The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

The present invention relates to a solid composition containing calcium silicate hydrate and at least one water-swellable polymer which can form a hydrogel, and also to a process for preparing the composition, to the use thereof as a setting accelerator, and as a grinding aid in cement production. It also relates to building material mixtures which comprise the compositions.

The invention relates 6-acyl-(6H)-dibenz[c,e][1,2]oxaphosphorin-6-oxides of the formula ##STR1## wherein each of R1, R2 and R3 may be present one or more times and R1, R2 and R3 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms and wherein Ar represents an aromatic hydrocarbon group having from 6 to 10 carbon atoms.The invention further relates to a process for the preparation of the afore-mentioned compounds and polymerizable compositions containing them as an essential ingredient as a photo-initiator. Finally the invention relates to 6-alkoxy-(6H)-dibenz[c,e][1,2]oxaphosphorin of the formula II ##STR2## wherein each of R1 and R2 may be present once or more times and R1 and R2 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms, at least one R1 being, however, halogen and wherein R4 represents alkyl having from 1 to 6 carbon atoms.

A circuit arrangement and method couple a hardware-based pseudorandom number generator (PRNG) to an execution unit in such a manner that pseudorandom numbers generated by the PRNG may be selectively output to the execution unit for use as an operand during the execution of instructions by the execution unit. A PRNG may be coupled to an input of an operand multiplexer that outputs to an operand input of an execution unit so that operands provided by instructions supplied to the execution unit are selectively overridden with pseudorandom numbers generated by the PRNG. Furthermore, overridden operands provided by instructions supplied to the execution unit may be used as seed values for the PRNG.

Examples disclose a computing system comprising a computing device with a display surface to detect a selection of functionality from a list of functionalities to be disabled on a calculator. Further, the computing device creates a custom configuration based on the selected functionality. Additionally, the examples also disclose a calculator with a processor to integrate the custom configuration, the custom configuration restricts the selected functionality on the calculator.

The invention provides a method for the manufacture of a catheter comprising a hydrophilic gel. The method comprising the steps of combining a polymeric photoinitiator of the general formula (I): R1(A1)r-(R2(A2)m-O)o—(R3(A3)n-O)p—R4(A4)s (I) with one or more gel-forming polymers and/or gel-forming monomers to form a matrix composition, curing the matrix composition by exposing it to UV radiation, exposing the matrix composition to a swelling medium and incorporating the hydrophilic gel into a catheter. The invention also provides autocuring of the polymeric photoinitiator (I) to provide a gel precursor, a hydrophilic gel and a catheter comprising or coated with the hydrophilic gel of the invention.

A durable ambient light curable waterproof liquid rubber coating with volatile organic compound (VOC) content of less than 450 grams per liter made from ethylene propylene diene terpolymer (EPDM) in a solvent, a photoinitiator, an additive, pigments, and fillers, and a co-agent and a method for making the formulation, wherein the formulation is devoid of thermally activated accelerators.

A durable ambient light curable waterproof liquid rubber coating with volatile organic compound (VOC) content of less than 450 grams per liter made from ethylene propylene diene terpolymer (EPDM) in a solvent, a photoinitiator, an additive, pigments, and fillers, and a co-agent and a method for making the formulation, wherein the formulation is devoid of thermally activated accelerators.

A bus interconnect interfaces a host system to a radio frequency (RF) generator that is coupled to a plasma chamber. The bus interconnect includes a first set of host ports, which are used to provide a power component setting and a frequency component setting to the RF generator. The ports of the first set of host ports are used to receive distinct variables that change over time. The bus interconnect further includes a second set of generator ports used to send a power read back value and a frequency read back value to the host system. The bus interconnect includes a sampler circuit integrated with the host system. The sampler circuit is configured to sample signals at the ports of the first set at selected clock edges to capture operating state data of the plasma chamber and the RF generator.

Disclosed is a reactor and agitator useful in a high pressure process for making 1-chloro-3,3,3-trifluoropropene (1233zd) from the reaction of 1,1,1,3,3-pentachloropropane (240fa) and HF, wherein the agitator includes one or more of the following design improvements: (a) double mechanical seals with an inert barrier fluid or a single seal;(b) ceramics on the rotating faces of the seal;(c) ceramics on the static faces of seal;(d) wetted o-rings constructed of spring-energized Teflon and PTFE wedge or dynamic o-ring designs; and(e) wetted metal surfaces of the agitator constructed of a corrosion resistant alloy.

