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Novel ADC continues on path to blockbuster status

Tokyo’s Daiichi Sankyo has submitted a supplemental New Drug Application (sNDA) for trastuzumab deruxtecan…



  • Asia Pacific/AstraZeneca/Biotechnology/Daiichi Sankyo/Enhertu/Focus On/Japan/Oncology/Regulation/Research/trastuzumab deruxtecan/UK

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Half of Spaniards will see lockdown eased from Monday as death toll falls

Spain's daily death toll from the coronavirus fell to its second lowest since mid-March on Saturday, as half the country prepared to move to the next phase of an exit from one of Europe's strictest lockdowns.




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United States Files Suit Against Missouri-Based Pharmaceutical to Block Manufacturing and Shipping of Unapproved Drugs

The United States has filed a lawsuit to block KV Pharmaceutical Company, its subsidiaries, ETHEX Corp. and Ther-Rx Corp., and its principal officers from making and distributing adulterated and unapproved drugs. At the same time, KV agreed to the injunction in a consent decree.



  • OPA Press Releases

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Federal Court Blocks Chicago Tax Preparation Firm from Claiming Improper Tax Credits

A federal court has barred a Chicago tax preparation firm, El Caminante, Inc. and its principal operator, Maria Colica, from preparing federal income tax returns claiming false tax credits. The company and Colica agreed to the injunction. The Government civil injunction complaint filed in the case alleged that Colica fraudulently claimed fuel tax credits for customers who were not entitled to them.



  • OPA Press Releases

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Government Files Seven Lawsuits Nationwide to Block Alleged Scheme Involving Fraudulent Tax-Refund Claims

The federal suits – filed in Los Angeles; Panama City, Fla.; Salt Lake City; Nashville, Tenn.; and Pocatello, Idaho – allege that the defendants promote a tax fraud scheme designed to siphon hundreds of millions of dollars from the U.S. Treasury through fraudulent tax refund claims.



  • OPA Press Releases

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Federal Court Permanently Blocks Tennessee Woman from Preparing Federal Tax Returns for Others

A federal court has issued a permanent injunction barring Karen Liane Miller of Nashville, Tenn., from preparing federal income tax returns for others.



  • OPA Press Releases

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Justice Department Sues to Block Alleged $15 Million Dollar Tax Fraud Scheme Operating in Southern California

The United States has sued a father and two sons, all of Huntington Beach, Calif., seeking to bar them and their business from preparing federal tax returns for others.



  • OPA Press Releases

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Justice Department Reaches Settlement with Blockbuster Inc. Under the Americans with Disabilities Act

The Justice Department today announced a settlement agreement under the Americans with Disabilities Act (ADA) with Blockbuster Inc. to ensure equal access to its stores nationwide for individuals with disabilities who use service animals.



  • OPA Press Releases

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Attorney General Expresses Opposition to Legislation Blocking Transfer of Guantanamo Detainees

Attorney General Eric Holder wrote to Senate Majority Leader Harry Reid and Senate Minority Leader Mitch McConnell today in opposition to language in the proposed 2011 Full-Year Continuing Appropriations Act.



  • OPA Press Releases

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Lockheed Martin to Pay $2 Million to Resolve Allegations Resulting from Fraudulent Submission of Government Contract

Lockheed Martin Inc. has reached a $2 million settlement with the United States to resolve False Claims Act claims in a whistleblower suit.



  • OPA Press Releases

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Justice Department Reaches Americans with Disabilities Act Settlement with H&R Block

The Justice Department today announced a comprehensive settlement agreement under the Americans with Disabilities Act with HRB Tax Group Inc., H&R Block Tax Services LLC and HRB Advance LLC (H&R Block) to ensure effective communication with individuals who are deaf or hard of hearing in the provision of income tax preparation services and courses at more than 11,000 owned and franchised offices nationwide.



  • OPA Press Releases

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U.S. Sues Two California Lawyers & Kentucky Financial Professional to Block Nationwide Promotion of "Intermediary Transaction" Tax Shelter

The United States has sued two Southern California attorneys and a Kentucky financial professional to bar them from promoting an allegedly abusive tax shelter known as an “intermediary transaction.”



  • OPA Press Releases

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Justice Department Files Antitrust Lawsuit to Stop H&R Block Inc. from Buying TaxACT

The Department of Justice filed a civil antitrust lawsuit today to block the proposed acquisition by H&R Block Inc. of TaxACT, a digital do-it-yourself tax preparation software provider.



  • OPA Press Releases

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Assistant Attorney General Christine Varney Holds Conference Call Regarding Justice Department Lawsuit to Stop H&R Block Inc. from Buying TaxACT

"We are blocking this transaction because the proposed merger would substantially lessen competition in the tax preparation software market, resulting in higher prices, lower quality and reduced innovation," said Assistant Attorney General Varney.




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Justice Department Files Lawsuit Against City of New Berlin, Wisconsin, for Blocking Affordable Housing

The Department of Justice announced today that it has filed a lawsuit against the city of New Berlin, Wis., alleging that the city violated the Fair Housing Act by repeatedly taking action to prevent the construction of an affordable housing development by a private developer, MSP Real Estate Inc.



  • OPA Press Releases

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Justice Department Files Antitrust Lawsuit to Block AT&s Acquisition of T-Mobile

The Department of Justice today filed a civil antitrust lawsuit to block AT&s proposed acquisition of T-Mobile USA Inc.



  • OPA Press Releases

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Justice Department Sues U.S. FDA Employee and Former N.Y. Corrections Official to Block Alleged Tax-Fraud Scheme

The United States has sued Rodney Chestnut and Nafeesah Hines to bar them from promoting an alleged tax fraud scheme.



