Pulitzer-winning cartoonists use humor to peer behind all the political posturing.

'A Short Hike" is a good example of how a familiar video game form can be made into something more quiet and unhurried.

The Democratic presidential candidate gets a shout-out in the new film.

"She’s the coolest superhero out there. She’s extremely confident. Sexy. Not surprised by anything," says Sanaa Lathan of Catwoman, her new role in DC Universe's "Harley Quinn" series.

For the first time in 50 years there won't be a San Diego Comic Con.

The former press secretary is reportedly writing a book about her tenure — adding to a growing list of White House advisers with stories to sell.

The rapper has been a supporter of the Democratic presidential candidate, and says she wants to help "a movement of young people to transform this country."

The senator from Vermont and the rapper bantered and got into the issues in a new campaign video.

The singer posted photos of the duo embracing after one of her concerts.

After taking a break from professional comedians, the organization has returned to tradition.

Famous supporters flocked to social media as Sen. Bernie Sanders ended his presidential campaign.

Bernie Sanders joined rapper Cardi B on her Instagram page to talk politics and nail care.

If you are using PayPal as the main payment gateway on your website, you may be wondering how you can complete a test transaction to ensure the payment process is running smoothly. In this tutorial, we will look at how you can use PayPal’s ‘test‘ mode known as Sandbox to complete test transactions with a […]

The post PayPal Test Cards (Sandbox Testing) appeared first on Tips and Tricks HQ.

It’s been frustrating to watch more moderate positions be characterized as solely driven by political calculations.

Maybe they need a new assignment.

How the president has proved himself a more successful socialist than Sanders is likely to ever be.

velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :)

San Diego, California

Bike tour from Vancouver, B.C. to San Jose, CA

The Amateur Traveler talks to Richard Miller of the SparkleTack podcast (about San Francisco history) about San Francisco. Richard guides us in a driving/walking tour from west to east. We start at lands end and end up near fisherman's wharf while talking about the sites and history of many of the places in between. This is a great companion episode with the 2 part soundseeing walking tour of San Francisco.

The Amateur Traveler talks to Ben Dixon about biking the route of the Camino di Santiago in northern Spain. The Camino di Santiago is a an ancient pilgrim trail that runs across northern Spain from the border with France to Santiago di Compostella. The cathedral in Santiago di Compostella reputedly holds the remains of St. James. Modern day pilgrims are sometimes drawn by faith and sometimes just drawn by the journey itself to trek for a month across the varied landscapes of northern Spain. As an American, Ben did not have a month of vacation but rather than be one of those pilgrims who only traverses the very end of the trail he chose to take on the pilgrim route on a bicycle. Along the way he stayed in the hostels that house the many pilgrims where he met people who had been walking from far beyond the border with France. Through countryside, cities and picturesque towns he rode in both sunshine and driving rain, but the highlight of the trip might not be what you think.

The Amateur Traveler talks to Vicente Perez about his home city of Pamplona, Spain. Pamplona is best known for the festival of San Fermin and of course for the running of the bulls. Vicente tells us more about that colorful festival, of which, the running of the bulls is actually a very small part. From the Txupinazo, the ceremonial firing of a rocket on July 6th until July 14th the population of Pamplona swells with celebrants. Processions of giant figures (the Comparsa), music, bull fights and lots and lots of partying fill the days and nights. But Vicente also tells of some of the other features of Pamplona and the Navarre region that can be enjoyed any time of year including wonderful food, beautiful mountains, castles, and the nearby cave of Zugarramurdi (Known for the Basque witch trials).

The Amateur Traveler talks to Carlos Gutierrez about his home town of San Antonio, Texas. Carlos gives us a guide to some of the obvious spots like the Alamo but also shares some of his favorite hole in the wall restaurants, a tip about the best time to come to San Antonio, and a great drive in the Texas countryside.

