To better understand how ADB’s developing members are weathering the COVID-19 crisis, the Economic Research and Regional Cooperation Department launched the ADB COVID-19 Policy Database.

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UNITED NATIONS: The United Nations called on governments, companies and billionaires on Thursday to contribute to a $6.7 billion fund for immediate needs in fighting the coronavirus pandemic in vulnerable countries, warning that a failure to help could lead to a hunger pandemic, famine, riots and more conflict.

UN humanitarian chief Mark Lowcock said that Covid-19 has now affected every country and almost every person on the planet. He said the UN’s initial $2 billion appeal unveiled March 25 was being increased because there is already evidence of incomes plummeting and jobs disappearing, food supplies falling and prices soaring, and children missing vaccinations and meals. He added that the peak of the pandemic isn’t expected to hit the worlds poorest countries for three to six months.

Lowcock said in a video briefing launching the new appeal that the poorest countries face a double whammy the health impact of Covid-19 and the impact of the global recession and the domestic measures taken to contain the virus.

We must be prepared for a rise in conflict, hunger, poverty and disease as economies contract, export earnings, remittances and tourism disappear, and health systems are put under strain, he warned. Lockdowns and economic recession may mean a hunger pandemic ahead for millions.

The executive director of the World Food Programme, David Beasley, said there are two keys to averting the possibility of 265 million people being on the brink of famine by the end of the year: providing money and keeping supply chains running smoothly.

The UN appeals to wealthy nations for funding all the time, he said, but the pandemic is a one-time phenomena, a catastrophe were hitting, so its not unreasonable to ask the wealthiest people and the wealthiest companies to give.

I don’t mean just a few million. I’m talking about hundreds of millions of dollars, billions, Beasley said.

He also urged action to address the breakdown of supply chains globally. Nations must ensure that we don’t have export-import bans, restrictions at borders, shutdown of ports, shutdown of distribution points, he said, saying that some countries have already imposed export bans that are having ripple effects on food supplies.

As an example, Beasley said that if young people in urban areas in Africa lose their jobs as a result of the economic impact of the pandemic, they don’t have bank accounts to fall back on. And if they don’t have food, you’re going to have protests, riots, unrest and destabilisation. Its going to cost the world a hundredfold more to react after the fact, he warned.

He said that if the world doesn’t respond with sufficient funding, it will be catastrophic.

Were facing famine of biblical proportions,” he said. We can avert famine if we act and we act now.

The UN’s initial $2 billion appeal has so far raised $1 billion, including a lot from Europe Germany, Britain, the European Commission with contributions also from Japan, Persian Gulf countries, Canada and others, Lowcock said.

The updated appeal adds nine vulnerable countries to the 54 nations covered in the initial appeal Benin, Djibouti, Liberia, Mozambique, Pakistan, the Philippines, Sierra Leone, Togo and Zimbabwe.

Lowcock said more countries are being monitored for possible addition to the list.

Published in Dawn, May 9th, 2020

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The Asian Development Bank (ADB) country partnership strategy (CPS), 2016–2020 for Papua New Guinea (PNG) sought to assist the country in planning and implementing a successful conversion of its resource wealth into inclusive and environmentally sustainable economic growth. ADB’s sovereign program, comprising approved, completed, and ongoing loans, grants, and technical assistance (TA), totaled $2.11 billion during the period 2016 to May 2019. Transport was the sector receiving the largest amount of support (72% of total financing), followed by health (15%), and energy (9%). 

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This working paper proposes flood footprint and accountability to coordinate risk management projects through appropriate spatial planning at river basin scale.

To better understand how ADB’s developing members are weathering the COVID-19 crisis, the Economic Research and Regional Cooperation Department launched the ADB COVID-19 Policy Database.

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Many countries are focusing coronavirus testing on people who have covid-19 symptoms. But regularly testing all essential workers would have more of an impact

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ABSTRACT

Selectable markers are indispensable for genetic engineering, yet their number and variety are limited. Most selection procedures for prototrophic cells rely on the introduction of antibiotic resistance genes. New minimally invasive tools are needed to facilitate sophisticated genetic manipulations. Here, we characterized three endogenous genes in the human fungal pathogen Aspergillus fumigatus for their potential as markers for targeted genomic insertions of DNAs of interest (DOIs). Since these genes are involved in uptake and metabolization of pyrimidines, resistance to the toxic effects of prodrugs 5-fluorocytosine and 5-fluorouracil can be used to select successfully integrated DOIs. We show that DOI integration, resulting in the inactivation of these genes, caused no adverse effects with respect to nutrient requirements, stress resistance, or virulence. Beside the individual use of markers for site-directed integration of reporter cassettes, including the 17-kb penicillin biosynthetic cluster, we demonstrate their sequential use by inserting three genes encoding fluorescent proteins into a single strain for simultaneous multicolor localization microscopy. In addition to A. fumigatus, we validated the applicability of this novel toolbox in Penicillium chrysogenum and Fusarium oxysporum. Enabling multiple targeted insertions of DOIs without the necessity for exogenous markers, this technology has the potential to significantly advance genetic engineering.

