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Body Dissatisfaction and Mental Health Outcomes of Youth on Gender-Affirming Hormone Therapy

OBJECTIVES:

Our first aim was to examine baseline differences in body dissatisfaction, depression, and anxiety symptoms by gender, age, and Tanner (ie, pubertal) stage. Our second aim was to test for changes in youth symptoms over the first year of receiving gender-affirming hormone therapy. Our third aim was to examine potential differences in change over time by demographic and treatment characteristics. Youth experiences of suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) are also reported.

METHODS:

Participants (n = 148; ages 9–18 years; mean age 14.9 years) were receiving gender-affirming hormone therapy at a multidisciplinary program in Dallas, Texas (n = 25 puberty suppression only; n = 123 feminizing or masculinizing hormone therapy). Participants completed surveys assessing body dissatisfaction (Body Image Scale), depression (Quick Inventory of Depressive Symptoms), and anxiety (Screen for Child Anxiety Related Emotional Disorders) at initial presentation to the clinic and at follow-up. Clinicians completed the Quick Inventory of Depressive Symptoms and collected information on youth experiences of suicidal ideation, suicide attempt, and NSSI.

RESULTS:

Affirmed males reported greater depression and anxiety at baseline, but these differences were small (P < .01). Youth reported large improvements in body dissatisfaction (P < .001), small to moderate improvements in self-report of depressive symptoms (P < .001), and small improvements in total anxiety symptoms (P < .01). No demographic or treatment-related characteristics were associated with change over time. Lifetime and follow-up rates were 81% and 39% for suicidal ideation, 16% and 4% for suicide attempt, and 52% and 18% for NSSI, respectively.

CONCLUSIONS:

Results provide further evidence of the critical role of gender-affirming hormone therapy in reducing body dissatisfaction. Modest initial improvements in mental health were also evident.




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Validation of a Prediction Rule for Mortality in Congenital Diaphragmatic Hernia

BACKGROUND:

Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with a mortality of ~27%. The Congenital Diaphragmatic Hernia Study Group (CDHSG) developed a simple postnatal clinical prediction rule to predict mortality in newborns with CDH. Our aim for this study is to externally validate the CDHSG rule in the European population and to improve its prediction of mortality by adding prenatal variables.

METHODS:

We performed a European multicenter retrospective cohort study and included all newborns diagnosed with unilateral CDH who were born between 2008 and 2015. Newborns born from November 2011 onward were included for the external validation of the rule (n = 343). To improve the prediction rule, we included all patients born between 2008 and 2015 (n = 620) with prenatally diagnosed CDH and collected pre- and postnatal variables. We build a logistic regression model and performed bootstrap resampling and computed calibration plots.

RESULTS:

With our validation data set, the CDHSG rule had an area under the curve of 79.0%, revealing a fair predictive performance. For the new prediction rule, prenatal herniation of the liver was added, and absent 5-minute Apgar score was taken out. The new prediction rule revealed good calibration, and with an area under the curve of 84.6%, it had good discriminative abilities.

CONCLUSIONS:

In this study, we externally validated the CDHSG rule for the European population, which revealed fair predictive performance. The modified rule, with prenatal liver herniation as an additional variable, appears to further improve the model’s ability to predict mortality in a population of patients with prenatally diagnosed CDH.




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Apple iMovie

Apple's excellent entry-level desktop video editing application can turn your footage and photos into impressive productions.




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Infusionsoft by Keap

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Champions League Fantasy: Captain marvel

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Barcelona v Napoli facts

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The God of India, Singapore and the Middle East

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Fin24.com | INFOGRAPHIC: How to get a pay rise

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Fin24.com | SIM-swap scams: How Vodacom protects you

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Fin24.com | Gauteng, Western Cape and KZN top list for card fraud

Gauteng, the Western Cape and KwaZulu-Natal are the hot spots for card fraud in South Africa, according to a report on global fraud activity.




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24 Hours With the Apollo Mood-Altering Wearable

Developed by physicians and neuroscientists, Apollo isn't the sleekiest of wearables—you might mistake it for a court-ordered ankle bracelet—but it put a little pep in my step, and is an interesting talking point, if nothing else.




