Update used wrong data type, causing Tinder to Spotify to fall over

A change in the Facebook SDK backend managed to crash many popular iOS apps that integrated the code library, used for implementing various Facebook services.…

Ziggy, is that you?

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

Does a stooge prepare your income tax returns? Watch the Three Stooges prepare a tax return and learn from them. Don't be a stooge: hire a CPA to prepare your next tax return! Continue reading →

Hillary Faces Questions About Cash Donations to Clinton Foundation. Continue reading →

An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading →

Green Party's Jill Stein says that what we Fear from Donald Trump is what we have already seen from Hillary Clinton. Continue reading →

'Lesser of Two Evils' argument is not resonating with DNC protestors. Salon.com's Ben Norton says grassroots movements will be more mobilized under a Republican candidacy. "There?s no question that Trump would be horrific as a candidate but if we have 4 or 8 years of Clinton of more wars, of more austerity, of another economic crisis, and potential bailouts of banks and large corporations etc., you know you think Trump is bad now? Wait for what we'?ll see in 4 or 8 years." Continue reading →

Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading →

Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading →

Jill Stein thinks that Hillary Clinton is scarier than Donald Trump: "On this issue of war and nuclear war, Hillary is much scarier." Continue reading →

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

The DNC is a one big capitalistic gangbang of Democrats and corporate donors and lobbyists. Guess who is getting screwed? Continue reading →

Undone by Blood #3 is now due out June 10.

The post EXCLUSIVE: More meta revenge in UNDONE BY BLOOD #3 appeared first on The Beat.

At the Smarter Cities Forum in Shanghai today, IBM announced a collaboration with South China's largest hospital, Guang Dong Hospital of Traditional Chinese Medicine, to apply new analytics technology to help doctors uncover trends and new knowledge about disease treatment from thousands of anonymous Electronic Medical Records (EMR)The tool will also enable clinicians to perform empirical studies on the efficacy of certain traditional Chinese treatments.

IBM today announced that as part of its Celebration of Service, designed to allow employees, retirees, clients and business partners to donate their time and expertise during the company's Centennial year, 300,000 IBMers around the world -- close to three quarters of its global workforce -- are volunteering in more than 5,000 projects in 120 countries, meeting civic and societal challenges and serving millions in need.

Con la finalidad de apoyar el desarrollo de proyectos de alto impacto en la Ciudad de México, la Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología e IBM, ponen en marcha el día de hoy el programa de consultoría Corporate Service Corps (CSC), en su edición Ciudad de México.

IBM, Peace Corps y cuatro instituciones locales dieron inicio el día de hoy al programa de consultoría Corporate Service Corps (CSC), en su edición Cd. de Querétaro; con la finalidad de apoyar el desarrollo de proyectos de alto impacto en esta localidad. IBM y Peace Corps (PC) trabajarán en conjunto con la Secretaría de Desarrollo Social del Estado de Querétaro, el Instituto Queretano de las Mujeres, el Municipio de Querétaro - Delegación Santa Rosa Jáuregui, y la Universidad Politécnica de Santa Rosa Jáuregui (UPSRJ).

L’entité Sécurité d’IBM (NYSE: IBM) a annoncé aujourd'hui les résultats de son étude annuelle sur l'impact financier des violations de données sur les organisations. Selon le rapport, le coût d'une violation de données a augmenté de 12 % au cours des cinq dernières années et coûte désormais 3,92 millions de dollars en moyenne. Ces dépenses croissantes sont représentatives de l'impact financier pluriannuel des violations, de la réglementation accrue et du processus complexe de résolution des attaques criminelles .

L’entité sécurité d’IBM (NYSE : IBM) a publié aujourd'hui son rapport X-Force Threat Intelligence Index 2020, qui souligne la façon dont les techniques des cybercriminels ont évolué après des décennies d'accès à des dizaines de milliards de données d'entreprises et de particuliers et à des centaines de milliers de failles logicielles. Selon le rapport, 60% des entrées initiales observées dans les réseaux des victimes ont exploité soit des données d’identification volées précédemment, soit des vulnérabilités logicielles connues, ce qui a permis aux attaquants de moins recourir à la ruse pour y accéder.

Des avancées technologiques qui permettent d'accroître encore le leadership du mainframe et en font le système incontournable pour traiter les données critiques des entreprises

Depuis 30 ans, IBM me place au cœur de ses meilleures innovations technologiques pour contribuer au succès de Roland-Garros et améliorer l’expérience proposée aux fans, aux joueurs, aux entraîneurs et aux médias.

My week has been stressful. They called Thursday and offered me the half-time job. They needed to know that day -- we haven't heard back on the lucrative job James has applied for, so I declined, citing the fact that I'm the only breadwinner and James hasn't heard back about the job he was waiting to hear from (I didn't mention to the HR person that it's a job at my same employer, because it's probably not her fault they're lagging on his job, and I'm not an asshole). She wanted to know when I'd know, and I said, "Well, I was supposed to know two weeks ago, so I mean, soon, I hope, but no guarantees."

