A rendering of he new stadium and complex to be built near the Forum in Inglewood was released by the Hollywood Park Land Company, Kroenke Group and Stockbridge Capital Group earlier this month.; Credit: Courtesy Hollywood Park Land Company

A measure that would allow an 80,000-seat NFL-caliber stadium to be built in Inglewood could be on that city’s ballot by this summer after developers submitted almost three times as many signatures than needed for a voter initiative.

“22,216 signatures were submitted to the city clerk today,” said Gerard McCallum, project manager with the Hollywood Park Land Company. “It was unbelievable. The response was more than we could have ever anticipated.”

Normally, before construction can begin on any project there has to be an environmental review, but that can take a long time and time is something in short supply for St. Louis Rams Owner Stan Kroenke and his plan to move the team to L.A.

“We would be going through another three year project process, and the current construction wouldn’t allow that,” said McCallum, referring to the redevelopment of 238 acres of the old Hollywood Park site that was permitted in 2009.

“If we were going to make any modifications, it would have to be approved this year,” said McCallum.

To speed things up, developers decided to bring the stadium project directly to Inglewood voters, which required 8,000 signatures.

Once the signatures are verified, Inglewood’s City Council will consider the measure, then developers hope a special election would take place before the start of the next NFL season.

McCallum says construction would begin whether the Rams or any other team decides to move here, though on Monday Kroenke made another move suggesting a return of the NFL to Los Angeles could be closer than it has been at any point during the last two decades, though not until after the 2015 season. From The St Louis Post-Dispatch:

Rams management sent a letter to regional officials on Monday afternoon. The letter said the team was converting its 30-year lease to an “annual tenancy,” effective April 1 and, “in the absence of intervening events,” extending through March 31, 2016.

The notice, which has long been expected, does two things:

• It allows owner Stan Kroenke to pull the team out of St. Louis as soon as 2016, because the Rams lease will now expire at the end of every season. The original lease was to expire in 2025.
• It also legally binds the Rams to play at the Edward Jones Dome next fall — a point on which many here were uncertain.

This content is from Southern California Public Radio. View the original story at SCPR.org.

If we can’t secure the supply chain, eventually everything else will break

The post What happens when the global supply chain breaks? appeared first on WeLiveSecurity

While in France, a citizen of Brazil who resides in California books a bungee jump in New Zealand. Is it a leap of faith into the unknown, for both the operator and the thrill-seeker?

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Source: Streetwise Reports   05/04/2020

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS^® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

Disclosure:
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( Companies Mentioned: STML:NASDAQ, )

Hypoxia (low levels of oxygen) is widespread in the coastal waters of the Baltic Sea, according to recently published research. The trend of increasing hypoxia since the 1950 is alarming, although improvements can be seen in some areas as a result of measures to reduce inputs of organic material.

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A recent study has revealed how water use has changed across the world over the last 60 years. Growing populations and economic development, particularly in newly-emerging countries, have increased water demand, but technological developments have led to water efficiencies and savings, which moderate these demands.

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Misreported fishing catches in the Baltic Sea have probably led to incorrect fishing quotas, new research suggests. The study found that total catches between 1996 and 2009 have been underestimated for a significant period, skewing quota calculations.

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A map of science could assist research planning strategies by helping to identify emerging topics. The map — which is based on links to almost 20 million scientific articles that have been published over the past 16 years — clusters and links scientific disciplines by citation-based relationships and serves as a highly detailed and scalable infographic. The authors hope it will be used by research planners to help distinguish — and potentially forecast — the research areas in science which have longevity, and also those which are innovative.

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A new global study is the first to quantify the potential of water management strategies to increase crop production. It indicates that a combination of harvesting run-off water and reducing evaporation from soil could increase global crop production by 20 per cent.

Reindeer herding has a long history in the Arctic, but climate change and industrial activity are bringing this important economic and cultural tradition to breaking point. In a unique initiative, reindeer herders across the Arctic are leading an international team of scientists in using modern technology to adapt to global change and empower indigenous communities.

A global cropland percentage map and a global field size map have been created for the first time to guide scientists and policymakers interested in global agricultural modelling and assessment. Both maps are for the baseline year 2005 and combined multiple data sets from global, regional and national levels to achieve a high level of accuracy and 1 km2 resolution.

