Criminal Minds newcomer Damon Gupton (Stephen Walker) celebrated his birthday yesterday, January 4. He was born on that day in 1973. Here...

The Angels fell to the Cleveland Indians in a high-scoring game, and opening day starter Andrew Heaney and right-hander Jaime Barria were roughed up.

James Lipton, the Emmy-winning drama dean who hosted revealing conversations about the acting craft on "Inside the Actors Studio," has died at age 93.

Workers crammed virtually shoulder-to-shoulder to tend production lines moving at inexorable speeds, high rates of disease and injury, low pay and unforgiving rules on time off or meal and bathroom breaks. Descriptions of today's meatpacking industry sound lifted from Upton Sinclair.

Walter Thompson-Hernández's "The Compton Cowboys: The New Generation of Cowboys in America's Urban Heartland" tells a grand story in granular detail.

Southampton academy players visit Arthur House, a former Saints keeper whose playing career ended when he went to fight in World War II.

London : James Epps & Co., Limited, 1894.

Springfield, Virginia : National Technical Information Service, 1985.

A third person was rescued off the roof of the burning building after the house went up in flames at about 11 p.m. on Thursday.

Two additional men have been charged with first-degree murder in the death of a 17-year-old Brampton boy shot and killed on New Year's Eve.

Winds are from the West at 16.1 gusting to 28.8 MPH (14 gusting to 25 KT). The humidity is 42%. The wind chill is 35. Last Updated on May 9 2020, 11:55 am EDT.

Remember to Comply with the Health & Safety Executive Guidance Introduction The High Court (Queen's Bench Division) recently handed down judgment in the case of X v Northampton BC. The judgment is a reminder that a failure to comply with guidanc...

Antiretroviral therapy (ART) suppresses HIV-1 replication but fails to cure the infection. The presence of an extremely stable viral latent reservoir, primarily in resting memory CD4⁺ T cells, remains a major obstacle to viral eradication. The "shock and kill" strategy targets these latently infected cells and boosts immune recognition and clearance, and thus, it is a promising approach for an HIV-1 functional cure. Although some latency-reversing agents (LRAs) have been reported, no apparent clinical progress has been made, so it is still vital to seek novel and effective LRAs. Here, we report that thiostrepton (TSR), a proteasome inhibitor, reactivates latent HIV-1 effectively in cellular models and in primary CD4⁺ T cells from ART-suppressed individuals ex vivo. TSR does not induce global T cell activation, severe cytotoxicity, or CD8⁺ T cell dysfunction, making it a prospective LRA candidate. We also observed a significant synergistic effect of reactivation when TSR was combined with JQ1, prostratin, or bryostatin-1. Interestingly, six TSR analogues also show reactivation abilities that are similar to or more effective than that of TSR. We further verified that TSR upregulated expression of heat shock proteins (HSPs) in CD4⁺ T cells, which subsequently activated positive transcriptional elongation factor b (p-TEFb) and NF-B signals, leading to viral reactivation. In summary, we identify TSR as a novel LRA which could have important significance for applications to an HIV-1 functional cure in the future.

A cyclist has died after being involved in a collision with a van.

A motorcyclist has died after a crash on a busy road in north-east London.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

Southampton manager Ralph Hasenhuttl has revealed that Sir Alex Ferguson sent him a text message after watching Saints get hammered 9-0 by Leicester City.

Southampton captain Pierre-Emile Hojbjerg has responded after being linked with a summer move to Tottenham.

Southampton legend Matt Le Tissier has said that his proposed move to Tottenham in 1990 was the closest he came to leaving the south coast.

The elusive artist's latest work, Game Changer, is on display at Southampton General Hospital.

Hampton Roads Sanitation District (HRSD), based in Virginia Beach, Va., has agreed to pay a $900,000 civil penalty and to take corrective actions to reduce alleged sanitary sewer overflows from its collection system and nine sewage treatment plants that have polluted the Chesapeake Bay and its tributaries.

Two Latino men associated with the Compton 155 street gang pleaded guilty today to federal hate crime charges related to a racially motivated attack on African-American juveniles at a residence in Compton, Calif. on New Year’s Eve.

If this video of the 3rd annual Brompton World Championships got US folding bike enthusiasts excited, then they'll be delighted that for the first time ever, a national US Brompton championship is to be held in March

Major League Baseball (MLB) star Justin Verlander and his supermodel wife Kate Upton on Friday stepped in to help Detroit fight the pandemic after positive cases increased to nearly 30,000 in Michigan. There were 546 deaths recorded in the region. "@kateupton and I have been following the #COVID19 spread in Michigan and are heartbroken for Detroit, a city so close to our hearts. We've especially seen the impact on the Detroit Police Department and reached out to learn how we could help," Justin, who was with Detroit Tigers for 13 seasons before joining Houston Astros in 2017, wrote on Instagram.

