outer circumference of the end mill body with a predetermined distance apart from each other in the axial direction of the end mill body, wherein the plural inserts form plural insert rows which are provided in a circumferential direction of the end mill body, where the inserts are offset in the axial direction from each other between the different insert rows which are adjacent in the circumferential direction. The inserts have waveform cutting edges which face towards an outer circumferential side of the end mill body. One insert of one insert row and an insert of another insert row are positioned such that the waveform cutting edges of each of these inserts make up a waveform cutting edge row whose phase is continuous on a rotation trajectory around the axis.

A cutting insert (14) is formed with an insert aperture (32) opening out to insert top and bottom surfaces (14A, 14B) of the cutting insert (14). In a plan view of the insert top surface (14A), the cutting insert (14) and the insert aperture (32) both have oblong shapes which are elongated along a common insert longitudinal axis (AIL). The aperture (32) includes first and second side surfaces (32A1, 32A2) which each extend along the insert longitudinal axis (AIL), and aperture first and second end surfaces (32B1, 32B2) which each extend transverse relative to the insert longitudinal axis (AIL). At least one of the aperture first and second end surfaces (32B1, 32B2) is formed with a clamping lip (32C1, 32C2).

A projection exposure tool for microlithography for imaging mask structures of an image-providing substrate onto a substrate to be structured includes a measuring apparatus configured to determine a relative position of measurement structures disposed on a surface of one of the substrates in relation to one another in at least one lateral direction with respect to the substrate surface and to thereby simultaneously measure a number of measurement structures disposed laterally offset in relation to one another.

A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide two- to five-dimensional fluorescence images of samples, including two or three spatial dimensions, a spectral dimension (for fluorescence emission), and a temporal dimension (on a scale of less than approximately one second). Two-dimensional (spatial) images with a complete wavelength spectrum are generated from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The line scans may be formed using one or more of curved mirrors and lenses. The multiple beams may be formed using one of a grating, an array of lenses, and a beam splitter.

A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.

A switching circuit (400) comprising an inductive component (406) including at least one winding; and a switch (404) is configured to transfer power from a voltage source (402) to the inductive component (406) in accordance with a switch control signal (412). The switching circuit (400) also comprises a controller (408) configured to integrate the voltage across the inductive component (406) in order to generate a signal representative of magnetic flux in the inductive component (406); and use the signal representative of the magnetic flux in the inductive component to account for a peak magnetization current value in order to control the switch (404).

Provided is a configuration in which it is possible to mount an applied voltage suppression circuit configured to prevent voltage breakdown of a semiconductor switching element, and a set voltage thereof can be inspected without damaging an IC or the like of a peripheral circuit. In a power converter having a semiconductor switching element, an applied voltage suppression circuit configured to suppress a voltage applied to the semiconductor switching element and at least one component of constituent components of a driving circuit which causes the semiconductor switching element to be turned off if the component is absent are transferred to and disposed on a slave substrate (separate unit) which is divided from and electrically connected to a master substrate including the semiconductor switching element, the driving circuit, a control circuit, and the like mounted thereon.

A switching power converting apparatus includes a coil unit, a bipolar junction transistor (BJT) controlling power transfer through the coil unit, and a current sensing resistor sensing a current flowing through the BJT so as to produce a sensed voltage thereacross. A switching controller includes a current source supplying a first current, a current generating module generating, based on an input voltage associated with the sensed voltage, a second current, which is proportional to the current flowing through the BJT, a multiplexing module selecting one of the first and second currents as an output current, and a driving module outputting, based on the output current, a driving current, which is proportional to the output current, to the BJT to thereby conduct the BJT.

A flyback type switching power supply includes between P and N of a direct current output a sudden load change detector circuit, which normally has no power consumption, that detects only a transient fluctuation of a direct current output voltage, and starts the switching of a primary side semiconductor switch when there is no load or a light load, even when the semiconductor switch is in an off state, thereby enabling the detection of the direct current output voltage in a tertiary winding, and suppressing a drop in the direct current output voltage.

Methods and systems for managing link voltages in a power converter, where single phase, three phase or universal systems can be used. Common mode management refers to shifting of voltages in a particular direction to perform transition between input and output ports, in addition to maintaining soft switching property. Voltages in power converters can be freely increasing and decreasing, and thus damage to the circuit can be caused if these voltages change are not controlled.

A high voltage full wave rectifier and doubler circuit having complementary serially connected low voltage MOSFET stacks to provide high voltage capability. The state of the MOSFETs in the MOSFET stacks is controlled by means of resistors coupled between the circuit's outputs and a time varying input signal. The resistance values of the resistors are selected to maintain operation of the stacked MOSFETs below their breakdown voltages.

