Norwich : University of East Anglia : Social Work Today, 1984.

Athletic forward Satou Sabally is preparing to take the leap to the WNBA level following three productive seasons at Oregon. As a junior, she averaged 16.2 points and 6.9 rebounds per game while helping the Ducks sweep the Pac-12 regular season and tournament titles. At 6-foot-4, she also drained 45 3-pointers for Oregon in 2019-20 while notching a career-best average of 2.3 assists per game.

During Wednesday's "Pac-12 Perspective" podcast, Natalie Chou shared why she is using her platform to speak out against racism she sees in her community related to the novel coronavirus.

A distributed binary hypothesis testing (HT) problem over a noisy (discrete and memoryless) channel studied previously by the authors is investigated from the perspective of the strong converse property. It was shown by Ahlswede and Csisz'{a}r that a strong converse holds in the above setting when the channel is rate-limited and noiseless. Motivated by this observation, we show that the strong converse continues to hold in the noisy channel setting for a special case of HT known as testing against independence (TAI), under the assumption that the channel transition matrix has non-zero elements. The proof utilizes the blowing up lemma and the recent change of measure technique of Tyagi and Watanabe as the key tools.

Ammunition Depot comments on Judge Roger T. Benitez ruling that Californians may again purchase ammo without a background check and order ammo online.

(PRWeb April 24, 2020)

Read the full story at https://www.prweb.com/releases/gun_rights_california_gun_owners_ammo_dealers_fire_back_against_proposition_63/prweb17075447.htm

Some Democrats took "Believe Women" literally until Joe Biden was accused. Now they're relearning that guilt-by-accusation doesn't serve justice.

Philippe Gagnon, Alain Desgagné, Mylène Bédard.

Source: Bayesian Analysis, Volume 15, Number 2, 389--414.

Abstract:
Linear regression is ubiquitous in statistical analysis. It is well understood that conflicting sources of information may contaminate the inference when the classical normality of errors is assumed. The contamination caused by the light normal tails follows from an undesirable effect: the posterior concentrates in an area in between the different sources with a large enough scaling to incorporate them all. The theory of conflict resolution in Bayesian statistics (O’Hagan and Pericchi (2012)) recommends to address this problem by limiting the impact of outliers to obtain conclusions consistent with the bulk of the data. In this paper, we propose a model with super heavy-tailed errors to achieve this. We prove that it is wholly robust, meaning that the impact of outliers gradually vanishes as they move further and further away from the general trend. The super heavy-tailed density is similar to the normal outside of the tails, which gives rise to an efficient estimation procedure. In addition, estimates are easily computed. This is highlighted via a detailed user guide, where all steps are explained through a simulated case study. The performance is shown using simulation. All required code is given.

Luis Gutiérrez, Andrés F. Barrientos, Jorge González, Daniel Taylor-Rodríguez.

Source: Bayesian Analysis, Volume 14, Number 2, 649--675.

Abstract:
We propose a Bayesian nonparametric strategy to test for differences between a control group and several treatment regimes. Most of the existing tests for this type of comparison are based on the differences between location parameters. In contrast, our approach identifies differences across the entire distribution, avoids strong modeling assumptions over the distributions for each treatment, and accounts for multiple testing through the prior distribution on the space of hypotheses. The proposal is compared to other commonly used hypothesis testing procedures under simulated scenarios. Two real applications are also analyzed with the proposed methodology.

Qingyuan Zhao, Jingshu Wang, Wes Spiller, Jack Bowden, Dylan S. Small.

Source: Statistical Science, Volume 34, Number 2, 317--333.

Abstract:
Instrumental variable analysis is a widely used method to estimate causal effects in the presence of unmeasured confounding. When the instruments, exposure and outcome are not measured in the same sample, Angrist and Krueger ( J. Amer. Statist. Assoc. 87 (1992) 328–336) suggested to use two-sample instrumental variable (TSIV) estimators that use sample moments from an instrument-exposure sample and an instrument-outcome sample. However, this method is biased if the two samples are from heterogeneous populations so that the distributions of the instruments are different. In linear structural equation models, we derive a new class of TSIV estimators that are robust to heterogeneous samples under the key assumption that the structural relations in the two samples are the same. The widely used two-sample two-stage least squares estimator belongs to this class. It is generally not asymptotically efficient, although we find that it performs similarly to the optimal TSIV estimator in most practical situations. We then attempt to relax the linearity assumption. We find that, unlike one-sample analyses, the TSIV estimator is not robust to misspecified exposure model. Additionally, to nonparametrically identify the magnitude of the causal effect, the noise in the exposure must have the same distributions in the two samples. However, this assumption is in general untestable because the exposure is not observed in one sample. Nonetheless, we may still identify the sign of the causal effect in the absence of homogeneity of the noise.