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Hegerberg happy to share the love as role model

For Norwegian international striker Ada Hegerberg, inspiring the next generation of women's players is a personal goal. In an interview which appears in the Women's U17 EURO tournament programme, we hear that the Olympique Lyonnais star wants budding young players to feel her same love of the game.




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Fin24.com | Investors struggling to find returns and protect their capital in unusual prevailing climate

Extremely low or negative yields in global markets make it challenging for investors to generate meaningful returns, says Brian McMillan of Investec Structured Products.




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The God of India, Singapore and the Middle East

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.




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Legal clinic at Happy Valley LaunchBox expands scope in response to pandemic

Effective immediately and for the foreseeable future, the Entrepreneurship and Assistance Clinic is expanding its scope and service offerings to small Pennsylvania businesses, in response to the COVID-19 pandemic.




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New Virtual Idea TestLab application deadline is May 15

Happy Valley LaunchBox powered by PNC Bank is accepting applications through May 15 for its Idea TestLab that will now be hosted virtually in June. Open to the community, the four-week Idea TestLab program is designed to help teams evaluate the viability of their business ideas by coaching them through a proven method of customer discovery and problem analysis.




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AAP Publications Reaffirmed or Retired




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Fin24.com | Unit trusts appeal to me because:

Unit trusts appeal to me because:




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How to Free Up Space on Your Apple Watch

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Ditch That Headphone Splitter: How to Share Audio With Apple's AirPods

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The Best Apple AirPods Pro Tips and Tricks

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3 Apple Health Research Studies You Can Enroll In Now

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How to Automate Your Life With Apple's iOS Shortcuts App

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How to Track Your Sleep on Apple Watch

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Rumor: No Free Version of Apple's Streaming Service

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Apple Boosts AppleCare+ Battery Support

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Apple Music vs. Spotify: Which Is Best?

Today, Apple takes on the biggest name in music streaming, Spotify. How do they measure up to each other?




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Apple Needs New iPods, But Not for Music

New iPods can be a critical part of Apple's strategy. Just don't think of them as music players.




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Apple Refreshes iPod Touch With Better Camera, Chip

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A Visual History of the Apple iPod

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Apple iPod touch (2015)

The Apple iPod touch is the best media player there is if you don't want a cellular connection.




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Kids React to First-Gen Apple iPod

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Report: Apple Pushing iPods to Stores' Accessory Wall

Customers in the U.S. should begin noticing in-store changes starting today.




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Snag a 'Metal Gear Solid' Walkman (in Japan)

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Tidal's iPod? Hands On With Echobox's Flask-Shaped Explorer X1

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Why I Bought an Apple iPod Nano in 2016

Streaming services and complicated gadgets aren't for me. Sometimes single-purpose retro tech is all you need.




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5 Reasons to Buy Apple's New iPod Touch

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Apple iPod touch (2019)

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Velocity Micro Raptor Z55a (Ryzen 9 3950X)

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11 Apps and Services to Help You Stay Safe on Campus

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How to Capture Important Data With Scanning and OCR Apps

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Apple Music

Apple Music boasts a deep music well Siri and Apple Watch compatibility, but this well-rounded streaming music service falls just short of joining LiveXLive and Spotify as the best in class.




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Google Pulls Open-Source Android App for Having Donation Button

Google removes the free WireGuard app from the Play Store for having a donation button, reigniting a debate over whether its policy hurts the open-source community.




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15 Android Apps Actually Worth Paying For

Free apps are cool, but a few bucks can get you so much more. If you are looking to buy in the Google Play store, here are the best paid Android apps to put on your phone.




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The 30 Best Amazon Fire Tablet Apps

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The Best To-Do List Apps for 2020

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The 100 Best Android Apps for 2020

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The Best Fitness Apps for 2020

Whether you're looking to slim down, bulk up, run farther, bike faster, swim better, keep a new year's resolution, or just get healthier, these apps can help you meet your fitness goals in 2020.




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The Best Parental Control Apps for Your Phone

If you want to keep your kids safe online, you need a parental control solution that monitors all of their devices, including phones and tablets. These apps are the top cross-platform performers in our testing.




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Deals: Gaming PCs, Dell Laptops, Fitbit Tracker, Anker Accessories

Dell's SAVE15 coupon is still live, the Dell Vostro 14 3000 is back down to just $299, and Walmart's Overpowered gaming desktop is $800 off right now.