The Amateur Traveler talks to to Gary Arndt about the 4 micro-states in Europe: Andorra, Liechtenstein, Monaco, San Marino.  "They all have very unique histories and the one thing that they are all very small"

Hear about travel to Santa Fe, New Mexico as the Amateur Traveler talks to Billie Frank from SantaFeTravelers.com about her city, the second oldest in the United States and the oldest capital city in the U.S.

Hear about travel to the state of Guanajuato Mexico (including San Miguel de Allende) as the Amateur Traveler talks to Tim Leffel of perceptivetravel.com about his adopted home.

Hear about travel to Santa Barbara, California as the Amateur Traveler talks to Heather Simon from wellplannedtravel.net about the "American Riviera".

Hear about hiking the Camino de Santiago (the Way of St. James) in northern Spain as the Amateur Traveler talks to Linda Martin from The Indie Travel Podcast.

Linda says, "the thing about the Camino is that it is as long as you wanted to be."

Hear about travel to San Diego as the Amateur Traveler talks to Mike from MikesRoadTrip.com about this beautiful city in Southern California.

Hear about travel to San Francisco, California as the Amateur Traveler talks to Jill Robinson and Kimberley Levato authors of 100 Things to Do in San Francisco Before You Die.

The mainstream media is still a powerful entity in America, even as its influence wanes in favor of social media. The evidence of this has come again in recent polls that show Republican Gov. Rob DeSantis’ slipping poll numbers in Florida versus Democratic Gov. Andrew Cuomo’s rising numbers in New York. And the curious part…

The post Media Lies at Work: As NY Deaths Go Up, So Do Cuomo’s Polls – As FL Deaths Go Down, So Do DeSantis’ Polls appeared first on The Western Journal.

At least 65,116 individuals have been "forcibly disappeared" by the Syrian government, according to a new report by Amnesty International.

I was excited to finally get the word that an article I wrote sharing my love for my hometown – San Jose, California – is out in Delta Sky Magazine this month! Time Out: San José (Are you flying Delta this month? If so, pick up a copy for me! I’d love to see it […]

The article EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine originated at EverInTransit.com

Being a Parable for the Edification of Independents Seeking Independence

THE PARABLE

THE OSTENSIBLE CUSTOMER enters a deli and saunters up to the counter. The deli is tended by its rakishly handsome owner, THE SANDWICH GUY.

"Hi," says The Sandwich Guy. "What looks good to you today?"

"Slow down," says The Ostensible Customer, as THE LUNCH RUSH starts trickling in. "Lots of delis want my business, so, first I need to really understand what you can do for me."

"Well," says The Sandwich Guy, "I guess I can try to do what I do for everybody here and make you a customized version of any of the 15 awesome sandwiches you see on my menu. What're you hungry for?"

"Easy, easy, Ricky Roma! Before I make any decisions here I'm going to need to know a lot more about my options. Why are you so obsessed with 'what I want?'"

"Okay, sorry," says The Sandwich Guy, uneasily eyeing the growing queue of The Lunch Rush now piling up behind The Ostensible Customer. "What else can I do to help here?"

"That's better," says The Ostensible Customer. "Let's start by sitting down for a couple hours and going over all the ingredients you have back there."

The Sandwich Guy laughs congenially and hands The Ostensible Customer a menu. "Friend, I can make you whatever you want, but, if it helps, the 15 sandwiches listed here show all the ingredients--right there between the name and the price..."

"Whoa, whoa, whoa! The price?!? Already you're reaching for my wallet? Jeez, I barely just arrived."

The Lunch Rush is getting restless and grumbling audibly.

"Well. You know. I do sell sandwiches for a living," says The Sandwich Guy. "Did you have a certain budget in mind for your lunch?"

"Oh, God, no. I'm nowhere near that point yet. I still need to learn a lot more about how you work, and so, obviously, I have no idea what I want to pay. Obviously."

"Okay," says The Sandwich Guy, "but...I can't do much for you here without knowing either what you want to eat or how much money you want to spend. You get that, right?"

The Ostensible Customer is miffed.

