In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.

The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4b, R4c, R5, x and y are as defined in the specification. These compounds are particularly useful in the treatments of energy homeostasis and metabolism related (e.g. diabetes), food intake related and/or energy balance and body weight related diseases, disorders and/or conditions, including obesity, overweight and diseases, disorders and/or conditions associated with obesity and/or overweight, such as type 2 diabetes and metabolic syndrome.

Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab')2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

A system or method for inferring and selective display of visual and sound media content based on a pet(s)'s level of engagement or reactions to content displayed on any number of content display devices including, but not limited to, television screens, computer monitors, tablets, and cell phones and measured by a sensor. A content selection algorithm takes as input the sensor measurements and historical or pre-computed data to infer the pet(s)'s preference for content. A content modification algorithm interposes algorithmically computed shapes and sounds overlaid on top of the existing content to attract the attention of the pet(s) observing the display.

An optical film has a cellulose acylate film base material containing cellulose acylate and a plurality of sugar ester compounds having different ester substitution degrees in which an average ester substitution degree of the plurality of sugar ester compounds is from 60 to 94%, and an antistatic hardcoat layer formed from a coating composition containing at least an organic antistatic agent and a curable compound having a (meth)acryloyl group in a molecule of the curable compound.

A method for optimized launch of a vehicle is provided wherein a driveline of the vehicle at least includes an engine, an automatic transmission, a system for exhaust gas recirculation, which are controlled by a driveline management system, wherein the management system is able to determine the mass of the vehicle, and whereby a launching gear of the transmission is calculated dependent at least on the determined mass of the vehicle, whereby a launching gear is chosen dependent of the power loss caused by the EGR and wherein the power loss caused by the EGR is determined, the available power to launch the vehicle is determined, and the launching gear is recalculated dependent of the available power, and selecting said recalculated launching gear before launch of the vehicle, launch the vehicle with the recalculated launching gear.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

An optical disc device of the present invention comprises an insertion detection optical sensor which detects insertion of an optical disc based on light emitted from a first light emitting element to a first light receiving element being blocked, and an ejection detection optical sensor provided on the downstream side in the carry-in direction to the insertion detection optical sensor to detect ejection of the optical disc based on light emitted from a second light emitting element to a second light receiving element being blocked. The optical disc device is structured such that, in a state that the optical disc is attached onto the turntable, when the light of the first light emitting element is blocked and the light of the second light emitting element is not blocked, the optical disc device recognizes that a lens cleaner is attached onto the turntable as the optical disc, and the optical disc device performs a cleaning operation.

In an optical disc drive, a degradation of traveling performance of an optical pickup under hard acceleration or hard deceleration in a random access operation or the like results in a degradation of recording/reproducing performance. Groove structure is provided between two gears of a guide feed provided in an optical pickup, and the groove forms bending structure. Thus, the engagement state between a screw gear and the gears of the guide feed is stabilized. This makes it possible to prevent tooth jumping and step-out from occurring in the gears during the traveling of the optical pickup, achieving stable traveling. In consequence, the recoding/reproducing performance of the optical disc drive can be improved.

An optical disc device according to the present invention performs, in parallel, a first control to convey a first tray in the first optical disc drive group from the disc replacing position to the recording and reproducing position, and a second control to convey a second tray in the second optical disc drive group 40R from the recording and reproducing position to the disc replacing position. The second tray is opposed to the first tray.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

A disc drive including a tray, a housing configured to receive the tray, a pickup device installed on the tray, and a main circuit board installed on the tray and connected to the pickup device.

Provided is an object lens driving device that includes a wire holder coupled to a support portion and on which an end of a plurality of suspension wires are fixed. The wire holder includes a first area supported on the support portion and a second area extending from the first area and on which the end of each of the plurality of suspension wires is fixed. In this example, a thickness of the second area is thinner than a thickness of the first area.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

Provided is an optical disk drive including a carrying roller for carrying an optical disk in a first direction. The carrying roller includes a first roller portion and a second roller portion which are aligned in a second direction along the optical disk and orthogonal to the first direction and which are so disposed as to make contact with a surface on one side of the optical disk. An axis of the first roller portion is so inclined that a distance between the axis of the first roller portion and the one-side surface of the optical disk gradually increases toward a central portion of the carrying roller. An axis of the second roller portion is so inclined that a distance between the axis of the second roller portion and the one-side surface of the optical disk gradually increases toward the central portion.

