The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

Compositions and methods useful for point of care testing for hemophilia by measuring coagulation factor levels are provided.

The owners of Oakland's Homestead Restaurant have just debuted a new business concept that is meant to outlast the Covid-19 crisis.

Currently operating at the restaurant's 4029 Piedmont Ave. space Tuesdays through Saturdays from 10 a.m. to 6 p.m. via curbside pickup and Caviar or Doordash delivery, The Humble Sandwich comprises a selection of classic deli sandos made with the same high-quality ingredients for which the seven-year-old restaurant is revered.…

The owners of Oakland's Homestead Restaurant have debuted a new concept meant to outlast the COVID-19 crisis.

This month alone, Oakland-based, family-owned Mr. Espresso has already donated more than 2,500 pounds of coffee to Bay Area COVID-19 relief efforts.

Celebrated chef-restaurateur Kyle Itani, who helms both Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

Operating out of Itani Ramen and serving its fare via pickup and delivery, Nikkei Sushi will be open Wednesday through Sunday, 2 p.m. - 8 p.m. during its soft opening with hours extending in the future.…

Celebrated chef-restaurateur Kyle Itani, who helms Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

A conductive composite is provided, which includes a conductive conjugated polymer and a mixture. The mixture includes (a) boron oxide, and (b) sulfur-containing compound, nitrogen-containing compound, or a combination thereof. A capacitor is also provided, which includes an anode electrode, a dielectric layer on the anode electrode, a cathode electrode, and an electrolyte between the dielectric layer and the cathode electrode, wherein the electrolyte includes the described conductive composite.

A method and system for cooling a device (preferably a micro-device), comprising cooling the device by using a lower critical solution temperature (LCST) mixture. Enhancement of heat transfer rates is achieved during phase separation of a two-component system (two-component mixture) with a LCST. Convective heat transfer rates in small diameter pipes and over a vertical (hot) plate are demonstrated.

A household distribution box comprises a distribution box case; two service lines introduced from a transformer into the distribution box case of a consumer; three main lines installed in the distribution box case and provided with two lines and a second service line; two sub-lines installed in the distribution box case and formed by branching the second service line among the main lines into two lines; a first circuit breaker installed in the distribution box case; a second circuit breaker installed in the distribution box case; and a controller connected to the first circuit breaker.

An automation field device having a housing and a modular field device electronics unit located inside the housing. The electronics unit has a first circuit board having at least one first and one second plug-in connector element, wherein the first plug-in connector element is used to electrically connect a peripheral unit, wherein both the first and the second plug-in connector elements can be contacted essentially from the same preferred plug-in direction, and a second circuit board having at least one third plug-in connector element, wherein the circuit boards are arranged such that the second plug-in connector element is connected to the third plug-in connector element in a detachable manner to electrically connect the peripheral unit to the second circuit board, and the second circuit board has at least one opening, via which the first plug-in connector element of the first circuit board is accessible for connecting the peripheral unit.

The present invention is to provide a chassis switch, which comprises a chassis for accommodating a designated number of line cards therein; a backplane installed on the back side of the chassis and having a plurality of connectors disposed thereon; at least one line card plugged into one of the connectors corresponding thereto via a front side of the chassis and each having an access switch chip adapted to switch local network signals and an interconnect switch chip adapted to switch the signals between ports of the at least one line card; and a loop adapted to connect the corresponding ports of the access switch chip and the interconnect switch chip respectively through the connectors, so as to enable each line card plugged into the chassis switch to perform a local network switching function and a switching function between the at least one line card.

I was wondering why the iconic Civic Centre clock in Southampton is not lit up blue on Thursday at 8pm to clap for the NHS.

HE MAY NOT be held in the highest regard by the public but there’s something to love about Piers Morgan on Good Morning Britain.

Weeks have passed, and DJs the world over have settled into the reality of sheltering in place. As efforts to combat COVID-19 push on, the masses are staying at home. Clubs have shuttered their doors, bars and restaurants are no more, and non-essential businesses are closed. But in this primetime of social distancing, there has […]

The post Streaming L(o)ive In The Time of COVID-19: What’s the future for DJ live streaming? appeared first on DJ TechTools.

The live streaming scene might feel crowded, but this week Mixcloud has introduced their own endeavor. They’ve launched a streaming platform built specifically for DJs, Mixcloud Live—not only taking on streaming giants like Facebook, Twitch, and Youtube, but also creating much-needed relief for DJ streams that are continually flagged for copyright. The team at Mixcloud […]

The post Mixcloud Launches A DJ Live Streaming Platform With Copyright Figured Out appeared first on DJ TechTools.

The provocative A Human Ounce at Central Works asks whether the creator can be separate from the creation. Central Works opens its 30th anniversary season with A Human Ounce, a new play by Nicole Parizeau that poses provocative questions. What is the value of great art, literature, music, commerce, scientific discovery — even Peet's coffee — when scandalous information about its creators or owners comes to light?…

A product for use in a turbocharger system. A turbine housing may define a center core that is circular in shape with a circumference. The turbine housing may define a first volute that extends for a length around only a part of the circumference of the center core, and a second volute that may be positioned radially outside the first volute and that may extend entirely around the circumference of the center core. The first volute and the second volute may define first and second exhaust gas passages through the turbine housing that may be asymmetric. All points of the second volute may be radially outside the first volute from the center core over the entire length of the first volute.

