Mountain Gorillas in Uganda and Rwanda

The Amateur Traveler talks to Geoff Smith about his boyhood home of Nashville that he recently moved back to. What would bring a musician back to Nashville after he has lived all of the world? Geoff talks about the things that tourists come to see: the Grand Ole Opry, Honky Tonk Row (including his own piano bar the Big Bang Bar), the Country Music Hall of Fame, The Musicians Hall of Fame, The Opryland Hotel. Then Geoff tells us what he really loves about Nashville. Nashville is a place where creative and artistic people can live among the beautiful rolling hills of Tennessee in one of the USA’s big three music cities.

The Amateur Traveler travels to Geneva and experiences the Escalade which celebrates the defeat of the Savoy in 1602. Geneva is the home to many UN agencies, an old town, a cathedral and an excellent rare book collection. You can also find lots of ways to eat melted cheese and other Swiss treats on the shore of beautiful Lake Geneva. In this unusual episode Chris overcomes a technical microphone difficulty to record an episode on the road. This episode inlcudes some of the sounds of the Escalade festival.

Hear about travel to Memphis, Tennessee as the Amateur Traveler talks to Lance from tripsbylance.com about this city where he has lived on and off for 20+ years. Lance tells us that there is more to Memphis than Elvis and Graceland.

Hear about travel to the Tennessee River Valley as the Amateur Traveler talks to Chuck Prevatte from foodwinebeertravel.com about the region from Chatanooga, Teneesee to Huntsville, Alabama.

"We're writing off too many people," Rep. Mick Mulvaney (R-SC) says in "Immigration Battle," a feature film presentation from FRONTLINE and Independent Lens that airs tonight on PBS.

Brandon police officers are searching for a man who was caught on camera attempting to pump gas in his car – without prepaying.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Expert

Expert

Ryan A. Ristau
Nov 1, 2013; 26:211-215
From Research to Practice

Hong Kong Exchanges & Clearing Limited (HKEx) today announced that Charles Li will not seek reappointment as Chief Executive at the end of his current contract in October 2021.

The Government said it respected Mr Li's decision and expressed deep appreciation for his exemplary contribution to the development of the financial market during his tenure as HKEx Chief Executive in the past decade.

Since taking the helm in January 2010, he has led HKEx and Hong Kong’s capital market in achieving important breakthroughs one after another.

The vibrancy and growth that Mr Li has brought to Hong Kong in the capital market helps reinforce the status of Hong Kong as a leading international financial centre.

Financial Secretary Paul Chan said: "Thanks to his vision and leadership, Mr Li has laid a solid and strong foundation for our stock market, rendering Hong Kong the largest IPO market in the world for seven times in the past 11 years.

"He has been instrumental in the successful launch of mutual market access programmes between Hong Kong and the Mainland, notably the Shanghai-Hong Kong Stock Connect in 2014, which was expanded to include Shenzhen-Hong Kong Stock Connect in 2016 and Bond Connect in 2017.

"He also played a pivotal role in the launch of new listing regime in Hong Kong, the enhanced internationalisation of HKEx and its international visibility. These are all important achievements of HKEx in the past few years under Mr Li’s able leadership."

Mr Chan added that the Government is confident the HKEx board will continue to ensure the success of HKEx in the years to come.

(University of Warwick) Warm winter spells have increased in frequency and duration two- to three times over since 1878, according to scientists led by the University of Warwick.

(University of Tennessee Institute of Agriculture) David Mercker, an Extension forestry specialist with the University of Tennessee Department of Forestry, Wildlife and Fisheries, has been named 2020 Extension Forester of the Year by the Forest Landowners Association (FLA). FLA is a national organization that promotes and protects the interests of private forest landowners and bestows this award annually as determined by its board of directors.

A single tweet on the weekend about a possible collaboration between dancehall princess Shenseea and US rap sensation Nicki Minaj has left fans of the Romeich Entertainment singer bursting with excitement. Rumours of a pending project between...

Up-and-coming entertainer Shav-A says the COVID-19 pandemic made her reflect on her life. "I needed a reset. With all this downtime, I have realised that I needed to stop and rethink a lot of things that are going on in my life, and it also...

