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Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




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Small-scale handloom park to come up at Sengunthapuram

Ministers R. Gandhi and S.S. Sivashankar inspect the 13,205 sq. ft. site belonging to the Tamil Nadu Cotton Corporation at Sengunthapuram




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Site identified for small-scale handloom park in Karur




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Unsuccessful malls on the verge of closure

Poor management practices have resulted in many malls across the country becoming unviable spaces.




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Craft beer: Growth in small batches

A favourite with millennials and GenZ for their artisanal products, microbreweries are set to expand, backed by VCs 




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Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail

In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation”




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Policy prescription for economic and political maladies

Bimal Jalan delves deep into issues that are critical to the country with suggestions on how to overcome challenges 




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How can small-scale farmers benefit from trees on farms?

The adoption of agroforestry at scale in India by smallholders is currently stymied by ecological and socio-economic factors




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Above-normal pre-monsoon rain triggers agriculture activities in Raichur district of Karnataka

The district received 26.5 mm of rain in 72 hours against the average of 1.9 mm




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 Kuruvai coverage rose by 40% above normal in last five years

The normal coverage is about 3.24 lakh acres for the delta. However, going by the average for the last five years, the figure comes to 4.57 lakh acres — a nearly 40% rise.




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More aquatic animals were farmed than fished in 2022, for the first time ever

The total amount of aquatic animals captured in the wild fell to 91 million tonnes and the global production rose to 94.4 million in 2022, the FAO said




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Scientists found a bacteria tricked a wasp to get rid of its males

A new study reports Wolbachia may have taken it a bit too far, after scientists found it manipulated the evolution of Encarsia formosa wasps




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Mangrove restoration in T.N. makes a small but steady progress

The Tamil Nadu Forest Department and non-governmental organisations are working to restore mangroves at various sites of the Ennore-Pulicat wetlands. In the meantime, the National Centre for Coastal Research has identified land available for restoration in Cuddalore, Tiruvarur, Thanjavur, Pudukkottai, Ramanathapuram, and Thoothukudi




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ICAR team makes tool small enough to edit plant genomes

In a genome-editing landscape low on options for plants, the new tool has scientists enthused about its applications in agriculture




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PM Modi expresses condolences over demise of renowned organic farmer Pappammal

In 2021, she was given the Padma Shri award for popularising organic farming in India and was regarded as a pioneer in the agriculture field




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Shoppers’ paradise lost? Singapore’s malls suffer as locals, tourists curb spending




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Pammal Sambandha Mudaliar’s contribution to modern Tamil drama remembered

SASTRA’s the School of Arts, Sciences, Humanities and Education, in collaboration with Sahitya Akademi, organises seminar on the celebrated playwright in Thanjavur




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Kamal Haasan@70: Madras celebrates as its very own star




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Kamal Haasan tells people, fans to not address him as ‘Ulaganayagan’

The star also requested his fans, members of the film fraternity, media, party cadres and ‘fellow Indians’ to refer to him ‘simply as Kamal Haasan or Kamal or KH’




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Perumal Murugan’s Maadhorupaagan translated into French from Tamil

Major challenge in translating the book has been to find a way to avoid using past perfects en masse, says Leticia Ibanez




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Ion effects on minimally hydrated polymers: hydrogen bond populations and dynamics

Soft Matter, 2024, 20,8291-8302
DOI: 10.1039/D4SM00830H, Paper
Open Access
Eman Alasadi, Carlos R. Baiz
Compared to bulk water, ions in confined environments or heterogeneous solutions can significantly disrupt hydrogen bond networks.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-assembly of amphiphilic homopolymers grafted onto spherical nanoparticles: complete embedded minimal surfaces and a machine learning algorithm for their recognition

Soft Matter, 2024, 20,8385-8394
DOI: 10.1039/D4SM00616J, Paper
D. A. Mitkovskiy, A. A. Lazutin, A. L. Talis, V. V. Vasilevskaya
Amphiphilic macromolecules grafted onto spherical nanoparticles can self-assemble into morphological structures corresponding to the family of complete embedded minimal surfaces. They arise situationally, can coexist and transform into each other.
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Optimality and cooperativity in superselective surface binding by multivalent DNA nanostars

Soft Matter, 2024, 20,8515-8523
DOI: 10.1039/D4SM00704B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christine Linne, Eva Heemskerk, Jos W. Zwanikken, Daniela J. Kraft, Liedewij Laan
Our study shows that DNA nanostars with three binding sites (ligands) can (1) bind superselectively to surfaces based on receptor density, and (2) that interactions between ligands affect the optimum number of ligands required for superselectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Random field reconstruction of three-phase polymer structures with anisotropy from 2D-small-angle scattering data

