change States Must Change, Too For Blended Learning By feedproxy.google.com Published On :: Tue, 10 Mar 2015 00:00:00 +0000 Lisa Duty of The Learning Accelerator, a Rhode Island Department of Education (RIDE) and Highlander Institute funding partner, outlines the Rhode Islands's commitment to a blended learning future. She describes how the state is developing its new five-year strategic plan that's engaging RIDE's Ambas Full Article Rhode_Island
change Teachers union: Stagger school start times, change seating By feedproxy.google.com Published On :: Fri, 01 May 2020 00:00:00 +0000 Full Article Connecticut
change How One State Changed Its ESSA Plan in Response to the Trump Team By feedproxy.google.com Published On :: Mon, 10 Jul 2017 00:00:00 +0000 What have states actually done in response to U.S. Department of Education feedback on their plans for the Every Student Succeeds Act? Here's Delaware's answer. Full Article Delaware
change Land tax changes : the consultation proposals / presented by Bernie Walrut. Murray Chambers. By www.catalog.slsa.sa.gov.au Published On :: Full Article
change Land Tax Changes - The consultation Proposals - Bernie Walrut SLIDES. By www.catalog.slsa.sa.gov.au Published On :: Full Article
change Independent Review of the APS : priorities for change / Independent Review of the APS. By www.catalog.slsa.sa.gov.au Published On :: Full Article
change Evaluating behaviour change communication campaigns in health and safety : a literature review / TJ Bailey [and] LN Wundersitz. By www.catalog.slsa.sa.gov.au Published On :: Full Article
change The courage to be disliked : how to free yourself, change your life and achieve real happiness / Ichiro Kishimi and Fumitake Koga. By www.catalog.slsa.sa.gov.au Published On :: Self-actualization (Psychology) Full Article
change The greatest flight : reliving the aerial triumph that changed the world / Peter McMillan ; photographs by James L. Stanfield ; historical text by Terry Gwynn-Jones ; construction text by John La Noue ; foreword by Walter J. Boyne. By www.catalog.slsa.sa.gov.au Published On :: McMillan, Peter -- Travel. Full Article
change The way we eat now : strategies for eating in a world of change / Bee Wilson ; illustrations by Annabel Lee. By www.catalog.slsa.sa.gov.au Published On :: Food. Full Article
change Biodiversity and climate change : transforming the biosphere / edited by Thomas E. Lovejoy & Lee Hannah ; foreword by Edward O. Wilson. By www.catalog.slsa.sa.gov.au Published On :: Biodiversity -- Climatic factors. Full Article
change Don Dunstan : the visionary politican who changed Australia / Angela Woollacott. By www.catalog.slsa.sa.gov.au Published On :: Dunstan, Don, 1926-1999 -- Career in Politics. Full Article
change The gospel of climate skepticism : why evangelical Christians oppose action on climate change / Robin Globus Veldman. By www.catalog.slsa.sa.gov.au Published On :: Climatic changes -- Effect of human beings on -- Religious aspects -- Christianity. Full Article
change The golden thread : how fabric changed history / Kassia St. Clair. By www.catalog.slsa.sa.gov.au Published On :: Textile fabrics. Full Article
change Don't be a dick : change yourself, change your world / Mark B. Borg, Jr., PhD. By www.catalog.slsa.sa.gov.au Published On :: Change (Psychology) Full Article
change Will 3,000 Teachers in South Carolina Soon Retire Because of a Policy Change? By feedproxy.google.com Published On :: Fri, 22 Jun 2018 00:00:00 +0000 A program that lets retired teachers keep working while collecting retirement benefits is set to expire at the end of the month. Full Article South_Carolina
change Earth to earth : a plea for a change of system in our burial of the dead / by Francis Seymour Haden. By feedproxy.google.com Published On :: London : Macmillan, 1875. Full Article
change The electro-motive changes in heart-block / by G. A. Gibson. By feedproxy.google.com Published On :: London : British Medical Journal, 1906. Full Article
change A Florida City Forever Changed By feedproxy.google.com Published On :: Tue, 27 Feb 2018 00:00:00 +0000 The scene at Marjory Stoneman Douglas High School and the surrounding area after the shootings shifted from chaos and panic to grief, anger, and calls for swift and aggressive action to prevent other school attacks. Full Article Florida
change S.D. and Idaho Differ on Climate Change By feedproxy.google.com Published On :: Tue, 28 Feb 2017 00:00:00 +0000 South Dakota lawmakers have rejected a bill that would have allowed science teachers to discuss strengths and weaknesses of evolutionary and climate change theories. Full Article Idaho
