to write a marketing report

This brochure explores the 30-year partnership between the Asian Development Bank and the Kyrgyz Republic, sharing highlights from key sectors.

This report examines the progress of trade facilitation in Asia and the Pacific, highlights recent trends in paperless trade, and evaluates the impact of trade facilitation initiatives on trade costs and overall trade.

This brief shows how mainstreaming blue finance hinges on developing a solid regulatory framework that drives investment toward bankable marine-based projects and analyzes how to expand the sector in the People’s Republic of China (PRC).

This edition of the ASEAN+3 Bond Market Guide series focuses on updates in the Republic of Korea’s (ROK) market since the publication of the previous guide for the ROK in 2018.

This paper examines how booms and busts in peer-to-peer (P2P) lending in the People’s Republic of China (PRC) affect monetary policy transmission to inflation and output.

For approval in 2023.

After the release of a shocking video showing Olympic rider Charlotte Dujardin whipping a horse, it is time for equestrians to educate themselves on the science of horse training, says Christa Lesté-Lasserre

A contentious meeting of physicists highlighted concerns, failures and possible fixes for a crisis in condensed matter physics

An independent task force formed by NASA to look into unidentified anomalous phenomena found no evidence of alien craft, and suggests that if we want to find proof of visitors we need better data

Averting an asteroid strike will need many of the same skills we must hone to tackle climate change and future pandemics

Title: Bioengineering Could Replace Pacemakers
Category: Health News
Created: 8/30/2006 8:24:00 AM
Last Editorial Review: 8/30/2006 8:24:29 AM

Title: 6 Deaths Reported From Diabetes Drug Byetta
Category: Health News
Created: 8/28/2008 12:00:00 AM
Last Editorial Review: 8/28/2008 12:00:00 AM

Title: Tobacco Use Kills 6 Million People Annually: Report
Category: Health News
Created: 8/25/2009 4:10:00 PM
Last Editorial Review: 8/26/2009 12:00:00 AM

Title: Report: Vaccines Generally Safe, Cause Few Health Problems
Category: Health News
Created: 8/26/2011 11:01:00 AM
Last Editorial Review: 8/26/2011 12:00:00 AM

Title: Report: 164 Million Obese Adults by 2030
Category: Health News
Created: 8/26/2011 11:00:00 AM
Last Editorial Review: 8/26/2011 12:00:00 AM

Title: Little Evidence on Value of Treatments for Autism: Report
Category: Health News
Created: 8/28/2012 10:05:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Add Hurricane Menu to Your Storm Prep, Experts Say
Category: Health News
Created: 8/28/2012 10:05:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Most U.S. Schools Unprepared for Pandemics: Study
Category: Health News
Created: 8/30/2012 10:05:00 AM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: Most Medications OK During Breast-Feeding, Report Says
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: Fewer U.S. Kids Buying Tobacco Products: Report
Category: Health News
Created: 8/27/2013 4:36:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM

Title: Hundreds of Thousands of Teens Use Pot, Alcohol Each Day: Report
Category: Health News
Created: 8/29/2013 2:36:00 PM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: College Prep 101
Category: Health News
Created: 8/22/2014 12:36:00 PM
Last Editorial Review: 8/25/2014 12:00:00 AM

Title: Health Tip: Preparing for the First Day of School
Category: Health News
Created: 8/27/2014 7:35:00 AM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: Could a Laser Skin Test Someday Replace Biopsy to Spot Melanoma?
Category: Health News
Created: 8/21/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: 'Goth' Teens Report More Depression, Self-Harm
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: How Reliable Are Medical Studies? Half of Findings Couldn't Be Replicated
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Five Local Zika Cases Reported in Miami Beach
Category: Health News
Created: 8/19/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Five More Cases of Local Zika Infection Reported in Florida
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: New Case of Local Zika Infection Reported in Florida
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Title: Health Tip: Prepare for Your Child's Dental Procedure
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

Title: Obamacare Enrollee Numbers Aren't Falling: Report
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Title: First Death Tied to Lung Injury From Vaping Reported in Illinois
Category: Health News
Created: 8/23/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Every Sudden Infant Death Deserves a Closer Look: Report
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Confirmed Case of Coronavirus Reinfection Reported
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: There's No Safe Amount of Caffeine in Pregnancy: Report
Category: Health News
Created: 8/24/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: Olympian Usain Bolt Reported to Have COVID-19
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/26/2020 12:00:00 AM