 

 

 

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@kateupton and I have been following the #COVID19 spread in Michigan and are heartbroken for Detroit, a city so close to our hearts. With such deep ties to this amazing and resilient city we wanted to focus our efforts on supporting both the community and first responders. We’ve especially seen the impact on the Detroit Police Department and reached out to learn how we could help. Together we quickly identified their areas of need and are so grateful for several collaborations and extremely generous organizations that rushed to support: . Through a partnership with @bellacanvas, we are sending 25,000 masks to @detroit_police to be distributed among their officers. They are also stocking each patrol car with masks and distributing them to people and communities in need. . @ford through @fordfund is donating face shields for every single police officer, paramedic and fire fighter in Detroit! This is such an important and extra layer of protection while helping many who are sick and needing their assistance. . Also, in order to help slow the spread, the Detroit Police Dept. has instituted strict safety measures such as temperature checks for all staff members. They expressed a need for touchless thermometers and through a donation to and an incredible effort by @bethennyfrankel ‘s #bstrong and @globalempowermentmission they were able to help fill that deficit. . Lastly, getting food safely to those on the front lines is a major initiative, and we are donating to @feedthefrontlinesdetroit. They are working with local restaurants to deliver meals to healthcare workers and first responders. This is a wonderful initiative to support both the local restaurant industry and many who are on the front lines every day. . We’ve included more information and links to these inspiring organizations in our stories. Thank you to all who pulled together to help make an impact in #Detroit. Please stay safe and to all those working to help and heal our communities, thank you for all you do! #staysafe #stayhome #savelives #bellacanvas #fordfund #feedthefrontlinesdetroit

A post shared by Justin Verlander (@justinverlander) onApr 17, 2020 at 10:14am PDT

In his lengthy post, Justin explained how through partnerships, the couple managed to provide 25,000 masks for the Detroit Police Department, face shields for every police officer, paramedic and fire fighter. Touchless thermometers were given to cops. Safe delivery of food was conducted for those on the front line like healthcare workers and first responders.

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To consider and approve the financial results for the period ended......

Kimpton Hotels & Restaurants is pleased to announce the opening of Kimpton Hotel Fontenot, a 202-room boutique hotel located in the heart of New Orleans' Central Business District on the corner of Poydras and Tchoupitoulas Streets. The opening marks the brand's return after a fifteen-year absence from the Crescent City. Combining classic and modern design, Kimpton Hotel Fontenot's interiors are inspired by the city's iconic southern hospitality and famed jazz musicians, as well as the building's original architectural details. The lobby features a stunning variety of custom art, including a butterfly installation by Paul Villinski and a seven foot trombone installation honoring the city's musical roots. Upon arrival, hotel guests are welcomed with a complimentary local beer and the musical stylings of prominent and rising soul, blues, and big band artists. Each of the 202 beautifully appointed guest rooms offer bespoke amenities and feature a clean and modern design aesthetic with sof...

If we are to meet the goal of keeping global warming to 2 degrees, governments need to engage now to get on the right track to achieve zero‑net greenhouse emissions from combustion of fossil fuels in the second half of this century. Given the urgency of doing so, why does our dependence on fossil fuels appear to be unshaken?

"It is estimated that air pollution from diesel-fuelled road transport kills 10 times more people each year in France than those who die in road accidents": OECD Insights Blog's post by Simon Upton, head of the OECD Environment Directorate, founder and Chair of the Round Table on Sustainable Development, and former New Zealand environment minister.

Barcelona are weighing up a move for Ajax star Dusan Tadic after their pursuit of Valencia forward Rodrigo fell through, with the club still chasing a move for a new forward.

Argyll McCoist, 20, (pictured) was uninsured when he ran a red light and hit 21-year-old Stephen Murdoch in his £20,000 Audi in Bishopton, Renfrewshire, before driving off.

Paul told the Family Leader he had to skip the group's annual summit - of which he was a sponsor - because he had to attend an event in New York with his family.

Married At First Sight fans saw Michael Goonan, 28, and 'wife' Stacey Hampton, 26, have a fiery argument on the first morning of their honeymoon in Fiji. 

The veteran goalkeeper, could start for Liverpool away at Southampton on Saturday in the Premier League as they look to maintain their fast start to the season following their 4-1 victory over Norwich.

After Southampton took the lead late on, they were stunned by late goals from Lucas Moura and Son Heung-min as following a laboured performance Spurs set up a fifth round tie with Norwich.

Southampton midfielder James Ward-Prowse was taken off on a stretcher and given oxygen after being caught on the right leg by a late challenge from Ryan Sessegnon.

Jose Mourinho gave a frank assessment of his Tottenham stars after they edged through to the FA Cup fifth round against Southampton - admitting 'the best team lost the game'.

Southampton manager Ralph Hasenhuttl has revealed James Ward-Prowse is in contention to feature against Burnley on Saturday - just 10 days after suffering a nasty cut on his leg.

 A service station ice dealer cops the Jim Carrey edit, a 48-year-old woman invents a verb for menopause and the internet goes Sherlock Holmes on a woman's age.

Sportsmail revealed Leicester's bid at the weekend and the Premier League champions have now settled on a fee with Cracovia for an initial £5.4million, rising to £7.4m based on performance.

Southampton are weighing up a move for Spezia forward David Okereke as they grow increasingly frustrated with their attempts to land Che Adams.

The Premier League side have been pursuing Adams since January, offering £12million and £14m to no avail. However, the Saints have now had a £16m offer accepted for the 22-year-old striker.

Che Adams's £16m move from Birmingham to Southampton is now complete, and the Saints couldn't help but take a cheeky jibe at Liverpool in their unveiling video.