  • OPA Press Releases

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US Files Lawsuit in Miami to Block Promotion of Tax Fraud Scheme

The United States has sued Sharon Angulo and Claudia Zuloaga to bar them from promoting an alleged tax fraud scheme and from preparing federal tax returns for others.



  • OPA Press Releases

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California Federal Court Blocks Bogus Tax Credit Scheme

A federal court in Los Angeles has permanently barred Lamar Ellis of Brea, Calif., from promoting a scheme involving sales of bogus federal tax credits.



  • OPA Press Releases

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Lockheed Martin Corporation Reaches $15.85 Million Settlement with U.S. to Resolve False Claims Act Allegations

Lockheed Martin Corporation has agreed to pay $15,850,000 to settle allegations that it mischarged perishable tools used on numerous government contracts.



  • OPA Press Releases

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Justice Department Settles Lawsuit Against City of New Berlin, Wisconsin, for Blocking Affordable Housing

The Department of Justice announced today that it has settled its lawsuit against the city of New Berlin, Wis., for race discrimination in violation of the Fair Housing Act.



  • OPA Press Releases

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Justice Department Settles Lawsuit Against Sussex County, Delaware, for Blocking Affordable Housing

The Justice Department announced today that it has settled a lawsuit against Sussex County, Del., and the Planning and Zoning Commission of Sussex County for race and national origin discrimination in violation of the Fair Housing Act.



  • OPA Press Releases

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Justice Department Sues Nevada CPA to Block Promotion of Alleged Tax Fraud Scheme

The United States has sued a Las Vegas-based CPA and two others to stop an alleged tax-fraud scheme, the Justice Department announced today. Named as defendants in the civil injunction suit were CPA Wayne Reeves, Reeves’ wife, Diane Vaoga, and their alleged co-promoter, James Stoll. The government complaint was filed last month in Las Vegas with the U.S. District Court for the District of Nevada. Announcement of the court filing was delayed until Reeves was served with court papers this week.



  • OPA Press Releases

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Justice Department Enters Consent Decree with National Tax Preparer H&R Block Requiring Accessibility of Websites and Mobile Apps Under Americans with Disabilities Act

Acting Assistant Attorney General Jocelyn Samuels of the Civil Rights Division and U.S. Attorney Carmen M. Ortiz of the District of Massachusetts announced today that they have entered into a consent decree with HRB Digital LLC and HRB Tax Group Inc., subsidiaries of H&R Block Inc., to remedy alleged violations of the Americans with Disabilities Act.



  • OPA Press Releases

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U.S. Leads Multi-National Action Against “Gameover Zeus” Botnet and “Cryptolocker” Ransomware, Charges Botnet Administrator

The Justice Department today announced a multi-national effort to disrupt the Gameover Zeus Botnet – a global network of infected victim computers used by cyber criminals to steal millions of dollars from businesses and consumers – and unsealed criminal charges in Pittsburgh, Pennsylvania, and Omaha, Nebraska, against an administrator of the botnet.



  • OPA Press Releases

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Assistant Attorney General Leslie R. Caldwell Delivers Remarks for the Gameover Zeus and Cryptolocker Operations and Related Criminal Charges

Evgeniy Bogachev and the members of his criminal network devised and implemented the kind of cyber crimes that you might not believe if you saw them in a science fiction movie. By secretly implanting viruses on computers around the world, they built a network of infected machines – or “bots” – that they could infiltrate, spy on, and even control, from anywhere they wished.




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Deputy Attorney General James Cole Delivers Remarks at Press Conference for Gameover Zeus and Cryptolocker Operations

Today, we are here to announce that, over the weekend, the Department disrupted two extremely damaging cyber threats – the financial botnet known as Gameover Zeus and the malicious software known as Cryptolocker.




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Department of Justice Provides Update on Gameover Zeus and Cryptolocker Disruption

The Justice Department today filed a status report with the United States District Court for the Western District of Pennsylvania updating the court on the progress in disrupting the Gameover Zeus botnet and the malicious software known as Cryptolocker



  • OPA Press Releases

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FDA approval delayed for Sanofi Genzyme’s next blockbuster

Editor's note: This story was originally published Friday morning, and has been updated to reflect the FDA's decision regarding the drug later that day. A U.S. approval decision for a major drug planned to be marketed by Cambridge-based Sanofi Genzyme that had been expected last Friday has been delayed due to “deficiencies” found during a manufacturing site inspection in France. In its third quarter report, released Friday morning, French drugmaker Sanofi (NYSE: SNY) disclosed that “manufacturing…




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Launching a drug during lockdowns



  • Marketing to health care professionals
  • New Drug Launches

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California begins reopening economy as select businesses unlock doors

Parts of California, including Los Angeles County, are allowing some businesses to offer curbside service Friday.




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Letters to the Editor: The agony of having family in locked-down nursing homes

If nursing homes will remain closed until a COVID-19 vaccine is available, there will be no family visits for more than a year. That's intolerable.




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India's unemployment at record high amid tough COVID-19 lockdown




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Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis




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HIF1α blockade reduces kidney injury in lupus nephritis




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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TRAIL blockade improves heart function




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Coronavirus: share lessons on lifting lockdowns




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Mass spectrometry for future atomic clocks




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How swamped preprint servers are blocking bad coronavirus research




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Mechanisms by which angiotensin-receptor blockers increase ACE2 levels




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Impact of the COVID-19 lockdown on basic science research in ophthalmology: the experience of a highly specialized research facility in France




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Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice




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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation




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HIF1α blockade reduces kidney injury in lupus nephritis







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Vettel leads dominant Red Bull front-row lock out

Red Bull's Sebastian Vettel and Mark Webber silenced rivals' claims that the car was gaining an unfair advantage this season by locking out the front row of the grid in qualifying for the Chinese Grand Prix.