There are now 176 confirmed cases of COVID-19 in northeastern Ontario, and seven deaths.

This rapid and efficient method to prepare highly purified recombinant adeno-associated viruses (rAAVs) is based on binding of negatively charged rAAV capsids to an anion-exchange resin that is pH dependent.

A young boy is recovering in hospital after being hit by a car in Montreal's LaSalle borough Friday afternoon, police say.

Baltimore Orioles outfielder and first baseman Trey Mancini revealed Tuesday he is in the midst of six months of chemotherapy as he fights Stage III colon cancer.

What this country needs is another group with a very long name.

On Patriots' Day, we celebrate musician, publisher, and patriot Josiah Flagg (1737-1794), a friend of Paul Revere and major figure in Early American music.

"I have tied up with several NGO’s like Parivartan the change who donate food to over 500 people every day as well with welfare organisations like 4dogsakeindia where we feed over 200 street dogs."

On this week's edition of Olympic Games Replay, CBC Sports showcases some of the big moments from Canada's journey through the women's soccer tournament at the Rio Olympics.

Watch the Canadian women's soccer team compete at the Summer Games in Brazil.

More than a dozen First Nations in northeastern Ontario have closed their borders to outsiders during the pandemic. It's creating some friction, but in the long-run could help to better define what Indigenous self-government really means. 

Four-time All Pro tight end Rob Gronkowski has agreed to a reunion with Tom Brady. The trade, finalized Tuesday night, brings Gronkowski and a seventh-round pick to Tampa Bay in exchange for a fourth-round selection.

New England head coach Bill Belichick said not taking a quarterback in the Patriots' first post-Tom Brady draft "wasn't by design."

Despite sharp differences in the impact of COVID-19 in different parts of Ontario, the Ford government is rejecting a region-by-region approach to loosening emergency restrictions.

Some provinces are moving to allow people to double their so-called COVID-19 social bubbles. Chris Glover looks at why that's not yet happening in Ontario.

Approximately one out of every seven Ontarians who were working before the coronavirus pandemic hit the province have now lost their jobs, according to Statistics Canada's latest national labour survey.

Poor visibility from winter-like weather has put a halt on the Snowbirds aerobatics team's plans to fly over southern Ontario on Saturday.

Ontario reported its lowest new COVID-19 case count of the week on Saturday with 346 new confirmed cases of the virus. Meanwhile, the government has issued an emergency order allowing school board employees to be voluntarily redeployed to hospitals, long-term care homes, retirement homes and women's shelters.

The province's networks of labs processed 15,179 tests in the last 24 hours, more than any of the three days previous but still short of the 16,000 tests per day target set back in April.

After several days in which fewer than 400 cases of COVID-19 were added to the provincial tally, Friday's report was up again, with 477 new cases reported.

RCMP in Clearwater, B.C., are investigating an incident that took place at the Tiny House Warriors village in Blue River over the weekend. 

Ontario Premier Doug Ford says the Toronto Maple Leafs' parent company has been in contact with the province about the possibility of Canada's biggest city serving as a so-called "hockey pod" for teams should the NHL resume its season.

The province says no one has to tell others if they get COVID-19. The same goes for businesses or landlords, should employees or tenants get sick. But should you tell?

Government restrictions designed to limit the spread of COVID-19 have virtually crippled Ontario's wine-making industry, as retail and wholesale revenues dry up but the costs of producing wine remains constant.

Washington D.C., Apr 24, 2020 / 02:00 pm (CNA).- The Chinese Communist Party (CCP) covered up the spread of the new coronavirus within the country, suppressing the real rate of infection and violating the rights of its citizens as it did so, a Chinese human rights activist told a forum at The Catholic University of America on Friday.

“It is time to recognize the threat the Chinese Communist Party poses to all humanity. The CCP represses and manipulates information to strengthen its hold on power, regardless of the toll on human lives,” human rights lawyer Chen Guangcheng said April 24 during an online forum on the CCP and the new coronavirus.

The forum was hosted by Faith & Law in partnership with the Institute for Human Ecology at the Catholic University of America. Guanchen is Distinguished Visiting Fellow at Catholic University’s Institute for Policy Research and Catholic Studies.

Guangcheng is a blind human rights lawyer from China, who received sanctuary in the U.S. in 2012 after he was targeted by the CCP for his advocacy work. Guangcheng has sharply criticized the party for its human rights abuses, including from its one-child family planning policy.

He was sent to prison and subject to house arrest, during which he claims he and his family were repeatedly beaten and denied medical treatment.

