ut Acute Effects of Insulin in the Control of VLDL Production in Humans: Implications for the insulin-resistant state By care.diabetesjournals.org Published On :: 1996-04-01 Gary F LewisApr 1, 1996; 19:390-393Symposium On Insulin Resistance Full Article
ut Prevalence of Diabetes in Mexican Americans, Cubans, and Puerto Ricans From the Hispanic Health and Nutrition Examination Survey, 1982-1984 By care.diabetesjournals.org Published On :: 1991-07-01 Katherine M FlegalJul 1, 1991; 14:628-638Supplement 3: Diabetes in Hispanic Americans Full Article
ut Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2007-06-01 Tina VilsbøllJun 1, 2007; 30:1608-1610BR Emerging Treatments and Technologies Full Article
ut Precipitation of Autoimmune Diabetes With Anti-PD-1 Immunotherapy By care.diabetesjournals.org Published On :: 2015-04-01 Jing HughesApr 1, 2015; 38:e55-e57e-Letters: Observations Full Article
ut Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum By care.diabetesjournals.org Published On :: 2018-01-01 William T. CefaluJan 1, 2018; 41:14-31Diabetes Care Expert Forum Full Article
ut Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes: A Consensus Report of the American Association of Clinical Endocrinologists, the American Association of Diabetes Educators, the American Diabetes Association, the Endo By care.diabetesjournals.org Published On :: 2017-12-01 Gina AgiostratidouDec 1, 2017; 40:1622-1630Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
ut Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up By care.diabetesjournals.org Published On :: 2016-05-01 The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research GroupMay 1, 2016; 39:686-693Cardiovascular Disease and Diabetes Full Article
ut Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis By care.diabetesjournals.org Published On :: 2016-07-01 Sunder MudaliarJul 1, 2016; 39:1115-1122Diabetes Care Symposium Full Article
ut Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010 By care.diabetesjournals.org Published On :: 2012-07-01 Franca B. BartonJul 1, 2012; 35:1436-1445Diabetes Care Symposium Full Article
ut CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis By care.diabetesjournals.org Published On :: 2016-07-01 Ele FerranniniJul 1, 2016; 39:1108-1114Diabetes Care Symposium Full Article
ut Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study By care.diabetesjournals.org Published On :: 1995-09-01 Johanna M MooySep 1, 1995; 18:1270-1273Short Report Full Article
ut Impact of Recent Increase in Incidence on Future Diabetes Burden: U.S., 2005-2050 By care.diabetesjournals.org Published On :: 2006-09-01 K.M. Venkat NarayanSep 1, 2006; 29:2114-2116BR Epidemiology/Health Services/Psychosocial Research Full Article
ut Metabolic Implications of Body Fat Distribution By care.diabetesjournals.org Published On :: 1991-12-01 Per BjörntorpDec 1, 1991; 14:1132-1143Diet and Diabetes Full Article
ut Latin American business leaders optimistic about region’s post-pandemic economy By www.upi.com Published On :: Wed, 06 May 2020 18:44:51 -0400 Despite worrying economic projections, business leaders in Latin America remain optimistic about post-pandemic economy. Full Article
ut Report: South Korea tested new ballistic missile with larger warhead By www.upi.com Published On :: Thu, 07 May 2020 09:35:46 -0400 South Korea's military tested a ballistic missile capable of carrying a 2-ton warhead in March, according to local reports on Thursday. Full Article
ut Ex-South Korea comfort woman accuses activist of exploiting women, funds By www.upi.com Published On :: Thu, 07 May 2020 10:55:29 -0400 A former South Korean comfort woman accused an influential activist group of misappropriating funds and using past victims to advance their cause. Full Article
ut South Korea sees new cluster of COVID-19 cases tied to nightclubs By www.upi.com Published On :: Fri, 08 May 2020 07:16:30 -0400 Just days after South Korea loosened its social distancing guidelines, a new COVID-19 cluster of infections has sprung up in the capital city of Seoul tied to several nightclubs. Full Article
ut PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2019-09-01 Vanita R. ArodaSep 1, 2019; 42:1724-1732Emerging Therapies: Drugs and Regimens Full Article
ut Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum By care.diabetesjournals.org Published On :: 2018-01-01 William T. CefaluJan 1, 2018; 41:14-31Diabetes Care Expert Forum Full Article
ut Efficacy and Safety of Liraglutide 3.0 mg in Individuals With Overweight or Obesity and Type 2 Diabetes Treated With Basal Insulin: The SCALE Insulin Randomized Controlled Trial By care.diabetesjournals.org Published On :: 2020-05-01 W. Timothy GarveyMay 1, 2020; 43:1085-1093Emerging Therapies: Drugs and Regimens Full Article
ut Oral Semaglutide Versus Empagliflozin in Patients With Type 2 Diabetes Uncontrolled on Metformin: The PIONEER 2 Trial By care.diabetesjournals.org Published On :: 2019-12-01 Helena W. RodbardDec 1, 2019; 42:2272-2281Emerging Therapies: Drugs and Regimens Full Article
