Apple is preparing to reopen all four of its Apple Stores in Switzerland on May 12, as part of the iPhone maker's bid to slowly return its retail efforts back to normal around the world.

Ongoing practical friendship wins the trust of a family in Montenegro, opening a door of hope for their future.

Washington, D.C. Newsroom, May 7, 2020 / 02:40 pm (CNA).- The governor of Illinois has said he will continue to ban public gatherings of more than 50 people—including religious services—until a vaccine or treatment for coronavirus is available.

The announcement comes as the White House is reported to have shelved guidance from the Centers for Disease Control on gradually reopening sections of the American economy and society.

Illinois governor J.B. Pritzker announced Wednesday that gatherings of more than 50 people in the state would not be allowed until a coronavirus vaccine “or highly effective treatment” is “widely available.”

Public health officials, including Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, have cautioned that a COVID-19 vaccine is at least 12 to 18 months from being developed and made available.

According to Pritzker’s five-part plan for reopening the state, gatherings of ten or fewer people are not even allowed until phase 3, the “recovery” phase that can begin, at earliest, May 29. However, following a lawsuit last week, the governor has allowed citizens to leave their homes for religious services as long as ten or fewer people are gathered for worship.

Previously, religious services of any kind in the state—including drive-in and in-person services—were curtailed during the pandemic, and even other forms of sacramental practice such as drive-in confessions were not allowed.

The Archdiocese of Chicago announced on May 1 that public Masses with 10 or fewer people would resume.

Other dioceses across the United States have already begun rolling back total suspensions on the public celebration of Mass. 

Last week, CNA reported that the White House Domestic Policy Council held a series of conference calls with bishops who had begun the process of reopening churches in line with local public health orders.

During the calls, administration officials expressed their hope to be able to support faith communities with “sensitive and respectful guidance” to help restore public worship “as soon as it is feasible.”

The bishops were told that the Centers for Disease Control hoped that issuing guidance could help inform state and local leaders about the “essential” nature of religious practice, while still allowing for localized responses to the coronavirus and provide “helpful parameters” for state and local governments who are trying to safeguard public health. But, on Thursday, AP reported that the Trump administration had shelved a 17-page report titled “Guidance for Implementing the Opening Up America Again Framework.”

That document included a section on “Interim Guidance for Communities of Faith.”

According to AP, CDC officials expected the guidance to be released at the end of last week but were instead told it “would never see the light of day.” 

Peter Breen, executive director of the Thomas More Society,  told CNA that “policymakers that are making plans based on the development of a vaccine or other cure to this coronavirus are engaging in magical thinking.”

“While there is always a possibility that some miracle cure may emerge, that is entirely uncertain and should not be the basis for setting policy, especially policy in relation to our communities of faith,” Breen stated.

On April 30, the Thomas More Society filed a lawsuit on behalf of The Beloved Church in Lena, Illinois, and by that night, attorney Peter Breen told CNA, a paragraph had been added to an executive order of Pritzker’s allowing for people to leave their home for religious services.

“He [Pritzker] has at least brought churches out of the abyss of ‘non-essential,’ but he has not fully elevated them to the heights of being an ‘essential’ business or operation,” Breen told CNA on Wednesday, noting that businesses deemed “essential” to remain open were not subject to the 10-person rule.

In each village, a small crowd of people gathered, and children and adults watched the puppet theatre with much interest. The team also put on a concert featuring songs by Istvan Horvath, a member of the OM Hungary team, as well as English songs by the international team. during Easter

OMers work with a Hungarian church to invest in relationships through every season.

An unexpected connection on a prayer walk leads to multiple opportunities to share spiritual truth with one Muslim family.

The nation craves a plan, not hunches.

CNA Staff, May 7, 2020 / 07:00 am (CNA).- The sainthood causes of St. John Paul II’s parents were formally opened in Poland Thursday.

A ceremony launching the causes of Karol and Emilia Wojtyła took place at the Basilica of the Presentation of the Blessed Virgin Mary in Wadowice, John Paul II’s birthplace, May 7. 

