ears Hold the Champagne: Pandemic, recession fears hammer traditional European products By www.latimes.com Published On :: Fri, 8 May 2020 14:49:10 -0400 A looming recession due to the coronavirus imperils Champagne, buffalo mozzarella and other European delicacies. They're luxuries, but also livelihoods. Full Article
ears California voters asked to vote by mail in November due to coronavirus fears By www.latimes.com Published On :: Fri, 8 May 2020 15:32:02 -0400 Gov. Gavin Newsom ordered ballots be mailed to the state's 20.6 million voters for the November election while imposing new rules for in-person voting. Full Article
ears 'Every parent's nightmare': A child's death brings new coronavirus fears as more states reopen By www.latimes.com Published On :: Fri, 8 May 2020 16:57:34 -0400 The U.S. death toll in the coronavirus outbreak surpasses 77,000 as states continue to ease restrictions and President Trump pushes for faster reopening. Full Article
ears Hong Kong stock exchange CEO to depart after 10 years at helm By asia.nikkei.com Published On :: Full Article
ears SBI Clerk Cut Off 2020 released: Know Expected Cut off Marks & Previous Years Cutoff for GEN/OBC/SC/ST By www.jagranjosh.com Published On :: 2020-03-23T11:25:00Z SBI Clerk Cut off 2020 is provided here of the Prelims exam held in February and March 2020. The official SBI Clerk Cut-off to release soon along with prelims exam result at sbi.co.in. Know the expected cut off marks of SBI Clerk Prelims 2020 exam for GEN/OBC/SC/ST/PwD category candidates and Previous years official cut off. Full Article
ears Implementation of a statewide, multisite fetal tele-echocardiography program: evaluation of more than 1100 fetuses over 9 years By feeds.nature.com Published On :: 2020-05-07 Full Article
ears 10 years of biosimilars: lessons and trends By feeds.nature.com Published On :: 2020-05-01 Full Article
ears 50, 100 & 150 Years Ago By feeds.nature.com Published On :: 2018-10-16 Innovation and discovery as chronicled in Scientific American Full Article
ears Daily briefing: More than 1 billion people face unbearable temperatures within 50 years By feeds.nature.com Published On :: 2020-05-05 Full Article
ears Seasonal and pandemic influenza: 100 years of progress, still much to learn By feeds.nature.com Published On :: 2020-04-21 Full Article
ears 100 years of influenza research seen through the lens of Covid-19 By feeds.nature.com Published On :: 2020-05-01 Full Article
ears 'Some people in Pak feel China still thinks like it did in '60s, '70s. It has moved on... In recent years, it has only advised good ties with India'' By archive.indianexpress.com Published On :: Sat, 19 Oct 2013 22:50:43 GMT Pakistan's ex-Ambassador to US Husain Haqqani speaks about the battle for Pakistan. Full Article
ears Eurasian Ice Sheet collapse was a major source of Meltwater Pulse 1A 14,600 years ago By feeds.nature.com Published On :: 2020-04-20 Full Article
ears Boullier targets title tilt in three years By en.espnf1.com Published On :: Mon, 12 Dec 2011 15:23:50 GMT Renault team principal Eric Boullier is targeting race victories in the next three years and fourth place in the championship next season Full Article
ears Ukraine: Six years after the Maidan By webfeeds.brookings.edu Published On :: Fri, 21 Feb 2020 20:53:28 +0000 February 21 marks the sixth anniversary of the end of Ukraine’s Maidan Revolution. Three months of largely peaceful protests concluded in a spasm of deadly violence. President Victor Yanukovych fled Kyiv and later Ukraine, prompting the Rada (Ukraine’s parliament) to appoint acting leaders pending early elections. Today, Ukraine has made progress toward meeting the aspirations… Full Article
ears Crimea: Six years after illegal annexation By webfeeds.brookings.edu Published On :: Tue, 17 Mar 2020 15:28:06 +0000 March 18 marks the sixth anniversary of Russia’s illegal annexation of Crimea. Attention now focuses on the Russian-Ukrainian conflict in Donbas, a conflict that has taken some 14,000 lives, but Moscow’s seizure of Crimea — the biggest land-grab in Europe since World War II — has arguably done as much or more damage to Europe’s… Full Article
ears 20 years after Clinton’s pathbreaking trip to India, Trump contemplates one of his own By webfeeds.brookings.edu Published On :: Wed, 22 Jan 2020 15:00:19 +0000 President Trump is planning on a trip to India — probably next month, depending on his impeachment trial in the Senate. That will be almost exactly 20 years after President Clinton’s pathbreaking trip to India, Bangladesh, and Pakistan in March 2000. There are some interesting lessons to be learned from looking back. Presidential travel to… Full Article
ears Passages to India: Reflecting on 50 years of research in South Asia By webfeeds.brookings.edu Published On :: Wed, 18 May 2016 13:30:00 -0400 Editors’ Note: How do states manage their armed forces, domestic politics, and foreign affairs? Stephen Cohen, senior fellow with the India Project at Brookings, has studied this and a range of other issues in Southeast Asia since the 1960s. In a new book, titled “The South Asia Papers: A Critical Anthology of Writings,” Cohen reflects on more than a half-century of scholarship on India, describing the dramatic changes he has personally witnessed in the field of research. The following is an excerpt from the book’s preface. [In the 1960s, questions about how states manage their armed forces] were not only unasked in the South Asian context by scholars; they were also frowned on by the Indian government. This made preparation both interesting and difficult. It was interesting because a burgeoning literature on civil–military relations in non-Western states could be applied to India. Most of it dealt with two themes: the “man on horseback,” or how the military came to power in a large number of new states, and how the military could assist in the developmental process. No one had asked these questions of India, although the first was relevant to Pakistan, then still governed by the Pakistani army in the form of Field Marshal Ayub Khan. *** During my first and second trips [in the 1960s] my research was as a historian, albeit one interested in the army’s social, cultural, and policy dimensions. I discovered, by accident, that this was part of the movement toward the “new military history.” Over the years I have thus interacted with those historians who were interested in Indian military history, including several of my own students. While the standard of historians in India was high in places like the University of Calcutta, military history was a minor field, just as it was in the West. Military historians are often dismissed as the “drums and trumpets” crowd, interested in battles, regiments, and hardware, but not much else. My own self-tutoring in military history uncovered something quite different: a number of scholars, especially sociologists, had written on the social and cultural impact of armed forces, a literature largely ignored by the historians. While none of this group was interested in India, the connection between one of the world’s most complicated and subtle societies, the state’s use of force, and the emergence of a democratic India was self-evident. *** A new generation of scholars and experts, many of them Indians (some trained in the United States) and Indian Americans who have done research in India, have it right: this is a complex civilizational-state with expanding power, and its rise is dependent on its domestic stability, its policies toward neighbors (notably Pakistan), the rise of China, and