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Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Tiruchi Corporation office expansion plan witnesses more delay




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Nagapattinam MP presses for new express trains, railway line extensions




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Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers

Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time




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Pressure to possess

Buildings need to become simpler and smaller, without compromising on the essential needs.




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As India’s installed solar capacity crosses 90GW, a look at the journey 

Sun-sational growth: In September, India’s installed solar power capacity reached 90,762 MW. Given the current rate of monthly capacity additions, there is little doubt that installed capacity will exceed 100 GW in 2024-25.




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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge

Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed




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Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge




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Haryana Congress to move court over ‘violations’ by BJP during Assembly poll

Panel to gather information from party’s candidates about various violations




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Kejriwal sounds bugle, reaches out to AAP workers before Delhi Assembly poll

AAP chief asks supporters to devote as much time as possible to help the party win upcoming Delhi Assembly election, launches mobile number, website to register volunteers; playing victim card: BJP




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Delhi Assembly elections | Congress leader Mateen Ahmed joins AAP, AAP leader Harsharan Singh Balli returns to BJP

Setback for Congress as five-time MLA Mateen Ahmed jumps ship to Aam Aadmi Party, days after his son, daughter-in-law join Kejriwal-led party; former Minister Balli quits AAP and returns to BJP




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Delhi Cabinet passes proposal for reinstatement of bus marshals




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Kejriwal hints at fielding new faces in Delhi Assembly poll

By hinting at changing candidates, he has given silent approval to the accusations of corruption, extortion, coercion, and anarchy against his MLAs, says Sachdeva




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Eyebrows raised as Central team visits Anantapur to assess rabi drought during rainy kharif

The team choosing mandals like Vidapanakallu and Vajrakarur which received excessive rain in June, draws flak from farmers and district officials alike; farmers worry as to how to present their drought woes to the officials who are visiting their fields which are now rain-fed and green




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PM Modi expresses condolences over demise of renowned organic farmer Pappammal

In 2021, she was given the Padma Shri award for popularising organic farming in India and was regarded as a pioneer in the agriculture field




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Buttler Or Russell:Most Valuable Player?

Jos Buttler is still the front-runner to be this IPL's MVP.He still has at least two matches to play and one big knock will win it for him.Purnendu Maji and Srinivas Bhogle list Rediff.com's Most Valuable Players after the end of the 70 league matches in IPL 2022.




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Kohli surpasses Dravid's run record!

Virat Kohli surpassed Rahul Dravid to become the second highest run-scorer for India in international cricket.




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Zomato’s losses widen in FY16




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MOOCs are passe, say hello to SPOC

Emeritus's paid online education model is 'small and private' with personalised feedback




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Sensex hits seven-month high, crosses 27,000-mark

Bank, auto, real estate stocks among the top gainers




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Self-assembly of amphiphilic homopolymers grafted onto spherical nanoparticles: complete embedded minimal surfaces and a machine learning algorithm for their recognition

Soft Matter, 2024, 20,8385-8394
DOI: 10.1039/D4SM00616J, Paper
D. A. Mitkovskiy, A. A. Lazutin, A. L. Talis, V. V. Vasilevskaya
Amphiphilic macromolecules grafted onto spherical nanoparticles can self-assemble into morphological structures corresponding to the family of complete embedded minimal surfaces. They arise situationally, can coexist and transform into each other.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Retraction: Self-assembled organic nanotubes embedding hydrophobic molecules within solid bilayer membranes

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM90171A, Retraction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Naohiro Kameta, Masumi Asakawa, Mitsutoshi Masuda, Toshimi Shimizu
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00534A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Homa Ghaiedi, Luis Carlos Pinzon Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, Karthik Nayani
Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. Here, we demonstrate macroscopic alignment on collagen in 2-D substrates and 3-D hydrogels.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Entropically and enthalpically driven self-assembly of a naphthalimide-based luminescent organic π-amphiphile in water

Soft Matter, 2024, 20,8684-8691
DOI: 10.1039/D4SM00986J, Paper
Sk Mursed Ali, Sujauddin Sk, Shuvajyoti Sarkar, Sayani Das, Nayim Sepay, Mijanur Rahaman Molla
Entropically and enthalpically favourable vesicular self-assembly of a naphthalimide based water soluble luminescent organic dipolar building block is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The role of macrocycles in supramolecular assembly with polymers

Soft Matter, 2024, 20,8549-8560
DOI: 10.1039/D4SM01053A, Review Article
Ruslan Kashapov, Yuliya Razuvayeva, Elena Fedorova, Lucia Zakharova
Supramolecular self-assembly of polymers with macrocycles has attracted the attention because it enables the spontaneous creation of nanostructures with unique properties.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Co-assembly of Cellulose Nanocrystals and Gold Nanorods: Insights from Molecular Dynamics Modelling

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00871E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jiaxin Hou, William W Sampson, Ahu Gumrah Dumanli
A coarse-grained molecular dynamics model is developed to explore the co-assembly of cellulose nanocrystals (CNCs) and gold nanorods (AuNRs) under sedimentation conditions with varying vol- umetric concentration and particle-size ratios....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dynamics of switching processes: general results and applications to intermittent active motion

