The Head of Impact Assessment and Adaptation, Henry Neufeldt, UN Environment Programme Copenhagen Climate Centre, has called for increased climate adaptation funding, particularly for developing nations facing significant climate risks. UNEP’s latest report reveals an acute adaptation finance gap, with current international funding for developing countries at USD 30 billion—far below the USD 200 to 400 […]

It’s no coincidence that extreme heat is engulfing huge swaths of Asia, Europe and North America all at the same time.

Uncovering crucial gaps in climate change data systems reveals how these deficiencies hamper our understanding of climate impacts on vulnerable populations in developing Asia. How can we empower national statistical systems in collecting and analyzing data they need to effectively tackle climate change?

Understanding the roots and complexities of fragility helps ADB meet the challenges facing many countries in Asia and the Pacific.

ADB recently launched the Georgia Public–Private Partnership (PPP) Monitor. Helen Steward, Principal Markets Development Advisory Specialist in ADB’s Office of Markets Development and Public–Private Partnerships, explains what the PPP Monitor is all about.

This study examines the impact of economic development in forestry on the indigenous people who have traditionally lived in and obtained their livelihood from the forest. It takes villages in East Kalimantan, Indonesia, as a case study.

Bangladesh and India should pursue bilateral economic cooperation to enhance South Asian regional cooperation.

To attract infrastructure investment to meet national goals for providing electricity to consumers, India needs continued macroeconomic stability as well as an improved policy and regulatory environment.

India’s federal power minister on Tuesday asked the states that are away from coal resources to consider setting up nuclear-based power plants, besides identifying and listing the power utilities to meet investments to support growing power demand.

The Indian government in its federal budget this year had proposed to partner with private players to develop small nuclear reactors to increase the amount of electricity from sources that do not produce carbon dioxide emissions.

States should consider setting up nuclear power plants at the sites where coal-based thermal power plants have completed their life, Manohar Lal, the country’s power minister, told states as per a government statement.

India’s stringent nuclear compensation laws have hampered talks with foreign power plant builders such as General Electric GE.N and Westinghouse.

The country, which currently has about 8 gigawatts of nuclear capacity, aims to increase it to 20 GW by 2032.

The minister also asked the states to identify and list their power utilities in the country’s stock exchange to meet increasing investment demand in the power sector as well as improve the transmission system to add more renewable capacity.

India has pledged to achieve a net zero carbon emission target by 2070 and has a target of 500 GW of renewable energy by 2030.

The Pakistan Cricket Board (PCB) said on Tuesday it has asked the sport’s governing body to explain India’s refusal to send a team to Pakistan for the Champions Trophy next year.

The International Cricket Council (ICC) informed the PCB last week that India would not tour Pakistan for the eight-team tournament, leaving the fate of the event hanging in the balance.

Pakistan had previously rejected the option of a hybrid arrangement that would allow India to play their matches at neutral venues, for example in the United Arab Emirates.

“The PCB has responded to last week’s ICC letter seeking clarifications for the Indian Board’s decision not to travel to Pakistan for next year’s Champions Trophy,” Sami-Ul-Hasan told AFP.

Deteriorating political ties have meant the bitter rivals have not played a bilateral cricket series for over a decade — squaring off only in ICC multi-nation events.

Pakistani media reported on Tuesday that the PCB would be unwilling to accept security reasons for India’s refusal to visit.

New Zealand have toured Pakistan three times in the past two years, with England visiting twice and Australia once in the same period.

Pakistan also visited India for last year’s ODI World Cup and the PCB had expected the gesture to be reciprocated for the Champions Trophy.

The Champions Trophy is slated to be played across three venues — Lahore, Rawalpindi and Karachi — from February 19 to March 9 next year.

But a final schedule due to be announced this week has been postponed over the stand-off — which PCB chairman Mohsin Naqvi termed disappointing.

“Almost every country wants the tournament to be played in Pakistan and it will be disappointing if they don’t come,” Naqvi, who is also the interior minister, said last week.

“I don’t think anyone should make this a political matter. We’ll give every team as many facilities as we can.” Naqvi said Pakistan would consider pulling out of events in India as a response.

“Pakistan has shown great gestures to India in the past, and we’d like to say clearly India shouldn’t expect such friendly gestures from us every time”.

India is due to host the women’s ODI World Cup and Asia Cup next year and will co-host the Twenty20 World Cup with Sri Lanka in 2026.

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This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

This publication provides updated statistics on a comprehensive set of economic, financial, social, and environmental measures as well as select indicators for the Sustainable Development Goals (SDGs).

This paper examines how booms and busts in peer-to-peer (P2P) lending in the People’s Republic of China (PRC) affect monetary policy transmission to inflation and output.

