Systemic responses occur after burn injury that lead to widespread changes to the body, including the heart. Elevated levels of catecholamines and stress hormones have been found up to 3 years after severe burns. Little is known about the longer-term effects.

Children with burns had 1.3 times as many admissions and 2.3 times the number of days in hospital for circulatory diseases compared with uninjured children. Children with minor burns had an increased risk of incident admissions for circulatory diseases. (Read the full article)

Children with marked cerebral palsy (CP) are considered at greater risk of adverse events (AEs) after intramuscular injections of BoNT-A. To date there has been no randomized controlled trial examining safety of intramuscular BoNT-A injections in children with marked CP.

Children with nonambulatory CP had no greater risk of moderate or serious AEs after intramuscular injections of BoNT-A compared with a sham/control group. There was no greater risk of AEs for children receiving 2 compared with 1 episode of BoNT-A. (Read the full article)

Many families share genetic cancer risk information with their children, and some parents and providers believe BRCA1/2 testing should be permitted in adolescence. The psychosocial effects and impact on health and risk behaviors of this knowledge is unknown.

In our cohort of 869 mother-daughter pairs, we found no differences in general adjustment, but 10- to 13-year-old girls with breast cancer family histories reported higher breast cancer–specific distress and perceived breast cancer risk. Mother distress was associated with daughter distress. (Read the full article)

16 May 2013The Regulatory Reform (Scotland) Bill was introduced in the Scottish Parliament on 27 March 2013. This briefing provides background information on existing regulatory regimes, and the introduction of the Bill.

13 January 2013This briefing provides a summary of the parliamentary scrutiny of the Regulatory Reform (Scotland) Bill prior to Stage 3 proceedings which are scheduled to take place on 16 January 2014.

Even the best intentioned educators often harbor blind spots, write Re-Imagining Migration's Adam Strom and Veronica Boix Mansilla.

For the first time in 130 years, there will be no rallies and marches to celebrate what began as a campaign for an eight-hour working day.

In numerous countries, the exploitation of oil has generated debate about its economic, social and geopolitical consequences.

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

Ebola Virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The 2013–2016 epidemics resulted in over 11000 deaths, while another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type-I Interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort of finding novel EBOV inhibitors, a screening of a small set of flavonoids was performed, showing that Quercetin and Wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, Quercetin, showing an IC₅₀ value of 7.4 μM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-α and thus restoring P-STAT1 nuclear transport and IFN genes transcription. Quercetin significantly blocked viral infection, specifically targeting EBOV VP24 anti-IFN-I function. Overall, Quercetin is the first identified inhibitor of the EBOV VP24 anti-IFN function, representing a molecule interacting with a viral binding site that is very promising for further drug development aiming to block EBOV infection at the early steps.

Olivia M. Vaz
Feb 1, 2020; 145:e20190620-e20190620
ARTICLES

After a successful pilot, a professional development program is looking to expand its lesson-study approach to rural teachers.

As the Apple iPod turns 14, we take a look back at its history and influence over the last decade-plus.

Before there were smartwatches, digital watches were the most high-tech timepieces you could buy. We explore the evolution of the digital watch from 1972 to present day.

G. C. Liggins
Oct 1, 1972; 50:515-525
ARTICLES

The IMpact-RSV Study Group
Sep 1, 1998; 102:531-537
ARTICLES

Juan Roberto Meléndez-Colón was exonerated, in 2002, after nearly 18 years on death row for a crime he did not commit. He visited Penn State Fayette, The Eberly Campus to share his story on March 5.

029 - Six clubs fulfil conditions set out by CFCB

Technology like DNA testing and facial recognition has helped me piece together a family history torn apart by war. But honoring Holocaust Remembrance Day is about more than remembering the past.

Successful intervention for inborn errors of metabolism (IEMs) is a triumph of modern medicine. For many of these conditions, medical foods are the cornerstone of therapy and the only effective interventions preventing disability or death. Medical foods are designed for patients with limited or impaired capacity to ingest, digest, absorb, or metabolize ordinary foods or nutrients, whereby dietary management cannot be achieved by modification of the normal diet alone. In the United States today, access to medical foods is not ensured for many individuals who are affected despite their proven efficacy in the treatment of IEMs, their universal use as the mainstay of IEM management, the endorsement of their use by professional medical organizations, and the obvious desire of families for effective care. Medical foods are not sufficiently covered by many health insurance plans in the United States and, without insurance coverage, many families cannot afford their high cost. In this review, we outline the history of medical foods, define their medical necessity, discuss the barriers to access and reimbursement resulting from the regulatory status of medical foods, and summarize previous efforts to improve access. The Advisory Committee on Heritable Disorders in Newborns and Children asserts that it is time to provide stable and affordable access to the effective management required for optimal outcomes through the life span of patients affected with IEMs. Medical foods as defined by the US Food and Drug Administration should be covered as required medical benefits for persons of all ages diagnosed with an IEM.

