Friends who blow hot and cold put more strain on your physical and mental health than enemies. Here's how to spot them and handle them

Binding of arbitrary information into distinct memory representations that can be used to guide behavior is a hallmark of relational memory. What is and is not bound into a memory representation and how those things influence the organization of that representation remain topics of interest. While some information is intentionally and effortfully bound—often the information that is consistent with task goals or expectations about what information may be required later—other information appears to be bound automatically. The present set of experiments sought to investigate whether spatial memory would be systematically influenced by the presence and absence of distinct categories of stimuli on a spatial reconstruction task. In this task, participants must learn multiple item-location bindings and place each item back in its studied location after a short delay. Across three experiments, participants made significantly more within-category errors (i.e., misassigning one item to the location of a different item from the same category) than between-category errors (i.e., misassigning one item to the location of an item from a different category) when categories were perceptually or semantically distinct. These data reveal that category information contributed to the organization of the memory representation and influenced spatial reconstruction performance. Together, these results suggest that categorical information can influence memory organization, and not always to the benefit of overall task performance.

Hepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) is a long noncoding RNA (lncRNA) gene physically located next to the transcription factor HNF4A gene in the human genome. Its transcription products have been reported to inhibit the progression of hepatocellular carcinoma (HCC) and negatively regulate the expression of cytochrome P450s (CYPs), including CYP1A2, 2B6, 2C9, 2C19, 2E1, and 3A4. By altering CYP expression, lncRNA HNF4A-AS1 also contributes to the susceptibility of drug-induced liver injury. Thus, HNF4A-AS1 lncRNA is a promising target for controlling HCC and modulating drug metabolism. However, HNF4A-AS1 has four annotated alternative transcripts in the human genome browsers, and it is unclear which transcripts the small interfering RNAs or small hairpin RNAs used in the previous studies are silenced and which transcripts should be used as the target. In this study, four annotated and two newly identified transcripts were confirmed. These six transcripts showed different expression levels in different liver disease conditions, including metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and obesity. The expression patterns of all HNF4A-AS1 transcripts were further investigated in liver cell growth from human embryonic stem cells to matured hepatocyte-like cells, HepaRG differentiation, and exposure to rifampicin treatment. Several HNF4A-AS1 transcripts highly displayed correlations with these situations. In addition, some of the HNF4A-AS1 transcripts also showed a strong correlation with CYP3A4 during HepaRG maturation and rifampicin exposure. Our findings provide valuable insights into the specific roles of HNF4A-AS1 transcripts, paving the way for more targeted therapeutic strategies for liver diseases and drug metabolism.

Recent studies have demonstrated promising results of fibroblast activation protein (FAP) inhibitor (FAPI) PET in prognosticating and monitoring interstitial lung diseases (ILDs). As a first step toward successful translation, our primary aim was to validate the FAPI PET uptake through immunohistochemistry in patients with advanced ILD who underwent lung transplantation after a FAPI PET scan. Methods: This is a preliminary analysis of a single-center, open-label, single-arm, prospective exploratory biodistribution study of ⁶⁸Ga-FAPI-46 PET imaging in patients with ILD (NCT05365802). Patients with ILD confirmed by high-resolution CT and scheduled for lung transplant were included. Tissue samples of explanted lungs were obtained from both the central and peripheral lung parenchyma of each lobe. Additional samples were obtained from areas of the lung corresponding to regions of FAPI PET activity. Immunohistochemical staining was performed with an anti-FAP antibody. Percentages of FAP immunohistochemistry-positive area were measured semiautomatically using QuPath software. SUVs in the areas of pathologic samples were measured on FAPI PET/CT by referencing the gross photomap of the explanted lung. A Spearman correlation coefficient test was used to assess the relationship between FAPI PET uptake and FAP immunohistochemical expression in each specimen. Results: Four patients with advanced ILD who underwent FAPI PET/CT before lung transplantation were included. The types of ILD were idiopathic pulmonary fibrosis (n = 2), rheumatoid arthritis–associated ILD (n = 1), and nonspecific interstitial pneumonia (n = 1). FAPI uptake was visualized mainly in the fibrotic area on CT. Twenty-nine surgical pathology samples from 3 patients were analyzed. FAP staining was predominantly positive in fibroblastic foci. FAPI PET SUV_max and SUV_mean showed a positive correlation with the immunohistochemical FAP expression score (SUV_max: r = 0.57, P = 0.001; SUV_mean: r = 0.54, P = 0.002). Conclusion: In this analysis conducted in patients who underwent lung transplantation after a FAPI PET scan, FAPI PET uptake was positively correlated with FAP immunohistochemistry. These findings provide a rationale for further investigation of FAPI PET as a potential imaging biomarker for ILD.

Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. Methods: This was a multisite prospective observational study in which mCRPC patients underwent both ¹⁸F-FDG and ⁶⁸Ga-prostate-specific membrane antigen (PSMA)–617 PET/CT scans. A third scan with ⁶⁸Ga-DOTATATE, a potential biomarker of neuroendocrine differentiation, was performed if an ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found. Per-tracer lesion positivity was defined as having an uptake at least 50% above that of the liver. IIH prevalence was defined as the percentage of participants having at least 2 lesions with discordant features on multitracer PET. Results: IIH was observed in 81 patients (82.7%), and at least 1 ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found in 45 patients (45.9%). Of the 37 participants who also underwent ⁶⁸Ga-DOTATATE PET/CT, 6 (16.2%) had at least 1 ⁶⁸Ga-DOTATATE–positive lesion. In total, 12 different combinations of lesion imaging phenotypes were observed. On the basis of our prespecified criteria, 52 (53.1%) participants were determined to be eligible for PSMA RPT, but none for DOTATATE RPT. Patients with IIH had a significantly shorter median overall survival than patients without IIH (9.5 mo vs. not reached; log-rank P = 0.03; hazard ratio, 2.7; 95% CI, 1.1–6.8). Conclusion: Most mCRPC patients showed IIH, which was associated with shorter overall survival. On the basis of a triple-tracer PET approach, multiple phenotypic combinations were found. Correlation of these imaging phenotypes with genomics and treatment response will be relevant for precision medicine.

We primary care clinicians, scholars, and leaders ascribe value to Barbara Starfield’s core tenets of primary care—the 4 Cs: first contact, comprehensiveness, coordination, and continuity. In today’s era of rapid technological advancements and dwindling resources, what are the implications for face-to-face interactions of patient-clinician relationships? We propose adding a 5th C: "Contiguity." Contiguity—or physical proximity and presence—is a key dimension that not only enables the necessary technical aspects of a physical exam but also authenticates the most human aspects of a relationship and occurs specifically when we are physically vulnerable and responsible for the other before us. This, in turn, may best enable us to bridge difference and nurture trust with our patients. We measure what we value and, thus, naming Contiguity as a core tenet assures that we will not lose sight of this keystone in a patient’s relationship with their personal physician.

Artificial intelligence can be the key to unlocking better relationships with work, HP revealed in its new Work Relationship Index (WRI) report. “AI represents a significant opportunity to transform our work dynamics and unlock a more positive and productive environment for all,” stated Dave Shull, president of HP Workforce Solutions at HP Inc.. “To foster […]

Jill Parton, 46, suffered fatal injuries when she was hit by a freight train in Heaton Chapel in the early hours of June 3 this year, an inquest heard

Libra and Capricorn compatibility blends charm and ambition. Discover how this air-earth duo balances romance and practicality in love, friendship, and relationships.

Discover the compatibility between Libra and Aquarius in love, friendship, and more. Explore their strengths, challenges, and what makes this zodiac pairing unique.

Canadian political leaders are congratulating Donald Trump on winning back the U.S. presidency — a victory that raises questions about what Canada-U.S. relations will look like over the next four years.

As Americans prepare to vote in the presidential election, Canadians and Mexicans mull the likely impact. 

By Mike Cloonan, CEO of Sionna Therapeutics, as part of the From The Trenches feature of LifeSciVC An insightful piece on this blog following the JPM healthcare conference noted the “refreshing burst of enthusiasm” in the biotech sector. It’s true

The post Lessons From A Private Funding Round: Science, Relationships, And Experience appeared first on LifeSciVC.

Jun 10, 2022

This book is intended to advance the next phase of the U.S.-Colombia relationship. In a rapidly changing world, the following chapters present a roadmap for a new type of engagement that challenges our ambitions and extends the ties that bind our countries. 

