The second College Football Playoff rankings produced some positives and negatives for teams. Here are the winners and losers from Tuesday's reveal:

The second College Football Playoff rankings dropped on Tuesday night with Oregon retaining its status as the No. 1 team in the country ahead of No. 2 Ohio State and No. 3 Texas. College Football Playoff:

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

Purdue women's basketball suffered its first defeat of the season on Sunday night as No. 6 Notre Dame came into Mackey Arena and handed the Boilermakers a 102-58 loss. The Boilermakers have now lost nine straight games to the Fighting Irish, since taking a 14-5 lead in the series back in 2005. The in-state rivalry was halted, playing just once between 2012 and 2023, but the Fighting Irish resumed their success over the Boilermakers in each of the last two seasons.

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Sharon G. Kujawa
Nov 11, 2009; 29:14077-14085
BehavioralSystemsCognitive

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.

A new exhibition co-presented by the National Portrait Gallery and the Archives of American Art explores the seminal artist’s work

5 December 2014, Rome – At the closure of the FAO Council held today, the [...]

Addressing the plenary meeting in the closing session of the 159^th Session of the Council, the Director-General expressed his appreciation to delegates for their commitment and hard work to [...]

Watch a video on the restoration of Gorongosa Park. The video was originally featured on Foreign Exchange with Fareed Zakaria and produced by the Pulitzer Center on Crisis Reporting.

Humans don't just impact the interconnected web of life—we depend on it.

Read more about the Hindenburg disaster: https://www.smithsonianmag.com/smithsonian-institution/80th-anniversary-hindenburg-disaster-mysteries-remain-180963107/ Seventy-five years after the tragedy, a curator at the National Postal Museum made a discovery that shed new light on what happened to the doomed dirigible

This year marks the 100 year anniversary of Japan's gift of cherry blossoms to Washington, D.C.

Christopher Nolan's epic new film "Oppenheimer" is no mere biopic… nor is it the first attempt to capture the father of the atomic bomb in fiction. We look at prior dramatizations of this very complicated man—including one wherein J. Robert Oppenheimer played himself!—and examine why they worked or didn't. In the episode: Physicist-turned-photographer Minesh Bacrania shares his experience photographing inside the top-secret labs at Los Alamos National Laboratory, where J. Robert Oppenheimer and other scientists created the first nuclear weapon. Next, with Christopher Nolan’s film Oppenheimer exceeding commercial expectations, Smithsonian magazine writer Andy Kifer discusses the complexities of Oppenheimer's genius and how prior attempts to depict him in film and television and on stage have fared. Read Andy Kifer’s “The Real Story Behind Christopher Nolan’s Oppenheimer” here (https://www.smithsonianmag.com/history/the-real-history-behind-christopher-nolans-oppenheimer-180982529/) . See Minesh Bacrania’s photographs of Los Alamos and read Smithsonian senior editor Jennie Rothenberg Gritz’s text here (https://www.smithsonianmag.com/history/exclusive-behind-scenes-look-los-alamos-lab-where-robert-oppenheimer-created-atomic-bomb-180982336/) or in the July/August 2023 issue of Smithsonian. There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Genevieve Sponsler, Adriana Rozas Rivera, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz. Music by APM Music.

"Le Lyonnais" descended into the depths off the coast of Massachusetts after colliding with the "Adriatic," a sailing vessel that left the floundering steamship to fend for itself

The discoveries include sharks, shorebirds, mammals and saber-toothed salmon, with the oldest remains dating to almost nine million years ago

Female worker bees, which forage for the whole colony, struggle more to detect scents in the heat than males do, per the recent research

More than 250 years after a teenage Mozart wrote "Serenade in C," a copy of the piece has surfaced in the collections of a German library

Researchers recently identified James Fitzjames, a captain on the ill-fated HMS Erebus that went looking for the Northwest Passage in 1845

A SpaceX mission arrived at the International Space Station with two astronauts instead of four to leave room for NASA astronauts Suni Williams and Butch Wilmore on the return trip in early 2025

A recurrent nova, known as the Blaze Star or T Coronae Borealis, is predicted to soon appear in the night sky. But the exact timing of the rare eruption remains unknown

The HMS "Trooper" likely sank after hitting an underwater German mine off the coast of an island in the Aegean Sea in 1943

History forgot about "Gibbet Hill" for more than a century—until a fan of the Gothic horror writer stumbled upon the haunting tale at the National Library of Ireland

Geologists suggest the catastrophic impact of "S2" delivered key nutrients to the oceans, prompting microorganisms to thrive

By analyzing an old lidar survey, researchers found evidence of more than 6,500 ancient structures in a previously unexplored area of Campeche

The one-minute composition, which dates to the 1830s, was found on a piece of paper about the size of an index card at a museum in New York City

On this day in 1912, a team found the remains of Robert Falcon Scott and the crew of the "Terra Nova" expedition. A would-be rescuer said he was forever haunted by the "horrible nightmare"

The A.C. Hunter Public Library wants people in St. John’s to know that it’s open and accessible, despite how the entrance looks. The main staircase is under repair but there’s plenty of signs directing folks to other entrances. Still, librarians say people are judging this book by its cover and assuming the library is closed.

People using the library in the Arts and Culture Centre in St. John's are being forced to use alternate entrances due to an unsafe staircase in front of the building.

A Port Hawkesbury woman has long imagined a Remembrance Day with her great-uncle's war medals. It will happen this year for the first time thanks to some sleuthing and the kindness of her great-uncle's foster family.

A Whitehorse homeowner has been charged in connection with an explosion last year that destroyed his home and killed a man in a neighbouring house. 

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

With flinty perseverance and a golden touch, Belinda Mulrooney earned an unlikely fortune in the frozen north and reshaped the Canadian frontier

The Sacro Bosco's meaning is the subject of debate, with scholars alternatively describing the sprawling complex as a memorial, an allegorical site or a tribute to ancient civilizations

Former Ohio state Senator Nina Turner discusses the 2024 elections.

In the new year, Ontario is supposed to be fully accessible for disabled people, but advocates say the province is ‘nowhere near’ meeting standards it created 20 years ago.

Hamilton's Santa Claus Parade will take place on the mountain this year, starting on Upper Sherman Road at 2 p.m. on Saturday.

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

Head coach Corey Mace, quarterback Trevor Harris and linebacker Jameer Thurman talk about coming up short in the CFL West Final. The Roughriders lost the the Winnipeg Blue Bombers 38-22 sending the Bombers to their fifth straight Grey Cup.

It was only the second time the Saskatchewan Huskies and the Regina Rams have met in the Hardy Cup championship game. This time it was the Rams coming out on top 19-14. Huskies head coach Scott Flory says there were too many turnovers and too many plays left on the field after a hard fought game.

Malls and transit will operate under regular hours in Windsor, Ont., while museums and libraries will be closed on Remembrance Day.

Canadian swingman RJ Barrett was upgraded to day-to-day and engaged in non-contact practise on Monday, two days before Toronto hosts the Cleveland Cavaliers at Scotiabank Arena.

OM Montenegro holds a programme for local friends to learn and talk about God.

OM Montenegro has discovered that if they are faithful and patient, they can eventually walk through doors that had once seemed closed.

SolidWorks Helps Make Replacement Fingers a Reality