The Democratic presidential candidate likes to highlight his vote against the No Child Left Behind Act in 2001, although his record on the issue of high-stakes standardized testing isn't black and white.

Slovenia's 1-0 first-leg defeat of Spain ended a string of streaks held by the European champions, including 27 straight wins and unbeaten runs of more than a decade.

Inventory management is more than simply knowing what's left in the warehouse. Today these systems track the warehouse, a product's shelf life, and even your customers' experience. We test top players to help you choose.

The inventory table, unfortunately, can only be applied selectively.

Preschool-age children who frequently play number-related games at home show better math skills and growth by the end of kindergarten, finds a new study in the journal Child Development.

$600 million settlement over 2017 Equifax data breach includes up to $425 million in consumer restitution Attorney General Kathy Jennings Monday announced a settlement with Equifax as the result of an investigation into the largest-ever breach of consumer data. Under the terms of the settlement, Equifax agreed to provide a single Consumer Restitution Fund of […]

An archaeological study years in the making has revealed a wealth of new information about some of Delaware’s earliest colonial settlers and shed new light on what life would have been like in the region three centuries ago.

Highlights include programs on African-American life at the John Dickinson Plantation in the 18th century, the evolution of black recorded music and African-American archaeology in Delaware.

Highlights include programs on women's suffrage, Harriet Tubman and the female vocalists of the Victor Talking Machine Company.

Carlton Hall, a cultural preservation specialist and historian with the Delaware State Historic Preservation Office (SHPO), earned a place on the inaugural “40 Under 40” list recently unveiled by the National Trust for Historic Preservation.

Program will explore what life would be like for a two-month crossing of the Atlantic Ocean from Europe to the New World.

Highlights include programs on the Underground Railroad, black recording artists and record labels from the early 20th century, and First African Baptist Church cemeteries in Philadelphia.

Activities honor and celebrate women's lives and historic achievements.

Event will include scholarly presentations on the history and archaeology of the lower Delaware Valley including the Avery’s Rest and Fort Casimir archaeological sites.

"Such coercive and forcible extraction of personal information from an individual is unheard of in a democratic and republic setup and it is attribute of a dictatorial system," the petition said.

Airports Economic Regulatory Authority of India Act 2008

Owners of farm markets, produce stands, garden centers, agritourism businesses, riding stables, farms offering hay sales, and other agricultural retail operations are being sought to be featured in the latest edition of the Delaware Agricultural Directory.

Governor John Carney announced that more than 134,000 acres of Delaware farmland are now permanently preserved for future generations. This is the 23rd consecutive year of easement selections by the Delaware Agricultural Lands Preservation Foundation. Many of the farms in this round would not have been preserved without matching funds from multiple sources, including the […]

Agency: HSS Closing Date: 6/12/2020

As retail prices of petroleum products are mapped with international rates, the steep fall of global crude prices in Q4FY20 meant that by the time refiners sold their products after processing crude, retail rates had fallen.

Kerala Chief Minister Pinarayi Vijayan on Friday said that those coming from red zones will have to be in mandatory institutional quarantine for 14 days and would be moved to the quarantine facility...

Six special programs held in celebration of National Women’s History Month.

DOVER – With Delaware’s annual spring wild turkey hunting season approaching, DNREC’s Division of Fish & Wildlife Hunter Education Program reminds both resident and non-resident hunters age 13 and older that they must pass a Division-Approved turkey hunting course before they can legally hunt turkeys in the First State. Also, hunters age 13 and older born after Jan. 1, 1967, must have completed an approved basic hunter education safety course and have a course card/number. These hunter education requirements have collectively helped Delaware turkey hunters achieve an excellent hunting safety record.

Actress Millicent Sparks to portray the noted Underground Railroad conductor.