bili Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability [Enzymology] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, with T50 values of ∼30–40 °C. Reconstructed ancestral cytochrome P450 enzymes tend to have variable substrate selectivity compared with related extant forms, but they also have higher thermostability and therefore may be excellent tools for commercial biosynthesis of important intermediates, final drug molecules, or drug metabolites. The mammalian ancestor of the cytochrome P450 1B subfamily was herein characterized structurally and functionally, revealing differences from the extant human CYP1B1 in ligand binding, metabolism, and potential molecular contributors to its thermostability. Whereas extant human CYP1B1 has one molecule of α-naphthoflavone in a closed active site, we observed that subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open active site with four ligand copies. A structure of the ancestor with 17β-estradiol revealed only one molecule in the active site, which still had the same open conformation. Detailed comparisons between the extant and ancestor forms revealed increases in electrostatic and aromatic interactions between distinct secondary structure elements in the ancestral forms that may contribute to their thermostability. To the best of our knowledge, this represents the first structural evaluation of a reconstructed ancestral cytochrome P450, revealing key features that appear to contribute to its thermostability. Full Article
bili Social media and the visibility of horrific violence By feedproxy.google.com Published On :: Thu, 07 May 2020 08:53:25 +0000 7 May 2020 , Volume 96, Number 3 Constance Duncombe Read Online Images are central to social media communication. Billions of images are shared across different social media platforms every day: photos, cartoons, GIFs and short video clips are exchanged by users, facilitating or framing discourse on participatory sites such as Twitter, Facebook and Instagram. Many of these images depict events of extreme violence, which circulate uninhibited by the conventional constraints associated with traditional news media censorship. A question arises here as to how such images mobilize public and policy-making responses to atrocities. This article examines the political dynamics of violent social media images. I argue that the particular qualities of social media can play an important role in how the digital visibility of horrific violence influences policy-making as a response to such atrocities. There is an important connection between the properties of social media platforms that allow user images to reach a global audience in real time and the emotional responses that this level of circulation generates. In turn, the pressure created by events made globally visible through the circulation of violent images and the audience responses to those images puts governments in a position where they are forced to act, which has significant implications for policy-making. Full Article
bili Accountability, denial and the future-proofing of British torture By feedproxy.google.com Published On :: Thu, 07 May 2020 09:24:20 +0000 7 May 2020 , Volume 96, Number 3 Read online Ruth Blakeley and Sam Raphael When powerful liberal democratic states are found to be complicit in extreme violations of human rights, how do they respond and why do they respond as they do? Drawing on the example of the United Kingdom's complicity in torture since 9/11, this article demonstrates how reluctant the UK has been to permit a full reckoning with its torturous past. We demonstrate that successive UK governments engaged in various forms of denial, obfuscation and attempts to obstruct investigation and avoid accountability. The net effect of their responses has been to deny the victims redress, through adequate judicial processes, and to deny the public adequate state accountability. These responses are not simply aimed at shielding from prosecution the perpetrators and those who have oversight of them, nor preventing political embarrassment. The various forms of denial and obstruction are also designed to ensure that collusion can continue uninterrupted. A core concern of intelligence officials and ministers has been to prevent any process that would lead to a comprehensive prohibition on involvement in operations where torture and cruel, inhuman and degrading treatment are a real possibility. The door remains wide open, and deliberately so, for British involvement in torture. Full Article
bili Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis By feedproxy.google.com Published On :: 2007-12-01 Dawn L. BrasaemleDec 1, 2007; 48:2547-2559Thematic Reviews Full Article