IMPORTANCE This work reports the discovery of a novel genetic toolbox comprising multiple, endogenous selectable markers for targeted genomic insertions of DNAs of interest (DOIs). Marker genes encode proteins involved in 5-fluorocytosine uptake and pyrimidine salvage activities mediating 5-fluorocytosine deamination as well as 5-fluorouracil phosphoribosylation. The requirement for their genomic replacement by DOIs to confer 5-fluorocytosine or 5-fluorouracil resistance for transformation selection enforces site-specific integrations. Due to the fact that the described markers are endogenously encoded, there is no necessity for the exogenous introduction of commonly employed markers such as auxotrophy-complementing genes or antibiotic resistance cassettes. Importantly, inactivation of the described marker genes had no adverse effects on nutrient requirements, growth, or virulence of the human pathogen Aspergillus fumigatus. Given the limited number and distinct types of selectable markers available for the genetic manipulation of prototrophic strains such as wild-type strains, we anticipate that the proposed methodology will significantly advance genetic as well as metabolic engineering of fungal species.

Finding common ground and building trust between local stakeholders could help prevent violent encounters between police and young black men, new research finds.

BACKGROUND Pregnant patients from rural counties of Western North Carolina face additional barriers when accessing comprehensive perinatal substance use disorders care at Project CARA as compared to patients local to the program in Buncombe County. We hypothesized regional patients would be less engaged in care.

METHOD Using a retrospective cohort design, univariate analyses (², t-test; P < .05) compared patients' characteristics, engagement in care, and delivery outcomes. Engagement in care, the primary outcome, was operationalized as: attendance at expected, program-specific prenatal and postpartum visits, utilization of in-house counseling, community-based and/or inpatient substance use disorders treatment, and maternal urine drug screen at delivery negative for illicit substances.

RESULTS Regional patients (n = 324) were more likely than Buncombe County patients (n = 284) to have opioid [209 (64.5%) versus 162 (57.0%)] or amphetamine/methamphetamine use disorders (25 [7.7%] versus 13 [4.6%]), but less likely to have cannabis use (19 [5.9%] versus 38 [13.4%]; P = .009) and concurrent psychiatric disorders (214 [66.0%] versus 220 [77.5%]; P = .002). Engagement at postpartum visits was the significantly different outcome between patients (110/221 [49.8%] versus 146/226 [64.6%]; P = .002).

LIMITATIONS Outcomes were available for 66.8% of regional and 79.6% of Buncombe County patients of one program in one predominately white, non-Hispanic region of the state.

CONCLUSION Contrary to our hypothesis, regional and Buncombe County women engaged in prenatal care equally. However, a more formal transition into the postpartum period is needed, especially for regional women. A "hub-and-spokes" model that extends delivery of perinatal substance use disorders care into rural communities may be more effective for engagement retention.

Identifying gene variants causing monogenic diabetes (MD) increases understanding of disease etiology and allows for implementation of precision therapy to improve metabolic control and quality of life. Here, we aimed to assess the prevalence of MD in youth with diabetes in Lithuania, uncover potential diabetes-related gene variants, and prospectively introduce precision treatment. First, we assessed all pediatric and most young-adult patients with diabetes in Lithuania (n = 1,209) for diabetes-related autoimmune antibodies. We then screened all antibody-negative patients (n = 153) using targeted high-throughput sequencing of >300 potential candidate genes. In this group, 40.7% had MD, with the highest percentage (100%) in infants (diagnosis at ages 0–12 months), followed by those diagnosed at ages >1–18 years (40.3%) and >18–25 years (22.2%). The overall prevalence of MD in youth with diabetes in Lithuania was 3.5% (1.9% for GCK diabetes, 0.7% for HNF1A, 0.2% for HNF4A and ABCC8, 0.3% for KCNJ11, and 0.1% for INS). Furthermore, we identified likely pathogenic variants in 11 additional genes. Microvascular complications were present in 26% of those with MD. Prospective treatment change was successful in >50% of eligible candidates, with C-peptide >252 pmol/L emerging as the best prognostic factor.

Background:

We assessed the ability to supplement existing epidemiologic/etiologic studies with data on treatment and clinical outcomes by linking to publicly available cancer registry and administrative databases.

Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed a case–cohort study including incident cases of breast (n = 207), colorectal (n = 111), lung (n = 70), and prostate (n = 201) cancer as well as a subcohort (n = 465) within the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort. Relative counts of neutrophils, monocytes, and lymphocyte sublineages were measured by qRT-PCR. HRs and 95% confidence intervals were used to measure the associations between relative counts of immune cell and cancer risks. When relative counts of immune cell types were taken individually, a significant positive association was observed between relative counts of FOXP3+ regulatory T cells (Tregs) and lung cancer risk, and significant inverse associations were observed between relative CD8+ counts and risks of lung and breast cancer (overall and ER+ subtype). Multivariable models with mutual adjustments across immune markers showed further significant positive associations between higher relative FOXP3+ T-cell counts and increased risks of colorectal and breast cancer (overall and ER− subtype). No associations were found between immune cell composition and prostate cancer risk. These results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.Significance:This epidemiologic study supports a role for both regulatory and cytotoxic T cells in determining cancer risk among healthy individuals.See related commentary by Song and Tworoger, p. 1801

शहीद कर्नल आशुतोष शर्मा की पत्नी पल्लवी ने भी हिम्मत दिखाते हुए कहा है कि पति की शहादत पर आंसू नहीं बहाऊंगी। उनकी कुर्बानी मेरे लिए और देश के लिए गर्व की बात है। मेरे आंसू उन्हें ठेस पहुंचाएंगे।

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Shannon's said: “OCRO HLI RGWR NMIELWIS”

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