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Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice

Food Funct., 2020, 11,2898-2909
DOI: 10.1039/C9FO03015H, Paper
Ting Xia, Bo Zhang, Shaopeng Li, Bin Fang, Wenhui Duan, Jin Zhang, Jia Song, Min Wang
Vinegar extract inhibited alcohol-induced ROS generation and inflammation. Vinegar extract modulated gut microbiota and improved intestinal homeostasis, which could be used as a novel gut microbiota manipulator against alcohol-induced liver damage.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Seaweed Porphyra yezoensis polysaccharides with different molecular weights inhibit hydroxyapatite damage and osteoblast differentiation of A7R5 cells

Food Funct., 2020, 11,3393-3409
DOI: 10.1039/C9FO01732A, Paper
Ling-Hong Huang, Hong Liu, Jia-Yun Chen, Xin-Yuan Sun, Zhi-hui Yao, Jin Han, Jian-Ming Ouyang
Porphyra yezoensis polysaccharide could effectively reduce the cell damage and osteogenic transformation of vascular smooth muscle cells induced by hydroxyapatite crystals.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

Food Funct., 2020, 11,3632-3644
DOI: 10.1039/D0FO00187B, Paper
Peichao Chen, Ya Zhang, Man Xu, Hongjun Chen, Huixi Zou, Xu Zhang, Haibin Tong, Cuiping You, Mingjiang Wu
The polysaccharides extracted from Sargassum fusiforme delays the aging process via mitochondria-associated anti-oxidation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective

Food Funct., 2020, 11,2792-2804
DOI: 10.1039/D0FO00357C, Review Article
Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun Wang
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00342E, Paper
Oscar Galarce-Bustos, Mª Teresa Fernández-Ponce, Antonio Montes, Clara Pereyra, Lourdes Casas, Casimiro Mantell, Mario Aranda
The wastes generated by cherimoya cultivation and processing industries should be contemplated as a valuable source of bioactive alkaloids, with potential in pharmaceutical applications for the treatment or prevention of chronic diseases.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00732C, Paper
Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang
Pterostilbene is more effective than resveratrol in alleviating liver injury, facilitating redox status, and improving mitochondrial function of piglets.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Production of GABA-enriched idli with ACE inhibitory and antioxidant properties using Aspergillus oryzae: the antihypertensive effects in spontaneously hypertensive rats

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02854D, Paper
Mohsen Zareian, Ehsan Oskoueian, Marjan Majdinasab, Bita Forghani
The present study aimed to develop a fermented food (idli) with enhanced γ-aminobutyric acid (GABA) and angiotensin I-converting enzyme (ACE) inhibitory properties using a GABA-producing fungus.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00711K, Paper
J. Q. Ma, Yun-Zhi Sun, Qing-Lei Ming, Zhi-Kai Tian, Yu-Jia Zhang, Chan-Min Liu
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential renoprotective properties. Here we examined the protective effects of GAS against carbon tetrachloride (CCl4)-induced kidney inflammation and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2×2 factorial design

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02751C, Paper
Jinyu Wang, Ke Xiong, Qiuzhen Wang, Shanliang Zhao, Yufeng Liu, Aiguo Ma
Background and objective: Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment...
The content of this RSS Feed (c) The Royal Society of Chemistry




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With 30 days more to pay premium, make sure you don't let your policy lapse

Usually, general insurers give 30 days for health and 90 days for auto insurance policyholders to pay renewal premiums, even after the due date has passed




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Flipkart, ICICI Lombard offer health plan for Covid-19 with instant claim

'Covid-19 Protection Cover' provides an instant Rs 25,000 benefit plan for to the customer if he tests positive for Covid-19




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Be flexible with your financial plan, don't make big commitment

Clearly, these are unusual times. So, things need to be done differently




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Avoid banks and NBFCs with high proportion of unsecured and SME loans

Longer-term investors with a three-five-year horizon have an opportunity to pick quality stocks, which in calmer times tend to trade at exorbitant valuations




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Dealing with Covid-19: Keep your vehicle in good shape during lockdown

Fill fresh engine oil and coolant before you store it away




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Apple Introduces watchOS 2 with Native Apps and New Apple Watch Sport Models

Apple has introduced new Apple Watch cases and bands, available starting today, including new gold and rose gold aluminum Apple Watch Sport models. watchOS 2 — which arrives as a free update on September 16 — makes apps faster and more fluid by running natively on Apple Watch, and introduces new watch faces, the ability for third-party apps to display information on the watch face as complications, and an innovative way to see future events, past headlines, and more with Time Travel. Apple Watch collections are expanding with new case colors and fresh new bands. With new standalone Sport Bands that range from rich vibrant colors to more neutral tones, Apple Watch is now more customizable than ever.




