Geneticists and anthropologists studying historical records and modern-day genomes are finding traces of previously unknown migrants to Latin America in the 16th and 17th centuries, when Asians, Africans, and Europeans first met indigenous Latin Americans. Sarah Crespi talks with contributing correspondent Lizzie Wade about what she learned on the topic at the American Association of Physical Anthropologists’s annual meeting in Austin. Sarah also interviews Kang-Keun Ni about her research using optical tweezers to bring two atoms—one cesium and one sodium—together into a single molecule. Such precise control of molecule formation is allowing new observations of these basic processes and is opening the door to creating new molecules for quantum computing. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Juan Fernando Ibarra; Music: Jeffrey Cook] 

Who were the first horse tamers? Online News Editor Catherine Matacic talks to Sarah Crespi about a new study that brings genomics to bear on the question. The hunt for the original equine domesticators has focused on Bronze Age people living on the Eurasian steppe. Now, an ancient DNA analysis bolsters the idea that a small group of hunter-gatherers, called the Botai, were likely the first to harness horses, not the famous Yamnaya pastoralists often thought to be the originators of the Indo-European language family. Sarah also talks with News Intern Katie Langin about her feature story on a single salmon gene that may separate spring- and fall-run salmon. Conservationists, regulators, and citizens are fiercely debating the role such a small bit of DNA plays in defining distinct populations. Is the spring run distinct enough to warrant protection? This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Jessica Piispanen/USFWS; Music: Jeffrey Cook] 

DNA fingerprinting has been used to link people to crimes for decades, by matching DNA from a crime scene to DNA extracted from a suspect. Now, investigators are using other parts of the genome—such as markers for hair and eye color—to help rule people in and out as suspects. Staff Writer Gretchen Vogel talks with Sarah Crespi about whether science supports this approach and how different countries are dealing with this new type of evidence. Sarah also talks with Jill Fernandes of the University of Queensland in Brisbane, Australia, about her Science Advances paper on a light-based technique for detecting Zika in mosquitoes. Instead of grinding up the bug and extracting Zika DNA, her group shines near-infrared light through the body. Mosquitoes carrying Zika transmit this light differently from uninfected ones. If it’s successful in larger trials, this technique could make large-scale surveillance of infected mosquitoes quicker and less expensive. In our monthly books segment, Jen Golbeck talks with author Sarah-Jayne Blakemore about her new work: Inventing Ourselves: The Secret Life of the Teenage Brain. You can check out more book reviews and share your thoughts on the Books et al. blog. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: National Institute of Allergy and Infectious Diseases, National Institutes of Health; Music: Jeffrey Cook]

First, we hear from science writer Joshua Sokol about his trip to the Cambrian—well not quite. He talks with host Megan Cantwell about his travels to a remote site in the mountains of British Columbia where some of Earth’s first animals—including a mysterious, alien-looking creature—are spilling out of Canadian rocks.   Also on this week’s show, host Sarah Crespi talks with James Hazel a postdoctoral research fellow at the Center for Genetic Privacy and Identity in Community Settings at Vanderbilt University in Nashville about a proposal for creating a universal forensic DNA database. He and his co-authors argue that current, invasive practices such as law enforcement subpoenaing medical records, commercial genetic profiles, and other sets of extremely detailed genetic information during criminal investigations, would be curtailed if a forensics-use-only universal database were created.     This week’s episode was edited by Podigy.   Read a transcript (PDF) Listen to previous podcasts.   About the Science Podcast  

In 1968, Science published the now-famous paper “The Tragedy of the Commons” by ecologist Garrett Hardin. In it, Hardin questioned society’s ability to manage shared resources, concluding that individuals will act in their self-interest and ultimately spoil the resource. Host Meagan Cantwell revisits this classic paper with two experts: Tine De Moor, professor of economics and social history at Utrecht University in the Netherlands, and Brett Frischmann, a professor of law, business, and economics at Villanova University in Pennsylvania. They discuss how premodern societies dealt with common resources and how our current society might apply the concept to a more abstract resource—knowledge. Not all human skulls are the same shape—and if yours is a little less round, you may have your extinct cousins, the Neanderthals, to thank. Meagan speaks with Simon Fisher, neurogeneticist and director of the Max Planck Institute for Psycholinguistics in Nijmegen, the Netherlands, about why living humans with two Neanderthal gene variants have slightly less round heads—and how studying Neanderthal DNA can help us better understand our own biology. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image: Phillip Gunz; Music: Jeffrey Cook]

Aseem Chhabra introduces you to the Irrfan you never knew.

Online Resource

Justice (retired) Fazal-e-Miran Chauhan submitted his detailed judgement on the case to the Pakistan Cricket Board, which made it public on its site.

Rotch Library - GF75.W375 2020

During the trial, 189 witnesses were examined between 2009 and 2012, of which 83 turned hostile.

The MZP is planning a "Long March for Peace" from Aizawl to the western town of Tuipuibari.

Will take action against those spreading rumours, say police

The panelists talk {Track:js} with Todd Gardner.

Panel: Charles Max Wood

Guest: Todd Gardner

This week on My JavaScript Story, Charles speaks with Todd Gardner. Todd is one of the co-founders of Track JS, which is a JavaScript error monitoring service. He first got into programming in Jr. High when he and his friends played around with computers they had dumpster dived for from their school in order to play video games. In High School, he learned how to create websites so that people could register for his LAN parties online. They also discuss the importance of finding passion in what you do as well as what Todd is most proud of contributing to the JS community.

