Canada Day celebrations and Live on the Waterfront programming will be delivered virtually in response to Ontario government orders, and physical distancing mandates, the City of Thunder Bay announced in a written release Thursday.

La tripulación de técnicos del Logos Hope sabe que el mantenimiento del barco es una forma de hacer ministerio.

People and businesses are rallying to support the Muslim community in Fort McMurray recover after widespread flooding that damaged many neighbourhoods.

About one in 12 Manitoba jobs disappeared during the first two months of the COVID-19 pandemic, according to Statistics Canada's latest monthly survey of Canadian employment.

Canada's Piper Gilles and Paul Poirier won the silver medal in ice dancing on Friday at the ISU Four Continents figure skating competition in Seoul, South Korea.

Canada's Joseph Phan was eighth after a highly competitive men's short program Wednesday at the world junior figure skating championships.

Bates: McHenry businesses adapt to COVID-19  Northwest Herald

11 startups to pitch at NEXT Canada's virtual Venture Reveal  BetaKit

In isolation with dog Charlie, Canadian soccer legend Christine Sinclair recalls "dream come true" of 2012 Olympic bronze and "heartbreak" of repeat in Rio in an interview with CBC Sports.

A showman and all-star with the Milwaukee Wave, Canadian Ian Bennett is a marquee goal-scorer in the Major Arena Soccer League. Still, the 36-year-old Hamilton native flies under the radar north of the border.

More than 1,000 people looking for work in the tech industry are signed up for a virtual job fair on Thursday afternoon.

Even though this year's food truck season is looking dicey, Tyler Schmidt says he's doing his best to find business where he can.

Last month, the National Arts Centre launched #CanadaPerforms, an initiative that pays musicians and writers to perform from their living rooms. Poet Zoey Roy gave an intimate performance from her living room in Kingston. 

Windsor's unemployment rate soared even higher in April, according to Statistics Canada numbers released Friday. 

Madagascar is putting its self-proclaimed, plant-based "cure" for COVID-19 on sale and several countries in Africa have already put in orders for purchase, despite warnings from the World Health Organization that its efficacy is unproven.

Carving out a section of low-hanging basement ceiling was a small price to pay to give Travis Bondy the space he needed to play in the Isolation Dart League.

The bonspiel took place in Edmonton March 11-14, starting the same day COVID-19 was declared a global pandemic.

Apple's higher-end 13-inch MacBook Pros are equipped to take advantage of 87W power adapters, though users won't see any charging speed benefits from the change.

The OM Madagascar team mobilises the Malagasy church for prayer through radio programmes and SMS messages.

Madagascar’s ongoing crisis continues to defy definition. Some call Andry Rajoelina’s taking power in March 2009 a popular uprising. Others say this was a military-supported coup, pure and simple. The legitimacy of the new regime remains in question both internally and externally, and peace agreements mediated by the international community lie in tatters.

While the reality and extent of the coup announced yesterday by military officers is still uncertain, the latest events demonstrate the fragility of the situation in Madagascar and the urgent need for a new international strategy to end the long crisis. Negotiations should now focus on international support to the electoral process based on strict conditions.

A l’approche de la décision de la SADC, il est important qu’elle porte toute son attention sur les mesures qui permettent de garantir l’équité de traitement entre les protagonistes. Sans modifier le texte de la feuille de route, les autorités ont la possibilité de prouver leur volonté de garantir la neutralité du processus, afin que l’opposition soit libre de faire le choix d’entrer ou non dans cette transition sur une base équilibrée. Le rejet des autorités de ces mesures exposerait leur absence de volonté de voir se dérouler une transition et des élections crédibles. Il démontrerait également leur choix de plonger le pays dans l’instabilité plutôt que d’accepter des mesures qui renforcent la transition. Le refus de l’opposition d’adhérer au processus ne pourrait plus être justifié par un déséquilibre de la solution proposée.

During the last few months, new options for resolving the Madagascar crisis have emerged in the form of the most recent roadmap proposed by the mediation team of the Southern African Development Community (SADC). Accepted by the authorities and rejected by elements of the opposition, the roadmap remains the subject of debate and there is still no agreement on how to achieve a peaceful transition. In a few weeks from now, the SADC is due to make a statement on the document and accept, reject or amend it. There are other options for changing the course of events without changing the roadmap and these should be explored as quickly as possible.

Madagascar, one of the world’s poorest countries, has been mired in political crisis, since 2009, when 34-year-old former radio disc jockey Andry Rajoelina toppled President Marc Ravalomanana in a military coup d’état.

Madagascar’s recent elections marked an ostensible return to democracy, but unless the new government works hard to implement meaningful political, economic and social reforms, the prospect of further crisis is just a matter of time.

Canada shed three million jobs in the last two months due to the coronavirus lockdown, causing the unemployment rate to shoot up to 13% in April, the government reported Friday.

Moonlight, Film 4, Wednesday, 9pm

Over 500 000 children in the United States sustain a traumatic brain injury (TBI) each year. Headaches are commonly reported after TBI in adults, but little is known about the epidemiology of headache after pediatric TBI.

