FA Cup teams are eagerly awaiting to find out who they will face in the Fifth Round, and Express Sport has simulated the FA Cup draw ahead of the clashes. Manchester United will host Manchester City, while Liverpool are dealt a kind draw. Chelsea take on Arsenal at the Emirates Stadium, and Newcastle face Portsmouth.

INFINITY pools can offer a dreamy escape from the current situation with seamless views over dazzling skylines, land and sea.

Government officials are concerned about the prospect of title celebrations if the Premier League and Championship seasons are resumed.

Manchester United have made Jude Bellingham one of their top transfer targets, although the Red Devils face competition from Liverpool and Manchester City to sign the Birmingham City star.

Jude Bellingham is set to make a big decision at the end of the season when he will most likely leave Birmingham on a permanent transfer.

The summer transfer window is nearly upon us as Manchester United, Chelsea, Liverpool, Arsenal and the rest of the Premier League look to strengthen for whenever the new season starts. Express Sport brings you the latest updates throughout the day.

Christian Pulisic has sent a message to Liverpool manager Jurgen Klopp regarding his time at Borussia Dortmund.

Timo Werner looks set to leave RB Leipzig at the end of the season and he already has his heart set on Liverpool.

FA Cup ball numbers for the fourth round draw have been confirmed as Manchester United and Liverpool sweat on their spot after being held to draws.

Liverpool are well on their way to a first-ever Premier League title, but the Reds are far from the most successful team since the formation of the new English top flight.

The January transfer window is just around the corner, so which players are most likely to move?

Liverpool and Newcastle are leading the way for Kalidou Koulibaly.

The summer transfer window is nearly upon us as Manchester United, Chelsea, Liverpool, Arsenal and the rest of the Premier League look to strengthen for whenever the new season starts. Express Sport brings you the latest updates throughout the day.

Manchester United hero Wayne Rooney has been named as the most influential Premier League player of all time, but who else makes the top 20?

Christian Pulisic has sent a message to Liverpool manager Jurgen Klopp regarding his time at Borussia Dortmund.

Manchester United are hoping to sign Jadon Sancho this summer as part of a revamp under Ole Gunnar Solskjaer, Newcastle are keen on landing Philippe Coutinho and Liverpool may be able to sign Timo Werner on the cheap.

Manchester United have been warned about their transfer activity.

Brownsburg, Broad Ripple Haverford fighting for spots in Great Lakes Regional.

BBC Sport looks back to the 2012 FA Cup final when goals by Ramires and Didier Drogba gave Chelsea victory over Liverpool.

Sidewalk splash pools have long been a summertime staple, particularly for families with young kids. But the virus pandemic has boosted their appeal.

Pool parties are frowned on, as health officials offer guidelines for the use of apartment and HOA pools and spas.

Andy Carroll opens the scoring and Craig Bellamy is also on the scoresheet as Liverpool pick up a comfortable 3-0 win at Wolves.

Expectations were high for Jacksonville heading into the season. The game charters at Pro Football Focus ranked them as the league’s top secondary, the second-best pass rush and the seventh-best run-stopping unit in 2018.

The Patriots put their stamp back on the AFC East after throttling the Miami Dolphins 38-7 on Sunday. The Colts are next.

Houston’s defensive front, featuring one-man wrecking crew J.J. Watt, has the sixth-highest adjusted sack rate.

Colts have the the fifth-best run-stopping unit per PFF and the fourth-highest stuff rate per Football Outsiders.

Pittsburgh is stuffing 25 percent of rushers in 2018, eighth-most in the NFL.

Against No. 1 receiver types like Mike Evans, the Panthers rank fourth-best per Football Outsiders' Defense-adjusted Value Over Average.

Kansas City's opponent, Arizona, is scoring slightly more than a point per possession, making it the NFL's second-worst offense.

The Chargers are scoring 2.4 points per drive, the sixth-most this season, and are only forced to go three-and-out once out of every four drives.

