Wink customers will soon have to pay a monthly subscription fee to access any of the smart home hardware that they have purchased.

A pair of model numbers recently discovered in multiple international regulatory filings hinted at a next-generation Beats headphone, but new information suggests the device may actually be related to an existing product that's already in circulation.

Apple has refreshed the 13-inch MacBook Pro with Magic Keyboard, the start of Apple's online WWDC has been announced, the iPad Pro Smart Keyboard gets a teardown, and your hosts provide a massive roundup of HomeKit and smart home devices.

Being able to have an overview of changes to designs since initial release is an important aspect to time-efficient engineering. Making use of an automatically updated revision table helps with that.  What version are we using? Who has made these

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CNA Staff, May 7, 2020 / 03:45 pm (CNA).- Hours after the publication of a controversial open letter regarding the coronavirus pandemic, the prefect of the Church’s dicastery for liturgy and sacraments, listed among the signers of the letter, said he did not sign it.

The letter, titled “Appeal for the Church and the World,” says the coronavirus pandemic has been exaggerated to foster widespread social panic and undercut freedom, as a preparation for the establishment of a one-world government.

Cardinal Robert Sarah, prefect of the Vatican's Congregation for Divine Worship and Sacraments, tweeted: “I share on a personal basis some of the questions or concerns raised with regard to restrictions on fundamental freedoms, but I have not signed this petition.”

“A cardinal prefect of the Roman Curia must observe a certain reserve in political matters, Sarah wrote in another tweet, “so I explicitly asked this morning the authors of the petition titled ‘for the Church and for the world’ not to mention me.”

Sarah was listed as a signatory of the letter when it was published May 7 by the National Catholic Register, LifeSiteNews, and other websites. Sarah's denial raises questions about the legitimacy of other reported signatories to the letter.

Jeanette DeMelo, editor of the National Catholic Register, told CNA that the principal author of the letter is Archbishop Carlo Vigano, a former papal emissary to the United States.

Vigano made headlines for an August 2018 letter that alleged Vatican officials had ignored warnings about the sexual abuse of disgraced former cardinal Theodore McCarrick. Since that time, Vigano has released numerous letters expressing his viewpoints on matters in the Church, which include criticisms of Pope Francis and other curial officials.

DeMelo said that Vigano had vouched for the authenticity of Sarah's signature.

“The Register contacted Archbishop Vigano, the principal author, and asked him specifically about the authenticity of the signature of Cardinal Sarah and he said ‘I can confirm 100% that Cardinal Sarah signed it.,” DeMelo told CNA.

The letter laments the social distancing and stay-at-home orders issued to slow the spread of the coronavirus pandemic, suggesting they are contrived mechanisms of social control, with a nefarious purpose.

“We have reason to believe, on the basis of official data on the incidence of the epidemic as related to the number of deaths, that there are powers interested in creating panic among the world’s population with the sole aim of permanently imposing unacceptable forms of restriction on freedoms, of controlling people and of tracking their movements,” the letter said.

“The imposition of these illiberal measures is a disturbing prelude to the realization of a world government beyond all control,” it added. (bold original)

Among the letter’s reported signatories are four cardinals: Sarah, who has now indicated he is not a signatory; Cardinal Gerhard Muller, former prefect of the Congregation for the Doctrine of the Faith, Cardinal Joseph Zen, emeritus bishop of Hong Kong, and Cardinal Janis Pujats, emeritus archbishop of Riga, Latvia.

Two U.S. bishops are also alleged signatories: Bishop Rene Gracida, emeritus bishop of Corpus Christi, and Bishop Joseph Strickland, the Bishop of Tyler, Texas. 

Strickland told CNA by email May 7 that he “did sign off on this letter.”

Along with several other bishops, the well-known auxiliary bishop of Astana, Kazakhstan, Bishop Athanasius Schneider, is listed as a signer of the letter.

Another reported signatory is Fr. Curzio Nitoglia, a priest of the Society of St. Pius X, a traditionalist group in “irregular communion” with the Church. Nitoglia is the author of “The Magisterium of Vatican II,” a 1994 article that claims that “the church of Vatican II is therefore not the Apostolic and Roman Catholic Church instituted by our Lord Jesus Christ.”

The May 7 letter argued that the coronavirus pandemic has been sensationalized and exploited, to impede civil rights and exact government control over individuals and families.

