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tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00281J, Paper
Xianghe Meng, Chaosheng Xia, Qin Ye, Xiaohua Nie
Autophagy mediate by p53/Akt/mTOR signaling was linked to overproduction of ROS by tert-butyl-p-benzoquinone.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00342E, Paper
Oscar Galarce-Bustos, Mª Teresa Fernández-Ponce, Antonio Montes, Clara Pereyra, Lourdes Casas, Casimiro Mantell, Mario Aranda
The wastes generated by cherimoya cultivation and processing industries should be contemplated as a valuable source of bioactive alkaloids, with potential in pharmaceutical applications for the treatment or prevention of chronic diseases.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enzyme reaction-guided identification of active components from the flowers of Sophora japonica var. violacea

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00625D, Paper
Yunci Zhang, Dongyu Gu, Shuai He, Jing Meng, Jifeng Wang, Yunxiao Wang, Yi Wang, Jing Tian, Yi Yang
The flower of S. japonica is a favorite food and used as traditional medicine.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quick approval, grace period: Medical insurance process eased amid Covid-19

Use instalments to increase cover; benefit from quick approvals




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7 personal finance tips to guide you through these unprecedented times

Coming out of these unusual times financially fitter and stronger would require discipline, perseverance, conservancy tricks and fortitude. Here are some handy tips for millennials





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Yeh Saali Aashiqui Review

'Yeh Saali Aashiqui held my attention purely for audacity,' says Sukanya Verma.





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Parliament must pass a law to build Ram Mandir: Suresh Jain

Interview with Vishwa Hindu Parishad leader




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We are confident BJP will build the temple: Surendra Jain

Interview with Joint general secretry of Vishva Hindu Parishad




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Air France to check passengers' temperatures, require masks - Times of India

Air France to check passengers' temperatures, require masks - Times of India




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Delhi: NBW against AAP MLA, aide for abetting doctor's suicide | Delhi News - Times of India

Delhi: NBW against AAP MLA, aide for abetting doctor's suicide | Delhi News - Times of India




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Delhi: Woman commits suicide at AIIMS after her mother dies of cancer

Delhi: Woman commits suicide at AIIMS after her mother dies of cancer




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[ASAP] Dysidealactams and Dysidealactones: Sesquiterpene Glycinyl-Lactams, Imides, and Lactones from a <italic toggle="yes">Dysidea</italic> sp. Marine Sponge Collected in Southern Australia

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00041




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[ASAP] Bioactive <italic toggle="yes">seco</italic>-Sativene Sesquiterpenoids from an <italic toggle="yes">Artemisia desertorum</italic> Endophytic Fungus, <italic toggle="yes">Cochliobolus sativ

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01148




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[ASAP] Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian <italic toggle="yes">Dysphania</italic> Species That Suggests a Putative Biogenetic Link to Zerumbone

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01039




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[ASAP] Sesquiterpenoids from Cultures of the Basidiomycetes <italic toggle="yes">Irpex lacteus</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01177




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[ASAP] The Oxidation of Phytocannabinoids to Cannabinoquinoids

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01284




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[ASAP] Cyperane-Type and Related (Nor)Sesquiterpenoids from the Root Bark of <italic toggle="yes">Acanthopanax gracilistylus</italic> and Their Inhibitory Effects on Nitric Oxide Production

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00913




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[ASAP] Spiroseoflosterol, a Rearranged Ergostane-Steroid from the Fruiting Bodies of <italic toggle="yes">Butyriboletus roseoflavus</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01282




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[ASAP] Advances in the Biosynthesis of Pyranocoumarins: Isolation and <sup>13</sup>C-Incorporation Analysis by High-Performance Liquid Chromatography–Ultraviolet–Solid-Phase Extraction–Nuclear Magnetic Resonance Data

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00607




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[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




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Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries

Interview with Lawrence O. Gostin, JD, author of Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries




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Primary Health Care in Low-Income Countries: Building on Recent Achievements

Interview with Jeffrey D. Sachs, PhD, author of Primary Health Care in Low-Income Countries: Building on Recent Achievements




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Risk Factors Associated With Suicide in Current and Former US Military Personnel

Interview with Cynthia A. LeardMann, MPH, author of Risk Factors Associated With Suicide in Current and Former US Military Personnel




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Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial

Interview with Anthony D. Harris, MD, author of Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial




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2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)

Interview with Paul A. James, MD, author of 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)




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Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline

Interview with Ann Marie Navar-Boggan, MD, PhD, author of Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline




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A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions

Interview with Nancy L. Keating, MD, MPH, author of A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions




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Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review