change Teachers Shortchanged On Bonuses in Idaho By feedproxy.google.com Published On :: Tue, 22 Mar 2016 00:00:00 +0000 Idaho lawmakers were upset to learn that nearly $17 million dedicated to giving teachers in leadership positions and assistants bonuses hasn't been distributed. Full Article Idaho
change King Henri IV after his assassination is taken up to Olympus and received by the gods; France awards the regency to his widow Marie de' Medici. Engraving by G. Duchange, 1708, after J.M. Nattier after Sir P.P. Rubens. By feedproxy.google.com Published On :: Se vend à Paris (rue St. Jacques au dessus de la rue des Mathurins) : chez le S.r Duchange graveur ordinaire du Roy. Avec privilege du Roy, [1708?] Full Article
change Changes to Social Study Standards In Michigan Reversed After Outcry By feedproxy.google.com Published On :: Tue, 16 Apr 2019 00:00:00 +0000 Back is Martin Luther King Jr.'s "I Have a Dream" speech. Back is Roe v. Wade. Back is climate change. and the word "democratic." A new proposal incorporating those revisions was presented to the Michigan board of education last week. Full Article Michigan
change 'Slap Shot' still iconic in hockey despite sport's changes By sports.yahoo.com Published On :: Fri, 08 May 2020 18:32:06 GMT A few nights after one of their players was injured by a dirty hit, the Johnstown Jets plotted to exact some revenge on Buffalo's Greg Neeld. An all-out brawl broke out during warmups and the North American Hockey League game was postponed, much to the dismay of ownership and presumably the fans at a sold-out War Memorial Arena. It just so happened that director George Roy Hill was in the arena that night, cameras rolling. Full Article article Sports
change Policy and guidelines for the provision of needle and syringe exchange services to young people / Tom Aldridge and Andrew Preston. By search.wellcomelibrary.org Published On :: [Dorchester] : Dorset Community NHS Trust, 1997. Full Article
change Univariate mean change point detection: Penalization, CUSUM and optimality By projecteuclid.org Published On :: Mon, 27 Apr 2020 22:02 EDT Daren Wang, Yi Yu, Alessandro Rinaldo. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1917--1961.Abstract: The problem of univariate mean change point detection and localization based on a sequence of $n$ independent observations with piecewise constant means has been intensively studied for more than half century, and serves as a blueprint for change point problems in more complex settings. We provide a complete characterization of this classical problem in a general framework in which the upper bound $sigma ^{2}$ on the noise variance, the minimal spacing $Delta $ between two consecutive change points and the minimal magnitude $kappa $ of the changes, are allowed to vary with $n$. We first show that consistent localization of the change points is impossible in the low signal-to-noise ratio regime $frac{kappa sqrt{Delta }}{sigma }preceq sqrt{log (n)}$. In contrast, when $frac{kappa sqrt{Delta }}{sigma }$ diverges with $n$ at the rate of at least $sqrt{log (n)}$, we demonstrate that two computationally-efficient change point estimators, one based on the solution to an $ell _{0}$-penalized least squares problem and the other on the popular wild binary segmentation algorithm, are both consistent and achieve a localization rate of the order $frac{sigma ^{2}}{kappa ^{2}}log (n)$. We further show that such rate is minimax optimal, up to a $log (n)$ term. Full Article
change On change-point estimation under Sobolev sparsity By projecteuclid.org Published On :: Wed, 08 Apr 2020 22:01 EDT Aurélie Fischer, Dominique Picard. Source: Electronic Journal of Statistics, Volume 14, Number 1, 1648--1689.Abstract: In this paper, we consider the estimation of a change-point for possibly high-dimensional data in a Gaussian model, using a maximum likelihood method. We are interested in how dimension reduction can affect the performance of the method. We provide an estimator of the change-point that has a minimax rate of convergence, up to a logarithmic factor. The minimax rate is in fact composed of a fast rate —dimension-invariant— and a slow rate —increasing with the dimension. Moreover, it is proved that considering the case of sparse data, with a Sobolev regularity, there is a bound on the separation of the regimes above which there exists an optimal choice of dimension reduction, leading to the fast rate of estimation. We propose an adaptive dimension reduction procedure based on Lepski’s method and show that the resulting estimator attains the fast rate of convergence. Our results are then illustrated by a simulation study. In particular, practical strategies are suggested to perform dimension reduction. Full Article