the policies of the United States. The literature that predicts a conflict between the rising powers (India and China), and between them and America the “hegemon,” is misguided: the existence of nuclear weapons by all three states, plus Pakistan, ensures that barring insanity, any rivalries between rising and established states will be channeled into “ordinary” diplomatic posturing, ruthless economic competition, and the clash of soft power. In this competition, India has some liabilities and many advantages, and the structure of the emerging world suggests a closer relationship between the United States and India, without ruling out much closer ties between China and India. There remain some questions: Can the present Indian leadership show magnanimity in dealing with Pakistan, and does it have the foresight to look ahead to new challenges, notably environmental and energy issues that require new skills and new international arrangements? Importantly, some of the best work on answering these questions is being done in India itself, and the work of Kanti Bajpai, Amitabh Mattoo, Harsh Pant, C. Raja Mohan, Rajesh Basrur, and others reveals the maturity of Indian thinking on strategic issues. It has not come too soon, as the challenges that India will face are growing, and those of Pakistan are even more daunting. Authors Stephen P. Cohen Full Article
ears Five years after Busan—how does the U.S. stack up on data transparency? By webfeeds.brookings.edu Published On :: Wed, 13 Apr 2016 09:00:00 -0400 Publish What You Fund’s 2016 Aid Transparency Index is out. And as a result, today we can assess whether major donors met the commitments they made five years ago at Busan to make aid transparent by the end of 2015. The index is also a window into the state of foreign aid transparency and how the U.S.—the world’s largest bilateral donor—stacks up. The global picture On the positive side, the index found that ten donors of varied types and sizes, accounting for 25 percent of total aid, have met the commitment to aid transparency. And more than half of the 46 organizations included in the 2016 index now publish data to the International Aid Transparency Initiative (IATI) registry at least quarterly. At the same time, the index’s assessments show more than half of the organizations still fall into the lowest three categories, scoring below 60 percent in terms of the transparency of their information. The U.S. picture Continuing its leadership on transparency, the Millennium Challenge Corporation comes in second overall in the index, meeting its Busan commitment and once again demonstrating that the institutional commitment to publishing and using its data continues. Otherwise, at first glance, U.S. progress seems disappointing. The five other U.S. donors included in the 2016 index are all in the “fair” category. Seen through a five-year lens, however, these same five U.S. donors were either in the “poor” or “very poor” categories in the 2011 index. So, all agencies have moved up, and three of them—U.S. Agency for International Development (USAID), Department of the Treasury, and the U.S. President's Emergency Plan for AIDS Relief—are on the cusp of “good.” In the two biggest U.S. agencies that administer foreign assistance, USAID and the State Department, the commitment is being institutionalized and implemented through more systematic efforts to revamp their outdated information systems. Both have reviewed the gaps in their data reporting systems and developed a path forward. USAID’s Cost Management Plan identifies specific steps to be taken and is well under way. The State Department Foreign Assistance Data Review (FADR) involves further reviews that need to be executed promptly in order to lead to action. Both are signs of a heightened commitment to data transparency and both require continued agency leadership and staff implementation. The Department of Defense, which slid backwards in the last three assessments (and began at the "very poor" category in 2011), has for the first time moved into the "fair" category. It is still the lowest performing U.S. agency in the index, but it is now publishing 12 new IATI fields. It is moving in the right direction, but significant work remains to be done. The third U.S. National Action Plan (NAP) announced last fall—the strongest issued by the U.S. to date—calls for improvements to quality and comprehensiveness of U.S. data and commits the U.S. to doing more to raise awareness, accessibility, and demand for foreign assistance data. This gives all U.S. agencies the imperative to do much more to make their aid information transparent and usable. Going forward—what should the U.S. being focusing on? The overall challenge has been laid out in the third NAP: Almost all of the U.S. agencies need to improve the breadth and depth of the information they are publishing to meet IATI standards. Far too often, basic information—such as titles—are either not published or are not useful. The Millennium Challenge Corporation should continue its leadership role, especially on data use. All agencies should be promoting the use of data among their own staff and by external stakeholders, especially at country level. Feedback will go a long way toward helping them improve the quality of the data they are publishing and thereby help them meet the IATI standards. USAID must finish the work on its Cost Management Plan, including putting IATI in the planned Development Information Solution. Additionally, more progress needs to be made on the follow-up to the Aid Transparency Country Pilot Assessment to meet the needs of partners. The State Department needs to follow through on including IATI in the new integrated solution mapped out in its data review. The leadership of all foreign affairs agencies needs to work harder to make the business case for compiling, publishing, and using data on foreign aid programs. Open data, particularly when it is comparable, timely, accessible, and comprehensive, is an extremely valuable management asset. Agency leadership should be its champion. So far, we have not seen enough. U.S. progress on aid transparency was slow to start. It is still not where it needs to be. But with a modest but concerted push, three additional agencies will be in the “good” category and that is a story we can start to be proud of. We look forward to continued progress and to the day when all U.S. foreign aid meets transparency standards—a day I believe will be an important one for the cause of greater development, better governance, democratic participation, and reduced poverty worldwide. Authors George Ingram Full Article