Provided is an optical pickup device that compensates for an aberration caused by a beam splitter. When a beam of light is reflected from a disc and proceeds towards a beam splitter, the beam splitter is designed to allow the reflected beam to pass therethrough. However, the beam splitter can cause an astigmatism in the reflected beam due to diffraction. According to various aspects herein, an optical pickup device may include a compensation device that generates an inverse astigmatism to compensate for the astigmatism generated by the beam splitter.

Provided is an optical disc drive including a tray disposed in a case of the optical disc drive. The tray includes a guide fixed to the case, and a rail connected with the tray. The guide guides the rail as the tray is moved in and out of the optical disc drive. The rail further includes a supporter that is configured to stably support the rail with respect to the guide to prevent derailment of the rail from the guide.

An optical disc drive (ODD) including a tray having a spindle motor, an optical pickup unit, and a transfer motor, may have first and second flat cables. The first flat cable may be connected to the transfer motor, and the second flat cable may have a first terminal part connected to the first flat cable and a second terminal part connected to a circuit board. The circuit board may be arranged at the front of the tray. The second flat cable may include a plurality of signal lines covered by an insulator. One or more exposure parts may be formed in the second flat cable to expose at least one of the plurality of signal lines. An electric actuator of a locking unit may be connected to the one or more of the plurality of signal lines through the one or more exposure parts.

An optical disc device includes: a loader body having a guiding recess formed of a linear portion and a sloped portion; a traverse chassis mounted in the loader body and having a protrusion that is guided along the recess; a turntable mounted on the traverse chassis, for mounting the optical disc; and a clamper which clamps the optical disc between the clamper and the turntable when the traverse chassis ascends relative to the loader body to a clamp position, in which when the traverse chassis is at a position lower than the clamp position, the protrusion is guided along the recess, and when the traverse chassis is at the clamp position, the protrusion is positioned inside the sloped portion.

A spindle structure for an optical disc and an optical disc drive employing the spindle structure are provided. The spindle structure includes a spindle motor having a rotation axis, a spindle that is coupled to the rotation axis, and a sliding cone coupled to the spindle and inserted into a center hole of the optical disc. The sliding cone includes a plurality of hook-shaped guide rods extended toward the spindle, and the spindle includes guide holes, to which the plurality of hook-shaped guide rods are inserted into and coupled.

Provided are apparatuses for grounding the objective lens driving unit of an optical pickup device. An optical pickup device includes an objective lens driving unit and a base that supports the objective lens driving unit, and wherein the objective lens driving unit includes a moving structure including an objective lens and a plurality of drive coils; a static structure comprising magnets corresponding to the plurality of drive coils, a yoke that supports the magnets, and a wire holder that has a plurality of wiring layers including a ground wiring layer; a plurality of suspension wires that connect the plurality of drive coils to the plurality of wiring layers; a supporting portion connected to the yoke and fixed to the wire holder; a projection extending from the supporting portion and disposed adjacent to the ground wiring layer; and conductive bonding material connects the ground wiring layer with the projection.

Provided is an optical disc drive that may discharge static electricity externally. The optical disc drive may include a step motor that is configured to move an optical pickup back and forth and a cover disposed below the optical pickup. In one aspect, the cover includes an electrostatic discharge mechanism for moving static electricity generated on the step motor through the cover.

An agricultural combine has a threshing assembly for threshing a crop to produce chaff and grain, a cleaning assembly for removing the chaff from the grain, and a control system. The threshing assembly and the cleaning assembly operate at threshing and cleaning settings, respectively, for tending to produce a balance between a threshing load applied across the threshing assembly and a cleaning load applied across the cleaning assembly that tends to have a favorable influence on grain loss. The control system is for sensing an imbalance between the threshing load and the cleaning load tending to have an unfavorable influence on grain loss, and for concurrently adjusting the threshing and cleaning settings of the threshing and cleaning assemblies, respectively, for tending to convert the imbalance between the threshing and cleaning loads to a balance between the threshing and cleaning loads tending to have a favorable influence on grain loss.

A conveying apparatus has a conveying path to supply a plurality of products for consumption having soft parts and intended for processing to a processing device. A conveying intermediate space has conveying surfaces that face one another and receive the products for consumption between them while applying pressure thereto. A first conveying surface comprises a flexible surface-deformable conveying cover and a row arrangement of pressure elements that are arranged next to one another in a row extending transverse to the conveying direction, each having a pressure-applying transverse profile extending transverse to the conveying direction, and are held to be displaceable in the height dimension direction of the conveying intermediate space against a restoring force such that each pressure element co-operates with the surface-deformable conveying cover during the passage of the products for consumption through the conveying path in order to form a variable conveyor cross-section.

