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Mutant cells in the esophagus, and protecting farmers from dangerous pesticide exposure

As you age, your cells divide over and over again, leading to minute changes in their genomes. New research reveals that in the lining of the esophagus, mutant cells run rampant, fighting for dominance over normal cells. But they do this without causing any detectable damage or cancer. Host Sarah Crespi talks to Phil Jones, a professor of cancer development at the University of Cambridge in the United Kingdom, about what these genome changes can tell us about aging and cancer, and how some of the mutations might be good for you. Most Western farmers apply their pesticides using drones and machinery, but in less developed countries, organophosphate pesticides are applied by hand, resulting in myriad health issues from direct exposure to these neurotoxic chemicals. Host Meagan Cantwell speaks with Praveen Vemula, a research investigator at the Institute for Stem Cell Biology and Regenerative Medicine in Bengaluru, India, about his latest solution—a cost-effective gel that can be applied to the skin to limit pesticide-related toxicity and mortality. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image:Navid Folpour/Flickr; Music: Jeffrey Cook]




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Promising approaches in suicide prevention, and how to retreat from climate change

Changing the National Suicide Prevention Lifeline from 1-800-273- 8255 (TALK) to a three-digit number could save lives—especially when coupled with other strategies. Host Meagan Cantwell talks to Greg Miller, a science journalist based in Portland, Oregon, about three effective methods to prevent suicides—crisis hotlines, standardizing mental health care, and restricting lethal means. Greg’s feature is part of a larger package in Science exploring paths out of darkness. With more solutions this week, host Sarah Crespi speaks with A. R. Siders, a social scientist at the Disaster Research Center at the University of Delaware in Newark, about her policy forum on the need for “managed climate retreat”—strategically moving people and property away from high-risk flood and fire zones. Integrating relocation into a larger strategy could maximize its benefits, supporting equality and economic development along the way. This week’s episode was edited by Podigy. Ads on this show: KiwiCo; Kroger Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Scott Woods-Fehr/Flickr; Music: Jeffrey Cook] 




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Squeezing two people into an MRI machine, and deciding between what’s reasonable and what’s rational

Getting into an MRI machine can be a tight fit for just one person. Now, researchers interested in studying face-to-face interactions are attempting to squeeze a whole other person into the same tube, while taking functional MRI (fMRI) measurements. Staff Writer Kelly Servick joins host Sarah Crespi to talk about the kinds of questions simultaneous fMRIs might answer. Also this week, Sarah talks with Igor Grossman, director of the Wisdom and Culture Lab at the University of Waterloo, about his group’s Science Advances paper on public perceptions of the difference between something being rational and something being reasonable. This week’s episode was edited by Podigy. Read a transcript (PDF) Listen to previous podcasts. About the Science Podcast




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Ultra-trace determination of domoic acid in the Ebro Delta estuary by SPE-HILIC-HRMS

Anal. Methods, 2020, 12,1966-1974
DOI: 10.1039/C9AY02617G, Paper
Open Access
Cristina Bosch-Orea, Josep Sanchís, Damiá Barceló, Marinella Farré
Marine phytoplankton, such as diatoms, are responsible for a considerable part of carbon fixation and form the basis of the marine food web.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Analysis of amino acid enantiomers from aged fingerprints

Anal. Methods, 2020, 12,2052-2057
DOI: 10.1039/D0AY00096E, Technical Note
Open Access
Ward van Helmond, Maarten Weening, Vonne Vleer, Marcel de Puit
The use of the enantiomeric ratio of D/L-serine in fingerprints could pose as interesting target for age estimation techniques.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluation of segmented non-target data acquisition (SWATH/vDIA) in a QToF and QOrbitrap for pesticide residue analysis

Anal. Methods, 2020, 12,2027-2038
DOI: 10.1039/D0AY00290A, Paper
Łukasz Rajski, Iciar Beraza, María José Gómez Ramos, Carmen Ferrer, Amadeo R. Fernández-Alba
Two high-resolution instruments (a QToF and a QOrbitrap) were used to evaluate a segmented non-target MS2 (SWATH/vDIA) acquisition for pesticide residue analysis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Liquid–liquid microextraction of glyphosate, glufosinate and aminomethylphosphonic acid for the analysis of agricultural samples by liquid chromatography

Anal. Methods, 2020, 12,2039-2045
DOI: 10.1039/D0AY00120A, Paper
Javier Marín, Natalia Campillo, Manuel Hernández-Córdoba, Isabel Garrido, José Fenoll, Pilar Viñas
An ion-pair liquid–liquid microextraction procedure followed by LC tandem mass spectrometry allows a reliable and sensitive determination glyphosate, glufosinate y aminomethylphosphonic acid in agricultural samples.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Detection of prostate-specific antigen in semen using DNA aptamers: an application of nucleic acid aptamers in forensic body fluid identification