ut Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report By care.diabetesjournals.org Published On :: 2019-05-01 Alison B. EvertMay 1, 2019; 42:731-754Continuing Evolution of Nutritional Therapy for Diabetes Full Article
ut Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
ut Leukocyte Telomere Length, DNA Oxidation, and Risk of Lower-Extremity Amputation in Patients With Long-standing Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Telomere shortening and DNA oxidation are associated with premature vascular aging, which may be involved in lower-extremity amputation (LEA). We sought to investigate whether leukocyte telomere length (LTL) and plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidation, were associated with LEA in subjects with type 1 diabetes at high vascular risk. RESEARCH DESIGN AND METHODS LTL (quantitative PCR) and plasma 8-OHdG concentrations (immunoassay method) were assessed at baseline in the GENEDIAB (Génétique de la Néphropathie Diabétique) type 1 diabetes cohort. Logistic and Cox proportional hazards regression models were fitted to estimate odds ratio (OR) (at baseline) and hazard ratio (HR) (during follow-up), with related 95% CI, by increasing biomarker tertiles (T1, T2, T3). RESULTS Among 478 participants (56% male, mean ± SD age 45 ± 12 years and diabetes duration 29 ± 10 years), 84 patients had LEA at baseline. Baseline history of LEA was associated with shorter LTL (OR for T2 vs. T1 0.62 [95% CI 0.32–1.22] and for T3 vs. T1 0.41 [0.20–0.84]) but not with plasma 8-OHdG (1.16 [0.56–2.39] and 1.24 [0.61–2.55], respectively). New cases of LEA occurred in 34 (12.3%) participants during the 10-year follow-up. LTL were shorter (HR T2 vs. T1 0.25 [95% CI 0.08–0.67] and T3 vs. T1 0.29 [0.10–0.77]) and plasma 8-OHdG higher (2.20 [0.76–7.35] and 3.11 [1.07–10.32]) in participants who developed LEA during follow-up compared with others. No significant interaction was observed between biomarkers on their association with LEA. CONCLUSIONS We report the first independent association between LTL shortening and excess risk of LEA in type 1 diabetes. High plasma 8-OHdG was also associated with incident LEA but partly dependent on cofounding variables. Full Article
ut Respective Contributions of Glycemic Variability and Mean Daily Glucose as Predictors of Hypoglycemia in Type 1 Diabetes: Are They Equivalent? By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the respective contributions of short-term glycemic variability and mean daily glucose (MDG) concentration to the risk of hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS People with type 1 diabetes (n = 100) investigated at the University Hospital of Montpellier (France) underwent continuous glucose monitoring (CGM) on two consecutive days, providing a total of 200 24-h glycemic profiles. The following parameters were computed: MDG concentration, within-day glycemic variability (coefficient of variation for glucose [%CV]), and risk of hypoglycemia (presented as the percentage of time spent below three glycemic thresholds: 3.9, 3.45, and 3.0 mmol/L). RESULTS MDG was significantly higher, and %CV significantly lower (both P < 0.001), when comparing the 24-h glycemic profiles according to whether no time or a certain duration of time was spent below the thresholds. Univariate regression analyses showed that MDG and %CV were the two explanatory variables that entered the model with the outcome variable (time spent below the thresholds). The classification and regression tree procedure indicated that the predominant predictor for hypoglycemia was %CV when the threshold was 3.0 mmol/L. In people with mean glucose ≤7.8 mmol/L, the time spent below 3.0 mmol/L was shortest (P < 0.001) when %CV was below 34%. CONCLUSIONS In type 1 diabetes, short-term glycemic variability relative to mean glucose (i.e., %CV) explains more hypoglycemia than does mean glucose alone when the glucose threshold is 3.0 mmol/L. Minimizing the risk of hypoglycemia requires a %CV below 34%. Full Article
ut South American Immigrants in the United States By www.migrationpolicy.org Published On :: Tue, 06 Nov 2018 17:46:12 -0500 South Americans represent a small, but growing share of immigrants in the United States, composing 7 percent of country’s total foreign-born population. Recent growth has been marked by an uptick in arrivals from increasingly failing Venezuela, with an increase of 61,000 Venezuelan immigrants from 2016 to 2017. This article offers an interesting data snapshot of South American immigrants in the United States. Full Article
ut As Governments Build Advanced Surveillance Systems to Push Borders Out, Will Travel and Migration Become Unequal for Some Groups? By www.migrationpolicy.org Published On :: Tue, 10 Mar 2020 15:13:30 -0400 As governments seek to push their borders out by amassing ever more data on travelers and migrants, their creation of increasingly complex border surveillance systems and use of risk-assessment technologies could ease mobility for some while rendering other groups immobile based on hypothetical risk profiles and decisions that are not publicly known and cannot be challenged, as this article explores. Full Article