Headaches are more common 3 months after pediatric TBI than after arm injury. The frequency of headache after TBI is related to patient gender, age, and injury severity. Headaches after mild TBI were most common among girls and teenagers. (Read the full article)

Newborn screening (NBS) programs may store bloodspot samples and use them for secondary purposes, such as research. Recent public controversies and lawsuits over storage and secondary uses underscore the need to engage the public on these issues.

This public engagement study identifies values underlying citizens’ acceptance of and discomfort with research from NBS samples. Well-designed methods of public education and civic discourse on the risks and benefits of storage and secondary uses of NBS samples are required. (Read the full article)

Survival takes precedence for adolescent patients with cancer and their families. Patients may not discuss their treatments’ potential to damage their reproductive capacity, which has significant psychological late effects in survivorship.

Strong reproductive concerns of adolescents with cancer may not be captured on current health-related quality of life instruments and may be neglected by parents’ unawareness. Parent-proxy reports of adolescent reproductive concerns are not suitable for capturing specific emotions and feelings. (Read the full article)

We know that many evidence-based treatments for acute asthma are underused, and adherence with treatment guidelines is poor; however, studies have focused on β₂ agonists and corticosteroids, but little is known about intravenous magnesium, which has substantial evidence of benefit.

Magnesium is used infrequently in Canadian pediatric emergency departments in hospitalized children with acute asthma, with variation across sites. More than half of this population does not receive frequent bronchodilators and timely corticosteroids. (Read the full article)

Severe neonatal hyperbilirubinemia can lead to acute bilirubin encephalopathy and, subsequently, chronic bilirubin encephalopathy (CBE). This condition is preventable through routine identification and proper treatment; therefore, it is rare for permanent neurologic complications to occur.

This article describes the incidence of CBE in Canada, which is higher than previously reported in the literature. Furthermore, it describes the underlying causes of CBE and the spectrum of neurologic disease. (Read the full article)

Mortality of very low birth weight infants varies widely between regions and countries; however, the variation in morbidities after adjusting for confounders has not been adequately studied.

Composite outcome of mortality or short-term morbidity for very low birth weight infants was lower in Japan than in Canada. However, marked variations in mortality and individual morbidity exist, revealing areas for improvement in each country. (Read the full article)

National asthma treatment guidelines include the recommendation that all asthma patients receive a written asthma action plan. No previous study has sought to examine the readability, suitability, and content of asthma action plans within a nationally representative sample.

Although variability was found across written asthma action plans, and improvements in readability, suitability, and content are needed, there were also many common elements that would support a move to a single universal standard action plan. (Read the full article)

Several studies have investigated the prevalence of chronic daily headache (CDH) and analyzed the risk factors for its persistence. However, the etiologic factors that lead to new-onset CDH remain unsettled in adolescents.

This study was the first incidence study of CDH conducted in young adolescents. We reported the incidence rates and found that some risk factors for incident chronic migraine and chronic tension-type headache were different. (Read the full article)

Although unnecessary for children with headache and normal history, computed tomography (CT) scans are widely used. Fewer than 1% of pediatric brain abnormalities present with headache as the only symptom. Furthermore, repeated CT scans may increase lifetime risk of cancer.

CT scans continue to be used to diagnose isolated pediatric headaches despite existing practice parameters. Although emergency department visits were correlated with greater likelihood of CT scan use, these scans were widely used across a variety of clinical settings. (Read the full article)

Use of complementary and alternative medicine (CAM) is increasingly common among American youth; however, information on use of CAM among youth with recurrent headache (HA) is limited.

Youth across a range of chronic conditions experience HA. These youth are more likely to use CAM. Use and expenditures for conventional medical care, and increased difficulties in activity and functioning are greater for youth with HA who use CAM. (Read the full article)

Food insecurity is best measured by comprehensive assessments. However, rapid assessments can be useful in certain circumstances, but their validity is not characterized.

Rapid assessment of food insecurity is feasible among Inuit adults and children. (Read the full article)

Socioeconomic status (SES) often influences timeliness of health care delivery, even in publicly funded systems. Children need prompt surgical care for a variety of time-sensitive developmental conditions, and children of lower SES may be especially vulnerable to delays in surgery.

It is unknown whether a publicly funded system’s ability to provide timely pediatric surgical care is related to SES. In 39 327 consecutive surgical cases, we demonstrate that SES need not influence timeliness of surgical care in a publicly funded system. (Read the full article)

To date, studies of adaptive behavior in fragile X syndrome have focused on particular age points, either longitudinally or cross-sectionally across a broad age spectrum. Studies have shown variable patterns in adaptive behavior among people with fragile X syndrome.

This study fills a critical gap in knowledge about the profile of adaptive behavior across childhood, adolescence, and young adulthood in fragile X syndrome. This study is the first to incorporate longitudinal data from an age-matched typically developing group. (Read the full article)

Although headache is a common symptom after minor blunt head trauma in children, controversy exists whether the presence of headache increases the risk of traumatic brain injury.

