London (6 Pall Mall) : Messrs Moon, Boys & Graves ; Manchester : J.C. Grundy, July 2 1832.

London (96, Gracechurch Street) : Published by R. Lambe, May 10th. 1814.

[London], [between 1820 and 1829?]

[London], [1827?]

London (24, Cornhill) : Published by F.G. Harding ; [London] (147, Strand) : & J. McCormick, October 1831 ([London] : Printed by Lahee)

[London] (Haymarket) : Published ... for the proprietors, by T McLean, Septr. 1. 1836 ([London?] : Printed by Lahee & Co.)

London (No. 90, Cheapside, & 8, Pall Mall) : Published ... by Hurst, Robinson & Co., March 1st. 1824.

London (No. 90, Cheapside, & 8, Pall Mall) : Published ... by Hurst, Robinson & Co., March 1st. 1824.

[London], [1824]

[Paris] : Calcographie du Louvre, Musées Imperiaux, [1849?]

London (No. 29 Newman Street, Oxford Street) : Published ... by V. & R. Green, January 18th 1788

Helsinki : Department of Pharmacology and Toxicology, University of Helsinki, 1985.

Arizona's Aari McDonald and Pac-12 Networks' Ashley Adamson discuss the guard's decision to return for her senior season in Tucson and how she now has the opportunity to be the face of the league. McDonald, the Pac-12 Defensive Player of the Year, was one of the nation's top scorers in 2019-20, averaging 20.6 points per game.

Dale L. Zimmerman, Jun Tang, Rui Huang.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2416--2451.

Abstract:
We extend statistical shape analytic methods known as outline analysis for application to the strike zone, a central feature of the game of baseball. Although the strike zone is rigorously defined by Major League Baseball’s official rules, umpires make mistakes in calling pitches as strikes (and balls) and may even adhere to a strike zone somewhat different than that prescribed by the rule book. Our methods yield inference on geometric attributes (centroid, dimensions, orientation and shape) of this “called strike zone” (CSZ) and on the effects that years, umpires, player attributes, game situation factors and their interactions have on those attributes. The methodology consists of first using kernel discriminant analysis to determine a noisy outline representing the CSZ corresponding to each factor combination, then fitting existing elliptic Fourier and new generalized superelliptic models for closed curves to that outline and finally analyzing the fitted model coefficients using standard methods of regression analysis, factorial analysis of variance and variance component estimation. We apply these methods to PITCHf/x data comprising more than three million called pitches from the 2008–2016 Major League Baseball seasons to address numerous questions about the CSZ. We find that all geometric attributes of the CSZ, except its size, became significantly more like those of the rule-book strike zone from 2008–2016 and that several player attribute/game situation factors had statistically and practically significant effects on many of them. We also establish that the variation in the horizontal center, width and area of an individual umpire’s CSZ from pitch to pitch is smaller than their variation among CSZs from different umpires.

The military is preparing to deploy to the region to try to stop illegal logging and mining.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]

London : Cleanair Campaña para un Medio Ambiente Libre de Humo, [198-?]

Keep your feet comfy and your wallet fat.

This retro style is making a comeback for a reason.

The new style is available to shop today.

The womenswear line is new, and there’s already a variety of items to shop.

Benjamin E. Reese
Mar 2, 2005; 25:2167-2175
BehavioralSystemsCognitive

Fiona Doetsch
Jul 1, 1997; 17:5046-5061
Articles

Italian translation of the BIS press release about the BIS Quarterly Review, March 2018

Italian translation of the BIS Quarterly Review, March 2018

Italian translation of the BIS Quarterly Review, March 2019

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2018

Spanish translation of the BIS Quarterly Review, March 2018

Spanish translation of the BIS Quarterly Review, March 2019

Edge conditions and the change they drive are fascinating. Some people use the word "margin" because it's at the margin that things change. A situation exists more or less in equilibrium with the rest of its environment until in one way or another the stresses become so great that change happens. We have lots of metaphors, like "tipping point" and "the straw that broke the camel's back."

Oracle and Zoom just entered a deal that for once is more about technological audacity than about dollars -- a partnership to host Zoom on Oracle Cloud Infrastructure. In just a few months -- basically since the beginning of the novel coronavirus pandemic -- Zoom has seen demand for its service grow from about 10 million daily meeting participants to more than 300 million.

Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia's pathophysiology is still unclear, postmortem studies point toward a dysfunction of cortical interneurons as a central element. It has been suggested that alterations in parvalbumin-positive interneurons in schizophrenia are the consequence of a deficient signaling through NMDARs. Animal studies demonstrated that early postnatal ablation of the NMDAR in corticolimbic interneurons induces neurobiochemical, physiological, behavioral, and epidemiological phenotypes related to schizophrenia. Notably, the behavioral abnormalities emerge only after animals complete their maturation during adolescence and are absent if the NMDAR is deleted during adulthood. This suggests that interneuron dysfunction must interact with development to impact on behavior. Here, we assess in vivo how an early NMDAR ablation in corticolimbic interneurons impacts on mPFC and ventral hippocampus functional connectivity before and after adolescence. In juvenile male mice, NMDAR ablation results in several pathophysiological traits, including increased cortical activity and decreased entrainment to local gamma and distal hippocampal theta rhythms. In addition, adult male KO mice showed reduced ventral hippocampus-mPFC-evoked potentials and an augmented low-frequency stimulation LTD of the pathway, suggesting that there is a functional disconnection between both structures in adult KO mice. Our results demonstrate that early genetic abnormalities in interneurons can interact with postnatal development during adolescence, triggering pathophysiological mechanisms related to schizophrenia that exceed those caused by NMDAR interneuron hypofunction alone.

SIGNIFICANCE STATEMENT NMDAR hypofunction in cortical interneurons has been linked to schizophrenia pathophysiology. How a dysfunction of GABAergic cortical interneurons interacts with maturation during adolescence has not been clarified yet. Here, we demonstrate in vivo that early postnatal ablation of the NMDAR in corticolimbic interneurons results in an overactive but desynchronized PFC before adolescence. Final postnatal maturation during this stage outspreads the impact of the genetic manipulation toward a functional disconnection of the ventral hippocampal-prefrontal pathway, probably as a consequence of an exacerbated propensity toward hippocampal-evoked depotentiation plasticity. Our results demonstrate a complex interaction between genetic and developmental factors affecting cortical interneurons and PFC function.

A new simulation points to a previously untold chapter in Titan’s history

The pint-sized, mustachioed Gaul immortalized in the French cartoon has spawned films, a theme park and many other spin-offs

The new wound further diminishes Earth’s protective shield against damaging solar radiation

Nadia, a four-year-old Malayan tiger, is the first known animal to test positive for coronavirus in the United States

The prickly perch is an exciting sign of success for the birds, which came off the endangered species list in 2007

The solitary species is hard to spot on camera, and they're the only canine that lives in the Amazon rainforest

With Washington, D.C. COVID-19 state of emergency, Smithsonian officials say museums to close Saturday, March 14; events canceled through May 3

The 72-year-old animal was the third oldest in the North American population

A number of fishing zones in the Gulf of St. Lawrence have been closed after North Atlantic right whales were sighted earlier this week.

Oracle and Zoom just entered a deal that for once is more about technological audacity than about dollars -- a partnership to host Zoom on Oracle Cloud Infrastructure. In just a few months -- basically since the beginning of the novel coronavirus pandemic -- Zoom has seen demand for its service grow from about 10 million daily meeting participants to more than 300 million.