"Listen, here. What I 'get,' so-called Sandwich Guy, is that you're not going to rush me into some tricky lifetime sandwich commitment until I understand precisely who I'm working with. And, so far, I do not like what I see. Still. I intend to find out more. So, meet me in Canada tomorrow to talk about this for an hour."

The Lunch Rush begins waving their wallets as they lob their completed order forms at The Sandwich Guy's face.

"Sorry," says The Sandwich Guy. "I can't do that. How about I just make you a Reuben. It's really good, it's our most popular sandwich, and it only costs eight bucks."

"WHAT! EIGHT DOLLARS! 'Dollars' with a 'd?' That's way too much!"

"I thought you didn't have a budget," says The Sandwich Guy.

"Well, I don't. And, besides, I don't really 'need' a sandwich at all. Now, kindly fly to Canada."

"That's not going to happen, sir."

"Also," says The Ostensible Customer, "if I do decide to get a sandwich from you--and it's looking increasingly less likely that I will--I'll absolutely expect your deeply discounted price to reflect the fact that I'm not particularly hungry right now."

The Lunch Rush begins lighting torches and chanting a guttural chant, not unlike the haunting overtone singing of Tuvan herdsmen.

"Look," sighs The Sandwich Guy, "it sounds like you need a little more time. Here's a free Coke and a complimentary bowl of pickles. Please have a seat, take all the time you need, then just come on up whenever you're ready to order, okay?"

"‘READY?!?’ TO...‘ORDER?!?’ Are you out of your mind?"

"Mmmm...apparently."

Presently, The Ostensible Customer turns beet-red.

"This is an outrage! I can't even imagine how you stay in business when you treat your customers like this."

The Lunch Rush grows silent as The Sandwich Guy slowly leans over the counter and smiles--his nose one slice of corned beef from The Ostensible Customer's nose.

"Sir. First off: you aren't my customer yet. Right now, you're just some dude holding a bowl of free pickles."

"Buh?" fumbled The Ostensible Customer.

"And, second, the way I 'stay in business' is by making great sandwiches and having as few conversations like the one we're having as possible," The Sandwich Guy coos.

"Because, the truth is, my real customers are actually all those nice people standing behind you. They're the people who buy my sandwiches with real money over and over again. I really like them, and so I give them almost all of my attention."

The Sandwich Guy waves at The Lunch Rush. The Lunch Rush waves back. The Ostensible Customer looks stunned.

"Sir," says The Sandwich Guy "enjoy your Coke and your pickles with my compliments. But, please step aside. Because right now, there's a whole bunch of hungry people trying to buy sandwiches that won't require me flying to Canada. Next, please!"

The Lunch Rush roars approval. The Ostensible Customer is still stunned. Which is unfortunate.

Because, several men from the back of the line spontaneously rush forward to drag The Ostensible Customer, screaming and grasping, onto the busy sidewalk outside, where they proceed to devour his flesh like those street urchins who eat Elizabeth Taylor's cousin in Suddenly, Last Summer.

Meanwhile, The Sandwich Guy goes back to making sandwiches. And, The Lunch Rush goes back to eating them.

THE MORAL(S)?

1. The Sandwich Guy can't do much for you until you're hungry enough to really want a sandwich.
2. Once you're hungry enough, you still have to pay money for the sandwich. This won't not come up.
3. Few people become "a good customer" without understanding both 1 and 2.
4. Few companies become "a smart business" without understanding 1, 2, and 3.
5. Basing his business on an understanding of 1, 2, 3, 4, and 5 doesn't make The Sandwich Guy a dick; it makes him a smart business.
6. If you vacation with Elizabeth Taylor? Seriously. Avoid provoking the cannibalistic rent boys.

THE HOPE

Me? I just very much hope it takes you far less than 15 years to see and accept these sorts of things. Both as a customer and as a business.

Guys, avoid working for anyone who's not hungry enough to compensate you for your sandwich. It literally doesn't pay.