Title: Hospitals Must Report COVID-19 Data or Be Penalized
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: 'Vacation PrEP': Short-Term HIV Prevention a Viable Option
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Record High COVID Cases and Deaths Reported in Florida
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Title: Taking a Shot at Pain Relief After Knee Replacement
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Title: AHA News: New Report Details What to Know About Cardiovascular Disease Symptoms
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Title: New Reports on Polio: How Worried Should We Be?
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Title: What Are the Main Parts of the Male Reproductive System?
Category: Diseases and Conditions
Created: 7/7/2022 12:00:00 AM
Last Editorial Review: 7/7/2022 12:00:00 AM

Background:

Continuous glucose monitoring (CGM) for patients with type 1 and type 2 diabetes is associated with improved clinical, behavioral, and psychosocial patient health outcomes and is part of the American Diabetes Association’s Standards of Medical Care. CGM prescription often takes place in endocrinology practices, yet 50% of adults with type 1 diabetes and 90% of all people with type 2 diabetes receive their diabetes care in primary care settings. This study examined primary care clinicians’ perceptions of barriers and resources needed to support CGM use in primary care.

Artificial Intelligence (AI) is poised to revolutionize family medicine, offering a transformative approach to achieving the Quintuple Aim. This article examines the imperative for family medicine to adapt to the rapidly evolving field of AI, with an emphasis on its integration in clinical practice. AI's recent advancements have the potential to significantly transform health care. We argue for the proactive engagement of family medicine in directing AI technologies toward enhancing the "Quintuple Aim."

The article highlights potential benefits of AI, such as improved patient outcomes through enhanced diagnostic tools, clinician well-being through reduced administrative burdens, and the promotion of health equity by analyzing diverse data sets. However, we also acknowledge the risks associated with AI, including the potential for automation to diverge from patient-centered care and exacerbate health care disparities. Our recommendations stress the need for family medicine education to incorporate AI literacy, the development of a collaborative for AI integration, and the establishment of guidelines and standards through interdisciplinary cooperation. We conclude that although AI poses challenges, its responsible and ethical implementation can revolutionize family medicine, optimizing patient care and enhancing the role of clinicians in a technology-driven future.

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.

Internal ribosomal entry sites (IRESs) recruit the ribosome to promote translation, typically in an m7G cap-independent manner. Although IRESs are well-documented in viral genomes, they have also been reported in mammalian transcriptomes, where they have been proposed to mediate cap-independent translation of mRNAs. However, subsequent studies have challenged the idea of these "cellular" IRESs. Current methods for screening and discovering IRES activity rely on a bicistronic reporter assay, which is prone to producing false positive signals if the putative IRES sequence has a cryptic promoter or cryptic splicing sites. Here, we report an assay for screening IRES activity using a genetically encoded circular RNA comprising a split nanoluciferase (nLuc) reporter. The circular split nLuc reporter is less susceptible to the various sources of false positives that adversely affect the bicistronic IRES reporter assay and provides a streamlined method for screening IRES activity. Using the circular split nLuc reporter, we find that nine reported cellular IRESs have minimal IRES activity. Overall, the circular split nLuc reporter offers a simplified approach for identifying and validating IRESs and exhibits reduced propensity for producing the types of false positives that can occur with the bicistronic reporter assay.

Many RNA-binding proteins (RBPs) contain low-complexity domains (LCDs) with prion-like compositions. These long intrinsically disordered regions regulate their solubility, contributing to their physiological roles in RNA processing and organization. However, this also makes these RBPs prone to pathological misfolding and aggregation that are characteristic of neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) forms pathological aggregates associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that highly disordered, hydrophilic, and charged heat-resistant obscure (Hero) proteins may have similar effects. Specifically, Hero proteins can maintain the activity of other proteins from denaturing conditions in vitro, while their overexpression can suppress cellular aggregation and toxicity associated with aggregation-prone proteins. However, it is unclear how these protective effects are achieved. Here, we used single-molecule FRET to monitor the conformations of the aggregation-prone prion-like LCD of TDP-43. While we observed high conformational heterogeneity in wild-type LCD, the ALS-associated mutation A315T promoted collapsed conformations. In contrast, an Hsp40 chaperone, DNAJA2, and a Hero protein, Hero11, stabilized extended states of the LCD, consistent with their ability to suppress the aggregation of TDP-43. Our results link single-molecule effects on conformation to macro effects on bulk aggregation, where a Hero protein, like a chaperone, can maintain the conformational integrity of a client protein to prevent its aggregation.