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A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome




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Novel targeted drugs approved by the NMPA and FDA in 2019




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Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo




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Signal Transduction and Targeted Therapy




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The chromosome-scale genome reveals the evolution and diversification after the recent tetraploidization event in tea plant




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MdMYB6 regulates anthocyanin formation in apple both through direct inhibition of the biosynthesis pathway and through substrate removal




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A pentaploid-based linkage map of the ancestral octoploid strawberry <i>Fragaria virginiana</i> reveals instances of sporadic hyper-recombination




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Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer




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Erlotinib sensitivity of <i>MAPK1</i>p.D321N mutation in head and neck squamous cell carcinoma




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Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants




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Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo




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Light: Science & Applications




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SAS Samples25299: COMPARE Procedure, Chapter 13




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Cardiovascular response and sequelae after minimally invasive surfactant therapy in growth-restricted preterm infants




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Implementation of a statewide, multisite fetal tele-echocardiography program: evaluation of more than 1100 fetuses over 9 years




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Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy




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Treating osteoarthritis via gene therapy with rejuvenation factors




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Gene therapy for cardiovascular diseases in China: basic research




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Gene Therapy




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Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis




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A stereotyped light chain may shape virus-specific B-cell receptors in HCV-dependent lymphoproliferative disorders




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Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils




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Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes




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GCA relapse common in ustekinumab trial




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Physical therapy better than steroids for knee OA




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Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast




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The impact of 2018 ASCO-CAP HER2 testing guidelines on breast cancer HER2 results. An audit of 2132 consecutive cases evaluated by immunohistochemistry and in situ hybridization




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<i>KRAS</i> amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy




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Cost-effectiveness of <i>CYP2C19-</i>guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data




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Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy




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Association of <i>MICA</i>-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis




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Adoptive immunotherapy for myeloid malignancies




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Abstracts from the 2nd International Norges Teknisk-Naturvitenskapelige Universitet (NTNU) Symposium: Day 1—Immunotherapy and Hematology




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The Health-Wealth Gap

The growing gulf between rich and poor inflicts biological damage on bodies and brains




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Coronapod: What use are contact tracing apps? And new hopes for coronavirus drug remdesivir




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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform




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Tunable correlated states and spin-polarized phases in twisted bilayer–bilayer graphene




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Detection of metastable electronic states by Penning trap mass spectrometry




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Mapping the twist-angle disorder and Landau levels in magic-angle graphene




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Statin therapy is associated with lower prevalence of gut microbiota dysbiosis




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Worm brain, ocean giant and soothing Jupiter — April’s best science images




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Coronapod: The overlooked outbreaks that could derail the coronavirus response




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First CRISPR test for the coronavirus approved in the United States




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Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications’ door




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Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer




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Urate-lowering therapy exerts protective effects against hypertension development in patients with gout




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Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study




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Apixaban therapy is effective and safe for cancer-associated VTE