ears Five years after Busan—time to raise the bar in aid transparency By webfeeds.brookings.edu Published On :: Thu, 28 Apr 2016 10:36:00 -0400 Spring has sprung and once again Publish What You Fund has issued its Aid Transparency Index (ATI). Once again most of the multilateral development banks (MDBs) receive high grades rated as very good. And once again I ask whether those grades are well deserved? At the heart of my question is whether aid agencies are disclosing sufficient information during the critical implementation stage of a project. Last year we reviewed the practices of 8 aid agencies, 7 of which consistently receive the highest accolades in the ATI. What was evident from our review was the serious asymmetry of the type of aid data released to the public. A major target at Busan in 2011 when donors made commitments to aid transparency and in the establishment of the ATI has been the reporting of aid flows and the projects approved by each agency. There has been growing emphasis since then on reporting information on the results of those projects. But there has been very limited progress in the release of information during project implementation. The importance of such information should be obvious. It is during project implementation that the various stakeholders need to monitor project progress, report on issues requiring attention, and make changes to ensure achievement of the desired results. It is insufficient to only disclose who wins a contract; consideration should be given to publishing the contracts, reporting on its execution, and disclosing amendments to the contracts. And it is not enough to simply publish the resettlement action plan for a project; how that plan is being implemented must be reported. Real time reporting is the key to being able to adapt and make changes as projects evolve. Adapting the ATI It is very evident that the International Aid Transparency Initiative (IATI) and the ATI have had a major positive impact on raising the level of transparency of aid agencies. Discussions with various agencies illustrate how they are keen to getting higher scores each year, carefully analyzing the indicators to guide their actions. However, with only a limited focus and weighting of reporting on project implementation in the ATI, there is no incentive to fill this important gap. In its 2016 report, Publish What You Fund has indicated that it will be reviewing its indicators later this year and intends to raise the bar. It would be timely to include information on project implementation in those revisions. One challenge is how to develop indicators that are similarly relevant across a wide variety of aid agencies. Implementation information is most critical for agencies that finance longer-term projects, especially infrastructure, such as the MDBs. One option is to consider a set of indicators to better “incentivize” the relevant agencies and refer to these as ATI+. Reviewing the use and abuse of protecting deliberative information The MDB’s, in their major disclosure reforms since 2010, adopted a principle that “deliberative” information would not be disclosed in order to foster candid and open dialogue within the organization and between the organization and the client country. As per the World Bank’s policy, “The Bank, like any institution or group, needs space to consider and debate, away from public scrutiny.” This excludes emails, notes, and other exchanges either internally or with member countries. As a result, the project supervision reports, which managements use to monitor projects under execution and are generally published twice a year, were divided between disclosed versus undisclosed sections. The undisclosed sections would offer space for reporting on confidential project concerns including potential corruption. Our review of the disclosed reports suggests that most aid agencies’ task managers tend to take a cautious approach, placing most information in the undisclosed sections. Stakeholders outside the MDB, such as local civil society groups, then, often only see truncated information. While the adoption of the “deliberative” principle is understandable, its application places a serious responsibility on management to ensure that this is applied with considerable restraint. The MDBs should review the application of this principle and assess the type of information released during implementation. It is indeed time to raise the bar on transparency and to focus on the most critical information required to ensure results. This is not the moment for complacency with high grades. Authors Jeffrey Gutman Full Article
ears The Affordable Care Act at 10 years By webfeeds.brookings.edu Published On :: Fri, 13 Mar 2020 09:00:58 +0000 On March 23, 2010, President Barack Obama signed the Patient Protection and Affordable Care Act, perhaps the most significant change in health care policy since the passage of Medicare and Medicaid in 1965. But opposition to the law has been unrelenting since before its enactment, and efforts to repeal it in the courts are ongoing.… Full Article
ears The Asian financial crisis 20 years on: Lessons learnt and remaining challenges By webfeeds.brookings.edu Published On :: Wed, 05 Jul 2017 20:00:16 +0000 Twenty years ago, on July 2, 1997, the Thai baht broke its peg with the U.S. dollar, signalling the start of the Asian financial crisis. This soon developed into full-blown crises in Thailand, Indonesia, and eventually the much larger Korean economy, as domestic financial institutions failed and foreign exchange sources dried up. Growth plunged from positive… Full Article
ears Experts assess the nuclear Non-Proliferation Treaty, 50 years after it went into effect By webfeeds.brookings.edu Published On :: Tue, 03 Mar 2020 20:51:09 +0000 March 5, 2020 marks the 50th anniversary of the entry into effect of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT). Five decades on, is the treaty achieving what was originally envisioned? Where is it succeeding in curbing the spread of nuclear weapons, and where might it be falling short? Four Brookings experts on defense… Full Article
ears Building artists and leaders in Palestine: The Freedom Theater 10 years on By webfeeds.brookings.edu Published On :: Mon, 25 Apr 2016 00:00:00 -0400 “We are not buildings artists; we are buildings leaders in society.” These stirring words of Juliano Mer Khamis, the charismatic founder of The Freedom Theatre (TFT) in Jenin refugee camp in Palestine, are coming true, despite his assassination five years ago. Against all odds, The Freedom Theatre, a beacon of creativity, discipline, and vision located in the heart of Jenin refugee camp, recently celebrated its tenth anniversary. Known for its fierce fighters and its conservatism, Jenin refugee camp, where over 16,000 live on one square kilometer, increasingly is known as well for its art. Juliano Mer Khamis returned to Jenin during the second Intifada to find his mother’s Stone Theatre (Arna’s Children tells her story) reduced - like so much of the camp—to rubble by Israeli tanks, and many of his mother’s student actors killed. In 2005 he joined forces with Jonatan Stanczak, currently Managing Director of TFT and Zakaria Zbeidi, a “Stone Theatre child” turned head of the Al-Aqsa brigades in Jenin, who later renounced militancy for cultural resistance. Together they rebuilt a theater in the camp, which evolved into The Freedom Theatre. Mer Khamis urged his acting students to wage a cultural intifada, warning that the occupation of the mind was more dangerous than the occupation of the body. Unlike many charismatic leaders, Mer Khamis developed an institution, not a cult of personality (even though he was adored). Following Juliano’s untimely and unsolved murder in 2011 — he was shot sitting in his car just outside the theater, with his infant son in his lap - the devastated theater soldiered on, a living testament to the powerful impact of his teaching and vision. “When Juliano died he gave us the strength to continue and he showed us the strength we had in ourselves, so we kept going,” Ahmad Matahen, age 24, a typical “child of The Freedom Theatre”, explained to me. Matahen joined in 2006; first as an actor, then as Juliano encouraged him to discover and exploit his individual talents, he moved into technology, engineering and stage design. He now studies stage design in Bethlehem, with the support of TFT, where he hopes eventually to work. What a different future than Matahen might have had, if Mer Khamis