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00371A, Paper
Tetsuya Satoh, Seiya Kouroki, Yusuke Kitamura, Toshihiro Ihara, Kazutoshi Matsumura, Susumu Iwase
In forensics, body fluid identification plays an important role because it aids in reconstructing the crime scene. Therefore, it is essential to develop simple and reliable techniques for body fluid...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00305K, Paper
Xiao-fan Wang, You-xi Zhang, Hai-ying Ma
Targeted profiling of amino acid metabolome in serum by LC-MS: application to identify potential markers for diet-induced hyperlipidemia.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Determination of polychlorinated biphenyls and organochlorine pesticides in Chinese mitten crabs (Eriocheir sinensis) using modified QuEChERS followed by GC-MS

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00519C, Paper
Ting Liu, Jianguang Zhou, Li He, Jinhua Gan
A new QuEChERS method followed by GC-MS was developed for the simultaneous analysis of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in Chinese mitten crabs.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Colorimetric speciation analysis of chromium using 2-thiobarbituric acid capped silver nanoparticles

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00160K, Paper
Kamal Mousapour, Salahaddin Hajizadeh, Khalil Farhadi
Colorimetric determination of Cr(III) and Cr(VI) based on 2-thiobarbituric acid capped silver nanoparticles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Colorimetric indicators for volatile amines based on succinic anhydride (SAh)-grafted poly (lactic acid) (PLA)

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00550A, Paper
Adrian Lopera-Valle, Anastasia Elias
Smart materials that can undergo changes in color upon the detection of amines have the potential to provide information on the freshness of fish and meat.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Facile dispersive solid-phase extraction based on humic acid for the determination of aflatoxins in various edible oils

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00534G, Paper
Ping Liu, Yan-Hua Liao, Hao-Bo Zheng, Yang Tang
Aflatoxins (AFs), as the secondary metabolites produced by some toxigenic fungi of Aspergillus species, are well known to be extremely harmful to humans and animals because of their high toxicity, mutagenicity, carcinogenicity, and teratogenicity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Miniaturized QuEChERS method for determination of 97 pesticide residues in wine by ultra-high performance liquid chromatography coupled to tandem mass spectrometry

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00744G, Paper
Gabrieli Bernardi, Magali Kemmerich, Martha B Adaime, Osmar Damian Prestes, Renato Zanella
A miniaturized sample preparation method was developed and validated for the multiresidue determination of 97 pesticide residues in wine samples. The proposed extraction procedure is based on QuEChERS acetate method...
The content of this RSS Feed (c) The Royal Society of Chemistry




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LC-MS in combination with DMBA derivatization for sialic acid speciation and distribution analysis in fish tissues

Anal. Methods, 2020, 12,2221-2227
DOI: 10.1039/D0AY00100G, Paper
Junjie Du, Qiwei Zhang, Jianjun Li, Qi Zheng
For sialic acid speciation analysis, DMBA provides superior chromatographic separation efficiency and comparable MS/MS spectra with DMB.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple paper-based approach for arsenic determination in water using hydride generation coupled with mercaptosuccinic-acid capped CdTe quantum dots

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00273A, Paper
Oraphan Thepmanee, Kanlaya Prapainop Katewongsa, Obnithi Nooppha, Nuanlaor Ratanawimarnwong, Weena Siangproh, Orawon Chailapakul, Kriangsak Songsrirote
This research aims to develop a simple paper-based device for arsenic detection in water samples where a hydride generation technique coupled with mercaptosuccinic acid-capped CdTe quantum dots (MSA-CdTe QDs) as...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rapid and colorimetric detection of nucleic acids based on entropy-driven circuit and DNAzyme mediated autocatalytic reaction

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00341G, Paper
Hongli Shi, Jianyuan Dai, fang Wang, Yushun Xia, Dan Xiao, Cuisong Zhou
In this work, a novel, rapid and enzyme-free colorimetric biosensor for nucleic acids detection has been developed based on entropy-driven circuit (EDC) and DNAzyme mediated autocatalytic reaction. Upon sensing of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sharing mobilities: questioning our right to the city in the collaborative economy / Davide Arcidiacono and Mike Duggan

Rotch Library - HE305.A735 2020




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Back on track: American railroad accidents and safety, 1965-2015 / Mark Aldrich