At the ceremony, the Archdiocese of Kraków officially formed the tribunals that will seek evidence that the Polish pope’s parents lived lives of heroic virtue, enjoy a reputation for holiness and are regarded as intercessors. 

After the tribunals’ first session, Kraków Archbishop Marek Jędraszewski presided at a Mass, which was broadcast via livestream amid Poland’s coronavirus lockdown. 

Cardinal Stanisław Dziwisz, who served as Pope John Paul II’s personal secretary, attended the ceremony.

He said: “I want to testify here, at this point, in the presence of the archbishop and the assembled priests, that as a long-standing secretary of Cardinal Karol Wojtyła and Pope John Paul II, I heard from him many times that he had holy parents.”

Fr. Paweł Rytel-Andrianik, spokesman for the Polish bishops’ conference, told CNA: “The processes of beatification of Karol and Emilia Wojtyła ... testify above all to the appreciation of the family and its great role in shaping the holy and great man -- the Polish Pope.” 

“The Wojtyłas were able to create such an atmosphere at home and form children in such a way that they became outstanding people.” 

“Therefore, there is great joy of starting the beatification processes and great gratitude to God for the life of Emilia and Karol Wojtyła and for the fact that we will be able to get to know them more and more. They will become a model and example for many families who want to be holy.”

Postulator Fr. Sławomir Oder, who also oversaw the cause of John Paul II, told Vatican News that the ceremony was an occasion for rejoicing in Poland. 

He said: “In fact, looking at this event, I am reminded of the words that John Paul II pronounced during the Mass of canonization of St. Kinga, known as Cunegonda, celebrated in Poland in Stary Sącz, when he said that saints are born of saints, are nurtured by the saints, draw life from the saints and their call to holiness.” 

“And in that context he spoke precisely of the family as the privileged place where holiness finds its roots, the first sources where it can mature throughout life.”

The Basilica of the Presentation, where the Wojtyłas' cause was opened, is where St. John Paul II was baptised on June 20, 1920. The church is located across the street from the Wojtyła family home, which is now a museum, in Wadowice.

Karol Wojtyła, an army officer, and Emilia, a school teacher, were married in Kraków in 1906. They had three children. The first, Edmund, was born that year. He became a doctor but caught scarlet fever from a patient and died in 1932. Their second child, Olga, died shortly after birth in 1916. Their youngest, Karol junior, was born in 1920, after Emilia refused a doctor’s advice to have an abortion because of her frail health. 

Emilia worked as a part-time seamstress after her third child’s birth. She died on April 13, 1929, shortly before Karol junior’s ninth birthday, of myocarditis and renal failure, according to her death certificate.

Karol senior, who was born on July 18, 1879, was a non-commissioned officer of the Austro-Hungarian army and a captain of the Polish army. He died on Feb. 18, 1941, in Kraków amid the Nazi occupation of Poland.

The future pope, who was 20 at the time and working at a stone quarry, returned from work to find his father’s body. He spent the night praying beside the body and afterwards began to pursue his vocation to the priesthood. 

Veracruz, Mexico :: Visitors to Logos Hope are delighted to learn they have longer to visit the ship than originally scheduled.

A previously healthy 9-year-old immigrant girl from Mexico was evaluated in the emergency department (ED) with one week of fatigue, fevers, rhinorrhea, and cough. She initially presented to her primary pediatrician, where a complete blood count revealed neutropenia, prompting referral to the ED. In the ED, she was found to be influenza A–positive. Because of dehydration, she received intravenous fluids and was admitted to the pediatric hospital medicine service. After 2 days, influenza symptoms improved, and oral intake increased. However, she was noted to have decreased bilateral lower-extremity strength, absent Achilles reflexes, decreased lower-extremity sensation and proprioception, a positive result on the Romberg sign, and abnormal heel-to-shin testing results. These findings prompted an urgent neurology consultation. After extensive imaging, laboratory evaluation, and further consultations, a diagnosis was established.