Clinically important traumatic brain injuries are rare, and traumatic brain injuries on computed tomography are very uncommon in children with minor blunt head trauma when headaches are their only sign or symptom. (Read the full article)

Source: www.letfreedomringblog.com - Saturday, May 09, 2020
John Solomon has worked overtime and then some to rip Adam Schiff’s mask off. So have Catherine Herridge, Sara Carter, Lee Smith, Gregg Jarrett, Kim Strassel, Mollie Hemmingway and Byron York. Solomon’s article highlights how utterly dishonest Adam Schiff is. Ditto with the upper echelon of the FBI. Strap yourself in. This isn’t a short ride. The pursuit of the truth ended Thursday when the Justice Department formally asked a court to vacate Flynn’s conviction and end the criminal case, acknowledging the former general had indeed been cleared by FBI agents and that the bureau did not have a lawful purpose when it interviewed him in January 2017. Attorney General William Barr put it more bluntly in an interview Thursday : “They kept it open for the express purpose of trying to catch, to lay a perjury trap for General Flynn.” According to Solomon’s reporting, the FBI didn’t have a reason to investigate Gen. Flynn: 3. Case closed memo. FBI agents wrote a memo to close the investigation of Flynn on Jan. 4, 2017, writing they found “no derogatory” evidence that Flynn committed a crime or posed a national security threat. FBI management then ordered the closure to be rescinded and pivoted toward trying lure Flynn into an interview. https://justthenews.com/accountability/russia-and-ukraine-scandals/fbi-found-no-derogatory-russia-evidence-flynn-planned Corrupt FBI agent Peter Strzok allegedly ordered Crossfire Razor, the codename for th

Source: www.thestar.com - Saturday, May 09, 2020
Canada approved a verbal demarche to two senior WHO executives that urged them to allow Taiwan to be admitted as an observer to an upcoming meeting because its input would be “meaningful and important.”

Omadacycline is a novel aminomethylcycline with activity against Gram-positive and -negative organisms, including Haemophilus influenzae, which is one of the leading causes of community-acquired bacterial pneumonia (CABP). The evaluation of antimicrobial agents against H. influenzae using standard murine infection models is challenging due to the low pathogenicity of this species in mice. Therefore, 24-hour dose-ranging studies using a one-compartment in vitro infection model were undertaken with the goal of characterizing the magnitude of the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC ratio) associated with efficacy for a panel of five clinical H. influenzae isolates. These five isolates, which had MIC values of 1 or 2 mg/L, were exposed to omadacycline total-drug epithelial lining fluid (ELF) concentration-time profiles based on those observed in healthy volunteers following intravenous omadacycline administration. Relationships between change in log₁₀ colony forming units (CFU) from baseline at 24 hours and total-drug ELF AUC/MIC ratio for each isolate and the isolates pooled together were evaluated using Hill-type models and non-linear least squares regression. As evidenced by the high coefficient of determination (r²) of 0.88 to 0.98, total-drug ELF AUC/MIC ratio described the data well for each isolate and the isolates pooled together. The median total-drug ELF AUC/MIC ratio associated with net bacterial stasis and 1- and 2-log₁₀ CFU/mL reductions from baseline at 24 hours was 6.91, 8.91, and 11.1, respectively. These data were useful to support the omadacycline dosing regimens selected for the treatment of patients with CABP, as well as susceptibility breakpoints for H. influenzae.

Omadacycline, a novel aminomethylcycline antibiotic with activity against Gram-positive and -negative organisms, including tetracycline-resistant pathogens, received FDA approval in October, 2018 for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). A previously-developed population pharmacokinetic (PK) model based on Phase 1 intravenous and oral PK data was refined using data from infected patients. Data from 10 Phase 1 studies used to develop the previous model were pooled with data from three additional Phase 1 studies, a Phase 1b uncomplicated urinary tract infection study, one Phase 3 CABP study, and two Phase 3 ABSSSI studies. The final population PK model was a three-compartment model with first-order absorption using transit compartments to account for absorption delay following oral dosing and first-order elimination. Epithelial lining fluid (ELF) concentrations were modeled as a sub-compartment of the first peripheral compartment. A food effect on oral bioavailability was included in the model. Sex was the only significant covariate identified, with 15.6% lower clearance for females relative to males. Goodness-of-fit diagnostics indicated a precise and unbiased fit to the data. The final model, which was robust in its ability to predict plasma and ELF exposures following omadacycline administration, was also able to predict the central tendency and variability in concentration-time profiles using an external Phase 3 ABSSSI dataset. A population PK model, which described omadacycline PK in healthy subjects and infected patients, was developed and subsequently used to support pharmacokinetic-pharmacodynamic (PK-PD) and PK-PD target attainment assessments.

The all-time top UEFA women's club scorer among many, many honours: we salute Ada Hegerberg.

Penn State Behrend faculty member Michael Campbell has been named distinguished professor of biology. Campbell, who joined the college in 1994, also directs the Lake Erie Regional Grape Research and Extension Center.

Source: www.thestar.com - Friday, May 08, 2020
The unemployment rate jumped 5.2 points in April to 13 per cent in the first full month of economic restrictions.