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Could Sanofi and Regeneron's Dupixent also treat age-related macular degeneration?

Sanofi and Regeneron’s Dupixent has become a popular treatment for atopic dermatitis and asthma. Now, a research team in Japan has discovered that IL-4 and its receptor—which Dupixent inhibits—could be promising targets for treating the eye disease age-related macular degeneration.




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Precision in Oncology: Using the Macro and Micro

Last week, the New York Times had a nice piece “A Faster Way to Try Many Drugs on Many Cancers” on basket clinical trials, which matches patients to a therapy based on the genetics of their tumor as opposed to the site of their primary tumor. This type of trial feeds into the current excitement about precision

Read More




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Extending the Patentable Life of 3D Printers: A Lesson From the Pharmaceutical Industry

Modern innovation typically occurs one step-improvement at a time. Some clients initially question whether their new application of an existing technology is patentable. Usually, the answer is ‘yes.’ Under U.S. law (and most other jurisdictions), an innovation to an existing technology is patentable so long as at least one claim limitation is novel and non-obvious....… Continue Reading




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Pharmacy Compounders Practicing Pursuant to Section 503A Can Get in the Mix: Compounding Shortage Drugs for Hospital Patients, with Some Limitations

By Karla L. Palmer



  • COVID19
  • Prescription Drugs and Biologics

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EU battles to fend off China's 'mask diplomacy' in Balkans




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US deploys carrier strike group in middle east; Stevo Pendarovski wins North Macedonia's presidential election- Current Affairs

The carrier strike group is expected to be deployed in the US Central Command region, where the US Navy currently has no aircraft carrier stationed.




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Cadmium isotope fractionation reveals genetic variation in Cd uptake and translocation by <i>Theobroma cacao</i> and role of natural resistance-associated macrophage protein 5 and heavy metal ATPase-family transporters




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MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3β/β-catenin signaling




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Macrophage subsets at the maternal-fetal interface




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Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis




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The genetics of macrophage activation syndrome




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The Pharmacogenomics Journal




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Effect of non-pharmaceutical interventions to contain COVID-19 in China




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Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Machine intelligence lights up imaging




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Acta Pharmacologica Sinica




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Neuropsychopharmacology




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid

Cuevas-Cerveró, Aurora and Razquín-Zazpe, Pedro and Parra-Valero, Pablo and Barrios-Martínez, Cristina and Gómez-Hernández, José-Antonio . Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid., 2020 In: Competencia en Información y Políticas para Educación Superior: Estudos Hispano-Brasileiros. Universidad Complutense de Madrid, pp. 132-146. [Book chapter]




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Using physiologically-based pharmacokinetic modeling to assess the efficacy of glove materials in reducing internal doses and potential hazards of N-methylpyrrolidone during paint stripping




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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I could have been sixth - Schumacher

Michael Schumacher reckons he could have qualified in the top six in Abu Dhabi had he linked his three best sectors together in Q3




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Schumacher congratulates Vettel on title

Michael Schumacher congratulated close friend Sebastian Vettel on winning his first drivers' title after an Abu Dhabi Grand Prix that saw him walk away from a frightening collision with Tonio Liuzzi that could have ended in disaster




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Lauda slams Schumacher move

Triple world champion Niki Lauda has slammed Michael Schumacher's driving while competing with Rubens Barrichello at the Hungarian Grand Prix and labelled it "completely unacceptable"




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Irvine slams 'idiot' Schumacher

Eddie Irvine says that former Ferrari team-mate Michael Schumacher was 'an idiot' and 'arrogant beyond belief' after the German nearly drove Rubens Barrichello into the pit wall in the Hungarian Grand Prix




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Schumacher apologises to Barrichello

Michael Schumacher has admitted that his move on Rubens Barrichello was 'too hard' and has apologised to Rubens Barrichello for his actions




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Schumacher lucky not to be disqualified - Warwick

Hungaroring steward Derek Warwick has revealed he wanted to disqualify Michael Schumacher during Sunday's race




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Schumacher seeks rules clarification

Michael Schumacher has called for clarification of the safety car rules after the seven-time world champion completed his worst ever race finish in 259 grand prix starts




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From Digital Diplomacy to Data Diplomacy

The digital revolution arrived late at the heart of ministries of foreign affairs across the Western world. Ministries latched on to social media around the time of Tahrir Square and Iran’s 2009 Green Revolution, beguiled by a vision of the technology engendering a networked evolution toward more liberal societies.




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Micro-Multilateralism and the Impact of Urban Diplomacy on Global Diplomacy

Director of the Project on Europe and the Transatlantic Relationship and the Future of Diplomacy Project, Cathryn Clüver Ashbrook speaks to WDR 5 on micro-multilateralism and the impact of urban diplomacy global diplomacy, particularly on climate change.




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Nicholas Burns: Why Does Good Diplomacy Matter?

What role does diplomacy play in the modern world order, and what are the characteristics of a good diplomat? Which countries are the great powers today, and which will lead in 2050? Does NATO have a role in helping manage the political, economic, and military challenges facing the United States? And why is morale reportedly at a low ebb in the State Department? In this episode, former ambassador to NATO Nicholas Burns, the Goodman Family professor of the practice of diplomacy and international relations at Harvard Kennedy School, answers these questions and more, based on his long career in government service.




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Harvard Kennedy School’s Future of Diplomacy Project Launches Initiative to Modernize U.S. Foreign Service for the 21st Century

The Future of Diplomacy Project at Harvard Kennedy School’s Belfer Center this week launched a new initiative, The American Diplomacy Project: A Foreign Service for the 21st Century.




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Barrichello frustrated at Schumacher

Not for the first time this season, Rubens Barrichello has found himself on the wrong end of an incident involving former team-mate Michael Schumacher




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Schumacher sympathises with Ferrari

Michael Schumacher has sympathised with Ferrari's decision to implement team orders at the German Grand Prix




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Schumacher satisfied with 'straightforward' day

Michael Schumacher confessed himself satisfied with his performance after outpacing team-mate Nico Rosberg for the first time this season




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Button critical of Schumacher

Jenson Button criticised seven-time world champion Michael Schumacher for his move around the outside of him as he rejoined the circuit after his pitstop in the Spanish Grand Prix




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Schumacher content with fourth

Michael Schumacher confessed himself satisfied with his best result of the season after finishing fourth in the Spanish Grand Prix




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Schumacher disappointed with ninth

Michael Schumacher admitted that his ninth place starting position on the grid for the Chinese Grand Prix was below expectations




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'Too many bad emotions' - Schumacher

There was no disguising Michael Schumacher's frustration after another disappointing performance at the Chinese Grand Prix




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Brawn baffled by Schumacher's problems

Ross Brawn struggled to explain Michael Schumacher's lack of pace after the Chinese Grand Prix




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Emerging Issues in Economic Diplomacy

The nine issue papers contained in this report were proposed and written by graduate students at the Belfer Center for Science and International Affairs at Harvard Kennedy School. They present fact-based, nonpartisan analysis to help focus the next Administration on the key policy debates that must be resolved. And, they aim to create a platform for our students to engage with the most pressing policy issues of the day as they continue their careers in public service.




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Schumacher admits 'not particularly happy' after Singapore GP

Another disappointing weekend from Michael Schumacher served only to spark another round of speculation over his future with Mercedes