In particular, we dive pretty deep on:

• Track JS
• Stack trace
• Telemetry
• Decodes errors that are actually good to focus on
• How did you get into programming?
• Warcraft video game
• Started programming past gaming in High School
• LAN parties
• Pearl
• The importance of passion in programming
• C#
• He didn’t start off with programming as his focus
• Find the thing that inspires you and go do it!
• How did you wind up on JavaScript?
• Working as a consultant
• Knockout vs Backbone
• .net contractor to JS contractor
• Node JS
• What are you most proud of in JS?
• Understand that you’re never done with a JS app
• What are you doing now?
• And much, much more!

Links: 

• Track JS
• @ToddHGardner
• Todd.mn

Picks

Charles

• Eternium
• The E-Myth Revisited: Why Most Small Businesses Don't Work and What to Do About It by Michael E. Gerber
• My Business on Purpose Podcast
• Jamie Masters 
• Profit First by Mike Michalowicz
• The 12 Week Year by Brian P. Moran

Todd

• Smart Things
• Rage

Panel:

• Charles Max Wood
• AJ ONeal

Special Guests: Kurt Mackey

In this episode, the JavaScript Jabber panel talks to Kurt Mackey about Fly.io. At Fly.io, they are "building a JavaScript platform that gives you the power to build your own CDN." They talk about how Fly.io came to fruition, how CDN caching works, and what happens when you deploy a Fly app. They also touch on resizing images with Fly, how you actually build JavaScript platforms using Fly, and more!

In particular, we dive pretty deep on:

• Fly.io
• Building a programmable CDN
• High level overview of Fly.io
• How did this project come together?
• CDNs didn’t work with dynamic applications
• Has been working on this since 2008
• Extend application logic to the “edge”
• Putting burden of JavaScript “nastiest” onto the web server
• Fly is the proxy layer
• Getting things closer to visitors and users
• CDN caching
• Cache APIs
• Writing logic to improve your lighthouse score
• Have you built in resizing images into Fly?
• Managing assets closer to the user
• Can you modify your own JavaScript files?
• What happens when you deploy a Fly app
• Having more application logic
• DOM within the proxy
• Ghost
• React and Gatsby
• Intelligently loading client JavaScript
• How do you build the JavaScript platform?
• And much, much more!

Links:

• Fly.io
• JavaScript
• Ghost
• Gatsby
• React
• @flydotio
• @mrkurt
• Kurt at ARS Technica
• Kurt’s GitHub

Sponsors

• Kendo UI
• Sentry
• Digital Ocean

Picks:

Charles

• GitLab

AJ

• Gitea
• Black Panther

Kurt

• Packet.net
• The Three-Body Problem by Cixin Liu

Episode Summary

Todd Gardner is a software developer, podcaster on the show Script and Style, startup founder,  and comedy host for Pub Conf, a ‘comedy after party for developers’. Since he was last on the show 6 years ago, he has seen his startup TrackJS become quite successful. TrackJS is a JavaScript error monitoring service which gives you visibility into your client side experience. It’s different from other tools because focused on simplicity, so you’ll never need a guy on your team dedicated solely to TrackJS because everyone can use it.

The panel begins by talking about debugging methods and tools. Some rely solely on the debugger built into their platform while others prefer to use a third party service. They discuss the necessity of using a third party debugger and if there are better solutions than just the built in debugger. 

They then discuss what to do after you’ve fixed a bug, such as if it is necessary to write a test to make sure it was completely fixed They talk about things to do to make debugging more effective. Todd and Aimee believe that code needs to begin by being designed for debug-ability. 

The panel discusses issues with invisible boundaries encountered while debugging, such as running out of memory. They talk about ways to mitigate issues that happen outside of your code base. Todd talks about the dangers of ad-blockers, and the panel agrees that it is important to consider how your website will be crippled by the user’s own technology. The end user in a production environment will have a different experience than you did writing it on a professional computer. 

Todd talks about the difference between debugging for the web versus a mobile application. Todd has encountered particular problems with debugging on a remote device, and he talks about how he solved the issue. The show concludes with Todd giving a quick elevator pitch for TrackJS

Panelists

• Chris Ferdinandi

• Christopher Buecheler

• Aimee Knight

• Charles Max Wood

• Steve Emmrich

With special guest: Todd Gardner

Sponsors

• Adventures in Blockchain

• Sentry use the code “devchat” for 2 months free on Sentry’s small plan

• React Round Up

Links

• Track JS (free trial available)

• Script and Style podcast

• PubConf

• Console.log

• Blackbox for Firefox and Chrome

• Redux lager

• Remote JS 

Follow DevChat on Facebook and Twitter

Picks

Christopher Buecheler:

• React/TypeScript cheat sheet 

Chris Ferdinandi:

• Pokemon Brawl 

• Space Invaders game

• Gomakethings.com newsletter

Aimee Knight:

• TechLead Youtube channel

Charles Max Wood:

• Atomic Habits

• Getting up at 4 am

Steve Emmrich:

• Trello

• Babushkas and grandmas to help you with your newborn

Todd Gardner:

• PubConf

• Follow Todd @toddhgardner or todd.mn

In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

This cohort study assesses cardiovascular functional reserve before and after kidney transplant in patients with end-stage renal disease.

Seeman, Nadrian C., 1945- author

Wary about a sharp spike in kidney patients testing positive for the novel coronavirus, the state government has asked the private hospitals to keep the health officials in the loop on those undergoing dialysis.

Online Resource

Online Resource

Online Resource

Galliers, Robert, 1947-

Interview with Keith A. Josephs, MD, MST, MSc, author of Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

Interview with Jeanne Tie, author of Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

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Keane, John, 1949- author

As the founder of multiple biotech firms, C&EN's guest editor has learned a thing or two about the challenges and triumphs of starting a company. We asked her to share her best advice for budding academic entrepreneurs

The gene-editing tool CRISPR-Cas9 rerouted Doudna's career path. What hasn't changed for the renowned scientist and serial entrepreneur? Living and breathing the science