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Apple Brings Innovation Back to Television with All-New Apple TV

Apple has announced the all-new Apple TV, bringing a revolutionary experience to the living room based on apps built for the television. Apps on Apple TV let you choose what to watch and when you watch it. And with the new Siri Remote, you can search with your voice for TV shows and movies across multiple content providers simultaneously. Apple TV runs the all-new tvOS operating system, based on Apple’s iOS, enabling iOS developers to create new apps and games specifically for Apple TV and deliver them directly to users through the new Apple TV App Store. “There has been so much innovation in entertainment and programming through iOS apps, we want to bring that same excitement to the television,” said Eddy Cue, Apple’s senior vice president of Internet Software and Services. “Apps make the TV experience even more compelling for viewers and we think apps represent the future of TV.”




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Apple Updates iMac Family with Stunning New Retina Displays

Apple has updated the entire iMac family, bringing a new Retina 4K display to the 21.5-inch iMac for the first time and the Retina 5K display to every 27-inch iMac. The updated iMacs also feature more powerful processors and graphics, two Thunderbolt 2 ports, and new storage options that make the high-performance Fusion Drive even more affordable. Apple also introduced a new lineup of wireless accessories including the all-new Magic Keyboard, Magic Mouse 2, and Magic Trackpad 2. “From the first iMac to today, the spirit of iMac has never wavered — deliver the ultimate desktop experience with the latest technologies, gorgeous displays, and cutting-edge designs,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing. “These are the most stunning iMacs we’ve ever made. With our gorgeous new Retina displays, more powerful processors and graphics, and all-new Magic accessories, the new iMac continues to redefine the ultimate desktop experience.”




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Apple Advances Health Apps with CareKit

Apple today announced CareKit, a new software framework designed to help developers enable people to actively manage their own medical conditions. iPhone apps using CareKit make it easier for individuals to keep track of care plans and monitor symptoms and medication, providing insights that help people better understand their own health. “We believe that giving individuals the tools to understand what is happening with their health is incredibly powerful, and apps designed using CareKit make this a reality by empowering people to take a more active role in their care,” said Jeff Williams, Apple’s chief operating officer.




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Apple Introduces iPhone SE — the Most Powerful Phone with a 4-inch Display

Apple today introduced iPhone SE, the most powerful phone with a 4-inch display, in a compact aluminum design that has been updated with matte-chamfered edges, a color-matched stainless steel Apple logo, and four metallic finishes. iPhone SE offers the same 64-bit A9 chip offered in iPhone 6s and iPhone 6s. “iPhone SE is packed with a stunning 4-inch Retina display, advanced 64-bit A9 chip with M9 motion co-processor, longer battery life, 12-megapixel iSight camera with True Tone flash, Live Photos, 4K video, faster LTE and Wi-Fi, and Touch ID with Apple Pay. Everyone who wants a smaller phone is going to love iPhone SE,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing.





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China SUV maker begins upscale climb with luxury brand

Wei Jianjun's Great Wall Motor Co will unveil its WEY brand on November 16




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A mile-high club that comes with drinks, dinner

Airbus contemplating a new paradigm in passenger cabin design




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Google announces company holiday on May 22 to deal with ‘virus burnout’

Google announces company holiday on May 22 to deal with ‘virus burnout’




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Zaheer Iqbal on his bond with his mother

Zaheer Iqbal on his bond with his mother




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Anu Emmanuel to pair up with Udhayanidhi in Magizh Thirumeni's film?

Anu Emmanuel to pair up with Udhayanidhi in Magizh Thirumeni's film?




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Ariana Grande and Justin Bieber's quarantine anthem 'Stuck with U' is winning over the internet; watch

Ariana Grande and Justin Bieber's quarantine anthem 'Stuck with U' is winning over the internet; watch




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Lockdown effect: Junior badminton coach says feel like a counsellor dealing with frustrated players

Lockdown effect: Junior badminton coach says feel like a counsellor dealing with frustrated players




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Lufthansa Group airlines to take off again in June with 160 aircraft, 106 destinations

Lufthansa Group airlines to take off again in June with 160 aircraft, 106 destinations




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Lockdown 3.0: Tecno launches doorstep smartphone delivery with over 35,000 retailers - Times of India