had not invited in this street youth who had mocked the theater, and expressed his anger and frustration by throwing rocks at Israeli tanks. Matahen described the common attitude in Jenin: “When you go to the camp and ask people what they want, they say they want to die. They have no jobs, no hope.” When asked what he missed most after Juliano’s death, Matahen said “hugs”, something no one besides Juliano gave him. As a teenager, Ahmad, like so many of his contemporaries, saw his friends killed by the invading/occupying Israelis. Considered against the backdrop of trauma that pervades the camp, hugs are no small thing. They form the foundation for the self-confidence and sense of purpose that Matahen has gained from The Freedom Theatre. High school dropout Ameer Abu Alrob defied his family and left his village to live and work at The Freedom Theatre. He traveled to India last year with a TFT group that also included two female acting students, for a ground-breaking, three-month Palestinian-Indian collaboration and tour with Janam Theater. Ameer and half of the other Palestinian student actors had never previously traveled outside Palestine, much less flown in a plane. Through his experiences Ameer is not only broadening the horizons of his family and village, but, importantly, also introducing them to their own history through The Freedom Theatre productions such as The Siege. (One of the reasons Ameer dropped out was that school taught him nothing about his own environment and history). Performed to date in Palestine and Great Britain, The Siege brings to life on stage the incident in 2002 during the second Intifada when armed Palestinian fighters along with some two hundred Palestinian civilians escaped the onslaught of Israeli gunfire and tanks by taking refuge in Bethlehem’s renowned Church of the Nativity. The trapped Palestinians - without food, water, or medical supplies - struggled to remain “steadfast”. After thirty-nine days, they surrendered, responding to the plea of a young mother whose baby’s life was at risk because the siege prevented her taking the infant to the hospital. This decision, which reflected the fighters’ firm belief that the goal of their struggle was to help the Palestinian people, cost the insurgents dearly. In a European-brokered deal, they were exiled immediately upon exiting the Church — some to Europe and some to Gaza — with no hope of return (even though the European exile was supposed to last one year). Nabil Al-Raee, The Freedom Theatre’s artistic director, explained that he wanted to re-open this important incident to present the Palestinian side, absent in the media. “This is the first time that we speak about these freedom fighters and tell their stories.” One and a half years of research, with travel to Europe and skype conversations with Gaza to interview those in exile, including personal friends of Al-Raee’s, were distilled into a visually stunning and dramatically taut production. “The lesson of The Siege was putting weapons down,” according to one of the actors, Faisal Abu Alhayjaa, referring to the essential humanity of the Palestinian fighters, who would not harm a sick child for the sake of their cause. This powerful message apparently was lost on New York’s acclaimed Public Theater which cancelled the production scheduled for this May. This alarming trend of performances cancelled/censored (take your pick) for political reasons will be examined at a conference at Georgetown University this June, where Al-Raee will speak. Undeterred, The Freedom Theatre and its resolute supporters currently are seeking other American venues for The Siege. While some may see Palestinians on stage with machine guns, others, including sold-out audiences during The Siege‘s recent British tour, see, in the words of the Guardian review, “an unexpectedly compelling theatrical experience with a rough and ready energy, and in the very act of its telling, speaks for the voiceless and forgotten”. In the tinderbox that is Israel-Palestine, The Freedom Theatre defies its seemingly hopeless environment, and is making a tangible difference in Jenin camp and beyond. Another child of the Theatre, an actor in The Siege and in the forthcoming feature film The Idol, Ahmed Al Rokh, described the change. “We can feel the difference in the camp. Our audience is growing because the kids who first came now have families, and bring them. Now they understand that the theatre works for us and with us.” In contrast to the situation in the developed world, where art is often considered discretionary, Faisal Abu Alhayjaa described art and culture in Palestine as “essential like water and bread”. Inspiring as it is, The Freedom Theatre’s story is not unique. The Palestinian Performing Arts Network (PPAN) includes many ensembles and organizations striving for dignity and agency through art. Abu Alhayjaa sees the education and empowerment that comes through working in the arts generally, and The Freedom Theatre specifically, as vital to Palestine’s future. “If there will be a liberation for Palestine, it will come with a generation that knows what they want, and that knows to think critically.” That generation is being trained at The Freedom Theatre. This piece was originally published by The Huffington Post. Authors Cynthia P. Schneider Publication: The Huffington Post Image Source: © Mohamad Torokman / Reuters Full Article
ears Event recap: Lessons learned from two years of breakthrough therapy designation By webfeeds.brookings.edu Published On :: Thu, 14 May 2015 10:05:00 -0400 The breakthrough therapy designation (BTD) program was initiated by the U.S. Food and Drug Administration (FDA) in 2012 to expedite the development of treatments for serious or life-threatening illness that demonstrate “substantial improvement” over existing therapies. The program has since become a widely supported mechanism for accelerating patient access to new drugs. As of March 2015, FDA has received a total of 293 requests for BTD. However, it has granted just 82 (28%), which indicates an ongoing lack of clarity over what exactly meets the criteria for the designation. On April 24, the Center for Health Policy at Brookings convened a public meeting to explore the designation’s qualifying criteria and how FDA applies those criteria across therapeutic areas. Panelists used real-world and hypothetical case studies to frame the discussion, and highlighted major considerations for the application process, the FDA’s evaluation of the evidence, and the key factors for acceptance or rejection. The discussion also identified strategies to ensure that qualifying criteria are well understood. Here are the five big takeaways: 1. The BTD program is viewed positively by drug companies, researchers, advocates, and others Across the board, participants expressed enthusiasm for the BTD program. Industry representatives noted that their experience had been extremely positive, and that the increased cooperation with and guidance from FDA were very helpful in streamlining their development programs. Receiving the designation can also raise a drug company’s profile, which can facilitate additional investment as well as clinical trial patient recruitment; this is particularly important for smaller companies with limited resources. Patient and disease advocates were likewise supportive, and expressed hope that the early lessons learned from successful breakthrough therapy approvals (which have been mostly concentrated in the oncology and antiviral fields) could be translated to other disease areas with less success. However, while BTD is an important tool in expediting the development of new drugs, it is just one piece of broader scientific and regulatory policy landscape. Accelerating the pace of discovery and development of truly innovative new drugs will depend on a range of other factors, such as developing and validating new biomarkers that can be used to measure treatment effects at an earlier stage, as well as establishing networks that can streamline the clinical trial process. It will also be important to develop effective new approaches to collecting, analyzing, and communicating information about these treatments once they are on the market, as this information can potentially be used by FDA, providers, and patients to further improve prescription drug policy and medical decision-making. 