Hayden Library - HE1780.A75 2018




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Demographic determinants of testing incidence and COVID-19 infections in New York City neighborhoods [electronic resource] / George J. Borjas

Cambridge, Mass. : National Bureau of Economic Research, 2020




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The army and the Indonesian genocide [electronic resource] : mechanics of mass murder / Jess Melvin

Melvin, Jess, author




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[ASAP] Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05855




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[ASAP] Metal–Organic Framework-Enhanced Solid-Phase Microextraction Mass Spectrometry for the Direct and Rapid Detection of Perfluorooctanoic Acid in Environmental Water Samples

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05524




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Aurangabad train accident: NHRC issues notice to Maharashtra, says tragedy could have been averted

Meanwhile, the railway safety watchdog said the victims had gathered along the track under the impression that the train services have been suspended.




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Aurangabad train accident: MP government’s negligence led to deaths of 16 migrants, alleges Congress

The party said that the workers had applied to the state government for passes to return home, but the administration did not act on it.




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[ASAP] Reactivity Parameters and Substitution Effect in Organic Acids

The Journal of Physical Chemistry A
DOI: 10.1021/acs.jpca.9b10258




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[ASAP] Proton Transfer in Phosphoric Acid-Based Protic Ionic Liquids: Effects of the Base

The Journal of Physical Chemistry A
DOI: 10.1021/acs.jpca.0c02863




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Developing Super Tough Gelatin-based Hydrogels by Incorporating Linear Poly(methacrylic Acid) to Facilitate Sacrificial Hydrogen Bonding

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00422G, Communication
Hui Jie Zhang, Li Ni Wang, Xuechuan Wang, Qingxin Han, Xiangyou You
Mechanically robust protein-based hydrogels are strongly desired but their construction remains a significant challenge. In this work, gelatin, together with methacrylic acid, is used to construct a novel hydrogen-bonded hydrogel...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effect of polar amino acid incorporation on Fmoc-diphenylalanine-based tetrapeptides

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00320D, Paper
Alexandra Daryl Ariawan, Biyun Sun, Jonathan Pawel Wojciechowski, Ian Lin, Eric Y Du, Sophia C Goodchild, Charles Gordon Cranfield, Lars M Ittner, Pall Thordarson, Adam David Martin
Peptide hydrogels show great promise as extracellular matrix mimics due to their tuneable, fibrous nature. Through incorporation of polar cationic, polar anionic or polar neutral amino acids into the Fmoc-diphenylalanine...
The content of this RSS Feed (c) The Royal Society of Chemistry




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The Accidental Side Project

Drew McLellan puts the chairs up on the tables, sweeps the floor, and closes off our season, and indeed the entire 24 ways project with a look back at what it’s meant to run this site as a site project, and what impact side projects can have on the work we do. Will the last one out turn off Christmas the lights?


Brought to you by The CSS Layout Workshop. Does developing layouts with CSS seem like hard work? How much time could you save without all the trial and error? Are you ready to really learn CSS layout?


Fifteen years ago, on a bit of a whim, I decided it would be fun to have a Web Standards version of something like the Perl Advent calendar. A simple website with a new tip or trick each day leading the readers through December up until Christmas.

I emailed a bunch of friends that kept web design and development themed blogs (remember those?) suggesting the idea and asking if they’d like to contribute. My vision had been that each post would be a couple of paragraphs of information. A small nugget of an idea, or a tip, or a suggestion. What happened was something really amazing. I began to receive really insightful blog posts containing some of the most valuable writing I’d seen online all year.

Look at this piece from Ethan Marcotte on Centered Tabs with CSS, or this detailed piece on scripting block quotes from Jeremy Keith. I was blown away, and the scene was set.

Part of the original design. Photo by Bert Heymans.

Collaboration

What I hadn’t anticipated in 2005 was that this little side project would turn into a fixture of the industry calendar, would introduce me to a raft of field experts, and would have me working with an eclectic team of collaborators for fifteen long seasons.

And that last point is crucial. I’ve by no means produced this alone. Rachel Andrew has been a constant supporter in helping each year to see the light of day and producing our ebooks. After a couple of years, Brian Suda stepped in to help me plan and select authors. In 2008, I managed to persuade Tim Van Damme to replace my very basic site design with something altogether more fitting. In 2010, Anna Debenham came on board initially to help with the production of articles, but rapidly became a co-producer working with me on all aspects of the content. Owen Gregory joined up that same year to help with the proofing and editing of articles, and for many years did a fantastic job writing the home page article teasers, which are now but a shadow of their former selves.

Tim Van Damme’s 2008 redesign.