Horses experience hyperflexion, or rollkur, when their necks bend far towards their chests – it could place the animal at a greater risk of physical discomfort and stress

The Origins and Habitability Lab at NASA's Jet Propulsion Laboratory is a testbed exploring how geological conditions could impact life in environments such as early Earth, Mars or the icy moons of Jupiter

Unravelling the complex biological process that allows fish to regrow injured fins could help advance regenerative medicine in humans

A pair of ctenophores, or comb jellies, can fuse their bodies together, merging their digestive and nervous systems, without any issues with immune rejection

Our arm of the Milky Way is filled with older, metal-rich stars. New research suggests these might provide the best conditions for life to form on their planets

Past observations have indicated that the icy moon of Jupiter has a vast subsurface ocean. Launching in October, NASA’s Europa Clipper will go there in search of evidence that it could support life

We're finally pinning down the mechanisms that drive obsessive-compulsive disorder, revealing a complex combination of imbalanced brain networks, the immune system and even gut microbes

New research into the moments between wakefulness and sleep could bring hope for insomniacs and even make us more creative problem-solvers

From the vastness of the universe to the infinitesimal particles that comprise it, extremes of scale defy comprehension – and present a problem for physicists seeking a unified theory of everything

A mathematical study finds that three definitions of what it means for entropy to increase, which have previously been considered equivalent, can produce different results in the quantum realm

Earth appears to have less mass beneath a certain part of the Indian Ocean compared with the rest of the planet. Plumes of magma at the location could explain why

Microbes that rapidly convert CO2 to rock could lock away the greenhouse gas in deep underground storage sites, such as depleted oil and gas reservoirs

The Luna structure, a 1.8-kilometre-wide depression in north-west India, may have been caused by the largest meteorite to strike Earth in the past 50,000 years

A genetic study of nearly 2700 individuals has revealed the ancestry of Indian people, and gets scientists closer to reconstructing the genomes of ancient Neanderthals

Lake sediments reveal the ancient history of Aboriginal people’s use of fire to manage the landscape, a tradition that has benefits for biodiversity

An excavation on an island in the Coral Sea shows that Indigenous Australians were producing ceramics long before the arrival of Europeans

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The human major histocompatibility complex (MHC) is a ~4 Mb genomic segment on Chromosome 6 that plays a pivotal role in the immune response. Despite its importance in various traits and diseases, its complex nature makes it challenging to accurately characterize on a routine basis. We present a novel approach allowing targeted sequencing and de novo haplotypic assembly of the MHC region in heterozygous samples, using long-read sequencing technologies. Our approach is validated using two reference samples, two family trios, and an African-American sample. We achieved excellent coverage (96.6%–99.9% with at least 30x depth) and high accuracy (99.89%–99.99%) for the different haplotypes. This methodology offers a reliable and cost-effective method for sequencing and fully characterizing the MHC without the need for whole-genome sequencing, facilitating broader studies on this important genomic segment and having significant implications in immunology, genetics, and medicine.

Background:

The COVID-19 pandemic social distancing requirements encouraged patients to avoid public spaces including in-office health care visits. Ambulatory-care-sensitive conditions (ACSCs) represent conditions that can be managed with quality primary care and when access is limited, these conditions can lead to avoidable emergency department (ED) visits.

COPD and asthma are two of the most common chronic lung diseases, affecting over 545 million people globally and 34 million in the United States. Annual health care costs related to chronic lung disease are estimated at €380 billion in the European Union, and $24–$50 billion in the United States averaging to $4,000 in out-of-pocket costs per person in the U.S. A full-text literature search was conducted for English publications between January 1, 2005–March 18, 2024. It returned over 5,000 publications that were further narrowed using key search words, resulting in 172 peer-reviewed articles. Using their experience and subject expertise, the authors further narrowed the peer-reviewed articles to 55 that were in their opinion relevant. Also, 38 recently published industry reports and news articles specific to downstream effects of inhaler market changes and the future impact were included. The literature suggests that individuals with chronic lung disease face increased challenges with access to inhaled medication due to rising medication costs, discontinuation of branded medications, introduction of generic medications not covered by insurance, exclusionary preferred drug list tactics that force health care providers into non-medical switching of medication or devices, and ongoing medication shortages. Providers experience ongoing hurdles in prescribing appropriate inhaled medications for individuals with chronic lung disease, including increased time and costs spent on administrative tasks due to inhaler denials, a loss of patient trust, and limits on their ability to prescribe appropriate inhaled medication for individuals with chronic lung disease.

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Binding of arbitrary information into distinct memory representations that can be used to guide behavior is a hallmark of relational memory. What is and is not bound into a memory representation and how those things influence the organization of that representation remain topics of interest. While some information is intentionally and effortfully bound—often the information that is consistent with task goals or expectations about what information may be required later—other information appears to be bound automatically. The present set of experiments sought to investigate whether spatial memory would be systematically influenced by the presence and absence of distinct categories of stimuli on a spatial reconstruction task. In this task, participants must learn multiple item-location bindings and place each item back in its studied location after a short delay. Across three experiments, participants made significantly more within-category errors (i.e., misassigning one item to the location of a different item from the same category) than between-category errors (i.e., misassigning one item to the location of an item from a different category) when categories were perceptually or semantically distinct. These data reveal that category information contributed to the organization of the memory representation and influenced spatial reconstruction performance. Together, these results suggest that categorical information can influence memory organization, and not always to the benefit of overall task performance.