bili S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 S-Palmitoylation is a reversible post-translational lipid modification that dynamically regulates protein functions. Voltage-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in different S-palmitoylation states. Our aim was to investigate whether and how S-palmitoylation regulates Nav1.6 channel function and to identify S-palmitoylation sites that can potentially be pharmacologically targeted. Acyl-biotin exchange assay showed that Nav1.6 is modified by S-palmitoylation in the mouse brain and in a Nav1.6 stable HEK 293 cell line. Using whole-cell voltage clamp, we discovered that enhancing S-palmitoylation with palmitic acid increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces Nav1.6 current and shifts the steady-state inactivation in the hyperpolarizing direction. Three S-palmitoylation sites (Cys1169, Cys1170, and Cys1978) were identified. These sites differentially modulate distinct Nav1.6 properties. Interestingly, Cys1978 is exclusive to Nav1.6 among all Nav isoforms and is evolutionally conserved in Nav1.6 among most species. Cys1978 S-palmitoylation regulates current amplitude uniquely in Nav1.6. Furthermore, we showed that eliminating S-palmitoylation at specific sites alters Nav1.6-mediated excitability in dorsal root ganglion neurons. Therefore, our study reveals S-palmitoylation as a potential isoform-specific mechanism to modulate Nav activity and neuronal excitability in physiological and diseased conditions. Full Article
bili Social media and the visibility of horrific violence By feedproxy.google.com Published On :: Thu, 07 May 2020 08:53:25 +0000 7 May 2020 , Volume 96, Number 3 Constance Duncombe Read Online Images are central to social media communication. Billions of images are shared across different social media platforms every day: photos, cartoons, GIFs and short video clips are exchanged by users, facilitating or framing discourse on participatory sites such as Twitter, Facebook and Instagram. Many of these images depict events of extreme violence, which circulate uninhibited by the conventional constraints associated with traditional news media censorship. A question arises here as to how such images mobilize public and policy-making responses to atrocities. This article examines the political dynamics of violent social media images. I argue that the particular qualities of social media can play an important role in how the digital visibility of horrific violence influences policy-making as a response to such atrocities. There is an important connection between the properties of social media platforms that allow user images to reach a global audience in real time and the emotional responses that this level of circulation generates. In turn, the pressure created by events made globally visible through the circulation of violent images and the audience responses to those images puts governments in a position where they are forced to act, which has significant implications for policy-making. Full Article
bili Accountability, denial and the future-proofing of British torture By feedproxy.google.com Published On :: Thu, 07 May 2020 09:24:20 +0000 7 May 2020 , Volume 96, Number 3 Read online Ruth Blakeley and Sam Raphael When powerful liberal democratic states are found to be complicit in extreme violations of human rights, how do they respond and why do they respond as they do? Drawing on the example of the United Kingdom's complicity in torture since 9/11, this article demonstrates how reluctant the UK has been to permit a full reckoning with its torturous past. We demonstrate that successive UK governments engaged in various forms of denial, obfuscation and attempts to obstruct investigation and avoid accountability. The net effect of their responses has been to deny the victims redress, through adequate judicial processes, and to deny the public adequate state accountability. These responses are not simply aimed at shielding from prosecution the perpetrators and those who have oversight of them, nor preventing political embarrassment. The various forms of denial and obstruction are also designed to ensure that collusion can continue uninterrupted. A core concern of intelligence officials and ministers has been to prevent any process that would lead to a comprehensive prohibition on involvement in operations where torture and cruel, inhuman and degrading treatment are a real possibility. The door remains wide open, and deliberately so, for British involvement in torture. Full Article
bili Can Entrepreneurship Help Stabilize Conflict Zones? By feedproxy.google.com Published On :: Tue, 10 Apr 2018 00:00:00 +0100 Full Article
bili Corporations and Environmental Sustainability: Profit vs Planet? By feedproxy.google.com Published On :: Fri, 13 Apr 2018 00:00:00 +0100 Full Article
