Antimicrobial peptides and proteins play critical roles in the host defense against invading pathogens. We recently discovered that recombinantly expressed human and mouse serum amyloid A1 (rhSAA1 and rmSAA1) proteins have potent antifungal activities against the major human fungal pathogen Candida albicans. At high concentrations, rhSAA1 disrupts C. albicans membrane integrity and induces rapid fungal cell death. In the current study, we find that rhSAA1 promotes cell aggregation and targets the C. albicans cell wall adhesin Als3. Inactivation of ALS3 in C. albicans leads to a striking decrease in cell aggregation and cell death upon rhSAA1 treatment, suggesting that Als3 plays a critical role in SAA1 sensing. We further demonstrate that deletion of the transcriptional regulators controlling the expression of ALS3, such as AHR1, BCR1, and EFG1 in C. albicans results in similar effects to that of the als3/als3 mutant upon rhSAA1 treatment. Global gene expression profiling indicates that rhSAA1 has a discernible impact on the expression of cell wall- and metabolism-related genes, suggesting that rhSAA1 treatment could lead to a nutrient starvation effect on C. albicans cells.

Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here we extended this study and included isolates with acquired fluconazole resistance.

Isolates (n=835) were identified using CHROMagar, MALDI-TOF and, when needed, ITS-sequencing. EUCAST E.Def 7.3.1 susceptibility testing included manogepix, amphotericin B, anidulafungin, micafungin, fluconazole and voriconazole. Manogepix wildtype-upper-limit (WT-UL) values were established following EUCAST-principles for ECOFF setting allowing wildtype/non-wildtype classification. Drug-specific MIC correlations were investigated using Pearson's correlation.

Manogepix modal MICs were low (range 0.004-0.06 mg/L against 16/20 included species). Exceptions were C. krusei and C. inconspicua, and to a lesser extent C. kefyr and Pichia kluyveri. The activity was independent of Fks echinocandin hot-spot alterations (n=17). Adopting the WT-UL established for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis, 14/724 (1.9%) isolates were non-wildtype for manogepix. Twelve of these (85.7%) were also non-wildtype for fluconazole. A statistically significant correlation was observed between manogepix and fluconazole MICs for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis (Pearson r=0.401-0.575), but not between manogepix and micafungin or amphotericin B MICs for any species except C. tropicalis (r=0.519 for manogepix versus micafungin).

Broad-spectrum activity was confirmed for manogepix against contemporary yeast. However, a 1-4 two-fold-dilution increase in manogepix MICs is observed in a subset of isolates with acquired fluconazole resistance. Further studies on the potential underlying mechanism and implication for optimal dosing are warranted.

A winner of the European Women's Under-17 Championship with Poland in 2013, Ewa Pajor urges the players taking part in this year's final tournament in Bulgaria to seize the moment.

An unusual program in Cincinnati provides academic coaches to help high school players meet eligibility requirements to stay in the game.

The Czech Republic meet Serbia, France play Croatia, Romania take on Georgia and Hungary are up against Poland in September's UEFA Futsal EURO 2018 play-offs.

Serbia and Hungary secured narrow wins in the first legs of their play-offs while debut-chasing France and Georgia both found themselves pegged back. The second legs are on 26 September.

France beat Croatia to earn a final tournament debut, as they joined Serbia, Romania and Poland in qualifying for UEFA Futsal EURO 2018 via the play-offs.

Ricardinho has been named the first-ever official UEFA Futsal EURO Player of the Tournament after captaining Portugal to the title and finishing seven-goal top scorer.

"It's the same as an iPod except it sounds like God," Young said here at CES.

Yes, there are still portable music players in 2019, and we don't just mean the iPod touch. The question is whether you need one, and if so, which is the best MP3 player to buy?

While we wait for Apple Arcade to launch for iOS devices, Google is preparing its own app/game subscription service for Android called Play Pass.

With the tournament approaching its semi-final stage, the players give an insight into the lessons learned from playing in the heightened circumstances of a U19 EURO.

Lieke Martens has won the UEFA Women's Player of the Year award after her player-of-the-tournament performance at UEFA Women's EURO 2017.

Pernille Harder, Ada Hegerberg and Amandine Henry are shortlisted for the 2017/18 UEFA Women's Player of the Year award.

Pernille Harder of Wolfsburg and Denmark has been voted the 2017/18 UEFA Women's Player of the Year.

