metric Suction duct with adjustable diametric fit By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A suction duct for a compressor such as a scroll compressor may include a plastic ring body with a metal screen heat staked in a window of the ring body to filter refrigerant gas entering the motor cavity. The ring body may be in surrounding relation of the motor and resiliently compressed in the housing through intermittent contact with the inner housing surface to better seal around the inlet port. Oil drain channels and stabilizing ribs may be along the outside surface of the ring body. Full Article
metric Centrifugal blower with asymmetric blade spacing By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A centrifugal blower in a cooling system of an electronic device having asymmetrical blade spacing with acceptable balance. The asymmetrical blade spacing is determined according to a set of desired acoustic artifacts that are favorable and balance that is similar to that found with equal fan blade spacing. In one embodiment, the fan impeller can include thirty one fan blades. The perceived sound quality from the fan is improved with essentially no effect on the thermal performance of the fan. Full Article
metric Fiber with asymmetrical core and method for manufacturing same By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT An optical active fiber is configured with an asymmetrically-shaped core having at least one long axis and a shortest axis which extends transversely to the long axis. The outmost cladding of the active fiber is configured with a marking indicating the orientation of the short axis. The marking allows for bending the fiber so that the shortest axis extends along and lies in the plane of the bend thereby minimizing distortion of a mode which is guided by the asymmetrically-shaped core as light propagates along the bend. Full Article
metric Electronic transaction verification system with biometric authentication By www.freepatentsonline.com Published On :: Tue, 22 Sep 2015 08:00:00 EDT An electronic transaction verification system for use with transaction tokens such as checks, credit cards, debit cards, and smart cards that gathers and transmits information about the transaction token and biometric data. Customers can be enrolled in the system by receiving customer information that includes at least a biometric datum, associating the received customer information with a transaction instrument issued to the customers and storing the received customer information and the issued transaction instrument information in a database for future reference. Full Article
metric Turbomachine blade or vane having complementary asymmetrical geometry By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A turbomachine blade or vane is made of composite material including fiber reinforcement obtained by three-dimensional weaving of yarns and densified by a matrix. The blade or vane includes a first portion constituting at least an airfoil exhibiting two faces each connecting a leading edge to a trailing edge, the first portion forming a single part with at least one second portion present only on one of the faces of the airfoil, the second portion constituting a portion of at least one of the following elements: a flowpath delimiting outer portion of an inner platform, an inner portion of an inner platform, a flowpath delimiting inner portion of an outer platform, and an outer portion of an outer platform, the portions of the fiber reinforcement corresponding to the first and the second portions of the blade being at least partially mutually imbricated, with yarns of the first portion of the fiber reinforcement penetrating into the second portion of the fiber reinforcement. Full Article
metric Non-axisymmetric airfoil platform shaping By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Turbine blade assemblies of a turbine include airfoils that are mounted on bases. The leading and/or trailing edges of the bases are provided with curved portions. Likewise, curved portions may be provided on leading and/or trailing edges of the angle wings of a turbine blade assembly. Also, curved portions may be provided on the leading and/or trailing edges of nozzle assemblies of a turbine. Full Article
metric Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy By www.freepatentsonline.com Published On :: Tue, 24 Nov 2015 08:00:00 EST A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan. Full Article
metric Variable frequency ratiometric multiphase pulse width modulation generation By www.freepatentsonline.com Published On :: Tue, 04 Nov 2014 08:00:00 EST Groups of phase shifted Pulse Width Modulation signals are generated that maintain their duty-cycle and phase relationships as a function of the period of the PWM signal frequency. The multiphase PWM signals are generated in a ratio-metric fashion so as to greatly simplify and reduce the computational workload for a processor used in a PWM system. The groups of phase shifted PWM signals may also be synchronized with and automatically scaled to match external synchronization signals. Full Article