This week’s opponent, the Arizona Cardinals, gives Aaron Rodgers and the Packers a great chance to break their losing skid.

Thursday night matchups are historically difficult on road teams like Jacksonville. Since 2016, the road team is 17-33 in these games, and that includes a 3-12 record in 2018.

Atlanta is on a five-game losing streak but their offense is scoring 2.3 points per drive in 2018, the fifth-highest rate in the NFL. That should be more than enough against Arizona's awful offense.

Arsene Wenger says Liverpool will be regarded as 2019/20 Premier League winners even if the season is abandoned because of the coronavirus.

Liverpool, England

Rationale: Neuroinflammation has been implicated in Amyotrophic Lateral Sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, some challenges have to be overcome. We aimed to investigate whether multicenter data pooling of different TSPO tracers (¹¹C-PBR28 and ¹⁸F-DPA714) is feasible, after validation of an established ¹¹C-PBR28 PET pseudoreference analysis technique for ¹⁸F-DPA714. Methods: 7 ALS-Belgium (58.9±6.7 years,5M) and 8 HV-Belgium (52.1±15.2 years,3M); and 7 ALS-US (53.4±9.8 years,5M) and 7 HV-US (54.6±9.6 years,4M) from a previously published study (1) underwent dynamic ¹⁸F-DPA714 (Leuven, Belgium) or ¹¹C-PBR28 (Boston, US) PET-MR scans. For ¹⁸F-DPA714, volume of distribution (VT) maps were compared to standardized uptake value ratios (SUVR)40-60 calculated using the pseudoreference regions (1)cerebellum, (2)occipital cortex, and (3)whole brain without ventricles (WB-ventricles). Also for ¹¹C-PBR28, SUVR60-90 using WB-ventricles were calculated. Results: In line with previous studies, increased ¹⁸F-DPA714 uptake (17.0±5.6%) in primary motor cortices was observed in ALS, as measured by both VT and SUVR40-60 approaches. Highest sensitivity was found for SUVRWB-ventricles (average cluster 21.6±0.1%). ¹⁸F-DPA714 VT ratio and SUVR40-60 results were highly correlated (r>0.8, p<0.001). A similar pattern of increased uptake (average cluster 20.5±0.5%) in primary motor cortices was observed in ALS with ¹¹C-PBR28 using the SUVRWB-ventricles. Analysis of the ¹⁸F-DPA714 and ¹¹C-PBR28 data together, resulted in a more extensive pattern of significant increased glial activation in the bilateral primary motor cortices. Conclusion: The same pseudoreference region analysis technique for ¹¹C-PBR28 PET imaging can be extended towards ¹⁸F-DPA714 PET. Therefore, in ALS, standardized analysis across these two tracers enables pooling of TSPO PET data across multiple centers and increase power of TSPO as biomarker for future therapeutic trials.

Lee Call
Apr 29, 2020; 0:jlr.RA120000652v1-jlr.RA120000652
Research Articles

Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature, parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL); a multi component lipid emulsion, SMOFlipid (SMOF); a novel emulsion with a modified fatty-acid composition (EXP); or a control enteral diet (ENT) for 22 days. We assayed serum cholestasis markers; measured total bile acid levels in plasma, liver, and gut contents; and analyzed colonic bacterial 16S rRNA gene sequences and metabolomic profiles. Serum cholestasis markers (i.e. bilirubin, bile acids, and g-glutamyl transferase) were highest in IL-fed pigs and normalized in those given SMOF, EXP, or ENT. Gut bile acid pools were lowest in the IL treatment and were increased in the SMOF and EXP treatments and comparable to ENT. Multiple bile acids, especially their conjugated forms, were higher in the colon contents of SMOF and EXP than in IL pigs. Colonic microbial communities of SMOF and EXP pigs had lower relative abundance of several Gram-positive anaerobes, including Clostridrium XIVa, and higher abundance of Enterobacteriaceae than those of IL and ENT pigs. Differences in lipid and microbial-derived compounds were also observed in colon metabolite profiles. These results indicate that multi-component lipid emulsions prevent cholestasis and restore enterohepatic bile flow in association with gut microbial and metabolomic changes. We conclude that sustained bile flow induced by multi-component lipid emulsions likely exerts a dominant effect in reducing bile acid–sensitive, Gram-positive bacteria.