Aug 21, 2023

Foreign Affairs has recently published a number of articles on how the United States should engage with the Taliban government in Afghanistan, extremist forces within the regime, how the West can help ordinary Afghans, and the fate of the country’s women. To complement these essays, Foreign Affairs asked a broad pool of experts for their take. As with previous surveys, Foreign Affairs approached dozens of authorities with expertise relevant to the question at hand, along with leading generalists in the field. Participants were asked to state whether they agreed or disagreed with a proposition and to rate their confidence level in their opinion. Two Belfer Center experts participated, International Security Executive Editor Jacqueline L. Hazelton and Future of Diplomacy Project Senior Fellow Paula Dobriansky.

Apr 18, 2024

This was originally published in The Hill on April 18, 2024.

Jul 24, 2024

The defining tension in Middle Eastern politics today—and the most combustible pile of tinder—is between the State of Israel and the Islamic Republic of Iran. The antagonism between the two countries has existed for more than forty years. It has played out across the region for more than twenty years within the context of the Middle East’s wider tumult. It has not been restricted to diplomacy, either, but has played out through various means: covert, proxy, political and psychological warfare. Observers of this conflict have as a result tended to describe this state of affairs with obscure terms: “cold” war, “shadow” war, or other words that allude to the existence of an active and geopolitically consequential antagonism but imply an ambiguity that plain old “war” never could.

No Blank Screens, London

When it comes to performance under pressure, Dale Jr. and Goodyear are forged from the same fire. Like Goodyear, the Earnhardt name has a long history in NASCAR and we�re proud to say we�re Driven Like Jr.

Closer Relationships Live Here Every Day

Explore Marco Rubio's personal life: Meet his wife and their children. Get the full story now!

The post Who Is Marco Rubio’s Wife? Jeanette Dousdebes’ Kids & Relationship History appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Discover all about Quinn Ewers' girlfriend, and their relationship journey. Follow their story!

The post Who Is Quinn Ewers’ Girlfriend? Madelyn Barnes’ Instagram & Relationship History appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Kevin Federline is a popular disk jockey, dancer, and actor, arguably best known for his first marriage to pop star Britney Spears. As a dancer, he has worked with the likes of Michael Jackson, Justin Timberlake, and Pink. He also appeared alongside Spears on a reality TV series called Britney and Kevin: Chaotic. But, Federline […]

The post Who Is Kevin Federline’s Wife? Victoria Prince’s Job & Relationship History appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Research from the University of Illinois Urbana-Champaign highlights that feeling appreciated by loved ones, not just being grateful, is key to improving

Seema Sajdeh has opened up about how discussing relationship with beau Vikram with her son Nirvaan was "cathartic"

An enhanced Singapore-Australia free trade agreement (SAFTA) represents the biggest step-forward in over a decade in our economic relationship with Singapore.

1. Khushi Kapoor reacts to her rumoured relationship with Vedang Raina: 'It’s best to keep your personal lif  TOI Etimes
2. Khushi Kapoor opens up about her dating life amid romance rumours with Vedang Raina: ‘I understand the curiosity…’  Hindustan Times
3. Khushi Kapoor Confirms Dating Vedang Raina By Wearing Bracelet With His Name? See Here  News18
4. Khushi Kapoor’s bracelet spells out rumoured boyfriend Vedang Raina’s name, netizens ask, ‘Official finally?’  The Indian Express
5. Khushi Kapoor on public scrutiny of her dating life: Let work be the priority  India Today

One of the biggest superstars in South India, Surya talks about how and why he supported his wife cum actress Jyothika to return to movies in an interview recently. His exact words were, "Whatever a man needs a woman also needs

Constantly striving for the next big purchase or chasing after the latest trend can sometimes leave us feeling unfulfilled, especially when it comes to relationships. The more we focus on material gains, the less we may focus on what truly matters-genuine

In a relationship, every moment of connection counts from the small, everyday exchanges to the deeper, more meaningful conversations. While it's easy to assume that things will work out by themselves, there are certain topics that deserve to be addressed. Being

Responding to a question, US Defense Secretary Lloyd Austin said the most important thing on voter's minds was the economy, and that's what people voted on.

Manchester : Manchester University Press, [2018]

Manchester : Manchester University Press, [2018]

Manchester : Manchester University Press, [2018]

Berlin ; Boston : De Gruyter Saur, [2023]

London: Bloomsbury Academic. 2022

Manchester : Manchester University Press, [2018]