A prescription paper has reproduction material placed on selected areas of the back side of the paper so that prescription information can be transferred directly onto the patient's records while the prescription writer is writing the prescription. The reproduction material can be a carbonized backing or any other suitable reproduction material. The front side of the prescription paper comprises at least two lines that are separated by a pre-selected distance to match the distance between adjacent lines on the medical record. The prescription writer can align the lines on the prescription paper to the lines on the medical record so that information can be neatly transferred to the space between the lines on the medical record.

A prescription paper has reproduction material placed on selected areas of the back side of the paper so that prescription information can be transferred directly onto the patient's records while the prescription writer is writing the prescription. The reproduction material can be a carbonized backing or any other suitable reproduction material. The front side of the prescription paper comprises at least two lines that are separated by a pre-selected distance to match the distance between adjacent lines on the medical record. The prescription writer can align the lines on the prescription paper to the lines on the medical record so that information can be neatly transferred to the space between the lines on the medical record.

In one embodiment, a method includes passing a signal through a noise whitening filter, passing the signal through a soft detector to calculate first soft information, passing the signal through the soft decoder to calculate second soft information based on the first soft information, and sending the second soft information to the soft detector, wherein the noise whitening filter is configured to process the signal according to the following transfer polynomial: W(D)=1−(p1D+ . . . p1Dλ), where p1 . . . pλ are noise whitening coefficients, D is delay corresponding to bit duration, and a transfer polynomial of the tape channel is F(D)=1+f1D+ . . . +fLDL, wherein L represents a memory length of the tape channel, and wherein λ represents a memory length of the noise whitening filter. Other methods, systems, and computer program products are described in more embodiments.

In one embodiment, a system includes a robotic accessor for transporting media between multiple storage slots and one or more data storage drives; a controller for controlling the robotic accessor; a memory in communication with and/or integrated with the controller for storing information about the media and the storage slots, the information including data corresponding to a physical distribution of the media in the storage slots; and logic integrated with and/or executable by the controller, the logic being adapted to: position the robotic accessor at a computed optimal position during an idle period of the robotic accessor, the computed optimal position being based at least in part on the physical distribution of the media in the storage slots.

A heat-assisted magnetic recording (HAMR) air-bearing slider has an optically-transparent protective film over the near-field transducer (NFT) to protect the NFT from excessive heat caused by the accumulation of carbonaceous material on the slider's overcoat. The NFT is thus separated from the overcoat by the protective film. The protective film does not cover the write pole end, which is covered only by the overcoat, so there is no spacing loss between the write pole end and the recording layer on the disk. In one embodiment the protective film is coplanar with the recording-layer-facing surface of the slider and the overcoat covers both the protective film and the write pole end. In another embodiment the overcoat has a window that surrounds the protective film, with the protective film being substantially coplanar with the air-bearing surface (ABS) of the slider. In both embodiments the smooth topography of the slider's ABS is maintained.

In accordance with one embodiment, a computer program product includes a computer readable storage medium having computer readable program code that is readable and/or executable by a processor to: receive a signal including precoded data read from a magnetic tape medium and pass the signal through a soft detector to calculator first soft information about each bit of the signal and to provide adaptive compensation for the precoded data, send the first soft information to a soft decoder, pass the signal through the soft decoder to calculate second soft information about each bit the signal, and send the second soft information to the soft detector, wherein the precoded data is passed through at least one precoder prior to being written to the magnetic tape medium via a precoder that applies 1/(1⊕D2) to bits of data, where D is delay corresponding to bit duration

A system described herein includes a receiver component that receives third party code for execution in a host environment, wherein the third party code corresponds to a dynamic programming language, and wherein the third party code has at least one object reference to a first object that is used by the third party code. A detouring component automatically replaces the first object referenced by the third party code with a proxy object such that the third party code at runtime calls the proxy object instead of the first object.

Disclosed are various embodiments for automated service interface optimization. In one embodiment, a service client and/or a service provider is reconfigured to use an optimized version of a data transfer interface, where the optimized version transfers fewer data items from the service provider to the service client. In another embodiment, service calls from a service client for multiple different data objects are aggregated into an aggregated service call for a data object. In yet another embodiment, an optimized data object is provided to a service client in response to a request for an unoptimized data object. If the service client attempts to use a data item excluded from the optimized data object, the excluded data item is then provided to the service client.

A program (e.g., an operating system) is provided a warning that it has a grace period in which to perform a function, such as cleanup (e.g., complete, stop and/or move a dispatchable unit). The program is being warned, in one example, that it is losing access to its shared resources. For instance, in a virtual environment, a guest program is warned that it is about to lose its central processing unit resources, and therefore, it is to perform a function, such as cleanup.