bili A Transformative Agenda for Greater Sustainability in Trade By feedproxy.google.com Published On :: Fri, 15 Nov 2019 10:25:01 +0000 Corporate Members Event Nominees Breakfast Briefing Partners and Major Corporates 3 December 2019 - 8:00am to 9:15am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Christophe Bellmann, Associate Fellow, Hoffmann Centre for Sustainable Resource Economy, Chatham HouseCarolyn Deere Birkbeck, Associate Fellow, Global Economy and Finance Department and Hoffmann Centre for Sustainable Resource Economy, Chatham House International trade rules and policies are deeply relevant to environmental performance. On the one hand, trade flows, rules and policies can exacerbate environmental challenges as consumers regularly purchase goods produced or disposed of in unsustainable ways in other countries therefore 'exporting' environmental costs. On the other hand, trade rules and flows can be harnessed to support environmental agendas and impact commercial and trade prospects positively.The speakers will discuss the urgent need for greater political leadership and inclusive policy dialogue on environment and trade to address its development and competitiveness. Which priorities should form the heart of a forward-looking environment and trade 2.0 agenda in the context of the UN’s SDGs? What role can international trade play in helping deliver sustainable food and land use systems? And how can stakeholders promote the scaling-up of the many initiatives underway and serve as a vehicle for transformative change toward a more sustainable economy at the national and international level?This event is only open to Major Corporate Member and Partner organizations of Chatham House. If you'd like to attend, please RSVP to Linda Bedford.To enable as open a debate as possible, this event will be held under the Chatham House Rule. Members Events Team Email Full Article
bili China's 2020: Economic Transition, Sustainability and the Coronavirus By feedproxy.google.com Published On :: Tue, 04 Feb 2020 21:15:01 +0000 Corporate Members Event 10 March 2020 - 12:15pm to 2:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Yu Jie, Senior Research Fellow on China, Asia-Pacific Programme, Chatham HouseDavid Lubin, Associate Fellow, Global Economy and Finance Programme, Chatham House; Managing Director and Head of Emerging Markets Economics, CitiJinny Yan, Managing Director and Chief China Economist, ICBC StandardChair: Creon Butler, Director, Global Economy and Finance Programme, Chatham House Read all our analysis on the Coronavirus ResponseThe coronavirus outbreak comes at a difficult time for China’s ruling party. A tumultuous 2019 saw the country fighting an economic slowdown coupled with an increasingly hostile international environment. As authorities take assertive steps to contain the virus, the emergency has - at least temporarily - disrupted global trade and supply chains, depressed asset prices and forced multinational businesses to make consequential decisions with limited information. Against this backdrop, panellists reflect on the country’s nascent economic transition from 2020 onward. What has been China’s progress towards a sustainable innovation-led economy so far? To what extent is the ruling party addressing growing concerns over job losses, wealth inequality and a lack of social mobility? And how are foreign investors responding to these developments in China? Members Events Team Email Full Article
bili Strengthening National Accountability and Preparedness for Global Health Security (SNAP-GHS) By feedproxy.google.com Published On :: Thu, 19 Dec 2019 15:43:55 +0000 The project aims to identify the enablers and barriers to enhance data use by National Public Health Institutes (NPHIs), producing outputs that will facilitate strengthening of the role of NPHIs in monitoring potential public health threats, and in shaping and informing domestic policies on health security and preparedness. Global health security is underpinned by the actions taken at a national level to ensure capacities exist to sufficiently prepare for and respond to acute threats and crises. In many contexts, National Public Health Institutes (NPHIs) were first established because of, and in response to, specific public health challenges typically related to infectious diseases.The Strengthening National Accountability and Preparedness for Global Health Security (SNAP-GHS) project evolved from a series of roundtables and discussions hosted by the Centre on Global Health Security at Chatham House, in collaboration with the Graduate Institute of Geneva.The outcome of the project is a SNAP-GHS Toolkit to support NPHIs in better diagnosing and understanding the challenges to data use within their own institutes, as well as in relation to external stakeholders and agencies. The toolkit is intended to be used for further circulation and dissemination by the International Association of National Public Health Institutes (IANPHI).The project is led by the Centre on Global Health Security at Chatham House in collaboration with the Ethiopian Public Health Institute, the Nigeria Centre for Disease Control, and the National Institute for Health in Pakistan. Full Article
bili Will the ICJ Myanmar Ruling Help Bring Accountability for the Rohingya Crisis? By feedproxy.google.com Published On :: Wed, 06 May 2020 17:30:43 +0000 Source The Diplomat URL https://thediplomat.com/2020/03/will-the-icj-myanmar-ruling-help-bring-accountab... Release date 18 March 2020 Expert Dr Champa Patel In the news type Op-ed Hide date on homepage Full Article