Efficient data processing apparatus and methods include hardware components which are pre-programmed by software. Each hardware component triggers the other to complete its tasks. After the final pre-programmed hardware task is complete, the hardware component issues a software interrupt.

A system, method, and computer program product for automatically generating equivalent assertions in different forms for different verification tools, which may be analog or digital. A user submits a set of logic assertions that, if unclocked, are converted to clocked assertions by generating and skewing clocks to ensure simulator uniformity. A stimulus is generated, perhaps at random, or input. A test bench is either input or synthesized. For each verification tool, the test bench is simulated and simulation results are captured. An assertion status difference engine evaluates result differences between the verification tools, and identifies and outputs differences indicating a significant inconsistency. Errors in verification tool implementation and user assertion coding can be detected. The simulators used may include SPICE and Verilog, or any other simulators that differ in type, simulation algorithm, input format, or vendor implementation.

Methods and systems are described for placing arithmetic operators on a programmable integrated circuit device (e.g., a PLD). Placement of arithmetic operators of a data flow graph in one of multiple regions (e.g., a region of DSP circuitry blocks or a region of logic fabric circuitry) on the programmable integrated circuitry device may be determined (e.g., randomly). A score related to the performance of the graph (e.g., a score related to data flow graph routing delays or area consumed by the data flow graph) may be determined and this process may be repeated after one of the arithmetic operators of the data flow graph is moved. The placement of arithmetic operators that corresponds to the best value for the score related to the performance of the data flow graph may be stored. Accordingly, more arithmetic operators may be included on a programmable integrated device than in conventional devices.

A non-aqueous liquid cleaning composition for applicators used for applying non-aqueous hair removal compositions to the skin. The composition includes a solubilizing oil effective for solubilizing the non-aqueous hair removal composition, e.g., mineral oil, and an effective antibacterial amount of an antibacterial agent, e.g., triclosan. The composition may also include fragrances and additional bacteriocides, e.g., phenoxyethanol. When the applicator is contacted with the heated cleaning composition any hair removal composition and bacteria on the applicator are removed therefrom and the applicator is ready for reuse. It is preferred to use surgical stainless steel applicators. Also provided are methods of using these compositions and kits containing, among other items, such compositions and applicators.

Provided is a method of manufacturing a superconducting accelerator cavity in which a plurality of half cells having opening portions (equator portions and iris portions) at both ends thereof in an axial direction are placed one after another in the axial direction, contact portions where the corresponding opening portions come into contact with each other are joined by welding, and thus, a superconducting accelerator cavity is manufactured, the half cells to be joined are arranged so that the axial direction thereof extends in a vertical direction; and concave portions that are concave towards an outer side are also formed at inner circumferential surfaces located below the contact portions of the half cells positioned at a bottom; and the contact portions are joined from outside by penetration welding.

An apparatus includes a plurality of applications and an integrator having a voice recognition module configured to identify at least one voice command from a user. The integrator is configured to integrate information from a remote source into at least one of the plurality of applications based on the identified voice command. A method includes analyzing speech from a first user of a first mobile device having a plurality of applications, identifying a voice command based on the analyzed speech using a voice recognition module, and incorporating information from the remote source into at least one of a plurality of applications based on the identified voice command.

A time warp contour calculator for use in an audio signal decoder receives an encoded warp ratio information, derives a sequence of warp ratio values from the encoded warp ratio information, and obtains warp contour node values starting from a time warp contour start value. Ratios between the time warp contour node values and the time warp contour starting value are determined by the warp ratio values. The time warp contour calculator computes a time warp contour node value of a given time warp contour node, on the basis of a product-formation having a ratio between the time warp contour node values of the intermediate time warp contour node and the time warp contour starting value and a ratio between the time warp contour node values of the given time warp contour node and of the intermediate time warp contour node as factors.

Various arrangements for creating and using generic universal resource indicators are presented. To create a generic universal resource indicator, one or more parameters of a universal resource indicator may be identified. An interface that permits a parameter of the one or more parameters to be selected and mapped to a variable may be presented. A selection of the parameter for mapping may be received. An indication of the variable to map to the parameter of the selection may also be received. The generic universal resource indicator having a generic parameter corresponding to the parameter of the selection may be created.