A program (e.g., an operating system) is provided a warning that it has a grace period in which to perform a function, such as cleanup (e.g., complete, stop and/or move a dispatchable unit). The program is being warned, in one example, that it is losing access to its shared resources. For instance, in a virtual environment, a guest program is warned that it is about to lose its central processing unit resources, and therefore, it is to perform a function, such as cleanup.

A program (e.g., an operating system) is provided a warning that it has a grace period in which to perform a function, such as cleanup (e.g., complete, stop and/or move a dispatchable unit). The program is being warned, in one example, that it is losing access to its shared resources. For instance, in a virtual environment, a guest program is warned that it is about to lose its central processing unit resources, and therefore, it is to perform a function, such as cleanup.

The present invention provides a polymerizable compound represented by the following formula (I), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The polymerizable compound, polymerizable composition, and polymer have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.

An optics cleaning apparatus includes a buffing cloth section where the buffing cloth section includes a buffing cloth housing and a buffing cloth removal clip. A scrub pad section where the scrub pad section includes a scrub pad and a dust bush housing. And a cleaning section, where the cleaning section includes a dust brush, a reservoir section and a fluid applicator, where the fluid applicator is connected with the reservoir section and where the fluid applicator includes an air channel connected with the reservoir section and where the reservoir section includes a fluid cartridge.

Various embodiments provide for systems and methods for signal conversion of one modulated signal to another modulated signal using demodulation and then re-modulation. According to some embodiments, a signal receiving system may comprise an I/Q demodulator that demodulates a first modulated signal to an in-phase (“I”) signal and a quadrature (“Q”) signal, an I/Q signal adjustor that adaptively adjusts the Q signal to increase the signal-to-noise ratio (SNR) of a transitory signal that is based on a second modulated signal, and an I/Q modulator that modulates the I signal and the adjusted Q signal to the second modulated signal. To increase the SNR, the Q signal may be adjusted based on a calculated error determined for the transitory signal during demodulation by a demodulator downstream from the I/Q modulator.

A voicemail receptionist system includes a memory and a processor. The memory can store data relating to one or more users. An incoming communication can be handled by the voicemail receptionist system and provided with functionality based upon a user's preferences, for example. The data stored by the voicemail receptionist system can be updated at any time, or automatically updated upon updating of the data, or upon occurrence of a trigger event. Voicemail receptionist functionality can include standard voicemail system functionality as well as functionality relating to email, text messaging, MMS messaging, calendar features, schedule announcements, location data, as well as other features.

An optical unit includes: a heat sink that radiates heat from a light source; and a base portion including a reflector mounting section, a lens mounting section and a connecting section connecting the reflector mounting section and the lens mounting section. The base portion is configured such that the light from the light source is reflected by a reflector mounted onto the reflector mounting section and is incident onto a projection lens mounted onto the lens mounting section. The heat sink is exposed to a space surrounded by the lens mounting section, the connecting section and the reflector mounting section.

According to an embodiment of the present invention, a system optimizes an information processing environment, and comprises at least one processor. The system collects information pertaining to operational behavior of the information processing environment and including a plurality of parameters. A neural network structure is established to associate the parameters to a desired operational performance characteristic for the information processing environment. The neural network structure is trained with the collected information from the information processing environment to produce a model for the information processing environment. The model is optimized to determine values for the parameters and the information processing environment is adjusted based on the determined parameter values to attain the desired operational performance of the information processing environment. Embodiments of the present invention further include a method and computer program product for optimizing an information processing environment in substantially the same manner described above.

Data is secured on a device in communication with a remote location using a password and content protection key. The device stores data encrypted using a content protection key, which itself may be stored in encrypted form using the password and a key encryption key. The remote location receives a public key from the device. The remote location uses the public key and a stored private key to generate a further public key. The further public key is sent to the device. The device uses the further public key to generate a key encryption key, which is then used to decrypt the encrypted content protection key. A new content encryption key may then be created.

A data source may be configured to provide usage data including subscriber identifiers and associated information indicative of subscriber device locations and usage. A data warehouse server may be configured to perform operations including: decrypting subscriber identifiers included in usage data received from the data source using a two-way rolling key groups algorithm; re-encrypting the subscriber identifiers decrypted from the usage data to create secure encrypted identifiers using a one-way secured encryption algorithm; and correlating the subscriber identifiers in the decrypted usage data with the corresponding re-encrypted identifiers.