bili On the solvability of a class of nonlinear integral equations in the problem of a spread of an epidemic By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT A. G. Sergeev and Kh. A. Khachatryan Trans. Moscow Math. Soc. 80 (2020), 95-111. Abstract, references and article information Full Article
bili China's 2020: Economic Transition, Sustainability and the Coronavirus By feedproxy.google.com Published On :: Tue, 04 Feb 2020 21:15:01 +0000 Corporate Members Event 10 March 2020 - 12:15pm to 2:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Yu Jie, Senior Research Fellow on China, Asia-Pacific Programme, Chatham HouseDavid Lubin, Associate Fellow, Global Economy and Finance Programme, Chatham House; Managing Director and Head of Emerging Markets Economics, CitiJinny Yan, Managing Director and Chief China Economist, ICBC StandardChair: Creon Butler, Director, Global Economy and Finance Programme, Chatham House Read all our analysis on the Coronavirus ResponseThe coronavirus outbreak comes at a difficult time for China’s ruling party. A tumultuous 2019 saw the country fighting an economic slowdown coupled with an increasingly hostile international environment. As authorities take assertive steps to contain the virus, the emergency has - at least temporarily - disrupted global trade and supply chains, depressed asset prices and forced multinational businesses to make consequential decisions with limited information. Against this backdrop, panellists reflect on the country’s nascent economic transition from 2020 onward. What has been China’s progress towards a sustainable innovation-led economy so far? To what extent is the ruling party addressing growing concerns over job losses, wealth inequality and a lack of social mobility? And how are foreign investors responding to these developments in China? Members Events Team Email Full Article
bili Outcomes of the Meeting of the Friends of the Co-Chairs on liability and redress, Bonn, 7-10 May 2008. By www.cbd.int Published On :: Mon, 16 Jun 2008 00:00:00 GMT Outcomes of the Meeting of the Friends of the Co-Chairs on liability and redress, Bonn, 7-10 May 2008 Full Article
bili Press release: Agreement reached to work towards a legally binding instrument on Liability and Redress with regard to GMOs. By www.cbd.int Published On :: Wed, 18 Jun 2008 00:00:00 GMT Full Article
bili Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of the Cartagena Protocol on Biosafety on the Work of its First Meeting. By www.cbd.int Published On :: Thu, 18 Feb 2010 00:00:00 GMT Full Article
bili Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of The Cartagena Protocol on Biosafety on the Work of Its Second Meeting By www.cbd.int Published On :: Wed, 31 Mar 2010 00:00:00 GMT Full Article
bili Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of the Cartagena Protocol on Biosafety on the Work of its Third Meeting By bch.cbd.int Published On :: Thu, 22 Jul 2010 00:00:00 GMT Full Article
bili An Introductory Note in Preparation for Signature and Ratification of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By bch.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
bili The Nagoya - Kula Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety opens for signature at the United Nations Headquarters, New York. By www.un.org Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
bili New Publication: The Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety. English Version. By bch.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
bili The Nagoya - Kula Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety will be opened for signature on 7 March 2011, at the United Nations Headquarters, New York. By www.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
bili Report of the African Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Mon, 12 Sep 2011 00:00:00 GMT Full Article
bili Report of the Asia-Pacific Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Thu, 08 Dec 2011 00:00:00 GMT Full Article
bili Report of the Inter-Regional Workshop on Capacity Needs for the Implementation of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Tue, 26 Jun 2012 00:00:00 GMT Full Article
bili Germany ratified the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress on 27 August 2013. By bch.cbd.int Published On :: Thu, 29 Aug 2013 00:00:00 GMT Full Article
bili A downloadable/printable poster and a new factsheet are now available for the celebration of the entry into force of the Supplementary Protocol on Liability and Redress, 5 March 2018 By bch.cbd.int Published On :: Fri, 02 Mar 2018 00:00:00 GMT Full Article
bili Democratic People's Republic of Korea acceded to the Nagoya-Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety on 1 October 2019. By bch.cbd.int Published On :: Fri, 11 Oct 2019 00:00:00 GMT Full Article