2. BTD requests far outnumber those that actually meet the qualifying criteria Since the program began, less than 30 percent of requests have received BTD designation. A substantial majority were denied at least in part due to either a lack of data or problems with the quality of the data, or some combination of the two. For example, some sponsors requested the designation before they had any clinical data, or submitted the request using clinical data that was incomplete or based on flawed study designs. Many requests also failed to meet the Agency’s bar for “substantial improvement” over existing therapies. One reason for the high denial rate may be a lack of a clear regulatory or statutory bar that could be used as a definitive guide for sponsors to know what is needed to qualify for the designation. BTD denials are also confidential, which means that sponsors effectively have nothing to lose by submitting a request. Going forward, manufacturers may need to exercise more discretion in deciding to request the designation, as the process can be resource- and time-intensive for both sides. 3. There is no single threshold for determining what defines a breakthrough therapy About 53 percent of the 109 total BTD denials were due at least in part to the fact that the drug did not represent a substantial improvement over existing therapies. During the day’s discussion, FDA and sponsors both noted that this is likely because the criteria for BTD are inherently subjective. In practice, this means there is no clear threshold for determining when a new therapy represents a “substantial improvement” over existing therapies. Designation decisions are complex and highly dependent on the context, including the disease or condition being targeted, the availability of other treatments, the patient population, the outcomes being studied, and the overall reliability of the data submitted. Given the multiple factors at play, it can be difficult in some cases to determine when a new product is potentially “transformational” as opposed to “better,” especially for conditions that are poorly understood or have few or no existing treatments. In making its determinations, FDA considers the totality of the evidence submitted, rather than focusing on specific evidentiary requirements. 4. Early communication with FDA is strongly recommended for BTD applicants Roughly 72 percent of the BTD denials related at least in part to trial design or analysis problems, which led several people to suggest that sponsors engage with FDA prior to submitting their request. Though there are several formal mechanisms for interacting with the agency, informal consultations with the relevant review division could help sponsors to get a better and much earlier sense of what kind of data FDA might need. This early communication could both strengthen viable BTD requests and reduce the number of frivolous requests. 5. FDA may need more resources for implementing the BTD program Drugs that receive breakthrough designation are subject to much more intensive FDA guidance and review. However, when the program was established in 2012, Congress did not allocate funding to cover its costs. There have been ongoing concerns that the program is exacting a significant toll on FDA’s already limited resources, and potentially affecting the timeline for other drug application reviews. These concerns were reiterated during the day’s discussion, and some suggested that Congress consider attaching a user fee to the BTD program when the Prescription Drug User Fee Act comes up for reauthorization in 2017. Authors Gregory W. DanielElizabeth RichardsonCraig Streit Full Article
ears Employment in June appears to rebound after disappointing performance in May By webfeeds.brookings.edu Published On :: Fri, 08 Jul 2016 10:38:00 -0400 June’s jobs gains, released this morning, show that 287,000 new jobs were added in June, an impressive rebound after only 11,000 new jobs were added in May (revised down from from 38,000 at the time of the release). This year’s monthly job gains and losses can indicate how the economy is doing once they are corrected to account for the pattern we already expect in a process called seasonal adjustment. The approach for this seasonal adjustment that is presently used by the Bureau of Labor Statistics (BLS) puts very heavy weight on the current and last two years of data in assessing what are the typical patterns for each month. In my paper “Unseasonal Seasonals?” I argue that a longer window should be used to estimate seasonal effects. I found that using a different seasonal filter, known as the 3x9 filter, produces better results and more accurate forecasts by emphasizing more years of data. The 3x9 filter spreads weight over the most recent six years in estimating seasonal patterns, which makes them more stable over time than in the current BLS seasonal adjustment method. I calculate the month-over-month change in total nonfarm payrolls, seasonally adjusted by the 3x9 filter, for the most recent month. The corresponding data as published by the BLS are shown for comparison purposes. According to the alternative seasonal adjustment, the economy added 286,000 jobs in June (column Wright SA), almost identical to the official BLS total of 287,000 (column BLS Official). Data updates released today for prior months also reveal some differences between my figure and the official jobs gains from prior months. The official BLS numbers for May were revised down from 38,000 new jobs to a dismal 11,000. My alternative adjustment shows that the economy actually lost 6,000 jobs in May, down from 17,000 jobs gained at the time of the release. [i] The discrepancies between the two series are explained in my paper. In addition to seasonal effects, abnormal weather can also affect month-to-month fluctuations in job growth. In my paper “Weather-Adjusting Economic Data” I and my coauthor Michael Boldin implement a statistical methodology for adjusting employment data for the effects of deviations in weather from seasonal norms. This is distinct from seasonal adjustment, which only controls for the normal variation in weather across the year. We use several indicators of weather, including temperature and snowfall. We calculate that weather in June brought up the total by 25,000 jobs (column Weather Effect), but this should be considered a transient effect. Our weather-adjusted total, therefore, is 262,000 jobs added for June (column Boldin-Wright SWA). This is not surprising, given that weather in June was in line with seasonal norms. It’s good to see the jobs numbers rebounding this month. The May number was somewhat affected by the Verizon strike. Also, it is important to remember that pure sampling error in any one month’s data is large, and that could explain part of the weak employment report for May. Averaging over the last three months, employment is expanding by about 150,000 jobs per month—a healthy pace, although a bit of a step down from last year. a. Applies a longer window estimate of seasonal effects (see Wright 2013). The June 2015 to May 2016 values in this column have been corrected to remove a coding error that affected the previously reported values. b. Includes seasonal and weather adjustments, where seasonal adjustments are estimated using the BLS window specifications (see Boldin & Wright 2015). The incremental weather effect in the last column is the BLS official number less the SWA number. [i] Note that, due to a small coding error, my alternative seasonal adjustment for May, at the time of the release, should have been 17,000 new jobs, not -4,000, as was reported in my previous post. In addition to the underlying data revisions, and correcting for this error, the revised alternative seasonal adjustment for May is -6,000 jobs added (second row of column Wright SA). Authors Jonathan Wright Full Article