She called me back an hour later and offered to give me a week to decide (because they actually don't want the other two people who interviewed, is my surmise), so yeah, rollercoaster day on Thursday.

And then a student's mom called and cussed me out for like half an hour. I don't take that stuff personally, but it does wear on me. My co-workers marvelled over and over about how calm I stayed, and I said (and I meant it), "She was frustrated. That's understandable. And I don't have to attend every fight I'm invited to," which became a theme for the week.

My mom got in a fracas with another member of her senior center, and I shared my week's theme with her. I think she felt a little chastised, but she also seemed to latch onto the theme as a potential sanity saver.

And then today at the donut shop, I accidentally passed up another person who was waiting to pay (because I followed the person who gave me our donuts to the register and didn't notice the other person who was standing away from the registers at the window. She berated me for many minutes about how rude I was, and how I should give a bitch some space, and how in America, we call this White Privilege, and and and... I just apologized, didn't engage beyond that, (felt frankly detached and mildly amused -- not sure what that says about me) and then once she'd left, the cashier apologized to me for the customer.

Me: "Nah, she's not wrong. I didn't see her, but I did cut in front of her."

I mean, I don't like being yelled at, or having people behave in ways that I perceive as rude towards me, but I'm not gonna fault someone for standing up for their space when I've violated it, so long as they're not hitting me or something. Not a fight I need to get into; not a hill I'm gonna die on.

So yeah, stressful week for many reasons, but not something that's gonna ruin my Saturday, which will now be completed by spending many many many hours writing and catching up on webcomics.

And how are YOU, dear ones?

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Will He Get A Second Term?

Donald Trump has proven himself to be the most corrupt, dishonest, and incompetent president in American history. 

But despite all of the lies, abuses of power, and damage to the country – I must warn you – there’s a very real possibility he could be reelected. This doesn’t have to be the case. 

Let me explain.

Although Trump has been impeached and is one of the most unpopular presidents in modern history, he still has devoted support among his core base. Nearly 90 percent of Republicans still approve of the job he’s doing, a rate that’s held constant throughout his presidency. According to one survey, a third of Trump supporters said there was nothing he could do to lose their support.

Trump still maintains substantial support in key swing states as well. Recent polls show him neck and neck with leading Democratic candidates in the key states of Michigan, Pennsylvania, Wisconsin, Florida, Arizona, and North Carolina. Remember, Hillary Clinton won the popular vote in 2016 by 3 million votes but still lost the election because of the power of these states in the Electoral College.

Big money donors are also forking over record sums of money to keep Trump in office. In the last quarter of 2019 alone, he raked in a staggering $46 million, far outpacing any of his Democratic opponents. He now has more than $100 million in the bank, not to mention the millions raised by pro-Trump Super PACs. The GOP’s biggest donors – some of whom didn’t support him in 2016, but received massive windfalls from Trump’s tax cut – are now paying him back.  

At the same time, voter suppression is on the rise. To suppress turnout by likely Democratic voters, Republican officials have doubled down on their efforts to keep low-income and minority voters from the polls. They are intimidating immigrant voters, purging voter rolls, closing polling places, and making it harder to register in the first place. 

Florida went so far as to institute a modern-day poll tax, requiring people with past felony convictions to pay off any fines or fees before exercising their right to vote. In 2016, over 20 percent of black voting-age Floridians weren’t able to vote due to past felony convictions, and now, hundreds of thousands could still be prevented from going to the polls this November in this key state.

We are also at risk of foreign powers trying to interfere in the election, as they did in 2016. Experts warn that many states still lack the necessary safeguards to protect against interference. The FBI, Department of Justice and National Security Agency have also raised concerns that Russia, China, and Iran might attempt misinformation campaigns. I can’t believe I even have to say this, but foreign governments should not have a say in our elections.

So why am I telling you all of this? I don’t mean to scare you. And the last thing I want to do is cause you to be hopeless, and give up. To the contrary, I want you to be more determined than ever. Despite all these attacks on democracy, we have what it takes to make Trump a one-term president. But only if we remain focused and united.

It may seem daunting. We’re up against a full-fledged attack on our democratic institutions. But there is a way forward: 

We can defeat Trump and his enablers by building a multiracial, multi-class coalition. And we do that by supporting a true progressive with a bold vision for an economy and democracy that works for all Americans. That way enough voters will be inspired to show up to the polls and stop Trump’s authoritarian machine for good.

This isn’t a pipe dream. We already beat the liar-in-chief by 2.8 million votes in 2016. And the 2018 elections had the highest turnout of any midterm election since 1914 – handing House Republicans their most resounding defeat in decades. People are outraged – and we must keep fighting.

If we come together, we will prevail.