On Friday, the lawyer warned audience members against suggestions that other countries should emulate China’s authoritarian response to the new coronavirus (COVID-19).

There are currently more than 2.7 million confirmed cases of COVID-19 in the world.

The city of Wuhan is recognized as the epicenter of the global pandemic, and the government on Jan. 23 instituted a strict lockdown in the city of 11 million people. Guangchang cited reports of Chinese families being barricaded inside their own homes, and the group Human Rights Watch compiled stories of residents reportedly dying from lack of access to care during the lockdown.

“Whole families have been found dead in their apartments because they could not get out,” he said, noting that despite the CCP’s claim that it has the virus under control, lockdowns are currently in force in the city of Harbin.

“This is despite the authorities ordering everyone back to work and telling the outside world that they have the virus under control,” Guangcheng said. “The resurgence is directly related to the CCP hiding the truth, and cracking down on people who tried to share information on the virus.”

He also claimed that the CCP has been using the crisis caused by the pandemic to crack down on dissent, detaining human rights activists at separate “so-called quarantine sites.”

The wife of one human rights lawyer—who had just been released from prison told The Guardian that she feared the government was putting her husband under house arrest near where he was imprisoned, 400 kilometers away from her, under the guise of a quarantine.

According to World Health Organization (WHO) statistics, China’s number of COVID-19 cases rose considerably through January and February to 79,389 on Feb. 29 with 2,838 deaths, before its daily increase in case numbers slowed to a trickle in March including just one new reported case on March 22 in the country of more than 1.4 billion people.

Just 3,352 deaths were reported on April 16 before the reported number jumped to 4,642 the next day.

“There is nothing about the CCP’s numbers that are believable,” Guangcheng said. “What people are calculating is that roughly 700,000 may have died in China—in terms of people who have been infected, no one knows the numbers.”

For instance, he said, during the Wuhan lockdown citizen journalists claimed that the situation was far worse than the CCP was reporting; they recorded people collapsing in the streets and hearses and vans carrying body bags at all hours of the day.

“In summary, the CCP is the biggest and most serious virus of all, with over 193,000 people dead worldwide from the coronavirus,” the lawyer said. “There should be no question of the regime’s threat.”

He says yes. His positions on the issues suggest otherwise.

Minister of Employment and Labour Thulas Nxesi said on Thursday afternoon that the Unemployment Insurance Fund was going to be under "very serious strain" and that he foresaw a period where there would be heavy dependence on the state.

The pervasive fear of violence and intimidation in Zimbabwe’s 2013 elections contradicts political leaders’ rhetorical commitments to peace, and raises concerns that the country may not be ready to go to the polls.

OBJECTIVES:

Reduce postoperative hypothermia by up to 50% over a 12-month period in children’s hospital NICUs and identify specific clinical practices that impact success.

OM Panama team members struggle to continue ministry as the Gnöbe Buglé people protest and bring the country to a halt.

Following the recent protests and riots, OM Panama's Mission Extreme group helps clean the Volcán police station.

Lauren Taylor catches up with the popular TV chef, after he explores the Med for his new show and cookbook.

"If we are serious about planting churches among the least reached as how we do mission, we must always be willing to question, reconsider and reform our paradigms," says Shaun Rossi.

CHRISTMAS is coming, the goose is getting fat and there's no wine as flexible with the varied foods of the season than rioja, so let’s take a seasonal look at our favourite Spaniard.

Less than 20 percent of respondents to a new CoSN survey marked any items on a list of cybersecurity threats as "high-risk" from their perspective.

Many schools treat students with mental-health issues reactively, rather than proactively, write Catherine A. Hogan & Laura F. Main.

In this lesson, 7th grade English/language arts teacher Emily Park-Friend takes her students through a three-step interview activity.

There have been no previous large studies of congenital heart disease in very low birth weight infants.

This study characterized the frequency, mortality rate, and lesion distribution of serious congenital heart disease in very low birth weight infants by using a large international multicenter database. (Read the full article)

Chorioamnionitis is associated with preterm birth and an increased risk of common adverse outcomes of prematurity, including early-onset sepsis and neurodevelopmental impairment. The effect of chorioamnionitis on postnatal immune function and risk of late-onset infection is unknown.

Chorioamnionitis, which complicates many preterm births, is independently associated with a significantly reduced risk of late-onset sepsis in preterm infants. The findings suggest that chorioamnionitis may modulate the development of postnatal immunity in a clinically significant manner. (Read the full article)

Over the past decade, drug oversight committees and professional organizations have debated the evidence regarding cardiac screening to identify undiagnosed disorders associated with sudden cardiac death in youth with attention-deficit/hyperactivity disorder before beginning treatment with stimulants.