Pediatric thrombocytopenia has a wide differential diagnosis, and recently, genetic testing to identify its etiology has become more common. We present a case of a 16-year-old boy with a history of chronic moderate thrombocytopenia, who later developed constitutional symptoms and bilateral hand edema with cold exposure. Laboratory evaluation revealed evidence both of inflammation and elevated muscle enzymes. These abnormalities persisted over months. His thrombocytopenia was determined to be immune mediated. Imaging revealed lymphadenopathy and asplenia, and a muscle biopsy was consistent with tubular aggregate myopathy. Ophthalmology evaluation noted photosensitivity, pupillary miosis, and iris hypoplasia. Genetic testing demonstrated a pathogenic variant in STIM1 consistent with autosomal dominant Stormorken syndrome. Our case is novel because of the overlap of phenotypes ascribed to both gain-of-function and loss-of-function pathogenic variants in STIM1, thereby blurring the distinctions between these previously described syndromes. Pediatricians should consider checking muscle enzymes when patients present with thrombocytopenia and arthralgia, myalgia, and/or muscle weakness. Our case highlights the importance of both multidisciplinary care and genetic testing in cases of chronic unexplained thrombocytopenia. By understanding the underlying genetic mechanism to a patient’s thrombocytopenia, providers are better equipped to make more precise medical management recommendations.

The OM Ukraine team in Vinnitsa hosts a summer camp and experiences unity with churches and transformation with children.

The needs of the world have become real to Luz Ángela Miranda in OM Panama's Intensive School of Missions.

Words: Abbie Lyall

Sponsored Editorial

A NEW bar and fine dining restaurant offering dishes with “Glasgow at its very heart” is to open in a historic City Centre building.

We find out about a life-changing scheme in Bosnia and Herzegovina.

Against the backdrop of the global corona crisis and a collapse in flight operations, the Supervisory Board today set the important course for the development of the airport company after commissioning BER.

A glance through Jamie Genevieve's social media pages and a fairly intimidating impression emerges.

I’ve been longing to eat Korean food ever since seeing Bong Joon-Ho’s phenomenal Oscar-winning film, Parasite, his interrogation of class and wealth on the plate. The wealthy mother tells her housekeeper to prepare jjapaguri, essentially an everyday dish, commonly made with two sorts of instant noodles. What makes this one exclusive and upper class is its topping of steak, from indigenous, highly prized Hanwoo cattle, which is way more expensive than Waygu beef would be here. Only the Korean

Over 120 children from the Minsk area enjoyed football-based activities on the day of the Belarus Super Cup match, highlighting the link between grassroots and elite football.

AN EDINBURGH-BASED hydrogen technology firm is to open the first public hydrogen refuelling station for vehicles in Scotland’s central belt.

In this country, where the dank, grim days of winter are as short as a resigned sigh, the onset of some decent, dry spring weather doesn’t half raise the morale. Well, it would if the coronavirus wasn’t lurking all over the parish.

THE Open Championship will not take place at all this year.

Scottish Golf today revealed that no date has been set for the sport in this country to restart and stressed that lockdown restrictions will remain in place for the foreseeable future.

EDUCATION Secretary John Swinney does not expect schools to reopen overnight as he stressed they would only do so when it was safe for public health.

Schools in Wales could be allowed to reopen their doors next month in a phased approach, the first minister has said.

THE SCOTTISH Government “does not consider it likely” that schools will fully re-open “in the foreseeable future” - while working from home is “likely to persist as part of the new normal”.

The only way an ed-tech company can have a meaningful impact in schools is by addressing a specific problem and offering a real solution.

A textbook is no longer enough in many classrooms, writes Dan McDowell, but finding the right OER materials can be tricky.

For three decades now, the artist and playwright John Byrne has been sitting regularly for photographer David Eustace, the Glasgow-born photographer who left school at 16 and joined first the navy and then the prison service before settling on a career behind a camera.

Febrile neutropenia is a common complication in children with cancer. Traditionally, even low-risk episodes have been managed entirely in an inpatient setting, and discharge of the patients has been delayed until resolution of fever and sustainable hematopoietic recovery.

