The Mercedes C-Class Cabriolet is a plush and personal driving experience that makes a strong case for convertible cars

'It (the decision to pick Nitish ahead of Shardul) is also about moving forward and I feel that this is the best set of players that we have selected to do the job for the country.'

Young Arshdeep Singh is getting better continuously, and the left-arm seamer has attributed this to his ability to keep things simple and stay level-headed in pressure situations, which has helped him evolve into a death-overs specialist.

The National Institute of Design (NID) is inviting applications for Design Aptitude Test (DAT) for its Bachelor of Design (BDes) and Master of Design (MDes) programmes.

The National Institute of Design (NID) is inviting applications for Design Aptitude Test (DAT) for its Bachelor of Design (BDes) and Master of Design (MDes) programmes.

Ninja Van's country head Eric Saputra talks about the challenges and opportunities of operating in Indonesia.

The post Ninja Van sets its sights on Indonesia’s mom-and-pop e-commerce plays appeared first on DealStreetAsia.

It is generally perceived that whenever a person observes anyone, the eye goes from top to bottom. No one knows the reason but it is the fact. So the first thing which...

Company: Nanu India Recruitment Co
Qualification: Bachelor Of Technology (B.Tech/B.E), Diploma
Experience: 0 to 2
Salary: 1.70 to 4.20
location: Delhi, Gurgaon / Gurugram
Ref: 24828375
Summary: We have Hiring For Design Engineer Mechanical. Freshers also can apply

Company: Confidential
Qualification: Aviation, Bachelor of Arts (B.A), Bachelor of Architecture (B.Arch), Bachelor of Business Administration (B.B.A), Bachelor Of Computer Application (B.C.A), Bachelor of Commerce (B.Com), Bachelor Of Technology (B.Tech/B.E), Bachelors of Law (B.L/L.L.B), Bachelor Of Pharmacy....

England stars Maro Itoje and Mako Vunipola are yet to commit to playing for Saracens in the Championship next season. Two French clubs have already expressed interest in Itoje.

Every year 5 May is celebrated as International Midwives' Day to acknowledge the contribution of midwives in childbirth. Those who don't know, midwives are women who help pregnant women in giving birth to their child. In ancient times when there were

Buddha Purnima is one of the important festivals celebrated in Hinduism and Buddhism culture. It is the birth anniversary of Lord Buddha and is the annual festival celebrated by people belonging to the Buddhist community. Every year the festival is celebrated

Not all days are the same. There will be days when things may take a wrong turn than expected. You may not be able to control the consequences and thus, you may feel bad for yourself. But you can certainly control

What could be better than having a partner who cares for you like anything? When you find someone who genuinely cares about you and loves you unconditionally, life seems to be happier. However finding someone in the times of

World Red Cross Day is observed every year on 8 May to mark the birth anniversary of Henry Dunant, the founder of the Red Cross and International Committee of the Red Cross (ICRC). He was born on 8 May 1828 and

Bollywood actress Katrina Kaif has made numerous statements in her western outfits and there is no doubt she has left us absolutely stunned in each outfit of hers. But apart from it, she has also given us some ethnic

Every year the second Sunday in the month of May is observed as Mother's Day. This is the day dedicated to mothers and the amount of unconditional love they have for their children. The day is celebrated to acknowledge the bond

Online Resource

1. Jackie Trad resigns as Queensland's Deputy Premier and Treasurer, Steven Miles and Cameron Dick to take on portfolios  ABC News
2. Poster girl’s fall a shock for the left of politics  The Australian
3. Corruption investigation into Queensland Deputy Premier Jackie Trad has potential to unravel Labor Government's five-year reign  ABC News
4. Editorial: Premier, Queensland needs a new treasurer now  Courier Mail
5. Analysis: Latest investigation not a good look for Jackie Trad  Courier Mail
6. View Full coverage on Google News

Did last night get away from you? You find the meaning of life in an enlightening grease-soaked bag of fries sometime around 230AM when the bars had finally closed, and your booze-blinded ass somehow made it home? Or did you fail to achieve such lofty goals, and just mindlessly empty whatever bottle was set before you? And now today you're stomaching all the fleeting bliss of last night. Well, sit back, refill that that water glass, prop your feet up, loathe life, and maybe even find yourself laughing at these funny, unintentionally ironic church signs.

Princeton University has a substantial impact on the New Jersey economy, generating an annual total of $1.58 billion in economic output as an employer, research and innovation leader, sponsor of construction projects, purchaser of goods and services, and financial and civic contributor to local communities. That total supports an estimated 13,450 jobs with $970.7 million in earnings.

Princeton University has made public a preview version of a new design for its main website and is seeking comment from the University community and other visitors to the site. The preview site is at beta.princeton.edu.

Environmental News FOR IMMEDIATE RELEASE

Environmental News FOR IMMEDIATE RELEASE

DENVER (April 23, 2020)) - Today, the U.S. Environmental Protection Agency (EPA) recognized Sprouts Farmers Market Store #305 in Aurora, CO and Sprouts Farmers Market Store #325 in Englewood, CO, with 2019 Food Recovery Challenge Regional Awards.

Environmental News FOR IMMEDIATE RELEASE

Vincent Edwards signed with the Houston Rockets on Thursday, per the team.

Long-time Slashdot reader blackbearnh writes: Since the COVID-19 pandemic has made Personal Protective Equipment worth it's weight in gold, Makers have been trying to help bridge the gap. While sewn masks have been the most common solution, the 3D printing community has been pitching in as well. The Montana Mask has been one of the most popular designs... Thursday, the group Make the Masks announced that the design files and STLs to print the mask have been released under the GNU General Public License v3, allowing anyone to print, sell, remix or improve the design, as long as they conform to the license. Importantly, the GPLv3 includes an international non-exclusive patent grant, meaning that even if the inventors decide to apply for a patent, it will not restrict anyone from using the design.

Read more of this story at Slashdot.

Borussia Dortmund star Erling Braut Haaland has been backed to sign for Liverpool in the future, while Manchester United have been criticised for missing out on him.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.