ears 20 years after Clinton’s pathbreaking trip to India, Trump contemplates one of his own By webfeeds.brookings.edu Published On :: Wed, 22 Jan 2020 15:00:19 +0000 President Trump is planning on a trip to India — probably next month, depending on his impeachment trial in the Senate. That will be almost exactly 20 years after President Clinton’s pathbreaking trip to India, Bangladesh, and Pakistan in March 2000. There are some interesting lessons to be learned from looking back. Presidential travel to… Full Article
ears 75 years after a historic meeting on the USS Quincy, US-Saudi relations are in need of a true re-think By webfeeds.brookings.edu Published On :: Mon, 10 Feb 2020 15:00:42 +0000 On Valentine’s Day 1945, President Franklin D. Roosevelt met with Saudi King Abdul Aziz Ibn Saud on an American cruiser, the USS Quincy, in the Suez Canal. It was the dawn of what is now the longest U.S. relationship with an Arab state. Today the relationship is in decline, perhaps terminally, and needs recasting. FDR… Full Article
ears Europe 1989-2019: Lessons learned 30 years after the fall of the Berlin Wall By webfeeds.brookings.edu Published On :: Fri, 01 Nov 2019 20:19:23 +0000 The 30 years since the opening of the Berlin Wall on November 9, 1989 have been marked by incredible progress toward a Europe “whole and free.” The European Communities became the European Union, grew to 28 member states, and helped raise living standards across the continent. NATO survived the end of the Cold War and… Full Article
ears Oil prices are tumbling. Volatility aside, expect them to stay low over the next 20 years. By webfeeds.brookings.edu Published On :: Wed, 14 Nov 2018 15:59:29 +0000 Crude oil prices have dropped over 20 percent the past two weeks, reminding observers of just how uncertain the oil market has become. That uncertainty started in 1973 when the OPEC cartel first drove prices sharply higher by constraining production. During the 1980s and 90s, new offshore oil fields kept non-OPEC supplies growing and moderated… Full Article
ears Appellate Court vacancies may be scarce in coming years, limiting Trump’s impact By webfeeds.brookings.edu Published On :: Thu, 06 Dec 2018 13:09:46 +0000 The Trump White House, with Senate Republicans and the Federalist Society, has been appointing courts of appeals judges with bulldozer efficiency. The 29 circuit appointments to date is the highest number of any president at this point in his tenure, facilitated partly by a large number of vacancies. How many more appointments will occur in… Full Article
ears Judicial appointments in Trump’s first three years: Myths and realities By webfeeds.brookings.edu Published On :: Tue, 28 Jan 2020 20:59:35 +0000 A December 24 presidential tweet boasted “187 new Federal Judges have been confirmed under the Trump Administration, including two great new United States Supreme Court Justices. We are shattering every record!” That boast has some truth but, to put it charitably, a lot of exaggeration. Compared to recent previous administrations at this same early-fourth-year point… Full Article
ears 40 years later- The relevance of Okun’s "Equality and Efficiency: The Big Tradeoff" By webfeeds.brookings.edu Published On :: Mon, 04 May 2015 10:30:00 -0400 Event Information May 4, 201510:30 AM - 12:00 PM EDTFalk AuditoriumBrookings Falk Auditorium1775 Massachusetts Ave., NWWashington, DC 20036 Register for the EventForty years after its initial publication, Equality and Efficiency: The Big Tradeoff remains an influential work from one of the most important macroeconomists over the last century, Arthur M. Okun (1928-1980). Okun’s theory on market economies reminds readers of an engaging dual theme: the market needs a place, and the market needs to be kept in its place. Articulated in a way that remains relevant even during today’s discussions on broadening gaps in income inequality, Okun emphasized that institutions in a capitalist democracy prod us to get ahead of our neighbors economically after telling us to stay in line socially. On May 4, The Brookings Institution Press re-released Okun’s classic work with a new foreword from Former Treasury Secretary Lawrence H. Summers, in addition to “Further Thoughts on Equality and Efficiency,” a paper published by Okun in 1977. The event included opening remarks from Brookings Senior Fellow George Perry, with a keynote address from Larry Summers. Following these remarks, David Wessel moderated a panel discussion with former Chair of the Council of Economic Advisers Greg Mankiw, Economic Studies’ Melissa Kearney and Justin Wolfers, and Washington Center for Equitable Growth's Heather Boushey regarding the history and impact of Okun’s work. Download a copy of Lawrence Summers' opening remarks. Ted Gayer, Vice President and Director of Economic Studies and Joseph Pechman Senior Fellow, reads Lawrence Summers's opening remarks. David Wessel (right), Director of the Hutchins Center on Fiscal and Monetary Policy, moderates a panel discussion with N. Gregory Mankiw, Melissa Kearney, and Heather Boushey. Janet Yellen, Chair of the Board of Governors of the Federal Reserve System, listens to the discussion from the audience. To Yellen's right is former Congressional Budget Office director, Doug Elmendorf. Video 40 years later- The relevance of Okun’s "Equality and Efficiency: The Big Tradeoff" Audio 40 years later- The relevance of Okun’s "Equality and Efficiency: The Big Tradeoff" Transcript Uncorrected Transcript (.pdf) Event Materials 20150504_okun_equality_efficiency_transcript050415 Summers Okun Speech Full Article
ears The Arab Spring five years later: Toward greater inclusiveness By webfeeds.brookings.edu Published On :: Fri, 15 Jan 2016 10:15:00 -0500 Event Information January 15, 201610:15 AM - 11:45 AM ESTFalk AuditoriumBrookings Institution1775 Massachusetts Avenue NWWashington, DC 20036 Register for the EventFive years have passed since the self-immolation of Mohamed Bouazizi in Tunisia sparked revolts around the Arab world and the beginning of the Arab Spring. Despite high hopes that the Arab world was entering a new era of freedom, economic growth, and social justice, the transition turned out to be long and difficult, with the Arab world now in turmoil with revolutions, counter revolutions, wars, civil strife, and the worst refugee crisis of our times. The response to the Arab Spring and its aftermath has focused almost exclusively on political and security issues, and on the very divisive questions of national identity and political regimes. Economic and social questions have been put on the back burner. On January 15, Global Economy and Development at Brookings hosted a discussion on a new book, "The Arab Spring Five Years Later," which explores the critical economic and social issues driving the Arab Spring agenda and the real economic grievances that must be addressed in order to achieve peace, stability, and successful political transitions as well as provides an approach to addressing those grievances. Hafez Ghanem and Shinchi Yamanaka presented the key findings of the book, followed by a panel discussion. Audio The Arab Spring Five Years Later: Toward greater inclusiveness Transcript Uncorrected Transcript (.pdf) Event Materials 20160115_arab_spring_transcript Full Article