ut The Future of Refugee Resettlement: Made in Europe? By www.migrationpolicy.org Published On :: Sat, 08 Feb 2020 19:39:19 -0500 Europe's refugee resettlement capacity has grown dramatically, with resettlement places more than doubling since 2014, even as European countries have become an emerging center for innovation. As Europe accounts for a rising share of resettlement worldwide, will European policymakers claim a leadership role in shaping the global resettlement agenda or fall into this position by default? Full Article
ut Coronavirus Is Spreading across Borders, But It Is Not a Migration Problem By www.migrationpolicy.org Published On :: Tue, 03 Mar 2020 11:52:00 -0500 Travel bans, border closures, and other migration management tools did not prove effective at blocking COVID-19 from spreading across international borders. Yet as governments have shifted from containment to mitigation with the coronavirus now in community transmission in many countries, these restrictions are a logical part of the policy toolkit in the context of social distancing and restricting all forms of human movement, as this commentary explores. Full Article
ut “Cubicle Activism”: Companies Face Growing Demands from Workers to Cut Ties with ICE and Others in Immigration Arena By www.migrationpolicy.org Published On :: Tue, 29 Oct 2019 16:24:30 -0400 From online petitions to organized walkouts, corporate America is facing increasing employee activism over its business involvement with agencies implementing the federal government's immigration policies. This "cubicle activism," seen at companies ranging from Amazon and Google to Bank of America and Wayfair, has garnered mixed success to date, forcing divestiture from private prison contractors but fewer results in other contexts, as this article explores. Full Article
ut Policy Solutions to Address Crisis at Border Exist, But Require Will and Staying Power to Execute By www.migrationpolicy.org Published On :: Mon, 01 Apr 2019 14:51:59 -0400 Closing the U.S.-Mexico border and cutting off aid to Central America would only feed the crisis unfolding at key points along the U.S.-Mexico border. This commentary outlines a range of immediate and long-term policy responses that would more effectively address the complex mix of factors fueling rising Central American migration to the United States. Full Article
ut Policy Options for Responding to Changing Migration Flows at the Southwest Border By www.migrationpolicy.org Published On :: Wed, 03 Apr 2019 13:27:37 -0400 Testimony of Andrew Selee, President of MPI, before Senate Committee on Homeland Security and Governmental Affairs on April 4, 2019 regarding response to changing migration flows at the Southwest border. Full Article
ut Strategic Solutions for the United States and Mexico to Manage the Migration Crisis By www.migrationpolicy.org Published On :: Wed, 17 Jul 2019 09:07:25 -0400 Amid surging migration from Central America, the United States and Mexico in June 2019 agreed to a series of enforcement measures. Yet these near-term efforts will be difficult to maintain given chronic institutional weaknesses and poorly thought-out policy structures in both countries. This commentary, by the presidents of MPI and El Colegio de México, offers a set of long-term, collaborative solutions to dissuade illegal migration while ensuring fairness to those seeking protection. Full Article
ut Rutherford Test 2020_0226 By www.ada.org Published On :: Wed, 26 Feb 2020 14:56:59 -0600 Full Article
ut ADA supports proposed rules to update federal Anti-Kickback Statute, Stark Law By www.ada.org Published On :: Mon, 06 Jan 2020 14:32:00 -0600 The American Dental Association supports a new safe harbor for cybersecurity technology and services and modifying the existing safe harbor for electronic health records to add protections for cybersecurity. This was in response to the Office of the Inspector General and Centers for Medicare & Medicaid Services’ proposed changes to the federal Anti-Kickback Statute and Stark Law exceptions. Full Article
ut HHS releases video tutorial for searching list of excluded individuals/entities By www.ada.org Published On :: Thu, 09 Jan 2020 10:12:00 -0600 The Department of Health and Human Services released Nov. 25 a five-minute video explaining how to search its list of excluded individuals and entities, called LEIE. Full Article
ut Scholarship applicants sought for 2020 Institute for Teaching and Learning By www.ada.org Published On :: Tue, 28 Jan 2020 09:44:00 -0600 This year’s Institute for Teaching Learning program is scheduled for Aug. 23-26 in Atlanta. Now in its 14th year, with over 700 alumni, the program combines presentations, discussions, small group activities and peer-to-peer learnings to give participants new teaching skills. The onsite program is followed by a six-month distance learning experience that include online activities and interactive webinars. Full Article