Lyon trio Lucy Bronze, Ada Hegerberg and Amandine Henry are the UEFA Women's Player of the Year nominees.

Lyon and England right-back Lucy Bronze is the first defender to win the poll of coaches and journalists.

Don't expect Amazon to use this Print-Color display in a new Kindle any time soon, but we could see Print-Color eReaders in some form by mid-2020.

New European champion Renato Sanches has been chosen above Kingsley Coman and Portugal team-mate Raphael Guerreiro for the SOCAR Young Player of the Tournament award.

France forward Antoine Griezmann has been named as the UEFA EURO 2016 Player of the Tournament by UEFA's technical observers after finishing with six goals and two assists.

UEFA European Championships have a habit of kick-starting careers and UEFA EURO 2016 has been no different – we pick out eight players whose lives may never be the same again.

France forward Antoine Griezmann has received his award as the Player of the Tournament for UEFA EURO 2016 in the run-up to Les Bleus' European Qualifier against Bulgaria.

Fabián Ruiz has been chosen as the SOCAR Player of the Tournament at the 2019 UEFA Under 21 Championship.

Priced this low, it could sell out at any moment, and this deal is only valid until January 19, so order now.

Apple's new $4,999 Pro Display XDR monitor (and its $1,000 stand) may sound mighty expensive on the surface. It has the potential to upend a whole industry, however—it's made to compete with panels five to ten times the price. We have one in-house, and here are our first impressions.

Not exactly an impulse buy but priced well below Wacom pen displays like the Cintiq 16, the Wacom One is a fine product for students, doodlers, and casual artists who'd like to write and sketch digitally.

Apple's Pro Display XDR provides exceptional color accuracy and build quality at a price that's quite competitive with those of reference-grade pro monitors. It's exquisite enough that swallowing the wildly extravagant cost of its Pro Stand is worth it.

040 - Inaugural Best Women’s Player in Europe Award launched

043 - Draws to be held at UEFA headquarters on 9 August

UEFA Best Women’s Player in Europe 2012/13 – Shortlist of top three announced

045 - 2013/14 UEFA Women’s Champions League draws for rounds of 32 and 16 in Nyon

Award presented at Monaco ceremony

049 - Award presented during ceremony at UEFA Headquarters

053 - UEFA Club Financial Control Body investigatory chamber takes measures

Former Real Madrid striker Álvaro Morata has left Chelsea for Atlético.

Four top European players feature in the first episode of UEFA's new weekly vlog series designed to increase the visibility of women's football to teenage girls.

A freestyle world champion stars in an incredible keepy-up video across Europe to launch UEFA's #PlayAnywhere campaign, which also features eight top women's players and 13 unique locations.

UEFA's ground-breaking weekly vlog Press Play has now had over three million views on the Together #WePlayStrong Youtube channel.

UEFA is delighted to announce it will be the official sponsor of Rita Ora's The Girls Tour as part of our Together #WePlayStrong campaign.

Ivana Martinčić, once a player in the Croatian women's top division, speaks about her pride at being selected to referee the 2018 Women's U19 EURO final.

Nilla Fischer, Fran Kirby and Shanice van de Sanden feature in UEFA's new Strong Is... mini-series.

Europe's most famous footballing families are supporting a new TV campaign by UEFA which calls on dads to encourage their daughters to play football.

Lyon trio Lucy Bronze, Ada Hegerberg and Amandine Henry are the UEFA Women's Player of the Year nominees.

Lyon and England right-back Lucy Bronze is the first defender to win the poll of coaches and journalists.

We pick out ten young players to watch in the coming year – and decade.

Tottenham, Chelsea, Hertha Berlin, Dinamo Zagreb, Midtjylland, Dynamo Kyiv,, Montpellier and Lyon are through.

Two-time winners Spain will contest the play-offs for the 2016 FIFA Futsal World Cup along 13 other sides, with ten of the 12 UEFA Futsal EURO 2016 finalists through in total.

Two-time FIFA Futsal World Cup winners Spain will meet Slovenia for a place in the 2016 tournament in Colombia while Serbia are rematched with Portugal in the play-off draw.

Just over a month on from UEFA Futsal EURO 2016, Europe's finest are back in action in the FIFA Futsal World Cup play-offs with Serbia facing Portugal again.

The draw for the FIFA World Cup play-offs has been made: Northern Ireland v Switzerland, Croatia v Greece, Denmark v Republic of Ireland, Sweden v Italy.