Lawyer Nick Freeman (left) believes that many motorists are lulled into a false sense of security during the Covid-19 restrictions and has produced a list of things drivers need to know.

Parking officials in parts of Kent, including Sevenoaks, Tonbridge and Malling are pocketing their full public sector salaries despite thousands of workers across the country being furloughed.

Archives, Room Use Only - TK5263.R85 1878

One of Earth’s most evolutionarily unique species is also the world’s most trafficked mammal: pangolins, or “scaly anteaters.” A new study from the Smithsonian Conservation […]

The post Using genetics to help save world’s most trafficked mammal: the pangolin appeared first on Smithsonian Insider.

Osiris Martinez-Guzman, Mathilda M. Willoughby, Arushi Saini, Jonathan V. Dietz, Iryna Bohovych, Amy E. Medlock, Oleh Khalimonchuk, and Amit R. Reddi

Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins located throughout the cell. However, the mechanisms governing the mobilization of heme out of the mitochondria, and the spatio-temporal dynamics of these processes, are poorly understood. Herein, using genetically encoded fluorescent heme sensors, we developed a live cell assay to monitor heme distribution dynamics between the mitochondrial inner-membrane, where heme is synthesized, and the mitochondrial matrix, cytosol, and nucleus. Surprisingly, heme trafficking to the nucleus is ~25% faster than to the cytosol or mitochondrial matrix, which are nearly identical, potentially supporting a role for heme as a mitochondrial-nuclear retrograde signal. Moreover, we discovered that the heme synthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of the mitochondrial dynamics machinery, Mgm1 and Dnm1, and ER contact sites, Gem1, regulate the flow of heme between the mitochondria and nucleus. Overall, our results indicate that there are parallel pathways for the distribution of bioavailable heme.

Vaishnavi Ananthanarayanan
Apr 17, 2020; 133:jcs245928-jcs245928
Meeting Report

NASA should collaborate with the Federal Aviation Administration (FAA), industry, academia to research the full effects that increased unpiloted air vehicle traffic would have on society, including ramifications to sound, privacy, environmental matters, and cybersecurity, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Increasing noise levels are a global environmental concern, and have been linked to important health issues, such as heart disease and cognitive development. New Danish research has now shown that it is also associated with an increased risk of diabetes.

A recent pan-European study has reviewed the factors which influence how annoyed a person feels about road traffic and aircraft noise. Among its findings, residents in terraced housing or apartments were less annoyed by road traffic noise than residents in semi-detached or detached housing.

Increasing noise levels are a global environmental concern, and have been linked to important health issues, such as heart disease and cognitive development. New Danish research has now shown that it is also associated with an increased risk of diabetes.

A new World Health Organisation (WHO) study has estimated that the health impact of environmental noise in western Europe could be up to 1.6 million healthy life years lost annually through ill health, disability or early death.

New research in Spain has explored solutions to reducing traffic noise, and suggests that the best option is to combine global measures, such as speed restrictions, and local measures, such as noise screens.

A recent pan-European study has reviewed the factors which influence how annoyed a person feels about road traffic and aircraft noise. Among its findings, residents in terraced housing or apartments were less annoyed by road traffic noise than residents in semi-detached or detached housing.

Increasing noise levels are a global environmental concern, and have been linked to important health issues, such as heart disease and cognitive development. New Danish research has now shown that it is also associated with an increased risk of diabetes.

Digital noise maps developed under the EU’s Environmental Noise Directive (END) are a useful way of assessing traffic noise exposure for local residents, according to a recent Swedish study. The END maps could also be used to standardise noise exposure information in noise and health research.

A new mobile phone application which can help monitor traffic-noise exposure is presented in a recent study. The app, ‘2Loud?’, can measure indoor night-time noise exposure and, given large-scale community participation, could provide valuable data to aid urban planning, the researchers say. In an Australian pilot study, nearly half of participants who used the app found that they were exposed to potentially unhealthy levels of night-time noise.

Speed constraints for aircraft are put in place, at some airports, to minimise noise pollution in local areas, however, such practices can be very fuel-inefficient. New research has now shown that relaxing departure speed limits could substantially reduce CO2 emissions, while maintaining acceptable noise levels.

“Gaming traffic has increased by 50% in the last few weeks, with doubling of traffic in video streaming and collaborative work apps like Skype, Teams and Zoom,” said Ivo Ivanov, CEO of DE-CIX International, which runs an internet exchange in Mumbai.

There was significant spike in downloads and uploads per user, owing to the high volume of work and streaming content across India.

There was significant spike in downloads and uploads per user, owing to the high volume of work and streaming content across India.