change A primer on the characterization of the exchangeable Marshall–Olkin copula via monotone sequences By projecteuclid.org Published On :: Mon, 03 Feb 2020 04:00 EST Natalia Shenkman. Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 127--135.Abstract: While derivations of the characterization of the $d$-variate exchangeable Marshall–Olkin copula via $d$-monotone sequences relying on basic knowledge in probability theory exist in the literature, they contain a myriad of unnecessary relatively complicated computations. We revisit this issue and provide proofs where all undesired artefacts are removed, thereby exposing the simplicity of the characterization. In particular, we give an insightful analytical derivation of the monotonicity conditions based on the monotonicity properties of the survival probabilities. Full Article
change Failure rate of Birnbaum–Saunders distributions: Shape, change-point, estimation and robustness By projecteuclid.org Published On :: Mon, 04 Mar 2019 04:00 EST Emilia Athayde, Assis Azevedo, Michelli Barros, Víctor Leiva. Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 301--328.Abstract: The Birnbaum–Saunders (BS) distribution has been largely studied and applied. A random variable with BS distribution is a transformation of another random variable with standard normal distribution. Generalized BS distributions are obtained when the normally distributed random variable is replaced by another symmetrically distributed random variable. This allows us to obtain a wide class of positively skewed models with lighter and heavier tails than the BS model. Its failure rate admits several shapes, including the unimodal case, with its change-point being able to be used for different purposes. For example, to establish the reduction in a dose, and then in the cost of the medical treatment. We analyze the failure rates of generalized BS distributions obtained by the logistic, normal and Student-t distributions, considering their shape and change-point, estimating them, evaluating their robustness, assessing their performance by simulations, and applying the results to real data from different areas. Full Article
change Modified information criterion for testing changes in skew normal model By projecteuclid.org Published On :: Mon, 04 Mar 2019 04:00 EST Khamis K. Said, Wei Ning, Yubin Tian. Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 280--300.Abstract: In this paper, we study the change point problem for the skew normal distribution model from the view of model selection problem. The detection procedure based on the modified information criterion (MIC) for change problem is proposed. Such a procedure has advantage in detecting the changes in early and late stage of a data comparing to the one based on the traditional Schwarz information criterion which is well known as Bayesian information criterion (BIC) by considering the complexity of the models. Due to the difficulty in deriving the analytic asymptotic distribution of the test statistic based on the MIC procedure, the bootstrap simulation is provided to obtain the critical values at the different significance levels. Simulations are conducted to illustrate the comparisons of performance between MIC, BIC and likelihood ratio test (LRT). Such an approach is applied on two stock market data sets to indicate the detection procedure. Full Article
change SmartExchange: Trading Higher-cost Memory Storage/Access for Lower-cost Computation. (arXiv:2005.03403v1 [cs.LG]) By arxiv.org Published On :: We present SmartExchange, an algorithm-hardware co-design framework to trade higher-cost memory storage/access for lower-cost computation, for energy-efficient inference of deep neural networks (DNNs). We develop a novel algorithm to enforce a specially favorable DNN weight structure, where each layerwise weight matrix can be stored as the product of a small basis matrix and a large sparse coefficient matrix whose non-zero elements are all power-of-2. To our best knowledge, this algorithm is the first formulation that integrates three mainstream model compression ideas: sparsification or pruning, decomposition, and quantization, into one unified framework. The resulting sparse and readily-quantized DNN thus enjoys greatly reduced energy consumption in data movement as well as weight storage. On top of that, we further design a dedicated accelerator to fully utilize the SmartExchange-enforced weights to improve both energy efficiency and latency performance. Extensive experiments show that 1) on the algorithm level, SmartExchange outperforms state-of-the-art compression techniques, including merely sparsification or pruning, decomposition, and quantization, in various ablation studies based on nine DNN models and four datasets; and 2) on the hardware level, the proposed SmartExchange based accelerator can improve the energy efficiency by up to 6.7$ imes$ and the speedup by up to 19.2$ imes$ over four state-of-the-art DNN accelerators, when benchmarked on seven DNN models (including four standard DNNs, two compact DNN models, and one segmentation model) and three datasets. Full Article