ears The Arab Spring Five Years Later By webfeeds.brookings.edu Published On :: The dilemma felt by Arab youth was captured in Tunisia by the self-immolation in 2010 of Mohamed Bouazizi, who was frustrated by restrictions on his small street-vending business. His death became the catalyst that seemed to light up revolts throughout the Middle East. The frustration had been building for some time: large segments of society… Full Article
ears The Arab Spring Five Years Later: Vol 2 By webfeeds.brookings.edu Published On :: Volume 1 of The Arab Spring Five Years Later is based on extensive research conducted by scholars from a variety of backgrounds, including many associated with the Japan International Cooperation Agency. Now the original research papers are gathered in volume 2 and are available for readers who wish to go even further in understanding the… Full Article
ears The Arab Spring Five Years Later: Vol. 1 & Vol. 2 By webfeeds.brookings.edu Published On :: Thu, 29 Sep 2016 18:10:44 +0000 This two-volume set explores in-depth the economic origins and repercussions of the Arab Spring revolts. Volume 1 of The Arab Spring Five Years Later is based on extensive research conducted by scholars from a variety of backgrounds, including many associated with the Japan International Cooperation Agency (JICA). The original research papers are gathered in volume… Full Article
ears The Arab Spring five years later: Toward greater inclusiveness By webfeeds.brookings.edu Published On :: Five years have passed since the self-immolation of Mohamed Bouazizi in Tunisia sparked revolts around the Arab world and the beginning of the Arab Spring. Despite high hopes that the Arab world was entering a new era of freedom, economic growth, and social justice, the transition turned out to be long and difficult, with the… Full Article
ears The Council of Economic Advisers: 70 years of advising the president By webfeeds.brookings.edu Published On :: Thu, 11 Feb 2016 14:00:00 -0500 Event Information February 11, 20162:00 PM - 5:00 PM ESTFalk AuditoriumBrookings Institution1775 Massachusetts Avenue NWWashington, DC 20036 The White House Council of Economic Advisers (CEA) was created by Congress in 1946 to advise the president on ways “to foster and promote free competitive enterprise” and “to promote maximum employment, production and purchasing power.” President Truman, who signed the Employment Act of 1946 into law, was unenthusiastic about the Council and didn’t nominate members for nearly six months. Yet the CEA, comprised of three individuals whom Congress says are to be “exceptionally qualified,” has not only survived but also prospered for 70 years and remains an important part of the president’s economic policy decisionmaking. On February 11, the Hutchins Center on Fiscal and Monetary Policy at Brookings marked this anniversary by examining the ways the CEA and other economists succeed and fail when they set out to advise elected politicians and tap the expertise of some of the “exceptionally qualified” economists who have chaired the Council over the past four decades. You can join the conversation and tweet questions for the panelists at #CEAat70. Video Panel 1: The CEA in Moments of CrisisPanel 2: The CEA and PolicymakingPanel 3: Current Economic Policy Issues Audio The Council of Economic Advisers: 70 years of advising the president Transcript Uncorrected Transcript (.pdf) Event Materials 20160211_economic_advisers_transcript Full Article
ears 17 years after 9/11, people are finally forgetting about terrorism By webfeeds.brookings.edu Published On :: Tue, 11 Sep 2018 18:38:38 +0000 Full Article
ears Amid rising fears of ISIS, Obama must reassure By webfeeds.brookings.edu Published On :: Tue, 12 Jan 2016 12:45:00 -0500 As President Obama prepares to give the final State of the Union address of his presidency tonight, he’s promised to stay away from the technocrat’s laundry list of to-do’s. Instead, he’s expected to deliver a speech that will remind his fellow citizens of their ability to “come together as one American family.” It’s going to be a tough sell, especially when the citizens are terrified of outsiders and suspicious of one another. Most of the fear and paranoia revolves around the Islamic State group. Although the group poses far less of a threat to the United States than to our allies and friends in Europe and the Middle East, it is the sum of all fears in the minds of many Americans—an immigrant, terrorist, cyber, WMD, genocidal threat rolled into one. Its name alone can be invoked to indict Obama’s national security and immigration policies—substantive criticisms are unnecessary. [T]he Islamic State group...is the sum of all fears in the minds of many Americans. Most of those fears are overblown, but the president will want to tackle them each of them in his speech if he intends to calm fears and bring people together. He’ll explain why taking in refugees is not just living up to American values but also smart counterterrorism. He’ll showcase evidence that the military campaign against the Islamic State in the Middle East is bearing fruit. He’ll reassure Americans that the Islamic State can’t plant a skilled operative into this country and remind them that the best way to stop the unskilled lone wolf shooters inspired by the Islamic State is to close gun loop holes and monitor their behavior online before they act. He’ll demonstrate his commitment to blunting Islamic State recruitment, touting changes to how the government counters the Islamic State’s appeal online and in America’s big cities. All of that is well and good, but it’s a bureaucrat’s (or think tanker’s) effort at reassuring the public. To truly succeed in mitigating America’s fears and bringing citizens together, our country’s leader has to acknowledge that their fears are real and explain what our enemies hope to gain by engendering them. While Americans’ fears may be overblown, they won’t be deflated by technocratic hot air. Authors William McCants Full Article