New research has found a possible link between traffic-related air pollution outside people's homes and the onset of asthma in children during the first eight years of life. Higher levels of nitrogen dioxide, PM2.5 and soot were more likely to be recorded at the homes of those children who developed asthma and asthma symptoms.

One of the benefits of cycling is improved physical health. However, recent research suggests that cyclists inhale more air pollutants than motorists in traffic, mainly due to faster, deeper breathing. This suggests that town planners should carefully consider cycle routes.

Environmental policy makers increasingly rely on computer models to test traffic policies. Researchers have investigated the impact of reducing speed limits on traffic emissions using two different models, but the models produced some contradictory results. The researchers therefore warn policy makers to interpret model results very carefully and to avoid relying on simple 'macroscopic' models.

Low emission zones (LEZs) that restrict old vehicles in city centres may need implementation in combination with other traffic policies to have greater impacts on air quality, according to new research. A study that measured emission levels before and after the introduction of LEZs in five Dutch cities indicated that air pollution concentrations were reduced but not to a statistically significant level.

Low emissions zones (LEZs) can substantially reduce local levels of traffic-based air pollution, a new study has shown. Monitoring air pollution in Munich, Germany, researchers found that particulate matter from traffic sources dropped by 60% after implementation of an LEZ.

A strong link between long-term exposure to vehicle pollution and deaths from heart disease and lung cancer has been found in a study of over a million individuals. The researchers say their results are relevant to European policymaking relating to air quality.

Particulate matter (PM) emissions from domestic wood burning in London are higher than the PM reductions achieved through London’s Low Emission Zone, finds a new study. The research suggests that increases in wood burning could risk undermining policies aimed at meeting EU PM₁₀ targets.

High blood pressure is linked to long-term exposure to traffic-related air pollution, new research suggests. After accounting for lifestyle factors, socioeconomic status and pre-existing health conditions, the researchers found that a rise in traffic emissions of nitrogen dioxide corresponded to a rise in blood pressure of exposed individuals.

Traffic pollution contributes to childhood obesity, a recent study concludes. In the US investigation of over 4 500 children, the researchers estimated that air pollution increased the body mass index (BMI) of 10-year olds in the most polluted areas of study by 0.4 units, compared to those in the least polluted areas. It is thought that pollution may have slowed the children’s metabolism.

Our lifestyles determine how often we are exposed to cancer-causing chemicals, such as those in traffic emissions and cigarette smoke. A Swedish study reveals how exposure to these chemicals varies from person to person. Among its findings, the amount of time a person spends in traffic or refuelling their car significantly affects how much benzene and butadiene they could inhale.

Road traffic noise and air pollution both increase the risk of having a stroke, recent research from Denmark suggests. The results suggest that traffic noise is more strongly associated with ischaemic stroke, whereas only air pollution appears to be linked with more serious, fatal strokes.

Setting cycle and footpaths further back from the road can significantly lower the amount of air pollution that cyclists and pedestrians inhale, suggests new research. While wide gaps are not always practical, the study shows that even small increases in distance could substantially reduce the dose of pollution.

Long-term exposure to traffic-related air particle pollution is linked with type 2 diabetes, a new study in Germany has found. Furthermore, the study found that people living close to busy roads were at greater risk of developing the disease than those living further away.

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CULPEPER — The bridge on Route 250 (Ivy Road) over Little Ivy Creek near Ivy west of Charlottesville is open to traffic, one day ahead of its scheduled reopening. Crews are now working to remove signs and other detour indicators along Route 250 and Interstate 64.

CULPEPER —  A new traffic pattern will take effect next week as construction begins on the westbound Route 211/522 (Lee Highway) bridge over the...

CULPEPER — The Virginia Department of Transportation has begun rehabilitating the Route 707 (Blair Park Road) bridge over Lickinghole Creek in...

CULPEPER — The Virginia Department of Transportation will close the Route 674 (Clark Road) bridge over a branch of the Moormans River in Albemarle...

FREDERICKSBURG, Va. – The Virginia Department of Transportation (VDOT) will open the new overpass on Mudd Tavern Road tomorrow , Oct. 23  in...

FREDERICKSBURG, Va. ⸺  Long-term repair work is underway to rebuild state-maintained roads that sustained severe damage during Tropical Storm...

FREDERICKSBURG, Va. ˗˗  CSX will close Lansdowne Road in Fredericksburg to through traffic on Monday, Nov. 12 through early  Saturday, Nov. 17  to...

NOV. 12, 2018 UPDATE: All lanes of Route 3 over the Rappahannock River between Lancaster and Middlesex counties will remain open this evening, Nov....

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...

BRISTOL – In an effort to keep motorists informed, the Virginia Department of Transportation (VDOT) provides weekly information about highway...