The letter said that “the facts have shown that, under the pretext of the Covid-19 epidemic, the inalienable rights of citizens have in many cases been violated and their fundamental freedoms, including the exercise of freedom of worship, expression and movement, have been disproportionately and unjustifiably restricted.”

“Many authoritative voices in the world of science and medicine confirm that the media’s alarmism about Covid-19 appears to be absolutely unjustified.”

Nearly 4 million people worldwide have tested positive for the coronavirus, and at least 270,000 have died. In some countries, death rates in the months of the coronavirus pandemic have far exceeded death rates over the same months in previous years, suggesting to some demographers and epidemiologists that coronavirus deaths have been dramatically undercounted.

The pandemic, and the social distancing and stay-at-home orders issued to slow its spread, have become a source of considerable controversy in recent weeks. In the U.S., protests in several state capitals have gathered demonstrators in close proximity to one another, a move public health experts say could lead to new outbreaks of the disease.

The letter said that the economic crisis occasioned by the global pandemic “encourages interference by foreign powers and has serious social and political repercussions. Those with governmental responsibility must stop these forms of social engineering, by taking measures to protect their citizens whom they represent, and in whose interests they have a serious obligation to act.”

“The criminalization of personal and social relationships must likewise be judged as an unacceptable part of the plan of those who advocate isolating individuals in order to better manipulate and control them,” the authors added.

No cure or therapeutic treatment has yet been identified for the virus. In early weeks of the pandemic, President Donald Trump hypothesized that hydroxychloroquine, an inexpensive anti-malarial medication, could help treat the disease. U.S. researchers have largely moved away from the medication, especially after a study by the Veterans’ Administration found that administering the drug leads to higher death rates among patients receiving it.

Some, including television hosts Laura Ingraham and Sean Hannity have alleged that the study is inaccurate. Some protestors have suggested the VA study was intended to discredit Trump or profit vaccine manufacturers.

In an apparent reference to the hydroxychloroquine controversy, the letter said that: “Every effort must be made to ensure that shady business interests do not influence the choices made by government leaders and international bodies. It is unreasonable to penalize those remedies that have proved to be effective, and are often inexpensive, just because one wishes to give priority to treatments or vaccines that are not as good, but which guarantee pharmaceutical companies far greater profits, and exacerbate public health expenditures.” 

“Let us also remember, as Pastors, that for Catholics it is morally unacceptable to develop or use vaccines derived from material from aborted fetuses,” the letter added.

The U.S. bishops conference has also said vaccine development should avoid unethical links to abortion.

The letter argues that governments do not have the right to ban or restrict public worship or other kinds of ministry, and asks that any such restrictions be rescinded.

On the sacraments, which have been subject both to voluntary restrictions and public health orders in some states, the letter noted that “the Church firmly asserts her autonomy to govern, worship, and teach.”

“The State has no right to interfere, for any reason whatsoever, in the sovereignty of the Church. Ecclesiastical authorities have never refused to collaborate with the State, but such collaboration does not authorize civil authorities to impose any sort of ban or restriction on public worship or the exercise of priestly ministry. The rights of God and of the faithful are the supreme law of the Church, which she neither intends to, nor can, abdicate. We ask that restrictions on the celebration of public ceremonies be removed.”

While restrictions on public worship have been met with public criticism in many places, the objections have been most pronounced in Italy.

After Italy’s prime minister announced in late April new health measures that would continue prohibiting religious gatherings, the Italian bishops released a statement denouncing the decision, which the bishops criticized as “arbitrary.” Two days later, Pope Francis seemed to signal his own view, praying while celebrating Mass that Christians would respond to the lifting of lockdown restrictions with “prudence and obedience.”

Along with cardinals, bishops, and priests, the letter’s signatories also included some academics, journalists, and scientists. Included among them are Vatican journalists Marco Tosatti and Robert Moynihan, Lifesitenews editor John-Henry Westen, Stephen Mosher, president of the Virginia-based Population Research Institute, and the leaders of pro-life groups in Texas and Ohio.

The letter’s signatories encouraged Catholics, and “all men and women of good will” to “assess the current situation in a way consistent with the teaching of the Gospel. This means taking a stand: either with Christ or against Christ.” (bold original)
 
“Let us not allow centuries of Christian civilization to be erased under the pretext of a virus, and an odious technological tyranny to be established, in which nameless and faceless people can decide the fate of the world by confining us to a virtual reality. If this is the plan to which the powers of this earth intend to make us yield, know that Jesus Christ, King and Lord of History, has promised that ‘the gates of Hell shall not prevail’ (Mt 16:18).”