metric Device for regulating deformations of the bed of a geometrically aerodynamic mold and molding method with this device By www.freepatentsonline.com Published On :: Tue, 24 Feb 2015 08:00:00 EST The invention describes a regulating device that adapts to the aerodynamic profile of a mold bed made of composite material offsetting the geometrical deviations occurring in the mold bed. The device comprises some stiffening ribs (20) supported on a surface of the bed (10) of the mold and is equipped with actuators (21) that modify the curvature of the bed (10) of the mold. Full Article
metric Volumetric light emitting device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A volumetric light emitting device includes a substrate, a semiconductor light emitting diode disposed on the substrate and a reflector ring extending axially from the substrate. The reflector ring defines a first volume bounded by the substrate, an inner wall of the reflector ring, and a terminal plane at a distal end of the reflector ring. An encapsulant fills the first volume and encapsulates the semiconductor light emitting diode. A volumetric light conversion element surrounds the reflector ring and the first volume wherein the volumetric light conversion element is adapted to down-convert light emitted from the semiconductor light emitting diode at a first wavelength and emit the down-converted light at a second wavelength. A second volume of encapsulant or scattering material extends axially between the terminal plane and the volumetric light conversion element. Full Article
metric Bezel assembly comprising biometric authentication for use with an automated transaction device By www.freepatentsonline.com Published On :: Tue, 24 Feb 2015 08:00:00 EST The bezel assembly for data reception, for use with a bill validator in a financial transactional device, includes a bezel housing and a data reception assembly. The bezel housing includes a customer-facing front portion and a back plate connectable to the bill validator that is mounted within the transactional device cabinet. The front portion includes an insertion/dispensing slot for receiving currency and a projecting protrusion forward of the casing. The forward-extending protrusion accommodates at least a portion of the data reception assembly. The bezel assembly can include a wireless communication function that is communicably connectable with a mobile device via a wireless communication method, a manual entry function, a biometric reader, one or more cameras for scanning and decrypting 2D barcodes and the like, thus enhancing the overall functionality of the financial transactional device. Full Article
metric Tire comprising a tread with asymmetric groove profiles By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A pneumatic tire comprises an annular tread portion including a plurality of circumferentially extending main grooves comprising an innermost groove, an outermost groove, and at least one middle groove arranged between the innermost groove and the outermost groove. The outermost groove comprises an inner sidewall, an outer sidewall, a groove bottom, and a groove opening opposite to the groove bottom, wherein the outermost groove has an asymmetric cross section with respect to any straight line perpendicular to the groove opening, and wherein the outer sidewall of the outermost groove is tilted by more than 20° with respect to a straight line perpendicular to the groove opening. Full Article
metric SYSTEMS AND METHODS FOR ASYMMETRICAL FORMATTING OF WORD SPACES ACCORDING TO THE UNCERTAINTY BETWEEN WORDS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Asymmetrical formatting of word spaces according to the uncertainty between words includes an initial filtering process and subsequent text formatting process. An equivocation filter generates a mapping of keys and values (output) from a corpus or word sequence frequency data (input). Text formatting process for asymmetrically adjusts the width of spaces adjacent to keys using the values. The filtering process, which generates a mapping of keys and values can be performed once to analyze a corpus and once generated, the key-value mapping can be used multiple times by a subsequent text processing process. Full Article
metric Barometric relief air zone damper By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A control system for an HVAC system serving at least two zones, each zone receiving conditioned air by way of a zone duct, each zone duct including a zone damper having a first portion responsive to the static pressure in a HVAC system to open and bleed an amount of conditioned air past the damper when the static pressure of the system increases above a selected level, a second portion controlled by a actuator to move between an open and a closed position in response to a zone thermostat, and a coupling mechanism coupling the first and second portions to limit the relative movements of the two portions with respect to each other, and a biasing mechanism exerting a torque against the system static pressure differential. The first portion can be a single one-piece undivided blade pivotally mounted with a shell surrounding the zone damper. Full Article
metric Interchangeable cases for biometric monitoring devices By www.freepatentsonline.com Published On :: Tue, 15 Jul 2014 08:00:00 EDT A biometric monitoring device and multiple carrying cases for same are provided. In some implementations, the case may be made from a flexible viscoelastic material and the biometric monitoring device may be slipped into a receptacle in the case through an opening in the case; the opening may become distended during the insertion of the biometric monitoring device. In some implementations, the case may feature a display window that, in combination with materials of the biometric monitoring device, may mask a display of the biometric monitoring device from view when the display is off and may allow the display to be seen when the display is displaying content. Full Article
metric SYSTEM AND METHOD TO VERIFY INSTALLATION OF ASYMMETRIC PISTON By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT In one embodiment, a method may include retrieving, via a processor, a fundamental frequency of a cylinder type from a memory communicatively coupled to the processor, receiving, via the processor, a first signal from a first knock sensor disposed on a cylinder. The cylinder is disposed in an engine. The method may also include deriving whether a number of amplitudes of the first signal at the fundamental frequency and one or more harmonic frequencies exceed an undesired installation threshold value, and identifying an asymmetric piston as having an undesired installation if the undesired installation threshold value exceeds the number of amplitudes of the first signal and the one or more harmonic frequencies. Full Article
metric ASYMMETRIC COMMUNICATION By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The invention is in relation to a method initiating a device discovery process communications between user terminals capable of communicating on device-to-device and cellular communications links in the cellular communications network; determining a first parameter indicating interference of transmissions from a first user terminal on a device-to-device communications link to a second user terminal; determining a second parameter indicating interference of transmissions from the first user terminal on a cellular communications link; applying, on the basis of the first parameter exceeding the second parameter, asymmetric communications between the user terminals such that transmissions from the first user terminal to the second user terminal are communicated over the cellular communications links via infrastructure of the cellular communications network and transmissions from the second user terminal to the first user terminal are communicated over the device-to-device communications link. Full Article
metric Apparatus including an asymmetrical wedge-like member for controlling deflection in small diameter rolls of an open width stabilizer so as to create a straight line nip with uniform pressure across the nip By www.freepatentsonline.com Published On :: Tue, 31 Jan 2012 08:00:00 EST An improved apparatus for correcting deflection in small diameter feed and retard rolls of an open width stabilizer so as to create a straight line nip with uniform pressure across the nip. The improved apparatus provides apparatus for adjusting deflection of the rolls to thereby maintain a desired size to a passageway between them so as to optimize compaction of a fabric web material. A wedge-like member is disposed between, and in moving relationship to, feed and retard roller bearings. The wedge-like member is asymmetrical, has feed and retard sides that engage the feed and retard roller bearings, respectively, and exerts reaction forces against each of the respective bearings. Improvement resides in the reaction forces causing the rolls the rolls to not deflect downwardly. Full Article
metric ASYMMETRICAL UNIPOLAR FLAME IONIZER USING A STEP-UP TRANSFORMER By www.freepatentsonline.com Published On :: Thu, 25 May 2017 08:00:00 EDT A system and method for electrically charging a combustion flame with a power supply. Full Article
metric AXIALLY AND CENTRALLY SYMMETRIC CURRENT SOURCE ARRAY By www.freepatentsonline.com Published On :: Thu, 08 Jun 2017 08:00:00 EDT A current source device having a current source array includes a plurality of current source units, a plurality of least significant bits, and a plurality of most significant bits. The current source units are arranged along a plurality rows and columns of a current source array. Each of the least significant bits includes a first amount of current source units is placed at the geometric center of the current source array. Each of the most significant bits includes a second amount of current source units. The second amount is the first amount multiplied by a positive integer. The two adjacent bits in the most significant bits are centrally symmetrical to the geometric center. Full Article
metric Asymmetric body armor By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT Body armor includes a panel having a front, an opposed back, left and right sides, top and bottom, and a vertical axis extending through the panel at a location intermediate between the right and left sides. Opposed right and left shoulder cuts are formed in the panel between the right side and the top and between the left side and the top, and the right and left shoulder cuts are asymmetric to each other about the vertical axis. The right and left shoulder cuts are linear edges formed diagonally between the left and right sides and the top, and the right shoulder cut extends further inboard into the panel toward the vertical axis than the left shoulder cut. Full Article