Lockdown 3.0: Tecno launches doorstep smartphone delivery with over 35,000 retailers - Times of India




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Gujarat: Migrant workers clash with police in Surat | Surat News - Times of India

Gujarat: Migrant workers clash with police in Surat | Surat News - Times of India




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Tamil Nadu government's failure to comply with HC order results in closure of Tasmac shops

Tamil Nadu government's failure to comply with HC order results in closure of Tasmac shops




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Withdraw decision to stop MPLADS funding: DMK

Withdraw decision to stop MPLADS funding: DMK




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Cops to tread cautiously with drunk driving tests in Hyderabad

Cops to tread cautiously with drunk driving tests in Hyderabad




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Mumbai NGO reaches out to sex workers, nomads with ration during lockdown

Mumbai NGO reaches out to sex workers, nomads with ration during lockdown




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Maharashtra home minister thanks cops for Covid-19 fight with logo tribute

Maharashtra home minister thanks cops for Covid-19 fight with logo tribute




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Coronavirus | Phase-2 trial with three drugs offers hope

Testing in Hong Kong hospitals shows the regimen clears coronavirus in 7 days in the mildly ill.




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With 72 deals worth $3.7 bn, PE investments register growth in Oct: Report

Private equity investments witnessed a robust yearly growth in October with 72 PE deals garnering around USD 3.7 billion, even as merger and acquisition activity saw a downtrend, a report said on Thursday. According to Grant Thornton's monthly PE Dealtracker, private equity/venture capital transactions reported 22 per cent and 25 per cent increase in deal volumes and values, respectively as compared to October 2018. The rise in PE deal values was largely driven by the corporate tax rate cut, which has improved both investor sentiment and confidence. Last month, the average deal size stood at USD 52 million, up from USD 28 million recorded in September 2019. "There were 72 deals aggregating to USD 3.7 billion reported in October 2019. Upbeat PE/VC activity during the month offsets the shortfall in merger and acquisition (M&A) activity," Pankaj Chopda, Director, Grant Thornton India LLP said. "The key investments were primarily to pare debt, expand markets and capitalise on ...




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[ASAP] Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus <italic toggle="yes">Talaromyces</italic> sp.

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00024




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[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




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[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




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Fun and games with JavaScript

#484 — April 17, 2020

Unsubscribe  :  Read on the Web

???? If you're bored this weekend at all, consider joining the latest Ludum Dare — it's an online game jam that's been taking place for 18 years and more JavaScript entries are appreciated against all the Unity crowd ????

JavaScript Weekly

Writing an 'Emulator' in JavaScript (and Interfacing with Multiple UIs) — This is really neat. Tania built a Chip-8 interpreter in JavaScript and has gone into quite a bit of detail about what was involved here. Lots of neat bits and pieces to pick up from this.

Tania Rascia

jQuery 3.5.0 Released — I know many of you will groan, but I’m delighted when I see a new jQuery release. It’s still so heavily used. No headline features though, this is a security fix for a cross-site scripting vulnerability, plus some tweaks and fixes in preparation for jQuery 4.0 (yes!)

Timmy Willison (jQuery Foundation)

Build a Game of Battleship with TypeScript & Java. Free Course — Join over 2000 developers creating a game of Battleship with TypeScript, Spring Cloud Stream (Java), and PubSub+. This free 30-minute course is a great way to learn the basics of messaging and event-driven architecture with the Aurelia framework.

Solace sponsor

Profiling React.js Performance — Goes into detail on aspects of the React Profiler API, React’s new experimental Interaction Tracing API, and measuring custom metrics using the User Timing API.

Addy Osmani

Userscripts are Fun and Still Very Much Relevant — ‘Userscripts’ are basically JavaScript programs that run in the context of other Web pages so you can add your own features. They were really popular for a while but still exist and are still a neat use case for using JavaScript to improve your Web experience.

Eldad Bercovici

Another Look at What's New in ECMAScript 2020 — We linked to Dr Axel’s roundup recently, but here’s another take, looking at dynamic imports, nullish coalescing, optional chaining, BigInt, and more.

Ianis T.

⚡️ Quick Releases

???? Jobs

JavaScript Developer at X-Team (Remote) — Join the most energizing community for developers. Work from anywhere with the world's leading brands.

X-Team

Senior JavaScript Developer (Warsaw, Relocation Package) — Open source rich text editor used by millions of users around the world. Strong focus on code quality. Join us.