change Systems approaches to making change : a practical guide By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9781447174721 (electronic bk.) Full Article
change Climate change and soil interactions By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9780128180334 (electronic bk.) Full Article
change Climate change and food security with emphasis on wheat By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9780128195277 Full Article
change Jamboree Begins Construction on Capstone Development to Change... By www.prweb.com Published On :: In a public-private partnership to develop housing, resident services and hope for 102 working families in Haster Orangewood community, Jamboree Housing Corporation and the City of Anaheim announce...(PRWeb April 27, 2020)Read the full story at https://www.prweb.com/releases/jamboree_begins_construction_on_capstone_development_to_change_trajectory_of_neighborhood_in_anaheim_ca/prweb17073166.htm Full Article
change Consistent selection of the number of change-points via sample-splitting By projecteuclid.org Published On :: Mon, 17 Feb 2020 04:02 EST Changliang Zou, Guanghui Wang, Runze Li. Source: The Annals of Statistics, Volume 48, Number 1, 413--439.Abstract: In multiple change-point analysis, one of the major challenges is to estimate the number of change-points. Most existing approaches attempt to minimize a Schwarz information criterion which balances a term quantifying model fit with a penalization term accounting for model complexity that increases with the number of change-points and limits overfitting. However, different penalization terms are required to adapt to different contexts of multiple change-point problems and the optimal penalization magnitude usually varies from the model and error distribution. We propose a data-driven selection criterion that is applicable to most kinds of popular change-point detection methods, including binary segmentation and optimal partitioning algorithms. The key idea is to select the number of change-points that minimizes the squared prediction error, which measures the fit of a specified model for a new sample. We develop a cross-validation estimation scheme based on an order-preserved sample-splitting strategy, and establish its asymptotic selection consistency under some mild conditions. Effectiveness of the proposed selection criterion is demonstrated on a variety of numerical experiments and real-data examples. Full Article
change Detecting relevant changes in the mean of nonstationary processes—A mass excess approach By projecteuclid.org Published On :: Wed, 30 Oct 2019 22:03 EDT Holger Dette, Weichi Wu. Source: The Annals of Statistics, Volume 47, Number 6, 3578--3608.Abstract: This paper considers the problem of testing if a sequence of means $(mu_{t})_{t=1,ldots ,n}$ of a nonstationary time series $(X_{t})_{t=1,ldots ,n}$ is stable in the sense that the difference of the means $mu_{1}$ and $mu_{t}$ between the initial time $t=1$ and any other time is smaller than a given threshold, that is $|mu_{1}-mu_{t}|leq c$ for all $t=1,ldots ,n$. A test for hypotheses of this type is developed using a bias corrected monotone rearranged local linear estimator and asymptotic normality of the corresponding test statistic is established. As the asymptotic variance depends on the location of the roots of the equation $|mu_{1}-mu_{t}|=c$ a new bootstrap procedure is proposed to obtain critical values and its consistency is established. As a consequence we are able to quantitatively describe relevant deviations of a nonstationary sequence from its initial value. The results are illustrated by means of a simulation study and by analyzing data examples. Full Article