Interview with Rupert M. Pearse, MD, author of Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review




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Imposition of a MOC Requirement and Outcomes of Care

Interview with Bradley M. Gray, PhD, author of Association Between Imposition of a Maintenance of Certification Requirement and Ambulatory Care-Sensitive Hospitalizations and Health Care Costs




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Corticosteroids for Severe Community-Acquired Pneumonia

Interview with Antoni Torres, MD, PhD, author of Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response: A Randomized Clinical Trial




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Intuitive Control of a Powered Prosthetic Leg

Interview with Levi J. Hargrove, PhD, author of Intuitive Control of a Powered Prosthetic Leg During Ambulation: A Randomized Clinical Trial






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New Dietary Guidelines

The 2015-2020 US Dietary Guidelines for Americans were recently released. They are intended to provide guidance for health policy officials and clinicians regarding healthy diets and establishing goals for improving nutrition. These are important since bad eating habits are the underlying cause for a great deal of disease in the US and that these guidelines influence the operations of programs such as school lunch assistance, meals on wheels etc. Because these guidelines influence policy, they have been criticized by various investigators and special interest groups. Karen DeSalvo, MD, Acting Assistant Secretary for Health at HHS and author of Dietary Guidelines for Americans responds to some of these criticisms and explains how the guideline was created and what it is intended to do. Implementation of the guidelines dietary advice may be challenging and Deborah Clegg, RD, PhD, Professor of Internal Medicine at UCLA discusses how the various recommendations can be followed.




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Antibiotic Therapy for Community-Acquired Pneumonia in Adults

Community acquired pneumonia accounts for 600,000 hospital admissions a year. Many patients with this disease are quite ill and have a very high mortality. To save lives, the appropriate antibiotics should be given in a timely basis, but it is not clear what the best antibiotics are and how long they should be given. In this podcast we interview the author of a JAMA review on community acquired pneumonia, Dr Jonathan Lee, author of Antibiotic Therapy for Adults Hospitalized With Community-Acquired Pneumonia, who performed a systematic review of the literature to determine the best way to treat community acquired pneumonia.






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Fluid Resuscitation for Patients in Septic Shock

When managing septic shock, passive leg raising is the best test to determine if a patient is likely to respond to a fluid bolus, better than CVP lines or even bedside ultrasound. Dr Najib Ayas, Associate professor of Critical Care Medicine at the University of British Columbia, discusses shock management from the context of his Rational Clinical examination article in the September 27, 2016 issue of JAMA, entitled “Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids?




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Updated Guidelines for Sepsis Management

In 2017 the Society for Critical Care Medicine updated its guidelines for sepsis management. These new guidelines differ significantly from ones in the past in that they no longer recommend protocolized resuscitation and emphasize early and aggressive fluid resuscitation when patients present with septic shock. This is the first podcast in the Surviving Sepsis guideline series. The next episode discusses why the new sepsis guideline changed.

Article discussed in this episode: Management of Sepsis and Septic Shock

Speakers:

Laura Evans, MD, MSc, of Bellevue Hospital and NYU Medical Center

Andrew Rhodes, MBBS, MD, of St George’s University Hospitals NHS Trust and co-chair of the Surviving Sepsis guideline panel

Mitchell M. Levy, MD, of the Alpert Medical School of Brown University and Rhode Island Hospital

 




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Why the New Sepsis Guideline Changed

Recent guidelines for how to best manage septic shock have changed. Gone are recommendations for central venous oxygen saturation monitoring and goal-directed therapy. In is the concept that septic shock be treated as an emergency with rapid administration of antibiotics and large amounts of fluids. Our discussants Derek C. Angus, MD, MPH, and Michael D. Howell, MD, MPH, discuss why these recommendations have changed. This is the second podcast in the Surviving Sepsis guideline series. The first podcast reviewed what recommendations are in the guideline itself.

Article discussed in this episode: Management of Sepsis and Septic Shock

Speakers: JAMA Associate Editor Derek C. Angus, MD, MPH, University of Pittsburgh, and Michael D. Howell, MD, MPH, University of Chicago.









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Clandestine indoor marijuana grow operations : recognition, assessment, and remediation guidance / by Thomas D. Koch, Carol-Lynn Chambers, Stacy Bucherl, John Martyny, John Cotner, Stan Thomas

Koch, Thomas D, author




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Trapping and the detection, control, and regulation of tephritid fruit flies : lures, area-wide programs, and trade implications / edited by Todd Shelly, Nancy Epsky, Eric Jang, Jesus Reyes-Flores, Roger Vargas




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Harvest strategy policy and operational guidelines for the aquatic resources of Western Australia