And so that is what I call the birth of this woke industrial complex. It is a new leviathan, a new monster, that is far more powerful than what Thomas Hobbes might have envisioned 400 years ago, and it is the biggest threat to individual liberty today. It is not big government alone. Its conservatives are reciting lines that they memorized in 1980, thinking that big government was the threat to individual liberty. Maybe it was in 1980. It's not today. It is this new hybrid of big government and big business and big government not just in the United States but big government in places like China, co-mingled with big business creating the actual threat to our liberty and our prosperity. Continue reading →

1. Cindy Crossthwaite's estranged husband faces Supreme Court murder trial over mother of three's death  ABC News
2. 'Deep-seated hatred' for estranged wife led to killing, jury told  9News
3. 'Deep-seated hatred' for estranged wife led to killing, court hears  9News

1. Kristian White trial: CCTV reveals final moments before Clare Nowland Tasering in Cooma nursing home  Sydney Morning Herald
2. Jury shown footage of 95yo getting stuck in tree in weeks before being tasered by police officer  ABC News
3. Elderly woman 'unable to comply' before cop Tasered her, court hears  9News

Could the Solar System host traces of other intelligent life?

Cisco has released security updates to address a maximum severity security flaw impacting Ultra-Reliable Wireless Backhaul (URWB) Access Points that could permit unauthenticated, remote attackers to run commands with elevated privileges. Tracked as CVE-2024-20418 (CVS score: 10.0), the vulnerability has been described as stemming from a lack of input validation to the web-based management

The trains could be charged in a matter of minutes before setting off on their journeys

Children from backgrounds of poverty often lag behind more advantaged peers in early language skills, including breadth and depth of vocabulary knowledge. We report the results of a pilot study of an explicit and elaborated vocabulary intervention in preschool classrooms serving children from lower-income backgrounds. The intervention used multimodal instruction, including segments from public television children's programs and interactive games, to build children's knowledge of and semantic connections for 128 words across 18 weeks of daily lessons.

Realizing the Potential of Extractives for Industrial and Economic Development 18 October 2018 — 5:30PM TO 7:00PM Anonymous (not verified) 3 October 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE

Over the past two decades, the extractives industries have risen in importance for many low- and middle- income countries their prospects for economic development and poverty reduction. During a period of rising commodities prices, the development of extractives became increasingly attractive to both governments and companies. There was - and remains - much discussion about their potential to support inclusive development.

However, there are also risks and uncertainties associated with the extractives industries and many things can, and do, go wrong. Fluctuations in commodity prices can be hard to manage and can lead to considerable fiscal pressures. In the longer-term, climate change and the various policy responses to this, will profoundly affect the extractives sector as renewables replace fossil fuels in the global energy mix.

Managing the extractives sectors will therefore remain highly challenging especially in low-income countries where institutions are often weak. This roundtable will bring together some of the foremost academics and practitioners working in the extractives industries and also in economic development to discuss a major new UNU-WIDER study Extractive Industries: The Management of Resources as a Driver of Sustainable Development.

Attendance at this event is by invitation only.

Visual Abstract

Alison M. Kurimchak
Dec 1, 2020; 19:2068-2089
Research

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase therapeutic avenues for EC, we profiled the kinome of endometrial tumors and normal endometrial tissues using Multiplexed Inhibitor Beads and Mass Spectrometry (MIB-MS). Our proteomics analysis identified a network of kinases overexpressed in tumors, including Serine/Arginine-Rich Splicing Factor Kinase 1 (SRPK1). Immunohistochemical (IHC) analysis of endometrial tumors confirmed MIB-MS findings and showed SRPK1 protein levels were highly expressed in endometrioid and uterine serous cancer (USC) histological subtypes. Moreover, querying large-scale genomics studies of EC tumors revealed high expression of SRPK1 correlated with poor survival. Loss-of-function studies targeting SRPK1 in an established USC cell line demonstrated SRPK1 was integral for RNA splicing, as well as cell cycle progression and survival under nutrient deficient conditions. Profiling of USC cells identified a compensatory response to SRPK1 inhibition that involved EGFR and the up-regulation of IGF1R and downstream AKT signaling. Co-targeting SRPK1 and EGFR or IGF1R synergistically enhanced growth inhibition in serous and endometrioid cell lines, representing a promising combination therapy for EC.

Zimbabwe Futures 2030: Policy Priorities for Industrialization, Agri-Business and Tourism 6 June 2019 — 9:30AM TO 1:15PM Anonymous (not verified) 21 June 2019 Bulawayo, Zimbabwe

The USS Frank E. Petersen Jr. cleared another hurdle toward joining the Navy's fleet after it completed acceptance trials on Thursday.