Invitation Only Research Event

Due to improvements in quantitative SPECT/CT, voxel-based dosimetry for radionuclide therapies has aroused growing interest as it promises the visualization of absorbed doses at a voxel level. In this work, SPECT/CT-based voxel-based dosimetry of a 3D printed 2-compartment kidney phantom was performed, and the resulting absorbed dose distributions were examined. Additionally, the potential of the PETPVC partial-volume correction tool was investigated. Methods: Both kidney compartments (70% cortex, 30% medulla) were filled with different activity concentrations and SPECT/CT imaging was performed. The images were reconstructed using varying reconstruction settings (iterations, subsets, and post-filtering). Based on these activity concentration maps, absorbed dose distributions were calculated with pre-calculated ¹⁷⁷Lu voxel S values and an empirical kidney half-life. An additional set of absorbed doses was calculated after applying PETPVC for partial-volume correction of the SPECT reconstructions. Results: SPECT/CT imaging blurs the two discrete sub-organ absorbed dose values into a continuous distribution. While this effect is slightly improved by applying more iterations, it is enhanced by additional post-filtering. By applying PETPVC, the absorbed dose values are separated into 2 peaks. Although this leads to a better agreement between SPECT/CT-based and nominal values, considerable discrepancies remain. In contrast to the calculated nominal absorbed doses of 7.8/1.6 Gy (cortex/medulla), SPECT/CT-based voxel-level dosimetry resulted in mean absorbed doses ranging from 3.0-6.6 Gy (cortex) and 2.7-5.1 Gy (medulla). PETPVC led to improved ranges of 6.1-8.9 Gy (cortex) and 2.1-5.4 Gy (medulla). Conclusion: Our study shows that ¹⁷⁷Lu quantitative SPECT/CT imaging leads to voxel-based dose distributions largely differing from the real organ distribution. SPECT/CT imaging and reconstruction deficiencies might directly translate into unrealistic absorbed dose distributions, thus questioning the reliability of SPECT-based voxel-level dosimetry. Therefore, SPECT/CT reconstructions should be adapted to ensure an accurate quantification of the underlying activity and, therefore, absorbed dose in a volume-of-interest of the expected object size (e.g. organs, organ sub-structures, lesions or voxels). As an example, PETPVC largely improves the match between SPECT/CT-based and nominal dose distributions. In conclusion, the concept of voxel-based dosimetry should be treated with caution. Specifically, it should be kept in mind that the absorbed dose distribution is mainly a convolved version of the underlying SPECT reconstruction.

The problem occurs on a content release on the SAS Risk Governance Framework.

The problem occurs on a content release on the SAS Risk Governance Framework.

You can create create a Databricks table by using PROC SQL, but you cannot insert data into the table. PROC APPEND cannot create a new table or append data to an existing table.

It's been less than a year since the Giants selected Joey Bart with the second overall pick in the 2018 MLB Draft, but the 22-year-old catcher is already generating plenty of excitement within the organization.

Bruce Bochy isn't sure what his next step will be after he retires from managing the Giants at the end of the season, but it's safe to assume that a trip to Cooperstown is in his near future.

Western Bureau: A number of swimming officials in western Jamaica say that the region’s struggles with underdevelopment will continue even if the COVID-19 pandemic is brought under control. They say this is because they still lack proper pools to...

Larger portions of food increase consumption. Theresa Marteau, director of the Behaviour and Health Research Unit at the University of Cambridge, joins us to discuss how government action to tackle portion size and packaging could help reset our appetites and make us thinner. Read the full analysis: http://www.bmj.com/content/351/bmj.h5863

How should health professionals engage with this increasingly popular but unproved practice? Aubrey Cunnington, a consultant paediatrician from Imperial College London joins us to discuss. Read the full editorial: http://www.bmj.com/content/352/bmj.i227

There’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc. To make sense of that...

Machines that can learn and correct themselves already perform better than doctors at some tasks, but not all medicine is task based - but will AI doctors ever be able to have a therapeutic relationship with their patients? In this debate, Jörg Goldhahn, deputy head of the Institute for Translational Medicine at ETH Zurich thinks that the...

May 10, Mother’s Day, is a special day on the calendar when many people make big plans to spend the day or the weekend with their mothers. However, this year some people may rethink their plans as they would not want to expose their beloved mothers...

The mothballing of Britain’s Nightingale hospitals, some of which have yet to treat a single covid-19 patient, has raised questions about whether resources to fight the pandemic were...

THE ACQUISITION of Epping resulted in Total Jamaica controlling nearly a third of the retail gasolene market, but that’s not enough to lessen competition, the Fair Trading Commission, FTC, has found. “The acquisition is unlikely to have either the...

Governments on the receiving end of migrants and refugees reinforced their commitment to returns in 2017, sending or coercing migrants to move back to impoverished or violent homelands. The Dominican Republic pushed out some 70,000 Haitians and native born of Haitian descent, while more than 500,000 Afghans left Iran and Pakistan. Though many of these migrants chose to return, in practice the line between forced and voluntary returns is blurry.

Researchers have predicted that if climate change goes unabated, the planet will experience intolerable heat in several decades. But a new study has found that in certain global hot spots, it's already happening.

Just days after South Korea loosened its social distancing guidelines, a new COVID-19 cluster of infections has sprung up in the capital city of Seoul tied to several nightclubs.

The U.S. government is operating accelerated dockets to handle the rising number of cases of families in immigration court. While it is essential to have timely, fair case processing and removal of those who have truly had their day in court and been found to be removable, using “rocket” dockets to speed up proceedings only heightens the breakdowns that are a recurring feature of the court system on its best day, as this commentary explains.

The ADA is calling for nominations for two seats to represent the Association in the Dental Quality Alliance.