ut Member dentist honored for contributions in SNODENT development By www.ada.org Published On :: Wed, 29 Jan 2020 11:33:00 -0600 The international group SNOMED International honored ADA member dentist Dr. Mark Jurkovich with the Award of Excellence for spearheading the important work the ADA has done on SNODENT, the group announced Jan. 16. Full Article
ut CDC reminds clinicians to use standard precautions, recommends isolating patients with coronavirus symptoms By www.ada.org Published On :: Fri, 07 Feb 2020 13:41:00 -0600 In light of the “emerging, rapidly evolving” outbreak of the novel coronavirus 2019-nCoV, the Centers for Disease Control and Prevention is reminding clinicians to use standard precautions consistently and advising they isolate patients who show signs and symptoms of the virus. Full Article
ut Former executive director of FDI World Dental Federation dies By www.ada.org Published On :: Tue, 11 Feb 2020 07:37:00 -0600 Dr. Per Äke Zillen, executive director of the FDI World Dental Federation from 1989-2001, died Jan. 19 following a battle with cancer. Full Article
ut ADA releases coronavirus handout for dentists based on CDC guidelines By www.ada.org Published On :: Mon, 24 Feb 2020 11:53:00 -0600 The handout covers strategies for helping prevent the transmission of suspected respiratory disease in the dental health care setting and answers frequently asked questions related to the virus, based on guidelines from the Centers for Disease Control and Prevention. Full Article
ut American Institute of Dental Public Health mentors next generation of service-oriented dentists By www.ada.org Published On :: Tue, 25 Feb 2020 13:26:00 -0600 Dr. David P. Cappelli, Ph.D., acknowledges that as providers, we don’t often understand difficulties that some patients face to receive needed dental care. Full Article
ut Tampa Bay Lightning team dentist puts players’ mouths back together again By www.ada.org Published On :: Thu, 27 Feb 2020 09:54:00 -0600 When Dr. Gil Rivera became a dentist, he had no idea his career would take him to the bloodied and bruised front lines of the NHL, but nearly 18 years later, he continues to treat the ravaged mouths of professional hockey players as the team dentist of the Tampa Bay Lightning. Full Article
ut Connecticut Foundation for Dental Outreach postpones Mission of Mercy dental clinic amid coronavirus concerns By www.ada.org Published On :: Tue, 10 Mar 2020 15:36:00 -0500 The Connecticut Foundation for Dental Outreach has postponed the Connecticut Mission of Mercy Free Dental Clinic scheduled for March 20-21 in Danbury, Connecticut, "out of abundant caution" amid the coronavirus disease outbreak. Full Article
ut Association launches new ADA Science & Research Institute By www.ada.org Published On :: Thu, 12 Mar 2020 08:07:00 -0500 The American Dental Association launched the new ADA Science & Research Institute LLC on Jan. 1, bringing together the Science Institute in Chicago and research group in Gaithersburg, Maryland, that previously reported to the ADA Foundation. Full Article
ut ADA begins to address coding, billing procedures during COVID-19 outbreak By www.ada.org Published On :: Thu, 19 Mar 2020 16:52:00 -0500 The ADA is releasing a guide intended to help dental offices navigate issues related to coding and billing for virtual check-ins in the midst of the COVID-19 outbreak. Full Article
ut ADA, other organizations outline economic response needs to survive pandemic By www.ada.org Published On :: Fri, 20 Mar 2020 11:16:00 -0500 The ADA and nearly 100 other organizations are asking Congress and the White House to help businesses survive the coronavirus crisis by reducing their costs and increasing their cash flow as much as possible in the coming weeks. Full Article
ut ADA Member Advantage-endorsed company, Lenovo, offers remote work and school solutions By www.ada.org Published On :: Thu, 26 Mar 2020 13:48:00 -0500 Given recent school cancellations and state orders to shelter in place, some households may be experiencing the strain of sharing family computers. ADA Member Advantage states that members are eligible for savings of up to 46% on select items from their endorsed technology provider, Lenovo, during a special sale on computers. Full Article
ut FDA alerts health care providers of EpiPen auto-injector errors By www.ada.org Published On :: Thu, 26 Mar 2020 14:04:00 -0500 The U.S. Food and Drug Administration announced March 24 that it is alerting health care professionals, patients and caregivers of EpiPen autoinjector errors related to device malfunctions and user administration. Full Article
ut ADA Board authorizes two national searches for editors of JADA, JADA Open By www.ada.org Published On :: Fri, 27 Mar 2020 18:29:00 -0500 The ADA Board of Trustees has authorized the searches for the next editor of The Journal of the American Dental Association and the founding editor of JADA Open, a new peer-reviewed, open-access journal spanning basic and clinical sciences to advance research in oral health. Full Article