The results of this decision-analytic model evaluating low-risk febrile neutropenia episodes suggest that the substantially higher costs of inpatient management cannot be justified on the basis of safety and efficacy considerations or patient/parent preferences. Uncertainty remains whether intravenous or oral treatment might be the preferable route of drug administration in an ambulatory setting. (Read the full article)

Studies on vaccine safety are crucial to the ongoing success of our national immunization program. ITP has a known association with MMR in young children, occurring in 1 in 40 000 doses. The risk after other childhood vaccines is unknown.

This study found no increased risk of ITP after vaccines other than MMR in young children, confirmed an association of ITP with MMR, and also found that ITP may occur after certain other vaccines in older children. (Read the full article)

To date, 4 small to moderate sized studies have revealed conflicting results on the clinically important question whether thrombocytopenia contributes to persistent patent ductus arteriosus (PDA) in very immature, preterm infants.

Thrombocytopenia in the first 24 hours after birth was not associated with the incidence of PDA at postnatal day of life 4 to 5 in a large cohort of preterm infants with <1500 g birth weight. Platelet dysfunction, rather than platelet number, might play a role in ductus arteriosus patency. (Read the full article)

Clinically significant bleeding in pediatric immune thrombocytopenia (ITP) is rare. Evidence-based guidelines for the management of pediatric ITP recommend that patients with mild or no bleeding be followed with observation alone.

Many pediatric patients with newly diagnosed ITP continue to be managed in the inpatient setting. Bleeding events are rare in this setting. Although geographic variability exists, intravenous immunoglobulin is the most commonly used inpatient ITP treatment in the United States. (Read the full article)

Small-for-gestational-age neonates are at risk for thrombocytopenia during the first days and weeks after birth. However, the incidence, duration, severity, responsible mechanism, value of platelet transfusions, and risk of death from this variety of neonatal thrombocytopenia are unknown.

Ten percent of thrombocytopenic small-for-gestational-age neonates have a recognized cause for low platelets (aneuploidy, extracorporeal membrane oxygenation, disseminated intravascular coagulation); they have a high mortality rate (65%). Ninety percent have a moderate, transient (2 weeks), hyporegenerative thrombocytopenia with a low mortality rate (2%). (Read the full article)

Small for gestational age neonates (weight <10th percentile) are at risk for neutropenia during the first days after birth. However, the duration, responsible mechanism, and outcomes of this variety of neonatal neutropenia are not precisely known.

Six percent of small for gestational age neonates had neutrophils <1000/μL, with an average neutropenia duration of 7 days. Neutropenia was more closely linked with small for gestational age status than maternal hypertension. This neutropenia is associated with elevated nucleated red blood cell count and increased odds of necrotizing enterocolitis. (Read the full article)

From 9 a.m. to 3 p.m. Saturday, March 28, members of the Penn College community will welcome thousands of potential enrollees and their families, opening wide the doors to a landmark institution that has helped tomorrow makers fulfill their destinies for more than a century.

Objectives: Carbapenemase-producing Enterobacterales and specifically KPC-producing Klebsiella pneumoniae (KPC-Kp) are rapidly spreading worldwide. The prognosis of ventilator-associated pneumonia (VAP) caused by KPC-producing Klebsiella pneumoniae (KPC-Kp) is not well known. Our study tries to assess whether ventilator-associated pneumonia caused by a KPC-Kp strain is associated with higher all-cause mortality than if caused by carbapenem-susceptible isolates.

Study design and methods: This is a retrospective cohort study of patients with VAP due to K. pneumoniae from a 35-bed polyvalent Intensive Care Unit in a university hospital (> 40,000 annual admissions) between January 2012 and December 2016. Adjusted multivariate analysis was used to study the association of KPC-Kp with 30-day all-cause mortality (Cox regression).

Results. We analyze 69 cases of K. pneumoniae VAP of which 39 were produced by a KPC-Kp strain with high-level resistance to meropenem (MIC > 16 mg/mL). All-cause mortality at 30 days was 41% in the KPC-Kp group (16/39) and 33.3% in the carbapenem-susceptible cases (10/30). KPC-Kp etiology was not associated with higher mortality when controlled for confounders (adjusted hazard ratio [lsqb]HR[rsqb] 1.25; 95% CI: 0.46–3.41). Adequate targeted therapy (HR 0.03; 95% CI: <0.01–0.23) was associated with all-cause mortality.