THE RESERVE READING

• Bloodhounding Budgets - Cognition: The blog of web design & development firm Happy Cog

Tell them nicely that your price is a sucky $200K. The key here is to do so candidly, like you’re sitting on their side of the table and have to approve the budget with them. Admit that you’re way over the mark, and essentially apologize for it. I’ve said, “If you want to tell us to get lost, we understand”.

• Basement.org: Negotiation And Speculation: The Risk Of Selling Low

All those variables can change except your worth. That can’t change. It’s an undeniable fact beyond subjectivity and beyond the reality-bending rhetoric of your client-to-be. You are worth what you are worth and unless you’re feeling charitable something else has to give.

• Project Budgets and Secrets (thedesigncubicle.com)

Within the first few minutes of contact — in my effort to be as open and detailed on how I work as possible — the client counteracted by lying about not having a budget to clearly having a budget.

• Mule Design Studio’s Blog: Presenting Design Like You Get Paid For It

Unspoken expectations unmet lead to seething unspoken frustration which ultimately bursts forth in an ugly mess when you’ve run out of budget.

• Don’t Be Afraid of the S-Word :: Tips :: The 99 Percent

Remember that client who said that we were “pretty expensive” for them? A qualifying question in the first phone call could have saved us many hours of working on this deal. If you decide that the deal is unqualified, you just save it under another bucket: the unqualified deals bucket.

Médecins Sans Frontières, the medical humanitarian organization, has been awarded the Chatham House Prize 2015 for its life-saving work in combating the outbreak of Ebola in West Africa.

President Juan Manuel Santos of Colombia has been voted the winner of this year’s Chatham House Prize.

The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A2-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosanoid products. However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2γ (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids. Through strategic chemical derivatization, chiral chromatographic separation, and multistage tandem MS, here we first demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) and 2-arachidonoyl-lysophosphatidylethanolamine (2-AA-LPE). Next, we identified these two eicosanoid-lysophospholipids in murine myocardium and in isolated platelets. Moreover, we observed robust increases in 2-AA-LPC, 2-AA-LPE, and their downstream 12-LOX oxidation products, 12(S)-HETE-LPC and 12(S)-HETE-LPE, in calcium ionophore (A23187)-stimulated murine platelets. Mechanistically, genetic ablation of iPLA2γ markedly decreased the calcium-stimulated production of 2-AA-LPC, 2-AA-LPE, and 12-HETE-lysophospholipids in mouse platelets. Importantly, a potent and selective 12-LOX inhibitor, ML355, significantly inhibited the production of 12-HETE-LPC and 12-HETE-LPE in activated platelets. Furthermore, we found that aging is accompanied by significant changes in 12-HETE-LPC in murine serum that were also markedly attenuated by iPLA2γ genetic ablation. Collectively, these results identify previously unknown iPLA2γ-initiated signaling pathways mediated by direct 12-LOX oxidation of 2-AA-LPC and 2-AA-LPE. This oxidation generates previously unrecognized eicosanoid-lysophospholipids that may serve as biomarkers for age-related diseases and could potentially be used as targets in therapeutic interventions.

19 December 2019

Exame poderá detectar a doença na fase inicial. Pesquisadores da Faculdade de Medicina Osteopática da Universidade de Rowan, nos Estados Unidos, afirmam que estão perto de desenvolver um exame de sangue para detectar Alzheimer com precisão, o que dar...

The post Teste de sangue para detectar Alzheimer está próximo da realidade appeared first on Saúde Próspera.

Invitation Only Research Event

Event participants

Maria Shagina, CEES Postdoctoral Fellow, Center for Eastern European Studies, University of Zurich
Chair: Richard Connolly, Associate Fellow, Russia and Eurasia Programme, Chatham House

Montreal, 26 September 2008 - The province of Santa Elena, the newest province in Ecuador, emerged as the first jurisdiction in the world to proclaim a provincial day for protected areas, the Prefecta of the province, Ms. Ana Triviño Cisneros, has announced. To be celebrated annually on 23 September, the Day celebrates the designation of a new marine protected area off Ecuador's coast aimed at conserving about 47,000 hectares of some of the world's most spectacular biodiversity.