And it’s on sale at Nordstrom.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

Mitochondrial fission catalyzed by dynamin-related protein 1 (Drp1) is necessary for mitochondrial biogenesis and maintenance of healthy mitochondria. However, excessive fission has been associated with multiple neurodegenerative disorders, and we recently reported that mice with smaller mitochondria are sensitized to ischemic stroke injury. Although pharmacological Drp1 inhibition has been put forward as neuroprotective, the specificity and mechanism of the inhibitor used is controversial. Here, we provide genetic evidence that Drp1 inhibition is neuroprotective. Drp1 is activated by dephosphorylation of an inhibitory phosphorylation site, Ser637. We identify Bβ2, a mitochondria-localized protein phosphatase 2A (PP2A) regulatory subunit, as a neuron-specific Drp1 activator in vivo. Bβ2 KO mice of both sexes display elongated mitochondria in neurons and are protected from cerebral ischemic injury. Functionally, deletion of Bβ2 and maintained Drp1 Ser637 phosphorylation improved mitochondrial respiratory capacity, Ca²⁺ homeostasis, and attenuated superoxide production in response to ischemia and excitotoxicity in vitro and ex vivo. Last, deletion of Bβ2 rescued excessive stroke damage associated with dephosphorylation of Drp1 S637 and mitochondrial fission. These results indicate that the state of mitochondrial connectivity and PP2A/Bβ2-mediated dephosphorylation of Drp1 play a critical role in determining the severity of cerebral ischemic injury. Therefore, Bβ2 may represent a target for prophylactic neuroprotective therapy in populations at high risk of stroke.

SIGNIFICANCE STATEMENT With recent advances in clinical practice including mechanical thrombectomy up to 24 h after the ischemic event, there is resurgent interest in neuroprotective stroke therapies. In this study, we demonstrate reduced stroke damage in the brain of mice lacking the Bβ2 regulatory subunit of protein phosphatase 2A, which we have shown previously acts as a positive regulator of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1). Importantly, we provide evidence that deletion of Bβ2 can rescue excessive ischemic damage in mice lacking the mitochondrial PKA scaffold AKAP1, apparently via opposing effects on Drp1 S637 phosphorylation. These results highlight reversible phosphorylation in bidirectional regulation of Drp1 activity and identify Bβ2 as a potential pharmacological target to protect the brain from stroke injury.

Whether we categorize uneaten food as “lost” or “wasted” depends on where it goes out of the food supply chain. Imagine how everything we eat travels across a food supply chain, a complex journey that stretches from farm to table. Studies show that an astounding 1/3 of all the food we produce for human consumption never actually reaches our plates. Most [...]

“Children subjected to child labour need our support and action so they can enjoy their right to education and health and become productive farmers and workers as adults to escape poverty and hunger.” - José Graziano da Silva, FAO Director- General  Child labour is not unique to a particular country, ethnicity, culture, or ideology. Today, there are about 100 million boys [...]

Climate change is what most of us perceive as the top global threat, and the dangers it poses affect present and future generations alike.  How global warming is threatening the planet has been a theme in children’s books for all ages for some time.   How everyone, especially today’s youth, can make a difference to the future of the world [...]

It is well known that forests, especially rainforests, are key allies in our fight against climate change as they absorb greenhouse gas emissions. But did you know that oceans are the earth’s main buffer against climate change? In fact, about 25 percent of the greenhouse gases that we emit actually gets absorbed by the oceans, as does over 90 percent [...]

A review of FAO’s fight against hunger and malnutrition and challenges ahead with the participation of José Graziano da Silva, Director-General of FAO. 

Where: Sheikh Zayed Centre at FAO headquarters 

When: Friday, 26th [...]

Illustrators are sharing artwork of Amabie, a spirit first popularized during the Edo period, on social media

Universities, libraries and museums are among the organizations seeking personal stories about the pandemic's effects on daily life

Over the past three years, the disease has claimed the lives of seven of the famously resilient ponies

Helping health care workers treat patients and public safety officials contain the pandemic, these robots offer lessons for future disasters

Man working on a new building

Philip Roth's classic novel, newly adapted by HBO, envisions a world in which Charles Lindbergh wins the 1940 presidential election

The Kent State shootings further widened the chasm among a citizenry divided over the Vietnam War

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Whistleblower-Alternativen, Anonymous-Portrait, Jugendmedienschutz ...: Diese Woche wollen wir pr... http://bit.ly/fed0Um #Whistleblower</span></span>

"It is unfortunate that it has come to pass that we have to collectively and overtly publicly declare that we are unified," says Alberta Medical Association president Christine Molnar.