The worldwide decline of pollinators could increase cases of vitamin and micronutrient deficiencies in humans, new research suggests. For instance, pollination is needed for the crops that produce half of all plant-derived vitamin A across much of south-east Asia. Furthermore, areas which depend most on pollination for micronutrient supply tend to be poorer and already at higher risk of deficiencies.

The current economic and environmental crisis tells us that the time is ripe for governments around the world to implement a new kind of economy, which is resilient, sustainable, operates within the limits of our planet's resources and creates a fairer society. This thematic issue covers research which can help policy makers develop this Global Green Economy.

Researchers have developed a new energy map that traces the flow of global energy from the fuel sources to the final services provided. The study provides new insight into the potential of energy efficiency measures by focusing on technologies rather than economic sectors.

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There are no technical or economic barriers to providing all of the world’s energy from renewable sources, according to a recent study. With a concerted effort, including reduced demand and international cooperation, the researchers suggest that the world could be entirely reliant on renewable energy for electric power, transportation and heating/cooling by 2050.

Reindeer herding has a long history in the Arctic, but climate change and industrial activity are bringing this important economic and cultural tradition to breaking point. In a unique initiative, reindeer herders across the Arctic are leading an international team of scientists in using modern technology to adapt to global change and empower indigenous communities.

Some scientists have suggested that, when all potential inefficiencies are accounted for, local food distribution systems may be less sustainable than globalised systems. However, new research examining the behaviour of participants in local food networks in France suggests that they can be as energy efficient as globalised systems.

Research from the US helps paint a clearer picture of the extent of global sea level rise, by considering new satellite data on the Earth’s gravity. Its findings support reports of accelerating ice melt and suggest that most of the change in sea levels is caused by receding polar ice sheets and mountain glaciers.

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New areas of land suitable for agriculture will open up under climate change’s effects, new research predicts, particularly in far northern regions of the world. However, the overall quality of land for farming will decline and many regions, including Europe, could lose large areas of suitable land.

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A recent international analysis of waste electrical and electronic equipment (WEEE) management has indicated that current practices will not be able to deal with future increases in WEEE. It calls for rapid, co-ordinated and bold responses that are both technical and non-technical to deal with this ever-increasing global issue.

IT company Cognizant announced it will acquire Collaborative Solutions, a privately-held global consultancy specialising in Workday enterprise cloud applications for finance and HR.

In a freewheeling discussion with ETCIO, Miao Song, Global CIO & Global VP of MARS group emphasized this different Covid-19 challenge which is new for CIOs to tackle and difficult too.

Global demand for copper could increase by up to 341% by 2050, and energy use is likely to increase with it — rising to a possible 2.4% of global energy demand in 2050, according to new research. Policy actions to avoid such drastic changes could include improving copper recycling and using renewable technologies.

In a freewheeling discussion with ETCIO, Miao Song, Global CIO & Global VP of MARS group emphasized this different Covid-19 challenge which is new for CIOs to tackle and difficult too.

Our global customers are looking at the cloud to more effectively meet their toughest business challenges. Yet something is stopping them from making the most of what cloud can deliver

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Speed constraints for aircraft are put in place, at some airports, to minimise noise pollution in local areas, however, such practices can be very fuel-inefficient. New research has now shown that relaxing departure speed limits could substantially reduce CO2 emissions, while maintaining acceptable noise levels.

Travelling by coach or train has a lower impact on the climate than travelling by air or car, but using a small diesel car to carry several passengers can have similarly low impacts per person, new research suggests. Air travel is the worst form of transport, in terms of global warming impact, the researchers found, but the average percentage occupancy of a mode of transport significantly affects the impact per passenger.

Reducing forest fire risk within a tight budget can be successfully achieved, according to researchers. The study simulated the economic and fire risk effects of five management plans and found that a combination of removing low level trees and selective positioning of woodland produced the most economic and least destructive results

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Each person in the EU consumes the equivalent of 30% more global arable land than can be considered sustainable, according to a new study. As well as providing food for a growing population, the land is also increasingly used to grow biofuel crops.