Also in 2010, we produced a book in collaboration with Five Simple Steps and raising funds in the memory of Remy and Julie’s daughter, Tia Sharp.

The Five Simple Steps 24 ways book. Photo by Patrick Haney.

In 2013, Paul Robert Lloyd stepped up to the plate to provide us with the design you see today, which not only subtly shifts colours between each day, but across the years as well. Compare the reds of 2005 to the purples of 2019, and the warm tones of a Day 1 to its correspondingly cool Day 24. It’s a terrific piece of work.

Paul Robert Lloyd’s design plays subtly with colour shifts.

In 2014 we won a Net Award for Best Collaborative Project at a fancy ceremony in London. Many past authors were there, and as it was an aware for our collaborative efforts, we all posed with the glassware for photos.

We all went to a right fancy do.

Looking back, looking forward

But even I, Sea Captain Belly Button am not enough of a navel gazer to just be writing an article just about this website. As we draw our fifteenth and final year to a close, it’s important to reflect on what can be learned. Not from the articles (so much!) or from the folly of committing to a nightly publishing schedule for a month every year for fifteen years (don’t do it!) but from the value in starting something not because you have to, but just because you want to. From scratching an itch. From working with a friend just because you love spending time with them. Or for doing something because you see the opportunity for good.

As web designers and developers, we have the opportunity to turn the skills we use in our profession to so many different purposes. In doing so you never know what good might come from it.

Seeing the good

This week I asked around to find out what good others have seen from their side projects. Long time 24 ways contributor Simon Willison had this to say:

Simon went onto explain how it was a website side project that got him his first job in tech. After that, his personal blog lead him to getting a job at Lawrence Journal-World where he created Django. On his honeymoon, Simon and his new wife (and 24 ways contributor) Natalie Downe created Lanyrd, and Simon’s more recent Datasette project landed him a JSK Fellowship at Stanford. That’s an impressive record of side projects, for sure.

Others had similar stories. My good friend Meri Williams is currently CTO of challenger bank Monzo, as well as being a trustee at Stonewall and Chair of The Lead Developer conference.

Again, an impressive list of achievements, and I’m sure both Simon and Meri would have eventally found other routes to their individual success, but the reality is they did it through side projects. Through being present and active, contributing a little to their communities, and receiving so much more back in return.

Of course, not all projects have to be directly related to the web or software to be fulfilling. Of course they don’t. Mark Small and Jack Shoulder embraced their love of a good rear end and created MuseumBums, informally cataloging perfect posteriors for your perusing pleasure. On its success, Mark says:

Jack adds:

I had so many heartwarming responses to my request for stories, I really recommend you go over to the thread on Twitter and read it. It’s been one of my favourite set of replies in a long time.

Focussing on what’s important

As the years progressed, more and more publications sprang up both at Christmas and throughout the year with how-to articles explaining techniques. As a natural response, 24 ways started mixing up solution-based articles with bigger picture takes on a wider range of topics, but always with a practical takeaway to impress your friends.

After the embarrassment of white dudes that dominated the early years, we actively sought to open the opportunity to write to a wider and more diverse range of experts. While I don’t think we ever got as much racial diversity in our lineup as I would have liked to have achieved, I’m very proud that each season has been closely gender-balanced since 2012. This is something that was never forced or remotely hard to achieve, all it took was an awareness of the potential for bias.

Calling time

With all the benefits that side projects can bring, it’s also important to be mindful of downsides. Not every project will take flight, and those that do can also start to consume valuable time. That’s fine while it’s fun and you’re seeing the benefits, but it’s neither fun or healthy long-term to have no time away from something that might otherwise be your job.

Spending time with family, friends, and loved ones is equally important especially at this time of year. Just as anyone who does a lot of sport or fitness will tell you about the value of rest days between your activities to let the body recover, time away from ‘work’ is important to do the same for your brain.

Having run this site every Christmas for 15 seasons, it’s time to take a breather and give it a rest. Who knows if we might return in the future, but no promises. It’s been a good run, and an absolute privilege to provide this small tradition to the community I love.

So from me and the whole 24 ways family, Happy Christmas to all, and to all a good night.

Anna and Drew at the 2014 Net Awards dinner.

About the author

Drew McLellan is a developer and content management consultant from Bristol, England. He’s the lead developer for the popular Perch and Perch Runway content management systems, and public speaking portfolio site Notist. Drew was formerly Group Lead at the Web Standards Project, and a Search Innovation engineer at Yahoo!. When not publishing 24 ways, he keeps a personal site about web development, takes photos, tweets a lot and tries to stay upright on his bicycle.

More articles by Drew




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