A calendar watch includes a central date indicator (4). The indicator is united with a crown wheel (9) comprising teeth (11) forming a circular crown (12) arranged to be perpendicular to a face (13) of said wheel. The teeth (12) are driven by a finger (14) rotating in a plane intersecting said crown in its height. The finger is united with a date driving wheel (15). The invention permits easy transformation of a watch having its date display in a dial aperture to a watch having a date indicator rotating about the center of the movement.

A wind direction indicating and time display unit is provided for use at the tee areas of a golf course. The unit wind direction indicating device is mounted on an upper surface of a support structure and extends upwardly therefrom. The wind direction indicating device includes a support pole, a sleeve mounted for rotation on the pole at the top thereof, a wind direction indicating element, such as a flag, secured to the sleeve and movable in response to changes in wind direction, and a pole support fitting. Secured to the upper surface of the support structure. A time display device, such as a clock, is secured in a laterally facing wall surface of the support structure.

An equatorial sundial apparatus with an adjustable base assembly utilizing one or more concave cylindrical focusing mirrors. One of the benefits that is derived from this apparatus is the use of one or more concave cylindrical mirrors to project a focused beam of light onto a calibrated surface from which the time can be read. This sundial has the additional benefit of not suffering from blurring of the time indicator in a shadow or non-focused beam of light typical of other sundials. This sundial's focused light forms a sharply demarcated indicator from which time can be read to the minute. A further benefit of this apparatus is the ability to incorporate multiple concave cylindrical focusing mirrors to reduce the size of the visual field or screen where the time is read and to incorporate various shapes and designs for ornamental purposes without significant compromise of the sundials accuracy for telling time. An additional benefit of this apparatus is the ability to quickly, accurately and easily adjust the apparatus to the proper tilt upon setup according to the latitude where it will be located by means of an adjustable base assembly.

The coupled resonator comprises a first low frequency resonator, such as a balance spring (1) and a second higher frequency resonator, such as a tuning fork (2), the two resonators (1 and 2) including permanent mechanical coupling means. Application to the regulating system of a timepiece.

A wristwatch, which comprises an atomic oscillator comprising a system for detecting the beat frequencies obtained by the Raman effect.

Provided are methods for the treatment of a rheumatic disease, such as rheumatoid arthritis, ankylosating spondylitis and/or polymyalgia rheumatic, by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks. Also provided are methods for the treatment of osteoarthritis by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks.

Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

There is intended to provide the novel compounds which generate a base easily when irradiated with long wavelength light (active energy rays), a photobase generator containing the compounds and a photobase generation method, and the present invention relates to the compounds represented by the general formula [1], a photobase generator containing the compounds and a photobase generation method: (wherein, Ar represents any of groups with specific structures selected from the group consisting of an anthracenyl group, an anthraquinonyl group and a pyrenyl group; R1 and R2 each independently represent a hydrogen atom or a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms, or represent ones which can form an alicyclic ring containing nitrogen atom(s) or an aromatic ring containing nitrogen atom(s) together with a nitrogen atom to which they are bound, which the rings having 3 to 8 carbon atoms which may have a substituent, R3 and R4 each independently represent a hydrogen atom, a linear, branched or acyclic alkyl group having 1 to 10 carbon atoms).

The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and treatment of disease.

The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0;R represents a hydrogen atom or an alkyl group;Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; andZ1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, orZ1 and Z2 jointly form a methylene group.

Suspension concentrate compositions are disclosed for delivering S-(+)-Abscisic acid either alone or in combination with a second plant growth regulator to crop seed prior to planting as well as for foliar, soil drench, in-furrow and sprench (foliar spray and soil drench) applications are disclosed. The compositions, when properly combined in an aqueous carrier and processed through wet milling to achieve the desired particle size, will result in stable compositions that are desirable for treating crop seeds.

Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S;A1, A2, A3 and A4 are independently N or CR1, provided that only one of A1, A2, A3 and A4 is N; andR1, R2, R3 and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.