CKEditor

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Create a Particle Trail Animation in JavaScript — Particle animations are particularly (sorry) striking.. and in this article, Anna Prenzel shows how to easily create your own such effects with Anime.js.

Smashing Magazine

Strategies for Migrating to TypeScript — A quick overview of some strategies for migrating code bases from JavaScript over to TypeScript.

Dr. Axel Rauschmayer

Developing in a Monorepo While Still Using Webpack — Second part in a series discussing things the team at Etsy learned during the migration of a home-grown, Require.js-based build system to webpack, which took over a year.

Salem Hilal

A More Productive Way to Build Your JavaScript Apps — Write better code, debug it, and test it – all in one place. Try WebStorm. No configuration required.

WebStorm sponsor

▶  Let's Build a Digital Circuit Simulator in JavaScript — A special episode of the Low Level JavaScript series takes us on a brief journey into the world of digital logic.

Low Level JavaScript

How To Set Up an Express API Backend Project with PostgreSQL — A pretty extensive walkthrough of creating an HTTP API using Express with Node.js and Postgres on the backend, then deploying it all on Heroku.

Chidi Orji

Speed Up Your Angular App: 14 Optimization Tips — Tips on how to make your Angular app smaller, faster, and more responsive.

Marcelo Ricardo de Oliveira

Class-Related Types in TypeScript

Dr. Axel Rauschmayer

????▶ A Fireside Chat on the State of Microservices on April 21 — We recently helped The Software House with a developer survey (thanks to those who took it!) and now they’re doing a live chat on the state of microservices next Tuesday featuring Yan Cui, Alessando Vozza, and others.

The Software House

???? Code & Tools

Puppeteer 3.0: It Now Supports Firefox — Best known for as a way to headlessly control Chrome from Node, Puppeteer has recently seen some competition in the form of the cross-browser Playwright recently. But, no fear, Puppeteer is stepping up and can now work cross-browser too. We also learn Puppeteer is migrating to TypeScript.

Mathias Bynens

Open-Source Serverless CMS Powered by React, Node.js and GraphQL API — Build dynamic websites and apps with Webiny. 100% powered by JavaScript. Deploy your sites to AWS Lambda.

Webiny Serverless CMS sponsor

Rome: An Experimental JavaScript Toolchain — A compiler, linter, formatter, bundler, testing framework and more. Started by Sebastian McKenzie (of Babel and Yarn fame), Rome is now a project from the React Native team at Facebook. Related repo.

Facebook

Vime: A New, Modern Media / Video Player for the Web — Aims to be a ‘modern alternative to Video.js and Plyr’: “The idea behind Vime is we want you to control the player, not the other way around.” Modular, tree-shakable, and with potential for a plugin ecosystem. GitHub repo.

Rahim Alwer

Vuln Cost: An Open Source Security Scanner for VS Code — Free Snyk-powered VS Code extension that finds security vulnerabilities in npm packages, providing feedback in-line with your code, such as how many vulnerabilities a package has.

snyk

ip-num: A Library to Work with ASN, IPv4, and IPv6 Numbers — Happy in both Node and the browser.

dadepo

Flip: Animated Flip Counter Plugin to Add a Countdown to a Website — Adds an animated dynamic countdown timer to a page. No dependencies, responsive and mobile friendly, and fits any language, locale, or time zone.

Rik Schennink

The Perfect Partner to MongoDB Atlas. Try It for Free

Studio 3T sponsor

A JavaScript API for Controlling 'Simpsons: Hit & Run' — Including this as a bit of fun if you fancy noodling on something odd. Remote controlling games from JS seems neat, although I suspect just getting this running would take a while..

Tavis Ormandy




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Odisha tables revenue surplus budget with total outgo pegged at Rs 1.5 trn

Budget estimates fiscal deficit to be at 3.4%, within permissible limit of FRBM target




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Discussing Radiation Risks Associated With CT Scans With Patients

Interview with Mark Otto Baerlocher, MD, author of Discussing Radiation Risks Associated With CT Scans With Patients




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Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment

Interview with Nora D. Volkow, MD, author of Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment




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Prevention of Melanoma With Regular Sunscreen Use

Interview with June K. Robinson, MD, author of Prevention of Melanoma With Regular Sunscreen Use




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Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage

Interview with J. Michael McWilliams, MD, Phd, author of Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage




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Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




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Neuron Number and Size in Prefrontal Cortex of Children With Autism

Interview with Eric Courchesne, PhD, author of Neuron Number and Size in Prefrontal Cortex of Children With Autism




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Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial

Interview with Steven E. Nissen, MD, author of Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial