Both treatments rely on infusing patients with antibodies that latch onto the virus and block it from invading cells.

Jen Yamato is joining the Calendar staff as a film reporter beginning Jan. 2. 

Jimmy Nelson blew out his pitching shoulder in a baserunning mishap in 2017. Now the former Brewers starter is attempting a comeback with the Dodgers.

MLB scouts can't evaluate college and high school players during the coronavirus shutdown, casting doubt on whether the June amateur draft can be held.

As a divorce lawyer in 'Marriage Story,' Laura Dern calls out societal bias against mothers. She helped craft the speech with writer-director Noah Baumbach.

Bill Beaumont has vowed to make massive changes to the look of rugby if he is re-elected as chairman of World Rugby.

Rotnei Clarke and his wife packed for her and their three small children in less than three hours.

Amateur Traveler Live Dial-in Show

Amateur Traveler Live Dial-in Show

Hear about travel to India as the Amateur Traveler talks to participants from the Amateur Traveler trip to India in November of 2017. 

Data from March shows similarities in spending across various demographics.

The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer (PCa). However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary glands and kidneys. This study assessed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivary gland radiation exposure using a PSMA targeting radiotracer. Methods: This prospective, double-blind, placebo-controlled study enrolled 10 biochemically recurrent PCa patients. Each subject served as his own control. [¹⁸F]DCFPyl PET/CT imaging sessions were performed 3 – 7 days apart, following oral administration of either 12.7 g of MSG or placebo. Data from the two sets of images were analyzed by placing regions of interest on lacrimal, parotid and submandibular glands, left ventricle, liver, spleen, kidneys, bowel, urinary bladder, gluteus muscle and malignant lesions. The results from MSG and placebo scans were compared by paired analysis of the ROI data. Results: A total of 142 pathological lesions along with normal tissues were analyzed. As hypothesized a priori, there was a significant decrease in maximal standardized uptake values corrected for lean body mass (SULmax) on images obtained following MSG administration in the parotids (24 ± 14%, P = 0.001), submandibular glands (35 ± 11%, P<0.001) and kidneys (23 ± 26%, P = 0.014). Significant decreases were also observed in lacrimal glands (49 ± 13%, P<0.001), liver (15 ± 6%, P<0.001), spleen (28 ± 13%, P = 0.001) and bowel (44 ± 13%, P<0.001). Mildly lower blood pool SULmean was observed after MSG administration (decrease of 11 ± 13%, P = 0.021). However, significantly lower radiotracer uptake in terms of SULmean, SULpeak, and SULmax was observed in malignant lesions on scans performed after MSG administration compared to the placebo studies (SULmax median decrease 33%, range -1 to 75%, P<0.001). No significant adverse events occurred and vital signs were stable following placebo or MSG administration. Conclusion: Orally administered MSG significantly decreased salivary gland, kidney and other normal organ PSMA radiotracer uptake in human subjects, using [¹⁸F]DCFPyL as an exemplar. However, MSG caused a corresponding reduction in tumor uptake, which may limit the benefits of this approach for diagnostic and therapeutic applications.

The brain mechanisms underlying the association of hyperglycemia with depressive symptoms are unknown. We hypothesized that disrupted glutamate metabolism in pregenual anterior cingulate cortex (ACC) in type 1 diabetes (T1D) without depression affects emotional processing. Using proton magnetic resonance spectroscopy (MRS), we measured glutamate concentrations in ACC and occipital cortex (OCC) in 13 T1D without major depression (HbA1c=7.1±0.7% [54±7mmol/mol]) and 11 healthy non-diabetic controls (HbA1c=5.5±0.2% [37±3mmol/mol]) during fasting euglycemia (EU) followed by a 60-minute +5.5mmol/l hyperglycemic clamp (HG). Intrinsic neuronal activity was assessed using resting-state blood oxygen level dependent functional MRI to measure the fractional amplitude of low frequency fluctuations in slow-band 4 (fALFF4). Emotional processing and depressive symptoms were assessed using emotional tasks (Emotional-Stroop, Self-Referent-Encoding-Task SRET) and clinical ratings (HAM-D, SCL-90-R), respectively. During HG, ACC glutamate increased (1.2mmol/kg, +10%, p=0.014) while ACC fALFF4 was unchanged (-0.007, -2%, p=0.449) in T1D; in contrast, glutamate was unchanged (-0.2mmol/kg, -2%, p=0.578) while fALFF4 decreased (-0.05, -13%, p=0.002) in controls. OCC glutamate and fALFF4 were unchanged in both groups. T1D had longer SRET negative-word response-times (p=0.017) and higher depression-rating scores (HAM-D p=0.020; SCL-90-R-depression p=0.008). Higher glutamate change tended to associate with longer Emotional-Stroop response-times in T1D only. Brain glutamate must be tightly controlled during hyperglycemia due to the risk for neurotoxicity with excessive levels. Results suggest that ACC glutamate control mechanisms are disrupted in T1D, which affects glutamatergic neurotransmission related to emotional or cognitive processing. Increased prefrontal glutamate during acute hyperglycemic episodes could explain our previous findings of associations between chronic hyperglycemia, cortical thinning and depressive symptoms in T1D.