How practicing pediatricians have responded to this controversy is not known. We present results from a national sample of pediatricians regarding current attitudes, barriers, and practices for cardiac screening in youth with attention-deficit/hyperactivity disorder before prescribing stimulants. (Read the full article)

Recent studies have called into question the benefit of perioperative corticosteroids in children undergoing heart surgery, but have been limited by small sample size, the lack of placebo control, and the grouping of various steroid regimens together in analysis.

We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates and found no mortality or length-of-stay benefit associated with any regimen, and a higher risk of infection in certain subgroups. (Read the full article)

Limited data exist about the frequency and incidence of serious injuries due to physical abuse of children. Data from Child Protective Services, which are published yearly, do not have information about severity.

This is the first study to provide US estimates on the occurrence of serious injuries due to physical abuse. The incidence was highest in infants on Medicaid. Such data can be used to track changes due to prevention. (Read the full article)

General measures discourage all self-referrals to the emergency department. For adults, self-referral to the emergency department has been associated with nonsevere disease, whereas severity of illness of self-referred children is still unknown.

One in four parents properly judged and acted on their febrile child’s illness by presentation to the emergency department on their own initiative. Measures to discourage parents from self-referral may potentially result in delayed or missed diagnoses. (Read the full article)

Numerous late preterm infants undergo repetitive heel lancing procedures during their first hours of life to evaluate glycemic control. Heel lances are painful and 25% glucose solution is effective on reducing procedural neonatal pain scores and crying behavior.

This noninferiority randomized controlled trial demonstrated that compared with breast milk, 25% glucose provided lower pain scores and reduced duration of cry. Further research is necessary to clarify breast milk’s mechanisms and efficacy on neonatal pain relief. (Read the full article)

Disparities are known to exist in the prescription of opioid analgesics among racial and ethnic groups in the management of postoperative, cancer, and emergency department pain in patients across all ages, including children.

Race is associated with an unequal burden of perioperative pain and opioid adverse effects in children. Relatively, African American children had higher postoperative pain, and Caucasian children had higher incidences of opioid related adverse effects. (Read the full article)

Despite recommendations and a universal immunization program, a recent survey reported suboptimal influenza vaccination coverage in children aged 6 to 23 months in Ontario. Little is known about predictors of coverage in young children to target immunization strategies.

Full influenza vaccination coverage in young children in Ontario is <10% and declining since the 2006–2007 season. Medically high-risk children including low birth weight infants are more likely to be immunized, but maternal and health services characteristics remain important. (Read the full article)

To date, 4 small to moderate sized studies have revealed conflicting results on the clinically important question whether thrombocytopenia contributes to persistent patent ductus arteriosus (PDA) in very immature, preterm infants.

Thrombocytopenia in the first 24 hours after birth was not associated with the incidence of PDA at postnatal day of life 4 to 5 in a large cohort of preterm infants with <1500 g birth weight. Platelet dysfunction, rather than platelet number, might play a role in ductus arteriosus patency. (Read the full article)

National data from child protective services agencies have shown a 55% decrease in the incidence of substantiated cases of physical abuse from 1992 to 2009, but no study has tracked the occurrence of serious injuries due to physical abuse.

Using national data from hospitalized children, we found a statistically significant increase in the incidence of serious injuries due to physical abuse from 1997 to 2009. These results are in sharp contrast to data from child protective services. (Read the full article)

Medical imaging that uses ionizing radiation provides notable benefits in the clinical setting. Controversy regarding increased cancer risk, particularly in children, dictates that ordering practices and use of such medical imaging be evaluated to reduce unnecessary exposure to imaging-related radiation.

We evaluated the prevalence and characteristics of diagnostic imaging procedures in children. The proportion of higher radiation procedures is increasing, especially among children evaluated in the inpatient and emergency department settings and those with gastrointestinal and neurologic symptoms, and congenital anomalies. (Read the full article)

Tonsillectomy is one of the most commonly performed surgeries in children and is one of the most cumulatively expensive conditions in pediatric hospital care. Little is known about how the quality of tonsillectomy care varies across hospitals.

In a large cohort of low-risk children undergoing same-day tonsillectomy, there was substantial variation in quality measures of process, dexamethasone and antibiotic use, and outcome, revisits to the hospital within the first 30 days after surgery. (Read the full article)