change Sampling and estimation for (sparse) exchangeable graphs By projecteuclid.org Published On :: Wed, 30 Oct 2019 22:03 EDT Victor Veitch, Daniel M. Roy. Source: The Annals of Statistics, Volume 47, Number 6, 3274--3299.Abstract: Sparse exchangeable graphs on $mathbb{R}_{+}$, and the associated graphex framework for sparse graphs, generalize exchangeable graphs on $mathbb{N}$, and the associated graphon framework for dense graphs. We develop the graphex framework as a tool for statistical network analysis by identifying the sampling scheme that is naturally associated with the models of the framework, formalizing two natural notions of consistent estimation of the parameter (the graphex) underlying these models, and identifying general consistent estimators in each case. The sampling scheme is a modification of independent vertex sampling that throws away vertices that are isolated in the sampled subgraph. The estimators are variants of the empirical graphon estimator, which is known to be a consistent estimator for the distribution of dense exchangeable graphs; both can be understood as graph analogues to the empirical distribution in the i.i.d. sequence setting. Our results may be viewed as a generalization of consistent estimation via the empirical graphon from the dense graph regime to also include sparse graphs. Full Article
change Surface temperature monitoring in liver procurement via functional variance change-point analysis By projecteuclid.org Published On :: Wed, 15 Apr 2020 22:05 EDT Zhenguo Gao, Pang Du, Ran Jin, John L. Robertson. Source: The Annals of Applied Statistics, Volume 14, Number 1, 143--159.Abstract: Liver procurement experiments with surface-temperature monitoring motivated Gao et al. ( J. Amer. Statist. Assoc. 114 (2019) 773–781) to develop a variance change-point detection method under a smoothly-changing mean trend. However, the spotwise change points yielded from their method do not offer immediate information to surgeons since an organ is often transplanted as a whole or in part. We develop a new practical method that can analyze a defined portion of the organ surface at a time. It also provides a novel addition to the developing field of functional data monitoring. Furthermore, numerical challenge emerges for simultaneously modeling the variance functions of 2D locations and the mean function of location and time. The respective sample sizes in the scales of 10,000 and 1,000,000 for modeling these functions make standard spline estimation too costly to be useful. We introduce a multistage subsampling strategy with steps educated by quickly-computable preliminary statistical measures. Extensive simulations show that the new method can efficiently reduce the computational cost and provide reasonable parameter estimates. Application of the new method to our liver surface temperature monitoring data shows its effectiveness in providing accurate status change information for a selected portion of the organ in the experiment. Full Article
change Identifying multiple changes for a functional data sequence with application to freeway traffic segmentation By projecteuclid.org Published On :: Wed, 16 Oct 2019 22:03 EDT Jeng-Min Chiou, Yu-Ting Chen, Tailen Hsing. Source: The Annals of Applied Statistics, Volume 13, Number 3, 1430--1463.Abstract: Motivated by the study of road segmentation partitioned by shifts in traffic conditions along a freeway, we introduce a two-stage procedure, Dynamic Segmentation and Backward Elimination (DSBE), for identifying multiple changes in the mean functions for a sequence of functional data. The Dynamic Segmentation procedure searches for all possible changepoints using the derived global optimality criterion coupled with the local strategy of at-most-one-changepoint by dividing the entire sequence into individual subsequences that are recursively adjusted until convergence. Then, the Backward Elimination procedure verifies these changepoints by iteratively testing the unlikely changes to ensure their significance until no more changepoints can be removed. By combining the local strategy with the global optimal changepoint criterion, the DSBE algorithm is conceptually simple and easy to implement and performs better than the binary segmentation-based approach at detecting small multiple changes. The consistency property of the changepoint estimators and the convergence of the algorithm are proved. We apply DSBE to detect changes in traffic streams through real freeway traffic data. The practical performance of DSBE is also investigated through intensive simulation studies for various scenarios. Full Article
change ‘Selfish, tribal and divided’: Barack Obama warns of changes to American way of life in leaked audio slamming Trump administration By news.yahoo.com Published On :: Sat, 09 May 2020 07:22:00 -0400 Barack Obama said the “rule of law is at risk” following the justice department’s decision to drop charges against former Trump advisor Mike Flynn, as he issued a stark warning about the long-term impact on the American way of life by his successor. Full Article