The Trump administration’s plan to create a "merit-based" U.S. immigration system, lessening the longstanding focus on family reunification in favor of more economic migrants, has met with a lackluster response from Democrats and Republicans alike. This Policy Beat article explores how the Trump proposal would reshape immigration to the United States, and how it compares to selection systems in other countries and past debates about changing the U.S. system.

Fast-moving bills in two state legislatures could dictate to their education departments what goes into the states' accountability plans under the Every Student Succeeds Act.

Independent MHA Eddie Joyce is suing four people, including the premier, for defamation over the handling of a harassment complaint that saw him turfed from the Liberal cabinet and caucus in 2018.

Berlin’s airports are recording a drastic slump in passenger numbers. In March, a decline in passengers of 64.7 percent was recorded at Tegel and Schönefeld for the whole month. However, the number of passengers has continued to fall significantly over ...

Eoin Hayes's first-half strike earned the Group B points for Irish side Region 2 as Russia's South Region failed to convert their possession into a single shot on goal.

Few students become more engaged in clubs, academics and student life activities than Raquele Amato. A prominent figure on Penn State Schuylkill’s campus, Amato has served as an officer in more than half a dozen student organizations, swept spring awards ceremonies, worked as a resident assistant, and helped her family run their pizza shop in Frackville, Pennsylvania, all while maintaining a full-time course load. Before she closes the book on her time at Penn State Schuylkill, Amato reflected on her time at the campus and considered what’s next.

Mathematics Vision Project has dismissed the lawsuit after the surprising move the company made this summer to take legal action against one of its most vocal parent critics.

Apps like Instagram are largely reaching the first 150-200 million users. We are going after mass market users who consume content in regional languages.

The President of One America News Network, Charles Herring, has published a blistering letter calling on Vanity Fair to retract claims that Donald Trump’s eldest son secretly bought a stake in the news outlet.
Read Full Article at RT.com

In 2015, journalist Sandhya Ravishankar had written articles for the Economic Times on illegal beach sand mining in Tamil Nadu. A case of criminal defamation was filed against the journalist which was quashed by the Madras HC on Wednesday. The HC mad

Shah said migrant workers from West Bengal are also eager to reach home and the central government is also facilitating the train services.

A pair of applications filed by the Klamath River Renewal Corporation today with the Federal Energy Regulatory Commission puts into official motion a long-standing plan to remove four hydroelectric plants on the Klamath River.

Extreme storms Hurricane Florence and Typhoon Mangkhut have caused destruction and taken lives across the globe this week, forcing millions to evacuate their homes

Title: Amateur Boxers at Risk of Brain Injury
Category: Health News
Created: 5/3/2007 12:00:00 AM
Last Editorial Review: 5/3/2007 12:00:00 AM

Scientists are speculating as to how the two creatures managed to become preserved in such an unusual way.

"I think people are seeing that there is a problem. It's whether they are prepared to take that political risk to actually do something about it."

London's air quality has "dramatically improved" due to the drop in traffic amid the coronavirus lockdown, Sadiq Khan has said.

Working from home requires a lot of technical setup, which is ... not a smooth process for some. NPR's Scott Simon and Jessica Hansen play out a scenario many might be familiar with.

Mission is remembered as perhaps Nasa's finest, and most desparate, hour

"It is the collective wisdom of the marketplace that there is action and we will move with speed. That improves the confidence level of industry."

Financial inclusion and financial literacy will be the paramount objective while implementing reforms along with UID project to protect the interests of poor.

Major League Baseball will cut its amateur draft from 40 rounds to five this year, a move that figures to save teams about $30 million US, a person familiar with the decision told The Associated Press.

Victoria Cross recipient’s suit against Nine newspapers can’t be held until in-person hearings resume after coronavirus

The highly anticipated defamation trial brought by Victoria Cross recipient Ben Roberts-Smith against the Age and the Sydney Morning Herald will not go ahead next month after the federal court ruled a remote hearing under Covid-19 rules may breach national security.

The delay in the case came as justice Anthony Besanko said he had to consider whether to delay the trial despite a submission that Roberts-Smith and his family are suffering from the ongoing publication of articles by the Nine newspapers.

The Little Mix singer has reportedly broken up with former Love Island contestant Chris Hughes

MORNING BRIEFING: Police charge a man who allegedly returned a blood alcohol reading of 0.299 during a random breath test last night, and motorsport fans plan to protest against the NSW Government's decision to demolish the Parramatta Speedway.

A $2.9 million payout is being challenged in court today after it was found Nationwide News defamed actor Geoffrey Rush in a high-profile case earlier this year.

The money earmarked for sports will go to national and provincial organizations, Canadian sport institutes and Indigenous sport groups.

The nation's top high school point guard chose the G League over UCLA. He was scorned. European-born players turn pro as early as 13. They are praised.

There will not be any "dramatic overnight change" of the UK's lockdown rules, a cabinet minister has warned.

Kelvin Fletcher has taken a leaf out of Paddy McGuinness's book