Soft Matter, 2024, 20,8493-8504
DOI: 10.1039/D4SM00721B, Paper
Open Access
Stephen Kronenberger, Nitant Gupta, Benjamin Gould, Colin Peterson, Arthi Jayaraman
We present a computational method to analyze 2D small-angle scattering data from three-phase soft materials systems with structural anisotropy and output representative real-space structures of the three phases.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Modeling nematic phase main-chain liquid crystal elastomer synthesis, mechanics, and thermal actuation via coarse-grained molecular dynamics

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00528G, Paper
Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kroger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg
This paper presents a coarse-grained molecular dynamics simulation study of the synthesis, mechanics, and thermal actuation of nematic phase main-chain liquid crystal elastomers (LCEs), a type of soft, temperature-responsive, polymeric...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pickering emulsions for stimuli-responsive transdermal drug delivery: effect of rheology and microstructure on performance

Soft Matter, 2024, 20,8621-8637
DOI: 10.1039/D4SM00993B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Simona Migliozzi, Yiting He, Maryam Parhizkar, Yang Lan, Panagiota Angeli
Elucidating the impact of microgels attributes on the microstructure, rheology and functionality of Pickering emulsions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-consistent electrostatic formalism of bulk electrolytes based on the asymmetric treatment of the short- and long-range ion interactions

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01174K, Paper
Sahin Buyukdagli
Internal energy of monovalent electrolytes (left) and dimensionless screening parameter of multivalent electrolytes (right).
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Editorial. Small-scale commercial nuclear reactors, the way forward

It is increasingly being realised that achieving net-zero is not possible without nuclear energy




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Suryoday Small Finance Bank’s net profit dips 10% in Q2FY25 to ₹45 cr

Net interest margin rose to 9.7 per cent in Q2FY25 against 9.4 per cent in Q2FY24



  • Money & Banking

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Regional Rural Banks may see a fourth round of amalgamation; number of banks likely to come down from 43 to 28

The proposed move is part of the Government’s ‘One State-One RRB’ goal



  • Money & Banking

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Fervour marks annual ‘Pushpa Yagam’ at Tirumala

The festivities begin with ‘Snapana Thirumanjanam’ to the deities of Lord Malayappa and his two consorts




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Master plan soon to develop Srisailam and tourism in Nallamala, says Andhra Pradesh Chief Minister Chandrababu Naidu

A committee comprising three Cabinet Ministers will be constituted for the purpose, says Chandrababu Naidu; he warns of severe action against those resorting to character assassination of women and children




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Syed Iftekhar Jamal named for Urdu Academy award

Mr. Jamal has been writing Urdu poetry since 1987, many of his works were published in Urdu dailies and magazines like Saalar, Siyasat, Etemaad and Dabistan




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Functional equations and how to solve them [electronic resource] / Christopher G. Small

New York, N.Y. : Springer Science, 2007




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Poojary asks officials to hasten Karavali junction-Malpe stretch highway widening project by paying compensation to land losers by November 10




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Pilikula zoo gets new attractions in the form of Asiatic Lion, other animals and birds




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CAD Foundation of Mangaluru donates ECG machines for screening Sabarimala pilgrims in Kerala

With this, the foundation completes donating 1,000 ECG machines to many health facilities across India since 2018




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Komal Panda on being the national winner of the James Dyson Award 2024

Her Novocarry is a portable cooling solution designed for medications like insulin that require refrigeration during transport




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ISRO, IIT-M sign MoU to set up centre of excellence in fluid and thermal sciences

The institute gets ₹1.84 crore seed money to set up the centre of excellence




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Nirmala Sitharaman to meet State FMs for pre-Budget, GST Council meet on Dec 21-22

The meeting assumes significance as State Finance Ministers will present their recommendations for the 2025-26 Budget to be unveiled on February 1, 2025




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Will it be a normal monsoon this time?




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Positive response to Small and Medium REITs: SEBI Chief

There is an imbalance of power between large institutions and small investors, and regulations have helped foster trust in the system, Says Madhabi Puri Buch




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Nexus Select Trust in talks to acquire Axis Mall in Kolkata

The acquisition of the mall would require a different structure to be set in place since it does not have a single owner or promoter




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EFC gets SEBI nod for India’s first small & medium REIT IPO 

With plans for a ₹500 crore IPO through its subsidiary, EFC REIT, the company aims to enhance its investment management and commercial real estate operations.




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‘India an outlier as global real estate slowly returns to normalcy’

The big difference with India is that we saw when the GCCs retracted for a time, the Indian domestic market filled that void. And we’re about to see the largest take-up in offices probably in 2024. And that is a strong diversified market: William Beardmore-Gray




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Art in small packages

Watch A Short Film Festival on September 5