An asset health monitoring system (AHMS) can assign a confidence indicator to some or all the services of a computing service provider. In response to drops in the confidence indicators, the AHMS can automatically initiate testing of services and/or computing assets associated with the services in order to raise confidence that a particular service and its computing assets will perform correctly. Further, the AHMS can automatically initiate remediation procedures for the particular service and/or specific computing assets that fail the confidence testing. By automatically triggering testing and/or remediation procedures, the AHMS can increase reliability of the computing service provider by preemptively identifying problems.

There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1):wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, andwherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic cation or a metal cation,

The present invention relates to the use of polymeric photoinitiators based on polyalkyletherurethane backbones in the production of hydrophilic gels, in particular hydrogels. The invention relates to methods for manufacturing hydrophilic gels using said polymeric photoinitiators, and the hydrophilic gels thus obtained.

A centrifugal separator comprising: a driving portion; and a swing rotor including, a rotor body, a through-hole passing through the rotor body, pin insert grooves which are provided parallel to the through-hole so as to oppose each other and only partially penetrate the rotor body, and a bucket including, a bucket body that has a contact surface which is configured to contact the rotor body during centrifugal separation, and a cap assembly that seals the bucket body and has a swing shaft extending in a direction perpendicular to an longitudinal direction of the bucket, wherein the swing rotor is rotated when the bucket is inserted into the through-hole, to swing the bucket, and the swing shaft can be moved in the longitudinal direction of the bucket relative to the bucket body and rotated about a longitudinal central axis of the bucket.

An apparatus and method for separating a mixed flow into a higher-density component and a lower-density component is provided. The apparatus may include a casing having a fluid entrance assembly, a fluid outlet assembly, and a drain. The apparatus may also include a plurality of rotary separators disposed in the casing. Each of the plurality of rotary separators may include an inlet in fluid communication with the fluid entrance assembly, a discharge in fluid communication with the fluid outlet assembly, and an outlet passage in communication with the drain. At least one of the plurality of rotary separators may include a stationary housing and a rotatable drum disposed at least partially in the stationary housing. The stationary housing may define a slot at least partially providing the outlet passage, and the rotatable drum may be configured to centrifuge the mixed flow.

A separator includes a centrifugal drum having a vertical axis of rotation and a feed line for material to be centrifuged. A drive spindle for the centrifugal drum is rotatably mounted on a housing via a bearing, the housing being supported elastically on a machine frame. A drive device includes a motor housing and an electric motor having a stator and an armature which is aligned with the drive spindle. The drive device and the motor housing move with the drive spindle as co-vibrating units during an operation of the separator. The drive device is connected to the machine frame below the bearing at a lower axial end of the bearing via one or more joint elements.

A separator method and apparatus that includes a rotatable drum defining an annular passageway therein, a plurality of blades coupled to the rotatable drum and located in the annular passageway, each of the plurality of blades including a leading section, a trailing section, a concave surface, and a convex surface, the concave and convex surfaces extending from the leading section to the trailing section, each of the plurality of blades disposed circumferentially adjacent to at least another one of the plurality of blades so as to define blade flowpaths therebetween, and a housing at least partially surrounding the rotatable drum and defining a fluid collection chamber fluidly communicating with the annular passageway.

A vertical centrifugal separator includes a casing, a bowl that is rotatably housed in the casing and provided to separate a solution to be processed which is supplied to an interior of the bowl into a liquid and a solid by an action of centrifugal force and discharge the liquid and the solid, and a discharge assembly that is rotatably housed in the bowl and provided to discharge the solid in the bowl. The bowl and the discharge assembly each have an engagement portion that is engaged or disengaged when the bowl and the discharge assembly are moved relative to each other in an axial direction and a position adjustment mechanism for adjusting a phase between the discharge assembly and the bowl relative to a rotation axis, for example, at a single relative position.

A separation cone (30) is mounted into the interior chamber of a centrifugal separator rotor (10), which comprises a cover (14) releasably connected to a base (16), in order to provide a frusto-conical wall subdividing the chamber into upper and lower regions. This slows the passage of fluid from the upper to the lower region, which takes place via openings (24) and/or via a gap between the inner rim (32) of the cone (30) and the axial inlet tube (12). The separation cone (30) is connected to the cover (14) by a releasable snap fit arrangement, such as by deflectable tabs (38) around the periphery of the separation cone (30) engaging into a groove (15) around the interior surface adjacent a lower edge of the cover (14). This allows there to be a predetermined sequence of servicing operations and ensures that the separation cone (30) will reliably stay with the cover (14) when the cover is removed.