ears Desert Storm after 25 years: Confronting the exposures of modern warfare By webfeeds.brookings.edu Published On :: Thu, 16 Jun 2016 15:00:00 -0400 Event Information June 16, 20163:00 PM - 5:00 PM EDTSEIU Building1800 Massachusetts Ave. NWWashington, DC Register for the EventBy most metrics, the 1991 Gulf War, also known as Operation Desert Storm, was a huge and rapid success for the United States and its allies. The mission of defeating Iraq's army, which invaded Kuwait the year prior, was done swiftly and decisively. However, the war's impact on soldiers who fought in it was lasting. Over 650,000 American men and women served in the conflict, and many came home with symptoms including insomnia, respiratory disorders, memory issues and others attributed to a variety of exposures – “Gulf War Illness." On June 16, the Center for 21st Century Security and Intelligence at Brookings and Georgetown University Medical Center co-hosted a discussion on Desert Storm, its veterans, and how they are faring today. Representative Mike Coffman (R-Col.), the only member of Congress to serve in both Gulf wars, delivered an opening address before joining Michael O’Hanlon, senior fellow at Brookings, for a moderated discussion. Joel Kupersmith, former head of the Office of Research and Development of the Department of Veterans Affairs, convened a follow-on panel with Carolyn Clancy, deputy under secretary for health for organizational excellence at the Department of Veterans Affairs; Adrian Atizado, deputy national legislative director at Disabled American Veterans; and James Baraniuk, professor of medicine at Georgetown University Medical Center. Audio Desert Storm after 25 years: Confronting the exposures of modern warfare Transcript Uncorrected Transcript (.pdf) Event Materials 20160616_desert_storm_transcript Full Article
ears The G-20 Los Cabos Summit 2012: Bolstering the World Economy Amid Growing Fears of Recession By webfeeds.brookings.edu Published On :: Fri, 08 Jun 2012 14:48:00 -0400 Leaders will head to the G-20 Summit in Los Cabos, Mexico, among renewed serious concern about the world economy. The turmoil that started with the U.S. subprime mortgage crisis has resulted in now almost five years of ongoing instability. The emerging market economies fared much better than the advanced economies and pulled out of the crisis already in 2009, but the slowdown we are now facing in 2012 is again global, demonstrating the interdependence in the world economy. The emerging market economies have stronger underlying trend growth rates, but they remain vulnerable to a downturn in the advanced economies. The center of concern is now squarely on Europe, with a recession threatening most European countries, even those that had reasonably good performances so far. After an encouraging start in 2012, the U.S. economy, while not close to a recession, is also showing signs of a slowdown rather than the hoped for steady acceleration of growth. And the slowdown is spreading across the globe. At a time like this it would be desirable and necessary that the G-20 show real initiative and cohesion. The essays in this collection look at the challenge from various angles. There is concern that the G-20 is losing its sense of purpose, that cohesion is decreasing rather than increasing, and that policy initiatives are reactive to events rather than proactive. Let us hope that at this moment of great difficulty, the G-20 will succeed in giving the world economy a new sense of direction and confidence. It is much needed. Download » (PDF) Image Source: Andrea Comas / Reuters Full Article
ears Rightsizing fears about Taiwan’s future By webfeeds.brookings.edu Published On :: Mon, 01 Jul 2019 18:39:00 +0000 In recent decades, China has been plowing a sizable share of its growing economic strength into developing advanced military capabilities. As Beijing’s military build-up progresses, concerns naturally mount in Taiwan about its continued security. A certain amount of concern is healthy. It disciplines voters to ask hard questions of their leaders about the appropriate balance… Full Article
ears 6 years from the BP Deepwater Horizon oil spill: What we’ve learned, and what we shouldn’t misunderstand By webfeeds.brookings.edu Published On :: Six years ago today, the BP Deepwater Horizon oil spill occurred in the U.S. Gulf of Mexico with devastating effects on the local environment and on public perception of offshore oil and gas drilling. The blowout sent toxic fluids and gas shooting up the well, leading to an explosion on board the rig that killed… Full Article Uncategorized
ears 40 years later: America’s energy path and the road ahead By webfeeds.brookings.edu Published On :: Mon, 31 Oct 2016 18:58:42 +0000 In a 1976 Foreign Affairs article, Amory Lovins offered a novel—and controversial—vision for America’s energy strategy. With U.S. security and energy independence threatened by oil market instability, Lovins urged policymakers to move away from fossil fuels and nuclear and towards efficiency and renewable energy. This “soft energy path,” he argued, offered a myriad of clear… Full Article
ears Experts assess the nuclear Non-Proliferation Treaty, 50 years after it went into effect By webfeeds.brookings.edu Published On :: Tue, 03 Mar 2020 20:51:09 +0000 March 5, 2020 marks the 50th anniversary of the entry into effect of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT). Five decades on, is the treaty achieving what was originally envisioned? Where is it succeeding in curbing the spread of nuclear weapons, and where might it be falling short? Four Brookings experts on defense… Full Article
ears After 50 years, the U.S. and Cuba will finally have embassies to call home By webfeeds.brookings.edu Published On :: Wed, 01 Jul 2015 11:15:00 -0400 Today’s announcement of the restoration of diplomatic relations between Washington and Havana replaces over five decades of mutual hostility and aggressive name-calling with a new atmosphere of diplomatic civility. The re-opening of embassies in both capitals establishes platforms upon which to build more normal working relations. Now, the hard work begins, as the two nations gradually dismantle the comprehensive wall of restrictions separating them for two generations. Expectations are running high, especially in Cuba, that diplomatic engagement will catalyze economic betterment on the island. To stimulate more travel and trade, the U.S. government needs to clarify rules for engaging with the emerging Cuban private sector, and make it clear to U.S. banks that they are permitted to support the use of credit cards by U.S. visitors in Cuba. The administration should also begin to consider another round of liberalizing initiatives, some under consideration in the U.S. Congress, to further relax travel restrictions, and to enable more U.S. firms—beyond agriculture and medicines—to assist the Cuban people. For its part, the Cuban government should open efficient channels to facilitate the commercial exchanges now authorized by the Obama administration. Cuban entrepreneurs should be permitted ready access to U.S. firms wishing to sell building equipment for construction cooperatives, restaurant supplies for private-owned restaurants, and automotive spare parts for private taxis. Micro-enterprise lending should be authorized to support these emerging non-state enterprises. If both nations build upon today’s welcome announcement by further opening these channels to travel and commerce, Presidents Barack Obama and Raúl Castro can help to safeguard their joint legacy. By fortifying and expanding constituencies on both sides of the Florida Straits, immersed in daily exchanges to mutual benefit, the two governments can render their diplomatic accomplishment politically irreversible in both capitals. Authors Richard E. Feinberg Full Article
ears Iran’s economy 40 years after the Islamic Revolution By webfeeds.brookings.edu Published On :: Thu, 14 Mar 2019 18:01:37 +0000 Unlike the socialist revolutions of the last century, the Islamic Revolution of Iran did not identify itself with the working class or the peasantry, and did not bring a well-defined economic strategy to reorganize the economy. Apart from eliminating the interest rate from the banking system, which was achieved in name only, the revolution put… Full Article