change Detecting Structural Changes in Longitudinal Network Data By projecteuclid.org Published On :: Mon, 13 Jan 2020 04:00 EST Jong Hee Park, Yunkyu Sohn. Source: Bayesian Analysis, Volume 15, Number 1, 133--157.Abstract: Dynamic modeling of longitudinal networks has been an increasingly important topic in applied research. While longitudinal network data commonly exhibit dramatic changes in its structures, existing methods have largely focused on modeling smooth topological changes over time. In this paper, we develop a hidden Markov network change-point model (HNC) that combines the multilinear tensor regression model (Hoff, 2011) with a hidden Markov model using Bayesian inference. We model changes in network structure as shifts in discrete states yielding particular sets of network generating parameters. Our simulation results demonstrate that the proposed method correctly detects the number, locations, and types of changes in latent node characteristics. We apply the proposed method to international military alliance networks to find structural changes in the coalition structure among nations. Full Article
change Semiparametric Multivariate and Multiple Change-Point Modeling By projecteuclid.org Published On :: Tue, 11 Jun 2019 04:00 EDT Stefano Peluso, Siddhartha Chib, Antonietta Mira. Source: Bayesian Analysis, Volume 14, Number 3, 727--751.Abstract: We develop a general Bayesian semiparametric change-point model in which separate groups of structural parameters (for example, location and dispersion parameters) can each follow a separate multiple change-point process, driven by time-dependent transition matrices among the latent regimes. The distribution of the observations within regimes is unknown and given by a Dirichlet process mixture prior. The properties of the proposed model are studied theoretically through the analysis of inter-arrival times and of the number of change-points in a given time interval. The prior-posterior analysis by Markov chain Monte Carlo techniques is developed on a forward-backward algorithm for sampling the various regime indicators. Analysis with simulated data under various scenarios and an application to short-term interest rates are used to show the generality and usefulness of the proposed model. Full Article
change Comment: Empirical Bayes, Compound Decisions and Exchangeability By projecteuclid.org Published On :: Thu, 18 Jul 2019 22:01 EDT Eitan Greenshtein, Ya’acov Ritov. Source: Statistical Science, Volume 34, Number 2, 224--228.Abstract: We present some personal reflections on empirical Bayes/ compound decision (EB/CD) theory following Efron (2019). In particular, we consider the role of exchangeability in the EB/CD theory and how it can be achieved when there are covariates. We also discuss the interpretation of EB/CD confidence interval, the theoretical efficiency of the CD procedure, and the impact of sparsity assumptions. Full Article
change The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells By www.jneurosci.org Published On :: 1987-07-01 RU MullerJul 1, 1987; 7:1951-1968Articles Full Article
change Cortical Tonotopic Map Changes in Humans Are Larger in Hearing Loss Than in Additional Tinnitus By www.jneurosci.org Published On :: 2020-04-15T09:30:18-07:00 Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus. This large fMRI study on humans was intended to clarify the relations between hearing loss, tinnitus, and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high-frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness-matched pure-tone stimuli (0.25-8 kHz). In the bilateral auditory cortices, the high-frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared with the control group. This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group were significantly different from the controls, whereas the maps of those with tinnitus were not. These results show that higher response amplitudes and map reorganization are a characteristic of hearing loss, not of tinnitus. Both tonotopic maps and response amplitudes of tinnitus participants appear intermediate to the controls and hearing loss without tinnitus group. This observation suggests a connection between tinnitus and an incomplete form of central compensation to hearing loss, rather than excessive adaptation. One implication of this may be that treatments for tinnitus shift their focus toward enhancing the cortical plasticity, instead of reversing it. SIGNIFICANCE STATEMENT Tinnitus, a common and potentially devastating condition, is the presence of a "phantom" sound that often accompanies hearing loss. Hearing loss is known to induce plastic changes in cortical and subcortical areas. Although plasticity is a valuable trait that allows the human brain to rewire and recover from injury and sensory deprivation, it can lead to tinnitus as an unwanted side effect. In this large fMRI study, we provide evidence that tinnitus is related to a more conservative form of reorganization than in hearing loss without tinnitus. This result contrasts with the previous notion that tinnitus is related to excessive reorganization. As a consequence, treatments for tinnitus may need to enhance the cortical plasticity, rather than reverse it. Full Article