The Porcupine Health Unit is reporting the fifth COVID-19 related death in its area.

FSI Briefs No 2, April 2020. Guidance issued by financial sector authorities in response to the Covid-19 crisis seems to suggest that international efforts to come up with operational resilience standards should take into account at least the following elements: Critical/essential employees: identifying the critical functions and employees that support important business services, as well as ensuring employees' safety and that they can safely resume their duties (remotely, if necessary); IT infrastructure: ensuring that IT infrastructure can support a sharp increase in usage over an extended period and taking steps to safeguard information security; Third-party service providers: ensuring that external service providers and/or critical suppliers are taking adequate measures and are sufficiently prepared for a scenario in which there will be heavy reliance on their services; Cyber resilience: remaining vigilant in order to identify and protect vulnerable systems, and detect, respond and recover from cyber attacks..

For those working in CHSLDs — the province's long-term care homes which are the site of the most serious outbreaks — the bonus will amount to as much as $1,000 per month.

Asylum seekers make up a large portion of the "guardian angels" Quebec Premier François Legault has praised in his daily COVID-19 briefings: the orderlies who have no guarantee they'll be allowed to stay in Canada.

Prosecutors stunningly dropped all criminal charges Thursday against eight people in the Flint water scandal and pledged to start the investigation from scratch.

FIR against 15 members for song ’n dance event  Mumbai Mirror

The chief of Millbrook First Nation says the Nova Scotia RCMP's competition for its new communication centre was "distorted and biased," arbitrarily inflating the price of his community's proposal to reach a "predetermined outcome."

Are financial intermediaries inherently unstable and, if so, why? To address this, we analyse whether model economies with financial intermediation are particularly prone to multiple, cyclic or stochastic equilibria.

A number of popular iOS apps, including TikTok, Pinterest and Spotify, began to crash on Wednesday after an update to Facebook's SDK rolled out, software that many developers rely on to streamline the user login process.

Forty-five women from around the world begin their trek on 9 April to Mt. Everest Base Camp and summit of Kala Patthar Peak in Nepal.

CNA Staff, May 4, 2020 / 05:01 pm (CNA).- The Republic of Ireland’s Workplace Relations Commission has decided that an atheist child was discriminated against by his Catholic school when students were rewarded for attending a religious ceremony.

The commission, an independent, quasi-judicial forum, ruled that the Yellow Furze National School in County Meath had discriminated against an atheist student.

Early in the 2019 school year, the students had been promised a homework pass if they took part in the choir during a First Communion ceremony

The boy’s mother complained, but the school defended its policy.

"Any student, regardless of his/her religion in our school who opted not to participate in this extracurricular event was not 'rewarded,'" the school said, according to the Irish Post last year.

The school added that children of any religion were able to participate in the choir, and that the claim of discrimination was thus “wholly unfounded.”

The commission said the school “does not appreciate this action had an adverse effect on students who are not of a Catholic faith,” the Irish Times reported.

His mother said that "on that day my son was the only child in the class who was not participating. He was also the only non-Catholic child in the class." She added that “he came out of school crying.”

“We are atheist and this is not a choice that is open to him,” she said.

The Irish Post reported in 2019 that the boy was one of two pupils in his class of 33 to receive homework instead of attending the choir ceremony.

According to the commission the boy’s parents were “deeply hurt and upset” by the school.

“We felt that the school had disregarded the fact that we have a different set of beliefs,” the mother told RTE News. “We felt that our child had been singled out and punished for not being a Catholic,” and she added that she hoped the ruling would “change things for children here who are not Catholic".

The mother has since enrolled her son in a different school.

The commission ordered the school to pay €5,000 and demanded the school review its policies so it complies with the Equal Status Acts. The school will also have to post a memo of its compliance in a noticeable location within the school.

The mother told RTE News she will return the €5,000 to the school, “because it will be our friends and our neighbours who will be funding it, through school fundraising. We have been vindicated, but we feel that it would be wrong to accept this money.”

Catholic schools in Ireland make up 90% of all primary schools in the country, the Irish Times reported. The ruling is likely to affect how other schools promote and organize religious events.

New OM team members feel encouraged to be an instrument of God in Mexico.

Coatzacoalcos, Mexico :: A village gets its first library, with books and shelves donated by Logos Hope.

IF there's one thing that online news proves without any shadow of uncertainty, it's that there's no knowing what will capture the popular imagination.

THE people of Scotland have been offered a “light at the end of the tunnel” in the form of various potential relaxations to lockdown - but warned they will only get there if they double down on their compliance.

DAVE Rennie believes that Leinster deserve to be awarded the PRO14 title, and is convinced that such a solution would be better for player welfare and the integrity of the competition than dragging this season on into late summer or autumn.