metric LIGHT-ADDRESSABLE POTENTIOMETRIC SENSING UNITS By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT Light-addressable potentiometric sensing units are provided. A light-addressable potentiometric sensing unit comprises a conductive substrate, a metal oxide semiconductor layer, and a sensing layer. The metal oxide semiconductor layer is made of indium gallium zinc oxide, indium gallium oxide, indium zinc oxide, indium oxide co-doped with tin and zinc, tin oxide, or zinc oxide. The wide-band gap characteristic of the metal oxide semiconductor layer enables the light-addressable potentiometric sensing unit to resist the interference from visible light. The light-addressable potentiometric sensing unit therefore exhibits a more stable performance. Full Article
metric Volumetric Flow Regulation in Multi-Dimensional Liquid Analysis Systems By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled. Full Article
metric MULTI-PARAMETRIC ENVIRONMENTAL DIAGNOSTICS AND MONITORING SENSOR NODE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The multi-parametric environmental diagnostics and monitoring sensor node (10) provides monitoring and diagnostics of a variety of different ambient environmental factors and is powered by multiple sources of renewable energy. The multi-parametric environmental diagnostics and monitoring sensor node (10) includes a base (38) and a plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) mounted thereon. A controller (47) is also mounted on the base (38), the plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) being in communication therewith. An external photovoltaic cell (18) is mounted to the base and an internal photovoltaic cell (34) is mounted in an opposed orientation on a cover (32). The external photovoltaic cell (18) and the internal photovoltaic cell (34) charge a power storage module (52), which powers the plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) and the controller (47). Full Article
metric SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end. Full Article
metric Enhancing Flow Cytometry Discrimination with Geometric Transformation By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations. Full Article
metric MULTI-COLOR FLOW CYTOMETRIC ANALYSIS OF SAMPLES WITH LOW CELL NUMBERS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Aspects of the present disclosure include methods for processing a biological sample. Methods according to certain embodiments include contacting a biological sample having cells with an assay reagent that includes one or more analyte-specific binding members to produce a biological sample assay composition and introducing the biological assay composition into an inlet of a flow cytometer having an integrated acoustic separator. Systems, including a flow cytometer with integrated acoustic separator having one or more acoustic concentrator devices suitable for practicing the subject methods are also described. Full Article
metric DUAL VOLUTE TURBOCHARGER TO OPTIMIZE PULSE ENERGY SEPARATION FOR FUEL ECONOMY AND EGR UTILIZATION VIA ASYMMETRIC DUAL VOLUTES By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A product for use in a turbocharger system. A turbine housing may define a center core that is circular in shape with a circumference. The turbine housing may define a first volute that extends for a length around only a part of the circumference of the center core, and a second volute that may be positioned radially outside the first volute and that may extend entirely around the circumference of the center core. The first volute and the second volute may define first and second exhaust gas passages through the turbine housing that may be asymmetric. All points of the second volute may be radially outside the first volute from the center core over the entire length of the first volute. Full Article
metric SYSTEM AND METHOD FOR OXIDANT COMPRESSION IN A STOICHIOMETRIC EXHAUST GAS RECIRCULATION GAS TURBINE SYSTEM By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A system includes a gas turbine system having a turbine combustor, a turbine driven by combustion products from the turbine combustor, and an exhaust gas compressor driven by the turbine. The exhaust gas compressor is configured to compress and supply an exhaust gas to the turbine combustor. The gas turbine system also has an exhaust gas recirculation (EGR) system. The EGR system is configured to recirculate the exhaust gas along an exhaust recirculation path from the turbine to the exhaust gas compressor. The system further includes a main oxidant compression system having one or more oxidant compressors. The one or more oxidant compressors are separate from the exhaust gas compressor, and the one or more oxidant compressors are configured to supply all compressed oxidant utilized by the turbine combustor in generating the combustion products. Full Article
metric This Song: Metric By kutx.org Published On :: Mon, 02 Mar 2020 18:05:25 +0000 Emily Haines and Jimmy Shaw from Metric talk about hearing "Teardrop" by Massive Attack early in their musical partnership and how it inspired them, terrified them and helped them find a collaborative way of making music that still works for them today. Full Article This Song creativity inspiration Massive Attack Metric music music podcast podcast
