hop

NFL Week 16 ATS picks: Bears win, Texans put an end to Eagles playoff hopes

It hasn't been a great year for road favorites. Those who enjoyed a three-point advantage or more on the road have gone 21-30-2 against the spread.




hop

Presidential hopefuls swap the campaign trail for the field at Congressional Women’s Softball Game

The Members team ultimately fell 10-4 to the press team, despite valiant efforts from players such as 2020 presidential hopeful and team pitcher Kirsten Gillibrand.




hop

Priyanka Chopra is confronted by Pakistani at Beautycon over tweets about India

The "Quantico" actress was called out during her appearance for a tweet sent during military hostility between the neighboring, nuclear-armed countries.




hop

If even France can’t figure out a climate policy, what hope is there for the U.S.?

There are ways to curb the pain of economic and political changes.




hop

strataconf: A detailed agenda for #StrataRx 2013 is now posted: workshops, sessions, speakers + more http://t.co/RtaRpQroaN #healthdata

strataconf: A detailed agenda for #StrataRx 2013 is now posted: workshops, sessions, speakers + more http://t.co/RtaRpQroaN #healthdata




hop

Fin24.com | Blue Label hopeful of Cell C's prospects - despite its stake sitting at R0

Blue Label Telecoms wrote down its entire stake at Cell C in 2019. And after calling in a valuation specialist, its value remained at R0 in the first half of the group's 2020 financial year.




hop

Shopify launches post-COVID POS, Yelp rolls out omnichannel tools for SMBs

The companies are part of a shift toward deeper integration between online and offline operations.

Please visit Search Engine Land for the full article.




hop

Google’s got a new Shopping ad test — and it’s a weird one

A Shopping ad is accompanied by a clickable text unit.

Please visit Search Engine Land for the full article.




hop

Now, Shopify merchants can quickly turn their catalogs into shoppable Pins

The new Pinterest app on Shopify is now available in the U.S. and Canada.

Please visit Search Engine Land for the full article.




hop

A Note About the State of My Photography Tours and Workshops

This is a quick update about how things are going to be working with my travel photography tours during this time of crisis.  Obviously, with international travel nearly impossible right now, some changes needed to happen, and some adjustments are going to need to continue over the next couple months. Below, I chat quickly about […]

The post A Note About the State of My Photography Tours and Workshops appeared first on Brendan van Son Photography.



  • Travel Photography Blog

hop

Channel24.co.za | LISTEN: Miriam Makeba’s joyful Pata Pata re-recorded to spread information and hope in the time of Covid-19

You can listen to this version of the 'world's most joyous song' here.




hop

Sport24.co.za | Sharma hoping Aussie tour gets the go-ahead

India top-order batsman Rohit Sharma is hopeful their tour to Australia at the end of 2020 is allowed to proceed.




hop

MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out

The following article, MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out, was first published on 100PercentFedUp.com.

Last week, we reported about how Shelley Luther, owner of the Salon Á La Mode in North Dallas, Texas, who opened up her business in defiance of lockdown orders in the city. The salon owner said that she was ignoring a citation and a cease and desist order from the city to shut down. This one […]

Continue reading: MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out ...




hop

77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO]

The following article, 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO], was first published on 100PercentFedUp.com.

Emergency orders that “non-essential businesses” remain closed during the Covid-19 crisis have devastated small business owners across America. A wave of business owners across the nation are defying executive orders by their governors and opening their businesses anyhow. Yesterday, we reported about a small business owner in the state of Michigan, where Governor Gretchen Whitmer […]

Continue reading: 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] ...




hop

Owners of new retail cannabis store hoping to open soon in Pillette Village

At a time when store front vacancies are growing thanks to COVID-19, a new retail cannabis store in Pillette Village is hoping to open soon.




hop

Iran Workshop Series: Domestic, Regional and International Outlook

Invitation Only Research Event

17 December 2019 - 10:00am to 3:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

After a summer of regional tensions and continued uncertainty regarding the future of the JCPOA, the Chatham House MENA Programme held a closed workshop to examine the impact of the Trump administration’s maximum pressure campaign.

Discussions focused on the domestic developments and challenges inside Iran, prospects for new negotiations with Iran, and the regional issues facing the country. Participants also considered the differences between American and European approaches towards Iran.