change Rapid Release of Ca2+ from Endoplasmic Reticulum Mediated by Na+/Ca2+ Exchange By www.jneurosci.org Published On :: 2020-04-15T09:30:18-07:00 Phototransduction in Drosophila is mediated by phospholipase C (PLC) and Ca2+-permeable TRP channels, but the function of endoplasmic reticulum (ER) Ca2+ stores in this important model for Ca2+ signaling remains obscure. We therefore expressed a low affinity Ca2+ indicator (ER-GCaMP6-150) in the ER, and measured its fluorescence both in dissociated ommatidia and in vivo from intact flies of both sexes. Blue excitation light induced a rapid (tau ~0.8 s), PLC-dependent decrease in fluorescence, representing depletion of ER Ca2+ stores, followed by a slower decay, typically reaching ~50% of initial dark-adapted levels, with significant depletion occurring under natural levels of illumination. The ER stores refilled in the dark within 100–200 s. Both rapid and slow store depletion were largely unaffected in InsP3 receptor mutants, but were much reduced in trp mutants. Strikingly, rapid (but not slow) depletion of ER stores was blocked by removing external Na+ and in mutants of the Na+/Ca2+ exchanger, CalX, which we immuno-localized to ER membranes in addition to its established localization in the plasma membrane. Conversely, overexpression of calx greatly enhanced rapid depletion. These results indicate that rapid store depletion is mediated by Na+/Ca2+ exchange across the ER membrane induced by Na+ influx via the light-sensitive channels. Although too slow to be involved in channel activation, this Na+/Ca2+ exchange-dependent release explains the decades-old observation of a light-induced rise in cytosolic Ca2+ in photoreceptors exposed to Ca2+-free solutions. SIGNIFICANCE STATEMENT Phototransduction in Drosophila is mediated by phospholipase C, which activates TRP cation channels by an unknown mechanism. Despite much speculation, it is unknown whether endoplasmic reticulum (ER) Ca2+ stores play any role. We therefore engineered flies expressing a genetically encoded Ca2+ indicator in the photoreceptor ER. Although NCX Na+/Ca2+ exchangers are classically believed to operate only at the plasma membrane, we demonstrate a rapid light-induced depletion of ER Ca2+ stores mediated by Na+/Ca2+ exchange across the ER membrane. This NCX-dependent release was too slow to be involved in channel activation, but explains the decades-old observation of a light-induced rise in cytosolic Ca2+ in photoreceptors bathed in Ca2+-free solutions. Full Article
change 5 critical things we learned from the latest IPCC report on climate change By www.fao.org Published On :: Wed, 02 Apr 2014 00:00:00 GMT Today leading international experts on climate change, the IPCC, presented their latest report on the impacts of climate change on humanity, and what we can do about it. It’s a lengthy report, so we’ve shrunk it down to Oxfam's five key takeaways on climate change and hunger. 1. Climate change: the impacts on crops are worse than we thought Climate change has [...] Full Article
change Plant a seed, grow a garden, change a life! By www.fao.org Published On :: Wed, 21 May 2014 00:00:00 GMT ‘‘—the first 1000 days are a critical window in a child’s development, but let’s not forget this child on day 1,001.’’ School nutrition programmes help to address the +1,001 day gap. Today, perceptions of school gardens are changing in response to increasingly urgent needs for greater food security, environmental protection, more secure livelihoods and better nutrition. School gardens have new multiple [...] Full Article
change Inspiring the young generation to take action against climate change - in pictures By www.fao.org Published On :: Wed, 01 Jun 2016 00:00:00 GMT Climate change is what most of us perceive as the top global threat, and the dangers it poses affect present and future generations alike. How global warming is threatening the planet has been a theme in children’s books for all ages for some time. How everyone, especially today’s youth, can make a difference to the future of the world [...] Full Article