metric Geometrical hexafoil are thought to serve as a sign of protection. By www.abc.net.au Published On :: Wed, 17 Jul 2019 06:30:00 +1000 Geometrical hexafoil are thought to serve as a sign of protection. Full Article ABC South West Victoria southwestvic Community and Society:All:All Community and Society:Religion and Beliefs:All Community and Society:Religion and Beliefs:Ancient Religions Community and Society:Religion and Beliefs:Women Religious Australia:VIC:Terang 3264
metric Moldex-Metric, Inc. v. McKeon Products, Inc. By feeds.findlaw.com Published On :: 2018-06-05T08:00:00+00:00 (United States Ninth Circuit) - Reversing the district court's summary judgment in favor of the defendant in a suit for trademark infringement relating to foam earplugs in a specific bright green color used by the plaintiffs in their earplugs because the district court's conclusion that the green color mark was functional and therefore not protectable as trade dress was in error. The existence or nonexistence of alternative designs is probative of functionality or nonfunctionality and a genuine issue of fact regarding whether the color was functional remained. Full Article Trademark Intellectual Property Trade Dress
metric Moldex-Metric, Inc. v. McKeon Products, Inc. By feeds.findlaw.com Published On :: 2018-06-05T08:00:00+00:00 (United States Ninth Circuit) - Reversing the district court's summary judgment in favor of the defendant in a suit for trademark infringement relating to foam earplugs in a specific bright green color used by the plaintiffs in their earplugs because the district court's conclusion that the green color mark was functional and therefore not protectable as trade dress was in error. The existence or nonexistence of alternative designs is probative of functionality or nonfunctionality and a genuine issue of fact regarding whether the color was functional remained. Full Article Trademark Intellectual Property Trade Dress
metric Construction of a metric on the antitangent bundle By feedproxy.google.com Published On :: Tue, 28 Jan 2020 09:40:19 +0000 In a short preprint The super-Sasaki metric on the antitangent bundle, I explicitly show how to lift a Riemannian metric and an almost symplectic two-form on a manifold $latex M$ to a Riemannian metric on the antitangent bundle $latex Pi T M$, which is, of course, a supermanifold. This example was first given in Modular... Full Article SFN Blogs Post Doc Luxembourg Research work
metric Update on “The super-Sasaki metric on the antitangent bundle” By feedproxy.google.com Published On :: Wed, 05 Feb 2020 08:29:08 +0000 The short preprint The super-Sasaki metric on the antitangent bundle, has now been extensivly rewriten and improved. I wrote about the first draft here. One of the major improvments is that I now clearly link the construction to almost Hermitian manifolds, although the almost complex structure plays no direct role in the lifting the metric... Full Article SFN Blogs Post Doc Luxembourg Research work
metric Researchers Uncover Novel Way to De-anonymize Device IDs to Users' Biometrics By feedproxy.google.com Published On :: Tue, 28 Apr 2020 05:03:47 PDT Researchers have uncovered a potential means to profile and track online users using a novel approach that combines device identifiers with their biometric information. The details come from a newly published research titled "Nowhere to Hide: Cross-modal Identity Leakage between Biometrics and Devices" by a group of academics from the University of Liverpool, New York University, The Chinese Full Article
metric Metrics? USC looks to solidify a trip to the NCAA tournament with victories By www.latimes.com Published On :: Wed, 11 Mar 2020 19:34:59 -0400 An extended run through the Pac-12 tournament would certainly help ease the tension for both USC and UCLA. But a loss Thursday could put their fate in the hands of the numbers. Full Article
metric The NCAA’s lousy new metric is going to make March Madness even crazier By www.washingtonpost.com Published On :: Tue, 18 Dec 2018 12:45:56 +0000 The NCAA tournament could be more entertaining than usual, if only because seedings may be less accurate than in past years. Full Article
metric Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins By feedproxy.google.com Published On :: 2006-04-01 Leigh AndersonApr 1, 2006; 5:573-588Research Full Article
metric A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent By feedproxy.google.com Published On :: 1989-04-01 M el-SaadaniApr 1, 1989; 30:627-630Articles Full Article
metric The finiteness of the spectrum of boundary value problems defined on a geometric graph By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT V. A. Sadovnichii, Ya. T. Sultanaev and A. M. Akhtyamov Trans. Moscow Math. Soc. 80 (2020), 123-131. Abstract, references and article information Full Article
metric Axially symmetric solutions of the Allen-Cahn equation with finite Morse index By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Changfeng Gui, Kelei Wang and Jucheng Wei Trans. Amer. Math. Soc. 373 (2020), 3649-3668. Abstract, references and article information Full Article
metric The Kähler–Ricci flow around complete bounded curvature Kähler metrics By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Albert Chau and Man-Chun Lee Trans. Amer. Math. Soc. 373 (2020), 3627-3647. Abstract, references and article information Full Article