 

Event attributes

Chatham House Rule

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624




hop

NATO Hopes to Assure Allies While Saving Refugees

11 March 2016

Dr Beyza Unal

Senior Research Fellow, International Security Programme
NATO’s mission in the Aegean Sea seems aimed as much at deterring Russia as saving lives. It could lead to confrontation.

Early last month NATO launched a new maritime security mission, ostensibly to prevent people smuggling across the Aegean Sea. This mission, however, was not originally a reaction to the humanitarian catastrophe at sea. Instead, it was a response to growing Russian assertiveness.

A maritime patrol unit was first discussed in the North Atlantic Council in December 2015, when the Alliance agreed to provide a ‘tailored package of assurances’ to Ankara in a period of heightened tensions after Turkey shot down a Russian jet. The package included measures such as early reconnaissance planes (AWACS), air policing, naval presence in the Eastern Mediterranean, provisions for Maritime Patrol Aircrafts (MPA) and Intelligence, Surveillance & Reconnaissance (ISR), and port visits. None of the discussion at the time linked it with protecting refugees. Now framing this decision in that light creates a new mission for NATO’s Maritime Command (MARCOM), a mission that it has never conducted before.

Neither NATO’s founding documents or the most recent 2010 Strategic Concept provide for this type of mission, and NATO units are not trained to carry out an actual rescue mission. Protecting strategic assets and goods, such as oil tankers, escorting naval vessels providing food into conflict zones, deterring piracy and monitoring the Mediterranean for terrorist activity have been the main priorities for MARCOM in the post-Cold War period. These activities and maritime exercises were aimed at defence against non-state actors.

The positioning of NATO’s maritime fleet in the Aegean Sea to save refugees, however, has the potential to be used as a deterrent against Russia’s Anti Access/Anti-Denial capacity in the eastern Mediterranean. Russia, meanwhile, has increased its naval presence at the Tartus naval base in Syria, which it has used to support its air campaigns in Syria. This level of reciprocated military build-up is hard to sustain in the long-run.   

NATO−Russia tensions

Over the past few years, Russia’s assertive policies – its multiple military operations, the continuing modernization of its army and ‘simulated attacks’ such as the one in 2013 that tested Sweden’s air defence response mechanisms − have increasingly worried the Alliance and its partners. Clashing interests over Syria’s future and Russia’s attacks against the Western-supported rebel groups have also served to increase tensions between NATO member states and Russia. Recent analysis logged 60 dangerous incidents in the Euro-Atlantic area between Russia and NATO counties in the period between March 2014 and March 2015. NATO’s preparedness has been severely tested by these incidents, and has led the alliance to strengthen its presence on Europe’s southern flank.

Such increased tensions could create a situation whereby accidents and miscalculations lead to escalation. NATO forces and Russia are already engaged in further force posturing − the decision to accelerate Montenegro’s accession to NATO and the increased conduct of wartime exercises, such as NATO’s search for submarines in open waters (Dynamic Manta 2016), reconnaissance operations (Cold Operation 16) or Russia’s simulated exercises, for instance – which could undermine global stability. Three weeks after the Russian jet was shot down, a Russian patrol ship fired warning shots at a Turkish vessel to attract attention and avoid a collision. This event did not escalate but given the heightened tensions, similar events may spiral out of control.  

The tentative cease-fire in Syria is a confidence building measure that could normalize and rebuild relations. But further steps should be taken to establish political dialogue, open up the channels for potential meetings at the NATO−Russia Council, and increase transparency and risk mitigation in exercises and activities. The longer both sides wait, the more likely a confrontation will be.

To comment on this article, please contact Chatham House Feedback




hop

Making the Business Case for Nutrition Workshop

Invitation Only Research Event

28 January 2020 - 9:30am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

A ground-breaking research project from Chatham House, supported by The Power of Nutrition, is exploring the business case for tackling undernutrition, micronutrient deficiencies and overnutrition. Companies across all sectors hold huge, transformative power to save countless lives and transform their own financial prospects. To act, they need more compelling evidence of the potential for targeted investments and strategies to promote better nutrition and create healthier, more productive workforces and consumers.

At this workshop, Chatham House will engage business decision-makers in a scenario exercise that explores different nutrition futures and their commercial prospects in each before examining what different strategies business can pursue to maximize future profitability through investments in nutrition.