System and method for regulating a power converter. A system for regulating a power converter includes a controller, a first switch, and a second switch. The controller is configured to generate a first switching signal and a second switching signal. The first switch is configured to receive the first switching signal, the first switch being coupled to an auxiliary winding of the power converter further including a primary winding and a secondary winding. The second switch is configured to receive the second switching signal and coupled to the primary winding of the power converter. The controller is further configured to, change, at a first time, the second switching signal to open the second switch, maintain, from the first time to a second time, the first switching signal to keep the first switch open, and change, at the second time, the first switching signal to close the first switch.

A device and method for using the device arranged to maintain anatomical alignment between a joint by creating a dynamic load around the joint to restore and maintain the anatomical alignment. The orthotic device uses a hinge to create a directed force on a tibia by maintaining misalignment of an instant center of rotation (ICoR) of the hinge at a position relative to an anatomical knee joint.

An adjustable hinge having a first support arm, a second support arm, and a deformable insert that is between the first support arm and the second support arm.

A wound dressing including a hydrophilic layer and a hydrophobic layer is described. The hydrophilic layer absorbs exudate from a wound and the hydrophobic layer absorbs the exudate from the hydrophilic layer and traps the exudate. Because the hydrophilic layer is used adjacent to the wound, the exudate is readily absorbed thereby reducing the risk of maceration and infection of the wound tissue by the exudate. The hydrophobic layer receives the absorbed exudate from the hydrophilic layer and traps the exudate through an interaction that in turn prevents lateral diffusion of the exudate through the bandage to healthy portions of the skin. The hydrophilic and hydrophobic layers are fabricated from polymer fibers that can be spun to include components that facilitate wound healing, such as poly(hexamethylene biguanide) and/or hyaluronic acid.

The present invention relates to a vehicular air cleaner. A DOR (Direct Ozone Reduction) system for suppressing deterioration of a purifying function of an ozone purifying material is provided. Active oxygen is produced by an ozone purifying function of activated carbon. The probability that the active oxygen contacts with a fin of a radiator on a rear surface side is higher than that on a front surface side of the radiator. Accordingly, the activated carbon on the rear surface side of the radiator is easily oxidized as compared with the activated carbon on the front surface side. Therefore, in the fin, a coating amount of the activated carbon on the front surface side of the radiator is adjusted to be larger than a coating amount of the activated carbon on the rear surface side. Thus, the probability that the active oxygen contacts with the activated carbon can be reduced.

Oil compositions having a high concentration of polyunsaturated fatty acids are described for use in various applications including use as drying oils, in ink compositions and coating compositions. Oil compositions wherein the double bonds of the fatty acids are substantially epoxidized are described and used as plasticizers and thermal stabilizers for various halogenated polymer compositions.

Disclosed are soil additives capable of hydrophilizing soil particles and/or increase available water capacity in soil. The soil additive are capable of increasing the available water content/capacity (AWC) in soils, the additive in one embodiment comprising a polymer composition having a hydrophilic portion and a hydrophobic portion, wherein the hydrophobic portion of the copolymer binds with the soil particle surface and the hydrophilic portion of the copolymer can bind with water. This results in the prevention, arrest or decelerated loss of water from the targeted area, for example the plant root zone, which allows for improved water usage efficiency by plants, grasses, vegetation, etc.

Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.

An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.

A modular, adjustable, prosthetic hip/shoulder spacer adapted to being implanted in the hip or shoulder joint; the spacer comprises a frame that supports a rotatable cylinder from which a neck extends with the ball element of the joint attached to its end, and rotating the cylinder reposition the ball in the socket; the stem is connected to the base of the frame and is implanted in the long bone (femur or humerus); the stem may be modified to include a system for delivering medication to the implantation site following surgery. The stem leg and stem base may be modified to form a modular unit to adjust the relation between a center line of the stem leg and a center line of the frame and position of the neck and ball.

An implantable medical device for implantation in a hip joint of a human patient is provided. The medical device comprises: at least one artificial hip joint surface adapted to replace at least the surface of at least one of the caput femur and acetabulum. At least one artificial hip joint surface comprises: a positioning hole with at least one opening in said at least one artificial hip joint surface. The hole is adapted to be placed and dimensioned such that the medical device is adapted to be fitted using a positioning shaft and at least partly surround the shaft, for positioning the at least one artificial hip joint surface in a desired position in the hip joint. The hole is adapted to be fitted using the positioning shaft, when the shaft is stabilized and placed in at least one of the femoral bone and the pelvic bone for positioning said medical device inside the hip joint.

The present invention provides a switching element that has a stable bistable characteristic and a high transition voltage and demonstrates excellent cyclic performance. The switching element has two stable resistance values with respect to the voltage applied between electrodes, wherein a first electrode layer, an organic bistable material layer, and a second electrode layer are successively formed as thin films on a substrate and the organic bistable material constituting the organic bistable material layer is a quinomethane-based compound or a monoquinomethane-based compound. A metal constituting the second electrode layer is diffused into the organic bistable material layer. It is preferred that the second electrode layer be formed by vapor deposition and the temperature of the substrate during the vapor deposition be 30-150° C.

A breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative or a salt thereof.