Divergent Technologies developed a digital production system that can revolutionize automotive and industrial scale manufacturing. Divergent uses new manufacturing solutions and their Divergent Adaptive Production System (DAPS™) software to make […]

The post Transforming Industrial and Automotive Manufacturing appeared first on HPCwire.

The lawsuit, filed in 2014, alleges that the state was severely underfunding schools, forcing school districts to lean heavily on property taxes, which especially disadvantages students in property-poor areas.

What fueled the frenzy that sent so many to their deaths in colonial America? And how did Americans reckon with the aftermath of the panic? --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

Statistics Canada data reviewed by CBC Toronto shows a dramatic shift in criminal outcomes in Ontario over the last decade. The majority of criminal cases in the province have ended with charges being withdrawn, stayed, dismissed or discharged before a decision at trial since 2020.

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

Vault Structures Saves $150,000 in Prototyping Costs, Cuts Development Time by 70 Percent Using SolidWorks Software

Power of One project's goal is perfecting solar technology for tomorrow's hybrid cars as high oil prices peak interest in alternative vehicles

T-slotted frame manufacturer responds to market demand for downloadable 3D models

Designers and engineers preserve history by recreating products that no longer exist

U.K.

3D CAD software enables engineers to conduct more "what-if" scenarios for hoisting equipment used in the automotive, steel, railroad, and rapid transit industries

A Los Angeles judge ruled that a teenage football player may proceed to trial against the national Pop Warner organization, four years after he suffered an on-field injury that left him a quadriplegic.

A New York judge has declined to immediately postpone Steve Bannon's Dec. 9 trial on charges that he defrauded supporters of the "We Build the Wall" fundraiser.

In late 2023, the Penn State Law in University Park Civil Rights Appellate Clinic — along with the Employment Law Group, a Washington, D.C.-based boutique litigation firm — filed merits briefs with the Ninth Circuit to appeal the district court’s dismissal of an ADA case. On the basis of this briefing and subsequent oral argument, the Ninth Circuit reversed the lower court’s ruling and remanded the case for trial.

The Department of Justice has secured 40 convictions, including multiple murder and attempted murder charges, against two members of the violent Wilmington-area gang NorthPak, Attorney General Kathy Jennings announced Wednesday. “Thanks to an outstanding trial team and tireless investigators, led by the Wilmington Police Department, justice was delivered today,” said Attorney General Jennings. “These verdicts, […]

Two men have been found guilty of all charges relating to a January 2022 violent crime spree, marking the final conviction in a massive four-defendant indictment. Walike Parham, 24, and Kyair Keys, 20, could face life in prison for their roles in an eight-day violent crime spree involving four shootings, including one that shattered the […]

Are you ready to revolutionize your RF design experience? Look no further! Cadence AWR software is your gateway to mastering the intricacies of Radio Frequency (RF) circuit design, and now, you can explore its power with our exclusive Free Academic T...(read more)

The next technology revolution is here, and Japan is poised to be a major part of it. At NVIDIA’s AI Summit Japan on Wednesday, NVIDIA founder and CEO Jensen Huang and SoftBank Chairman and CEO Masayoshi Son shared a sweeping vision for Japan’s role in the AI revolution. Speaking in Tokyo, Huang underscored that AI Read Article

This paper examines the causes of export success in East and South East Asia and assesses the role of industrial policy.

This paper examines the technological capability of Indonesian industry.

Title: In Early Trial, Targeted Therapy Fights Advanced Melanoma
Category: Health News
Created: 8/25/2010 6:10:00 PM
Last Editorial Review: 8/26/2010 12:00:00 AM

Title: Alzheimer's Drug Shows Some Promise in Trials
Category: Health News
Created: 8/24/2012 2:05:00 PM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Monkey Trials Raise Hope for Non-Addictive Opioid Alternative
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM

Title: Men Should be Included in Breast Cancer Clinical Trials: FDA
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: New Multiple Sclerosis Treatment Shows Promise in Trial
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.

BACKGROUND AND PURPOSE:

Recently, artificial intelligence tools have been deployed with increasing speed in educational and clinical settings. However, the use of artificial intelligence by trainees across different levels of experience has not been well-studied. This study investigates the impact of artificial intelligence assistance on the diagnostic accuracy for intracranial hemorrhage and large-vessel occlusion by medical students and resident trainees.