The invention describes a color-developing composition that contains at least three major components: (1) a leuco dye or a combination of leuco dyes, (2) an color-developer or a combination of color-developers that can form colored complexes with the leuco dyes, and (3) a desensitizer to temporarily remove the effect of the developer so the leuco dye appears in its colorless form. An optional binder may be included so that the composition may be applied to a substrate as an ink. The ink composition may be applied to synthetic polymeric substrates and other substrates that are incorporated into absorbent articles or personal care products.

There is disclosed an indicator composition, the application thereof to substrates, and related products. The indicator composition comprises an organic solvent soluble polymer and a redox sensitive material which displays different visible properties in the oxidized and reduced forms. The organic solvent soluble polymer can be at least partially sulfonated polystyrene. The indicator composition can be dissolved in organic solvents such as acetone, ethanol and ethyl acetate to form inks which can be used in a variety of printing processes. The indicator composition can be used to detect oxidizing agents, oxygen, water, reducing agents, UV light, temperature and the passage of time.

Disclosed is a humidity indicator which contains no heavy metal and has good visibility of a color change that occurs when the humidity is increased. The humidity indicator can be produced by applying an aqueous coating comprising a leuco dye, an acidic compound which is in a solid state at ambient temperature, a deliquescent substance and an aqueous resin emulsion onto a substrate such as a resin film, a nonwoven fabric or a paper, and heating and drying the resulting product.

A production simulator (2), for simulating a mature hydrocarbon field, providing quantity produced (Qφktb) per phase, per well, per layer (or group of layers) and per time as a function of production parameters (PP), wherein the production simulator (2) matches history data (HD) of the mature hydrocarbon field and verifies a Vapnik condition.

The present invention aims to simulate a response more similar to a actual machine while inhibiting load increase in analog operation. Program configuration of the present invention is a component of a simulation program for circuit design, which is executed by a computer. The computer includes an operation portion, a storage portion, a manipulation portion, and a display portion, so that the computer exerts a function of a circuit design simulator, and as a macro model of an operational amplifier for use in the circuit design simulator, enabling the computer to act by simulating a response of the operational amplifier on the circuit design simulator. The macro model of the operational amplifier includes a control portion (LMT1) for generating output exception in the event of input exception or power supply exception of the operational amplifier.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.

A method for preparing a metal sulfide thin film using ALD and structures incorporating the metal sulfide thin film. The method includes providing an ALD reactor, a substrate, a first precursor comprising a metal and a second precursor comprising a sulfur compound. The first and the second precursors are reacted in the ALD precursor to form a metal sulfide thin film on the substrate. In a particular embodiment, the metal compound comprises Bis(N,N'-di-sec-butylacetamidinato)dicopper(I) and the sulfur compound comprises hydrogen sulfide (H2S) to prepare a Cu2S film. The resulting metal sulfide thin film may be used in among other devices, photovoltaic devices, including interdigitated photovoltaic devices that may use relatively abundant materials for electrical energy production.

Embodiments of the present invention include an apparatus and method for treatment of pain by a device that provides transcutaneous electrical nerve stimulation. The device includes an applicator equipped with an electric pulse provider that sends an electric pulse to a set of electrodes disposed in an applicator head. The device is placed onto the skin of a patient's body at the point where the patient experiences pain and such that the electrodes of the device contact the skin of the patient while an insulating land area between the electrodes compresses the nerve during transmittal of the electric pulse through the electrodes and into the patient's body.

It is critical in an inductively link medical implant, such as a visual prosthesis or other neural stimulator, to adjust the external coil to a location to maximize communication between the external coil and internal coil. Converting the signal strength between the coils to a signal easily discernible by a clinician, preferably an audible tone, facilitates the adjustment of the external coil to a preferred location.

A skin graft applicator with a handle member and a roller member is described for use in applying a skin graft to a patient. The skin graft applicator has a manipulator pad for positioning the skin graft, and a roller member for forcing air and fluid from underneath the skin graft ensuring the proper bond between graft and tissue.