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestatic and metabolic diseases. However, dissimilarities in BA metabolism between humans and mice complicate translation of preclinical data. Cytochrome P450 family 2 subfamily c polypeptide 70 (CYP2C70) was recently proposed to catalyze the formation of rodent-specific muricholic acids (MCAs). With CRISPR/Cas9-mediated somatic genome editing, we generated an acute hepatic Cyp2c70 knockout mouse model (Cyp2c70^ako) to clarify the role of CYP2C70 in BA metabolism in vivo and evaluate whether its activity modulates effects of pharmacologic FXR activation on cholesterol homeostasis. In Cyp2c70^ako mice, chenodeoxycholic acid (CDCA) increased at the expense of βMCA, resulting in a more hydrophobic human-like BA pool. Tracer studies demonstrated that, in vivo, CYP2C70 catalyzes the formation of βMCA primarily by sequential 6β-hydroxylation and C7-epimerization of CDCA, generating αMCA as an intermediate metabolite. Physiologically, the humanized BA composition in Cyp2c70^ako mice blunted the stimulation of fecal cholesterol disposal in response to FXR activation compared with WT mice, predominantly due to reduced stimulation of transintestinal cholesterol excretion. Thus, deletion of hepatic Cyp2c70 in adult mice translates into a human-like BA pool composition and impacts the response to pharmacologic FXR activation. This Cyp2c70^ako mouse model may be a useful tool for future studies of BA signaling and metabolism that informs human disease development and treatment.

Western Bureau: A number of swimming officials in western Jamaica say that the region’s struggles with underdevelopment will continue even if the COVID-19 pandemic is brought under control. They say this is because they still lack proper pools to...

As the U.S. health-care system sags under the strain of the COVID-19 pandemic, health-care workers are not only on the frontlines fighting the virus, they are also some of the most at-risk individuals, making it more essential than ever to have sufficient numbers of qualified health professionals. While 1.5 million immigrants and refugees are already working in the U.S. health-care system, an additional 263,000 immigrants and refugees in the U.S. with health-related college degrees are working in low-skilled jobs or are out of work.

London (Charlotte Street, Rathbone Place) : Published as the Act directs ... by Wm. Woollett, engraver to His Majesty, 4 June, 1778.

London : [Published not identified], 1872.

Winnipeg Blue Bombers GM Kyle Walters isn't spending much time evaluating Oklahoma defensive lineman Neville Gallimore and Notre Dame receiver Chase Claypool, as neither are expected to set foot in the CFL for some time, if ever.

The Pittsburgh Steelers selected Canadian receiver Chase Claypool in the second round of the NFL draft Friday night. Claypool was the 17th player taken in the round, 49th overall.

Booster seat use improves seat belt fit and reduces risk of injury for children <57 in tall. Booster seat use decreases between ages 4 and 8 years. Children observed riding with other children frequently do not use booster seats.

In this national survey of parents, we found that a majority of parents of 4- to 8-year-old children carpool, and when they carpool booster seat use is inconsistent. Social norms and self-efficacy appear to influence booster seat use when carpooling. (Read the full article)

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

An early Saúl Ñíguez goal in Madrid means holders Liverpool once again face a second-leg deficit against Spanish visitors.

Ten student teams will be funded to use AI for Good to build and submit a minimum viable product in the Nittany AI Challenge for a chance to compete for a portion of a $25,000 prize pool. Students were invited to submit their ideas to improve the world by providing solutions for problems within the areas of education, health, humanitarian challenges, sustainability and climate change.

Istanbul is the venue for the first all-English UEFA Super Cup as European champions Liverpool take on Chelsea.