Conclussion. Assuming the limitations due to the available sample size, the prognosis of VAP caused by KPC-Kp is similar to VAPs caused by carbapenem-susceptible K. pneumoniae when appropriate treatment is used.

Third-generation cephalosporin (3GC)-resistant Enterobacteriaceae are classified as critical priority pathogens, with extended-spectrum β-lactamases (ESBLs) as principal resistance determinants. Enmetazobactam (formerly AAI101) is a novel ESBL inhibitor developed in combination with cefepime for empiric treatment of serious Gram-negative infections in settings where ESBLs are prevalent. Cefepime-enmetazobactam has been investigated in a phase 3 trial in patients with complicated urinary tract infections or acute pyelonephritis. This study examined pharmacokinetic-pharmacodynamic (PK-PD) relationships of enmetazobactam, in combination with cefepime, for ESBL-producing isolates of Klebsiella pneumoniae in 26-hour murine neutropenic thigh infection models. Enmetazobactam dose fractionation identified time above a free threshold concentration (fT > C_T) as the PK-PD index predictive of efficacy. Nine ESBL-producing isolates of K. pneumoniae, resistant to cefepime and piperacillin-tazobactam, were included in enmetazobactam dose-ranging studies. The isolates encoded CTX-M-type, SHV-12, DHA-1 and OXA-48 β-lactamases and covered a cefepime-enmetazobactam MIC range from 0.06 to 2 μg/ml. Enmetazobactam restored the efficacy of cefepime against all isolates tested. Sigmoid curve fitting across the combined set of isolates identified enmetazobactam PK-PD targets for stasis and for a 1-log₁₀ bioburden reduction of 8% and 44% fT > 2 μg/ml, respectively, with a concomitant cefepime PK-PD target of 40 – 60% fT > cefepime-enmetazobactam MIC. These findings support clinical dose selection and breakpoint setting for cefepime-enmetazobactam.

Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor controlling capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem/vaborbactam in a KPC-3 producing K. pneumoniae isolate.

Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the dynamic in vitro CDC biofilm reactor (CBR). Two hypermutable P. aeruginosa strains, PAOmutS (MIC_{ciprofloxacin} 0.25 mg/L, MIC_meropenem 2 mg/L) and CW44 (MIC_{ciprofloxacin} 0.5 mg/L, MIC_meropenem 4 mg/L), were investigated for 120h. Concentration-time profiles achievable in epithelial lining fluid (ELF) following FDA-approved doses were simulated in the CBR. Treatments were ciprofloxacin 0.4g every 8h as 1h-infusions (80% ELF penetration), meropenem 6 g/day as continuous infusion (CI; 30% and 60% ELF penetration) and their combinations. Counts of total and less-susceptible planktonic and biofilm bacteria and MICs were determined. Antibiotic concentrations were quantified by UHPLC-PDA. For both strains, all monotherapies failed with substantial regrowth and resistance of planktonic (≥8log₁₀ CFU/mL) and biofilm (>8log₁₀ CFU/cm²) bacteria at 120h (MIC_{ciprofloxacin} up to 8 mg/L, MIC_meropenem up to 64 mg/L). Both combination treatments demonstrated synergistic bacterial killing of planktonic and biofilm bacteria of both strains from ~48h onwards and suppressed regrowth to ≤4log₁₀ CFU/mL and ≤6log₁₀ CFU/cm² at 120h. Overall, both combination treatments suppressed amplification of resistance of planktonic bacteria for both strains, and biofilm bacteria for CW44. The combination with meropenem at 60% ELF penetration also suppressed amplification of resistance of biofilm bacteria for PAOmutS. Thus, combination treatment demonstrated synergistic bacterial killing and resistance suppression against difficult-to-treat hypermutable P. aeruginosa strains.

The precious metal eased for a third day after US equities hit the highest in almost seven weeks as states including Florida took steps toward easing restrictions.

Global markets rallied on the back of optimism that most governments were gearing up to at least partially reopen their economies following lockdowns to prevent the spread of the coronavirus.