The Holy See has not yet commented on the letter.
 

This story has been updated since its original publication. It is developing and will continue to be updated.

The nutritional and immunologic properties of human milk, along with clear evidence of dose-dependent optimal health outcomes for both mothers and infants, provide a compelling rationale to support exclusive breastfeeding. US women increasingly intend to breastfeed exclusively for 6 months. Because establishing lactation can be challenging, exclusivity is often compromised in hopes of preventing feeding-related neonatal complications, potentially affecting the continuation and duration of breastfeeding. Risk factors for impaired lactogenesis are identifiable and common. Clinicians must be able to recognize normative patterns of exclusive breastfeeding in the first week while proactively identifying potential challenges. In this review, we provide new evidence from the past 10 years on the following topics relevant to exclusive breastfeeding: milk production and transfer, neonatal weight and output assessment, management of glucose and bilirubin, immune development and the microbiome, supplementation, and health system factors. We focus on the early days of exclusive breastfeeding in healthy newborns ≥35 weeks’ gestation managed in the routine postpartum unit. With this evidence-based clinical review, we provide detailed guidance in identifying medical indications for early supplementation and can inform best practices for both birthing facilities and providers.

Having car insurance is a legal requirement for motorists, but whether it’s valid or not depends on how accurate the current information your insurance company holds is.

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director.

OM Director's Update from Lawrence Tong, International Director

OM Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update by Lawrence Tong, International DIrector

OM Director's Update from Lawrence Tong

OM Director's Update from Lawrence Tong, International director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong

To say that amateur golf in Scotland has been slow to adapt to change is putting it kindly. But where the rise of the nomads, the Equality Act, the credit crunch and repeated faltering reform efforts have failed, perhaps Covid-19 will finally be the shock that thrusts the sector into a meaningful if seriously belated overhaul.

Scottish Golf today revealed that no date has been set for the sport in this country to restart and stressed that lockdown restrictions will remain in place for the foreseeable future.

Affinity groups known as caucuses let teacher-candidates at the University of Washington gather with others who share part of their identity, such as race, ethnicity, gender, or sexual orientation.

The Education Department wants states to re-submit "equity plans" to ensure that effective teachers are matched with disadvantaged and minority students.

Force or farce?

SOMETIMES, for a giggle, I like to imagine what Scotland would have been like had we kept the oil for ourselves. Like Saudi Arabia without the weather and executions, maybe? Or more like canny Norway, investing the cash in a big brolly for some future rainy day?

Without rigorous research that accurately reflects the current population, early education won't deliver for all students, write two education researchers.

Three teams of youngsters from the United States were given the chance to impress at the UEFA Champions Festival with a series of special exhibition matches in Munich.

OM Japan Tsunami April Update

Since it was announced publicly that OM Japan were ready to receive volunteers, many people wrote to express interest and requested for more information. This past week (23 - 27 May), OM Japan took their first volunteer group, consisting of 3 foreigners and 4 Japanese to Miyagi prefecture to help with clearing up rubble and bringing encouragement.

There are five key values to consider when separating campaign rhetoric from how a candidate would actually govern, writes Robert Feirsen.

Candidate genes involved in thrombophilia, inflammation, and preterm birth have previously been associated with cerebral palsy. Most studies to date have included small cohorts, did not allow for multiple testing, and require replication.

This study of children with cerebral palsy and their mothers did not confirm previously reported candidate gene associations. Prothrombin gene mutation was associated with hemiplegia in children born at term to mothers with a reported infection during pregnancy. (Read the full article)

Children and adolescents with attention-deficit/hyperactivity disorder are prone to sustaining trauma that requires emergency department (ED) admission. Methylphenidate can reduce attention-deficit/hyperactivity disorder symptoms and thus theoretically may reduce the risk of trauma-related ED admission, but previous studies did not provide a clear association.

For patients treated with methylphenidate, on-medication periods were associated with lower rates of trauma-related ED admission compared with off-medication periods. A similar protective association was found in both genders. Potential treatment benefit was greater for age ≥16 years. (Read the full article)

Discharge from the NICU requires coordination and may be delayed for nonmedical reasons. Predicting when patients will be medically ready for discharge can avoid these delays and result in cost savings for the hospital.

We developed a supervised machine learning approach using real-time patient data from the daily neonatology progress note to predict when patients will be medically ready for discharge. (Read the full article)

Central apnea sometimes complicates bronchiolitis. Because apnea tends to occur early in the course of bronchiolitis, there is a danger that infants may be discharged from the emergency department only to subsequently develop apnea at home.