metric Metric Spaces, Convexity and Nonpositive Curvature: Second Edition By www.ams.org Published On :: Athanase Papadopoulos, Universite de Strasbourg - A publication of the European Mathematical Society, 2013, 320 pp., Softcover, ISBN-13: 978-3-03719-132-3, List: US$58, All AMS Members: US$46.40, EMSILMTP/6.R This book is about metric spaces of nonpositive curvature in the sense of Busemann, that is, metric spaces whose distance function satisfies a... Full Article
metric Geometric designs in the snow by Simon Beck By www.ams.org Published On :: Tue, 21 Jan 2020 00:00:00 EST "Artist uses snow as canvas for massive geometrical designs," by Thomas Peipert, AP, January 16, 2020. Full Article
metric Hausdorff Dimension, Lagrange and Markov Dynamical Spectra for Geometric Lorenz Attractors By www.ams.org Published On :: Fri, 13 Mar 2020 16:19 EDT Carlos Gustavo T. Moreira, Maria José Pacifico and Sergio Romaña Ibarra Bull. Amer. Math. Soc. 57 (2018), 269-292. Abstract, references and article information Full Article
metric Inflammation-based index and 68Ga-DOTATOC PET-derived uptake and volumetric parameters predict outcome in neuroendocrine tumor patients treated with 90Y-DOTATOC By jnm.snmjournals.org Published On :: 2019-12-05T10:37:41-08:00 We performed post-hoc analyses on the utility of pre-therapeutic and early interim 68Ga-DOTA-Tyr3-octreotide (68Ga-DOTATOC) positron emission tomography (PET) tumor uptake and volumetric parameters and a recently proposed biomarker, the inflammation-based index (IBI), for peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumor (NET) patients treated with 90Y-DOTATOC in the setting of a prospective phase II trial. Methods: Forty-three NET patients received up to four cycles of 1.85 GBq/m²/cycle 90Y-DOTATOC with a maximal kidney biologic effective dose of 37 Gy. All patients underwent a 68Ga-DOTATOC PET/computed tomography (CT) at baseline and seven weeks after the first PRRT cycle. 68Ga-DOTATOC-avid tumor lesions were semi-automatically delineated using a customized standardized uptake value (SUV) threshold-based approach. PRRT response was assessed on CT using RECIST 1.1. Results: Median progression-free survival (PFS) and overall survival (OS) were 13.9 and 22.3 months, respectively. An SUVmean higher than 13.7 (75th percentile (P75)) was associated with better survival (hazard ratio (HR) 0.45; P = 0.024), whereas a 68Ga-DOTATOC-avid tumor volume higher than 578 ml (P75) was associated with worse OS (HR 2.18; P = 0.037). Elevated baseline IBI was associated with worse OS (HR 3.90; P = 0.001). Multivariate analysis corroborated independent associations between OS and SUVmean (P = 0.016) and IBI (P = 0.015). No significant correlations with PFS were found. A composite score based on SUVmean and IBI allowed to further stratify patients in three categories with significantly different survival. On early interim PET, a decrease in SUVmean of more than 17% (P75) was associated with worse survival (HR 2.29; P = 0.024). Conclusion: Normal baseline IBI and high 68Ga-DOTATOC tumor uptake predict better outcome in NET patients treated with 90Y-DOTATOC. This can be used for treatment personalization. Interim 68Ga-DOTATOC PET does not provide information for treatment personalization. Full Article
metric A Direct Fluorometric Activity Assay for Lipid Kinases and Phosphatases By feedproxy.google.com Published On :: 2020-04-27 Jiachen SunApr 27, 2020; 0:jlr.D120000794v1-jlr.D120000794Methods Full Article
metric A Direct Fluorometric Activity Assay for Lipid Kinases and Phosphatases [Methods] By feedproxy.google.com Published On :: 2020-04-27T13:30:26-07:00 Lipid kinases and phosphatases play key roles in cell signaling and regulation, and are implicated in many human diseases, and are hence thus attractive targets for drug development. Currently, no direct in vitro activity assay is available for these important enzymes, which hampers mechanistic studies as well as high-throughput screening of small molecule modulators. Here we report a highly sensitive and quantitative assay employing a ratiometric fluorescence sensor that directly and specifically monitors the real-time concentration change of a single lipid species. Due Because of to its modular design, the assay system can be applied to a wide variety of lipid kinases and phosphatases, including Class I phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN). When applied to PI3K, the assay provided the newdetailed mechanistic information about the product inhibition and substrate acyl acyl-chain selectivity of PI3K and allowed enabled rapid evaluation of its small molecule inhibitors. We also used this assay to quantitatively determine the substrate specificity of PTEN, providing new insight into its physiological functionThe assay also quantitatively determined the substrate specificity of PTEN, thereby providing new insight into its physiological function. In summary, we have developed a fluorescence-based real-time assay for PI3K and PTEN that we anticipate could be adapted to measure the activities of other lipid kinases and phosphatases with high sensitivity and accuracy. Full Article
metric Muscle Weakness: A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy By diabetes.diabetesjournals.org Published On :: 2006-03-01 Christer S. AndreassenMar 1, 2006; 55:806-812Complications Full Article