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Google removes the free WireGuard app from the Play Store for having a donation button, reigniting a debate over whether its policy hurts the open-source community.

Hotels are poised for a “stepped” reopening in Scotland once lockdown restrictions are eased, a sector expert has said.

The Herald is bringing you the latest coronavirus news and updates from Scotland, the UK and the world.

Denver Newsroom, Apr 21, 2020 / 03:15 pm (CNA).- An Argentine archbishop has proposed 13 measures that would aim to allow churches to reopen churches during the coronavirus pandemic while reducing the risk of contagion.

The proposal is an effort to balance safety and the need for Catholics to receive the Eucharist, Archbishop Víctor Fernández of La Plata said this week.

In response to the pandemic, Argentina has been under lockdown since March 20. According to John Hopkins University, there are 3,031 confirmed cases of COVID-19 with 145 deaths in the country.

Fernández said that although the Church is providing material sustenance to those hardest hit by the pandemic “when we think about sustaining the interior life of the faithful and encouraging its growth, we find ourselves in the serious difficulty of seeing them deprived of the Eucharist for a long time, and we can also foresee that this situation could last for several months.”

In a letter dated April 19 and addressed to the conference’s executive committee, the bishop said the Second Vatican Council teaches that “no Christian community is built up if it is not rooted and centered on the celebration of the Holy Eucharist,” and that Saint John Paul II emphasized that the Mass “rather than an obligation, should be felt as a requisite deeply inscribed in Christian existence.”

Fernández said the letter he sent puts together the suggestions of several bishops and that it is understandable “that many of the faithful are calling on us to find some way to make the Eucharist accessible again.”

“We tell them that they can experience other forms of prayer, and they do, but as Saint John Chrysostom has said “’You can also pray in your home, however, you cannot pray the same way you do in church where the brethren are gathered together.’”

Fernández noted that Pope Francis “teaches that God ‘in the culmination of the mystery of the Incarnation, chose to reach our intimate depths through a fragment of matter.’ It’s good that our faithful have learned that and so it’s not the same thing for them,” he said, adding that Catholics are eager “the food of the love that is the source of supernatural life.”

“It won’t be easy to prove that this situation is lasting too long, nor can we simply wait till the pandemic is completely over,” the prelate noted.

“We know that exposing yourself to infection is irresponsible especially because it involves exposing others to infection and indirectly could lead to a public health crisis that we don’t want to see in our country,” he said.

Aiming to send “a clear message to our People of God to show that we’re truly concerned and that we intend to take some steps that would allow us to resolve this situation as soon as possible,” without neglecting “the health concerns of the authorities” Fernández proposed a series of obligatory measures to celebrate the Eucharist publicly:
1) Keep a distance of two meters between people to the side, front and back. This will require removing or closing off half the pews in the church.
2) No more than two people per pew.
3) Once the pews are occupied in that manner, no more people are to be allowed to enter the church.
4) In the churches where there is usually a lot of people in attendance, the number of Masses should be increased so the faithful can spread themselves out over Saturday and Sunday at different times. Given the prevalence and closeness of churches this will not involve using transportation.
5) Mass should not be celebrated publicly at the most frequently visited shrines due to the difficulty of establishing appropriate controls.
6) There should be no line for communion, instead the Eucharistic ministers should go to the people positioned at the ends of the pews and place the Eucharist in the hand.
7) Every Eucharistic minister should wash his hands with soap before and after and apply alcohol gel.
8) The sign of peace and any physical contact should be omitted.
9) Mass should last no more than 40 minutes.
10) People should leave the church progressively, not all at once, and avoid greeting each other.
11) No intentions should be taken at Mass time, only those previously received by phone, mail or messages.
12) Those people who because of their age are prevented from attending may receive Communion at home.
13) The dispensation from the Sunday obligation should be temporarily maintained so that people who prefer to exercise extreme caution don’t feel obliged to attend.

The archbishop also pointed out in his letter that “if the economic impact has to be foreseen, it’s also appropriate to place a value on those things that provide consolation and strength to people during hard times.”

 

A version of this story was first published by ACI Prensa, CNA's Spanish-language news partner. It has been translated and adapted by CNA.