This study prospectively derived clinical decision rules to help emergency physicians admit infants at risk for apnea while discharging those not at risk. (Read the full article)

With Pennsylvania Gov. Tom Wolf’s March 25 “Stay at Home” order, Penn State is updating the status of its Abington, Brandywine and Great Valley campuses.

The FIFA Women's World Cup qualifying group stage has begun with the likes of England, Norway, Germany, Iceland and Austria all in goalscoring form.

European champions the Netherlands opened qualifying with a dramatic defeat of Norway as Iceland shocked Germany before being held themselves in October's fixtures.

England, Switzerland, Sweden, Italy, Spain and Finland maintained their perfect records but European champions the Netherlands were held by the Republic of Ireland.

Several of the already existing restrictions on U.S. Secretary of Education Betsy DeVos' authority to waive federal education law deal with school funding.

A new online newsletter offered by Penn State Extension will give readers “the scoop” on the spotted lanternfly.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lies behind the ongoing outbreak of coronavirus disease 2019 (COVID-19). There is a growing understanding of SARS-CoV-2 in the virology, epidemiology and clinical management strategies. However, no anti-SARS-CoV-2 drug or vaccine has been officially approved due to the absence of adequate evidence. Scientists are racing towards the development of treatment for COVID-19. Recent studies have revealed many attractive threptic options, even if some of them remain to be further confirmed in rigorous preclinical models and clinical trials. In this minireview, we aim to summarize the updated potential approaches against SARS-CoV-2. We emphasize that further efforts are warranted to develop the safest and most effective approach.

Background. CLSI and EUCAST susceptibility breakpoints for voriconazole and C. albicans differ by one dilution (≤0.125 and ≤0.06 mg/l, respectively) whereas the epidemiological cutoff values (ECOFF/ECV) with both methodologies are the same (0.03 mg/L). We therefore determined the pharmacokinetic-pharmacodynamic (PK/PD) breakpoints of voriconazole against C. albicans for both methodologies with an in vitro PK/PD model, which was validated using existing animal PK/PD data.

Methods. Four clinical wild-type and non-wild-type C. albicans isolates (voriconazole MICs 0.008-0.125 mg/l) were tested in an in vitro PK/PD model. For validation purposes, mouse PK were simulated and in vitro PD were compared with in vivo outcome. Human PK were simulated and the exposure-effect relationship fAUC_0-24/MIC was described for EUCAST and CLSI24/48h methods. PK/PD breakpoints were determined using the fAUC_0-24/MIC associated with half-maximal activity (EI₅₀) and Monte Carlo simulation analysis.

Results. The in vitro 24h-PD EI₅₀ of voriconazole against C. albicans were 2.5-5 (1.5-17) fAUC/MIC. However, the 72h-PD were higher, 133 (51-347) fAUC/MIC for EUCAST and 94 (35-252) fAUC/MIC for CLSI. The mean (95% confidence interval) probability of target attainment (PTA) was 100(95-100)%, 97(72-100)%, 83(35-99)%, and 49(8-91)% and 100(97-100)%, 99(85-100)%, 91(52-100)% and 68(17-96)% for EUCAST and CLSI MICs 0.03, 0.06, 0.125, and 0.25 mg/L, respectively. Significantly, >95% PTAs were found for EUCAST/CLSI MICs ≤0.03 mg/ll. For MICs 0.06-0.125 mg/l trough levels 1-4 mg/ll would be required.

Conclusion. A PK/PD breakpoint of C. albicans voriconazole at the ECOFF/ECV of 0.03 mg/L was determined for both EUCAST/CLSI methods, indicating the need for breakpoint harmonization for the reference methodologies.

Drug repositioning is the only feasible option to address the COVID-19 global challenge immediately. We screened a panel of 48 FDA-approved drugs against SARS-CoV-2 which were pre-selected by an assay of SARS-CoV and identified 24 potential antiviral drug candidates against SARS-CoV-2 infection. Some drug candidates showed very low micromolar IC50s and in particular, two FDA-approved drugs - niclosamide and ciclesonide – were notable in some respects.

OBJECTIVES:

Infantile hemangiomas (IHs) are common; some cases require timely referral and treatment to prevent complications. We developed and validated a reliable instrument for timely and adequate referral of patients with IH to experts by nonexpert primary physicians.