Attendance at this event is by invitation only.




hop

Phosphoproteome Analysis of E. coli Reveals Evolutionary Conservation of Bacterial Ser/Thr/Tyr Phosphorylation

Boris Macek
Feb 1, 2008; 7:299-307
Research




hop

Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis

Joris J. Benschop
Jul 1, 2007; 6:1198-1214
Research




hop

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

Claudio P. Albuquerque
Jul 1, 2008; 7:1389-1396
Research




hop

Quantitative Phosphoproteomics Applied to the Yeast Pheromone Signaling Pathway

Albrecht Gruhler
Mar 1, 2005; 4:310-327
Research




hop

Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2 [Genomics and Proteomics]

Leukocyte recruitment is a universal feature of tissue inflammation and regulated by the interactions of chemokines with their G protein–coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CC chemokine ligand 2 (CCL2), plays a central role in recruitment of monocytes in several inflammatory diseases. In this study, we used phosphoproteomics to conduct an unbiased characterization of the signaling network resulting from CCL2 activation of CCR2. Using data-independent acquisition MS analysis, we quantified both the proteome and phosphoproteome in FlpIn-HEK293T cells stably expressing CCR2 at six time points after activation with CCL2. Differential expression analysis identified 699 significantly regulated phosphorylation sites on 441 proteins. As expected, many of these proteins are known to participate in canonical signal transduction pathways and in the regulation of actin cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activating proteins. Moreover, we identified regulated phosphorylation sites in numerous proteins that function in the nucleus, including several constituents of the nuclear pore complex. The results of this study provide an unprecedented level of detail of CCR2 signaling and identify potential targets for regulation of CCR2 function.




hop

The politics of hope: privilege, despair and political theology

4 March 2020 , Volume 96, Number 2

Caron E. Gentry

Situated within feminist Christian Realism, this article looks at what political theology is and its relevance to International Relations. Hope is a central theme to political theology, underpinning the necessity to be witness to and to work against oppressive structures. Simply put, hope is the desire to make life better. For Christians, this hope stems from a belief in resurrection of Christ and the faith that such redemption is offered to all of humanity. Hope, however, is not limited to Christianity and, therefore, Christian theology. Thus, taking an intersectional approach, the article looks for similarities in how hope is articulated in three personal narratives: theologian Jürgen Moltmann, UK Muslim advocate Asim Qureshi, and Black Lives Matter co-founder Patrisse Khan-Cullors. Across all three personal narratives, the need for hope begins in a place of despair, signalling a need to recognize that hope and privilege are in tension with one another. Feminist Christian Realism acknowledges and embraces this tension, recognizing that hope cannot function if the pain, oppression and harm caused by privilege are erased or minimized.




hop

Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines [Research]

Acute myeloid leukemia (AML) is a clonal disorder arising from hematopoietic myeloid progenitors. Aberrantly activated tyrosine kinases (TK) are involved in leukemogenesis and are associated with poor treatment outcome. Kinase inhibitor (KI) treatment has shown promise in improving patient outcome in AML. However, inhibitor selection for patients is suboptimal.

In a preclinical effort to address KI selection, we analyzed a panel of 16 AML cell lines using phosphotyrosine (pY) enrichment-based, label-free phosphoproteomics. The Integrative Inferred Kinase Activity (INKA) algorithm was used to identify hyperphosphorylated, active kinases as candidates for KI treatment, and efficacy of selected KIs was tested.

Heterogeneous signaling was observed with between 241 and 2764 phosphopeptides detected per cell line. Of 4853 identified phosphopeptides with 4229 phosphosites, 4459 phosphopeptides (4430 pY) were linked to 3605 class I sites (3525 pY). INKA analysis in single cell lines successfully pinpointed driver kinases (PDGFRA, JAK2, KIT and FLT3) corresponding with activating mutations present in these cell lines. Furthermore, potential receptor tyrosine kinase (RTK) drivers, undetected by standard molecular analyses, were identified in four cell lines (FGFR1 in KG-1 and KG-1a, PDGFRA in Kasumi-3, and FLT3 in MM6). These cell lines proved highly sensitive to specific KIs. Six AML cell lines without a clear RTK driver showed evidence of MAPK1/3 activation, indicative of the presence of activating upstream RAS mutations. Importantly, FLT3 phosphorylation was demonstrated in two clinical AML samples with a FLT3 internal tandem duplication (ITD) mutation.