bili CBD News: Investing in the Future - Business for Biodiversity and Sustainability. By www.cbd.int Published On :: Mon, 16 Jun 2008 00:00:00 GMT Full Article
bili CBD News: Statement by the Executive Secretary Mr. Ahmed Djoghlaf on "Biological Diversity, Well-being and Sustainable Society" at the Sixth International Conference on Science and Technology for Sustainability 2008, 12 September 2008, Tokyo, Ja By www.cbd.int Published On :: Fri, 12 Sep 2008 00:00:00 GMT Full Article
bili CBD News: Statement by the Executive Secretary, Mr. Ahmed Djoghlaf, at the UNEP Informal Strategic Consultation on Sustainability beyond 2010: Perspectives from Experiences, Nairobi, 15 February 2009. By www.cbd.int Published On :: Sun, 15 Feb 2009 00:00:00 GMT Full Article
bili CBD News: New CBD publication on forests and climate change: Technical Series No. 43, "Forest Resilience, Biodiversity, and Climate Change", a synthesis report based on over 400 scientific articles about forest stability, health, and biodiversit By www.cbd.int Published On :: Mon, 26 Oct 2009 00:00:00 GMT Full Article
bili CBD News: Statement to UNFCCC SBSTA 31: Agenda Item 3 Nairobi Work Programme on Impacts, Vulnerability and Adaptation to Climate Change. By www.cbd.int Published On :: Thu, 10 Dec 2009 00:00:00 GMT Full Article
bili CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on biological Diversity, on the occasion of the UNCTAD Event on Redefining Sustainability in the International Agenda: Inspiring Greater Engagement in Biodiversity Issues, Gen By www.cbd.int Published On :: Wed, 20 Jan 2010 00:00:00 GMT Full Article
bili CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of Integrated Research System for Sustainability Science (IR3S) Public Symposium to Commemorate the International Year of Biodiversit By www.cbd.int Published On :: Sat, 27 Feb 2010 00:00:00 GMT Full Article
bili CBD News: Statement by Mr. Ahmed Djoghlaf, the Executive Secretary of the Convention on Biological Diversity, on the Occasion of the 2nd International Conference on Climate, Sustainability and Development in Semi-arid Regions, 16 august 2010, Fortaleza, B By www.cbd.int Published On :: Mon, 16 Aug 2010 00:00:00 GMT Full Article
bili CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the 15th Iuappa World Clean Air Congress "Achieving Environmental Sustainability in A Resource Hungry World", 12 Septembe By www.cbd.int Published On :: Sun, 12 Sep 2010 00:00:00 GMT Full Article
bili CBD News: Statement by Mr. Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the Pre-COP10-MOP5 Citizen Forum - Social Sustainability and Biological Safety Policy Reactions & Public Participation, Nagoya, Japan, 9 October 2010. By www.cbd.int Published On :: Sat, 09 Oct 2010 00:00:00 GMT Full Article
bili CBD Press Release: The Nagoya - Kuala Lumpur Protocol on Liability and Redress for Damage Resulting from Living Modified Organisms born in Nagoya By www.cbd.int Published On :: Tue, 12 Oct 2010 00:00:00 GMT Full Article
bili CBD Joint Press Release: Mobilizing society to support biodiversity: As Countdown 2010 initiative closes, local coordinated actions show way to solving the global biodiversity crisis. By www.cbd.int Published On :: Wed, 20 Oct 2010 00:00:00 GMT Full Article
bili CBD News: Statement by Mr Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the International Conference on Science and Technology for Sustainability 2010, 16 December 2010, Kanazawa, Japan. By www.cbd.int Published On :: Thu, 16 Dec 2010 00:00:00 GMT Full Article
bili CBD News: 15e École d'été en évaluation environnementale Évaluation de la durabilité du développement urbain et industriel: outils d'analyse de l'empreinte écologique et des impacts sociaux et sanitaires By www.cbd.int Published On :: Tue, 01 Feb 2011 00:00:00 GMT Full Article
bili CBD Communique: Panama and Peru sign the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress. By www.cbd.int Published On :: Thu, 05 May 2011 00:00:00 GMT Full Article
bili CBD Press Release: The 6th INTERNATIONAL GREEN AWARDST opens for entries and searches the globe for the true unsung sustainability heroes. By www.cbd.int Published On :: Mon, 20 Jun 2011 00:00:00 GMT Full Article
bili CBD Communiqué: World Association of Zoos and Aquariums mobilized for the United Nations Decade on Biodiversity By www.cbd.int Published On :: Fri, 14 Oct 2011 00:00:00 GMT Full Article
bili CBD Communiqué: Benin becomes sixty-sixth signatory of the Nagoya Protocol and the thirty-sixth signatory of the Nagoya-Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Mon, 31 Oct 2011 00:00:00 GMT Full Article
bili CBD Press Release: Latvia becomes the first country to ratify the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Wed, 07 Dec 2011 00:00:00 GMT Full Article
bili CBD Communiqué: The Green Wave to support forest rehabilitation in the devastated region of Tohoku, Japan By www.cbd.int Published On :: Mon, 16 Jan 2012 00:00:00 GMT Full Article
