Stone, E. Constance (Emma Constance), 1856-1902.

Extinction Rebellion (Organisation).

Advertising -- Psychological aspects.

Sisters -- Fiction.

Brill Online Books and Journals is the delivery platform that provides online access to the full text of individual Brill journals. The Wellcome Library offers access to selected titles from this publisher.

The Indiana state teachers' union is pushing to protect student and staff safety during active-shooter trainings.

London : J. Churchill, [1868]

[London?] : [publisher not identified], [1850]

Stuttgart : F. Enke, 1895.

Paris : Roret, 1834-1854.

Paris : Baudouin, 1803.

Few things in sports are better than overtime in the Stanley Cup Playoffs, and May 8 has seen the Boston Bruins play in a couple memorable games that required bonus hockey.

São Paulo : Governo do Estado de Sao Paulo, Secretaria da Segurança Pública, 1975.

São Paulo : Serviço Grafíco da Secretaria da Segurança Pública, 1976.

São Paulo : Serviço Grafíco da Secretaria da Segurança Pública, 1976.

One of the common tasks in unsupervised learning is dimensionality reduction, where the goal is to find meaningful low-dimensional structures hidden in high-dimensional data. Sometimes referred to as manifold learning, this problem is closely related to the problem of localization, which aims at embedding a weighted graph into a low-dimensional Euclidean space. Several methods have been proposed for localization, and also manifold learning. Nonetheless, the robustness property of most of them is little understood. In this paper, we obtain perturbation bounds for classical scaling and trilateration, which are then applied to derive performance bounds for Isomap, Landmark Isomap, and Maximum Variance Unfolding. A new perturbation bound for procrustes analysis plays a key role.

Official counts of COVID-19 deaths have been criticized for potentially including people who did not die of COVID-19 but merely died with COVID-19. I address that critique by fitting a generalized additive model to weekly counts of all registered deaths in England and Wales during the 2010s. The model produces baseline rates of death registrations expected in the absence of the COVID-19 pandemic, and comparing those baselines to recent counts of registered deaths exposes the emergence of excess deaths late in March 2020. Among adults aged 45+, about 38,700 excess deaths were registered in the 5 weeks comprising 21 March through 24 April (612 $pm$ 416 from 21$-$27 March, 5675 $pm$ 439 from 28 March through 3 April, then 9183 $pm$ 468, 12,712 $pm$ 589, and 10,511 $pm$ 567 in April's next 3 weeks). Both the Office for National Statistics's respective count of 26,891 death certificates which mention COVID-19, and the Department of Health and Social Care's hospital-focused count of 21,222 deaths, are appreciably less, implying that their counting methods have underestimated rather than overestimated the pandemic's true death toll. If underreporting rates have held steady, about 45,900 direct and indirect COVID-19 deaths might have been registered by April's end but not yet publicly reported in full.

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Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which mediate cell-to-cell inflammatory and trophic signaling, are thought be viable therapeutic targets. We recently showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of function after injury of the primary motor cortex, likely through enhancing plasticity in perilesional motor and premotor cortices. Here, using in vitro whole-cell patch-clamp recording and intracellular filling in acute slices of ventral premotor cortex (vPMC) from rhesus monkeys (Macaca mulatta) of either sex, we demonstrate that MSC-EVs reduce injury-related physiological and morphologic changes in perilesional layer 3 pyramidal neurons. At 14-16 weeks after injury, vPMC neurons from both vehicle- and EV-treated lesioned monkeys exhibited significant hyperexcitability and predominance of inhibitory synaptic currents, compared with neurons from nonlesioned control brains. However, compared with vehicle-treated monkeys, neurons from EV-treated monkeys showed lower firing rates, greater spike frequency adaptation, and excitatory:inhibitory ratio. Further, EV treatment was associated with greater apical dendritic branching complexity, spine density, and inhibition, indicative of enhanced dendritic plasticity and filtering of signals integrated at the soma. Importantly, the degree of EV-mediated reduction of injury-related pathology in vPMC was significantly correlated with measures of behavioral recovery. These data show that EV treatment dampens injury-related hyperexcitability and restores excitatory:inhibitory balance in vPMC, thereby normalizing activity within cortical networks for motor function.

SIGNIFICANCE STATEMENT Neuronal plasticity can facilitate recovery of function after cortical injury, but the underlying mechanisms and efficacy of therapeutic interventions promoting this plasticity in primates are not well understood. Our recent work has shown that intravenous infusions of mesenchymal-derived extracellular vesicles (EVs) that are involved in cell-to-cell inflammatory and trophic signaling can enhance recovery of motor function after injury in monkey primary motor cortex. This study shows that this EV-mediated enhancement of recovery is associated with amelioration of injury-related hyperexcitability and restoration of excitatory-inhibitory balance in perilesional ventral premotor cortex. These findings demonstrate the efficacy of mesenchymal EVs as a therapeutic to reduce injury-related pathologic changes in the physiology and structure of premotor pyramidal neurons and support recovery of function.

Despite the name, moon won’t have a rosy hue. The name alludes to flowers that bloom in April

Though not as plentiful as the Perseids in summer, the Lyrids can serve up some serious fireballs

Your feedback on our 50th anniversary issue showcasing success stories in conservation

In the 1920s, the U.S. was in full thrill-seeking mode. From horse-diving (you have to see it to believe it) to barnstorming. And at the center of many of these activities were a group of daring young women.

Fifty thousand jobs were lost in Nova Scotia in April, reflecting the devastating economic impact of the first full month of public health orders to prevent the spread of COVID-19.

P.E.I. had the lowest unemployment rate in the country in April, but behind that seemingly strong showing are hiding problems in the labour market.

Todd Colvin, Ambrosino Brothers

Larry Shover, Efficient Advisors

Bob Iaccino, Path Trading Partners

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Larry Shover, Efficient Advisors

Bob Iaccino, Path Trading Partners

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Todd Colvin, Ambrosino Brothers

Todd Colvin, Ambrosino Brothers