Our data show the potential of pY-phosphoproteomics and INKA analysis to provide insight in AML TK signaling and identify hyperactive kinases as potential targets for treatment in AML cell lines. These results warrant future investigation of clinical samples to further our understanding of TK phosphorylation in relation to clinical response in the individual patient.




hop

The Indo-Pacific: Geostrategic Perspectives to 2024 - Workshop 3

Invitation Only Research Event

17 October 2019 - 9:30am to 2:00pm

Institut Francais des Relations Internationales, 27 rue de la Procession, 75740 Paris Cedex 15, France

This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).

Attendance at this event is by invitation only.

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




hop

Making the Business Case for Nutrition Workshop

Invitation Only Research Event

28 January 2020 - 9:30am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

A ground-breaking research project from Chatham House, supported by The Power of Nutrition, is exploring the business case for tackling undernutrition, micronutrient deficiencies and overnutrition. Companies across all sectors hold huge, transformative power to save countless lives and transform their own financial prospects. To act, they need more compelling evidence of the potential for targeted investments and strategies to promote better nutrition and create healthier, more productive workforces and consumers.

At this workshop, Chatham House will engage business decision-makers in a scenario exercise that explores different nutrition futures and their commercial prospects in each before examining what different strategies business can pursue to maximize future profitability through investments in nutrition.

Attendance at this event is by invitation only.




hop

The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4

Invitation Only Research Event

26 November 2019 - 9:30am to 12:00pm

Gateway House, Stevens Street, Colaba

This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024.

Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence.

The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




hop

The Indo-Pacific: Geostrategic Outlook From Now to 2024 - Workshop 5

Invitation Only Research Event

18 February 2020 - 12:00pm to 4:30pm

Langafonua Centre

This roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).
 

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




hop

The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4

Invitation Only Research Event

26 November 2019 - 9:30am to 12:00pm

Gateway House, Stevens Street, Colaba

This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024.

Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence.

The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




hop

The Indo-Pacific: Geostrategic Outlook From Now to 2024 - Workshop 5

Invitation Only Research Event

18 February 2020 - 12:00pm to 4:30pm

Langafonua Centre

This roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).
 

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




hop

Report of the African Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress




hop

Report of the Asia-Pacific Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress




hop

Report of the Workshop on Capacity-building for research and information exchange on socio-economic impacts of Living Modified Organisms under the Cartagena Protocol on Biosafety




hop

Report of the workshop on capacity-building and exchange of experiences as related to the implantation of paragraph 2 of article 18 of the biosafety protocol now available.




hop

Report of the Pacific Sub-regional Workshop on Capacity-building for the Effective Implementation of the Biosafety Protocol




hop

Report of the Inter-Regional Workshop on Capacity Needs for the Implementation of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress




hop

Report of the Africa Regional Capacity-building Workshop on Public Awareness, Education and Participation concerning the Safe Transfer, Handling and Use of Living Modified Organisms




hop

Report of the Asia-Pacific regional training workshop on public awareness, education and participation concerning the safe transfer, handling and use of LMOs is now available.




hop

The Report of the Workshop of the Network of Laboratories for the Detection and Identification of LMOs is now available.




hop

The report of the workshop of the Network of Laboratories for the Detection and Identification of Living Modified Organisms is now available.




hop

The report of the GRULAC Workshop on the Detection and Identification of Living Modified Organisms is available.




hop

The report of the workshop on developing capacity for national border controls on living modified organisms in small island developing States in the Caribbean is available.




hop

The report of the workshop on developing capacity for national border controls on living modified organisms in Pacific small island developing States is now available.




hop

CBD Communiqé: Training Workshop for Government Officials in the Use of the Biosafety Clearing-House Successfully Concluded.




hop

CBD News: Message of the Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Technical Workshop on Protected Areas in the Amazon, 14-16 July 2008, Amacayacú National Park, Colombia.




hop

CBD News: Opening Remarks on behalf of the Executive Secretary at the Regional Capacity Development Workshop for the Pacific on National Biodiversity Strategies, Biodiversity Mainstreaming and the Integration of Climate Change, 2 February 2009, Nadi, Fiji




hop

CBD News: Welcoming Remarks by the Executive Secretary, Ahmed Djoghlaf, at the Opening of the Pacific Islands Subregional Workshop on Protected Areas, Nadi, Fiji, 9-12 February 2009.




hop

CBD News: Statement by Ahmed Djoghlaf, Exeutive Secretary of the Convention on Biological Diversity, at the Opening of the Expert Workshop on the Development of the City Biodiversity Index, Singapore 10-12 February 2009.




hop

CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of Diversity for Life - Planning Workshop, 17 July 2009, Bellagio, Italy.