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01054J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ion Santra, Deepak Gupta, Kristian S Olsen
Systems switching between different dynamical phases is an ubiquitous phenomenon. The general understanding of such a process is limited. To this end, we present a general expression that captures fluctuations...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mechanical properties soft hydrogels: assessment by scanning ion-conductance microscopy and atomic force microscopy

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00966E, Paper
Tatiana Tikhonova, Yuri M. Efremov, Vasilii Kolmogorov, Aleksei Iakovlev, Nikolay Sysoev, Peter S. Timashev, Victor Fadeev, Alexander Tivtikyan, Sergey Salikhov, Petr Gorelkin, Yuri Korchev, Alexandr Erofeev, Evgeny Shirshin
The growing interest in biomimetic hydrogels is due to their successful applications in tissue engineering, 3D cell culturing and drug delivery. Major characteristics of hydrogels include swelling, porosity, degradation rate,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ring-shaped nanoparticle assembly and cross-linking on lipid vesicle scaffolds

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01010H, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Gizem Karabiyik, Aldo Jesorka, Irep Gözen
We show the assembly and cross-linking of carboxylate-modified polystyrene nanoparticles into flexible circular, ring-shaped structures with micrometer sized diameters around the base of surface-adhered giant lipid vesicles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A multi-scale framework for predicting α-cyclodextrin assembly on polyethylene glycol axles

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01048E, Paper
Open Access
Cameron D. Smith, Chenfeng Ke, Wenlin Zhang
We predict the assembly and time-dependent distribution of cyclodextrin along PEG axles by combining atomistic molecular dynamics with an analytical treatment of bulk diffusion. Our kinetic Monte Carlo can aid in the design of polypseudorotaxanes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00907J, Paper
Nada Y. Naser, William C. Wixson, Helen Larson, Brandi M. Cossairt, Lilo D. Pozzo, François Baneyx
Exploiting the ability of a solid-binding elastin-like peptide to micellize, we mineralize monodisperse silica nanoparticles whose positive surface charge enables one-step electrostatic assembly of various mono- and bi-material superstructures.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Designer Ranna Gill brings the essence of Lake Como to the runway at the Lakme Fashion Week X FDCI

Twenty-five years of Ranna Gill, and she still lets the flowers do the talking in her garments. Ahead of her show at Lakme Fashion Week X FDCI, the designer gives us a sneak peek into her collection



  • Life & Style

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Editorial. Gold duty cut can help exporters and consumers if cost savings are passed on 

The customs duty cut on gold, silver and platinum will certainly bring down production costs in this thin-margin industry, helping Indian exports gain competitive edge in the global market




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Compliant with gold loan norms, will further strengthen audit processes: CSB Bank MD

Bank expects its advances and deposits to rise at least 30-50 per cent faster than the banking system



  • Money & Banking

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PB Fintech reports ₹51 crore profit in Q2, overcoming previous losses

Although this profit figure is lower than the ₹60 crore recorded in the previous quarter, it marks the fourth consecutive profitable quarter for the company.



  • Money & Banking

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ICICI Prudential Multi asset completes 22 years

A lump sum investment of ₹10 lakh at the time of inception in October 31, 2002 will be worth about ₹7.26 crore given compounded annual growth rate of 22 per cent



  • Money & Banking

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Srisailam temple witnesses high devotee influx amid Karthika Masam

Devotees are allowed darshan from 4.30 a.m. to 4 p.m. and from 5.30 p.m. to 11 p.m.




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Andhra Pradesh poised for growth under visionary leadership, asserts Lanka Dinakar

The annual budget balances welfare and development commendably, says chairman of the 20-Point Programme Committee




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Atchannaidu presents ₹43,403 crore Agriculture Budget in A.P. Legislative Assembly

Of the total outlay, ₹14,638 crore is for maintenance of irrigation projects; free power scheme gets ₹7,241 crore and ‘Annadata Sukhibhava - PM Kisan’, a Super Six scheme, is allocated ₹4,500 crore




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Need to create awareness on Budget preparation among new MLAs, says Andhra Pradesh Assembly Speaker

‘It will equip them to express their opinion and they are also supposed to know the allocations made to 39 departments’




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Andhra Pradesh Legislative Assembly sessions to continue till November 22

If former Chief Minister Jagan Mohan Reddy continues to skip the Assembly sessions, law will take its own course, says Speaker Ayyanna Patrudu




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Chief Minister Chandrababu Naidu encourages lawmakers to drive meaningful Assembly debates

Stressing public accountability, Mr. Naidu urged legislators to address the people’s issues in a responsible manner




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Andhra Pradesh government urged to move new Tenancy Bill in Assembly

Andhra Pradesh Tenant Farmers’ Association proposes 35 amendments to Andhra Pradesh Land Cultivators Rights Act, 2024, including provisions for tenant ryots to receive crop loans based on the scale of finance




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Reliance Industries to invest ₹65,000 crore in A.P. to set up compressed biogas projects

The project will result in the creation of 2.50 lakh jobs, and earn an estimated ₹57,650 crore in taxes and duties for Andhra Pradesh over a period of 25 years, according to the Memorandum of Understanding signed on Tuesday