The invention relates to a storage tank (1) in a motor vehicle for receiving an aqueous urea solution for the SCR of nitrogen oxide in the exhaust gas. The storage tank (1) comprises a tank body which forms a storage volume (2) for the urea solution. The storage tank (1) furthermore comprises a filling pipe for filling the storage volume (2) and means for venting the storage volume (2) during the refuelling, wherein the filling pipe (3) has a filling head (9) at a remote end, and the filling head (9) forms an orifice stub (10). The orifice stub (10) defines an orifice (11) for receiving a fuel pump nozzle. Said orifice stub furthermore has an external thread for receiving a complementary union thread of a refuelling cylinder for refuelling by the gas displacement method. The orifice stub forms at least one secondary air opening when the refuelling cylinder is attached, and therefore, when a refuelling cylinder is attached, a sealing seat is bridged by the refuelling cylinder and refuelling by the gas displacement method is possible even if counterflow venting through the filling tube (3) does not take place.

A gas turbine engine system and method of operating gas turbine engines are provided. The gas turbine engine assembly includes a gas turbine engine includes a power shaft configured to rotate about an axis of rotation. The gas turbine engine assembly also includes a first fan and a second fan coupled to the power shaft coaxially with the gas turbine engine. The gas turbine engine assembly also includes a first fan duct configured to direct a first stream of air to the first fan. The gas turbine engine assembly also includes a second fan duct configured to direct a second stream of air to the second fan. The gas turbine engine assembly also includes an exhaust duct configured to direct a stream of exhaust gases of the gas turbine engine in a direction of the axis of rotation.

The present invention relates to an optical clear resin and a method for producing a liquid optical clear photo-curable adhesive.

Embodiments of showerheads having a detachable gas distribution plate are provided herein. In some embodiments, a showerhead for use in a substrate processing chamber includes a body having a first side and an opposing second side; a gas distribution plate disposed proximate the second side of the body; and a clamp disposed about a peripheral edge of the gas distribution plate to removably couple the gas distribution plate to the body, wherein the body is electrically coupled to the gas distribution plate through the clamp.

A heat exchange apparatus includes a first heat exchanger configured to transfer heat between a refrigerant and another medium, a plurality of second heat exchangers configured to transfer heat between the refrigerant and the liquid, a compressor configured to pressurize the refrigerant and a plurality of expansion devices for each of the plurality of second heat exchangers and configured to expand the refrigerant pressurized by the compressor, wherein the refrigerant flows through the plurality of second heat exchangers in parallel, and the liquid flows through the plurality of second heat exchangers in series.

A device and method for heat distribution in a hybrid motor vehicle are provided. The device includes an engine cooling circuit; and a refrigerant circuit for a combined operation in a refrigeration heat pump mode and a reheating mode, includes an evaporator, a compressor, a heat exchanger to supply heat from the refrigerant to air being conditioned for a passenger compartment; and a heat exchanger to transfer heat between a refrigerant of the refrigerant circuit and coolant of the engine cooling circuit, wherein the heat exchanger operates as an evaporator for the heat transfer, and as a condenser for the heat transfer from the condensing refrigerant to the coolant.

As shocking fact is laid upon shocking fact, it becomes hard to judge SS Mendi- Dancing The Drill Of Death at NST City as a piece of theatre, such is one’s outrage at how the British behaved towards black people from the Empire a hundred years ago. But Isango Ensemble have created a powerful musical to tell the human story behind the appalling facts.

Women In Power at the Nuffield Southampton Theatres’ city venue is a new version of Aristophanes' Assemblywomen. It sticks pretty closely to the original story in which women take over the government from the weak and incompetent men.

Theatre Royal Winchester’s Beauty And The Beast manages to tell the romantic tale while still being a traditional panto.

Brian Batchelor, once described by the Daily Echo as ‘the most versatile singer in the South’, has died at the age of 87.

LIKE many drivers in Southampton, I will be delighted when the long-running roadworks near the Red Funnel ferry terminal at Town Quay finally comes to an end.

FIRST the good news: someone has suggested charging for the sick to stay in hospital.

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

Click the following text to download a letter-sized version of our poster.…

News you don't want to miss for April 20:

1. Fifty-one employees at Safeway's distribution warehouse in Tracy have been infected with covid-19, including one death, the San Francisco Chronicle reports.…

News you don't want to miss for April 24:

1. San Francisco Mayor London Breed provided a hint on Friday that the city's shelter in place order will be extended past May 4, possibly weeks or a month, KPIX reports.…

The LA Times drops into Richmond and gets it all wrong. Richmond, the second largest city in Contra Costa County, has had remarkable success fighting the coronavirus — so much so that it and the county are national models. Officials acted quickly and decisively to mobilize resources, info, and healthcare services while providing economic protections for renters and homeowners.…

News you don't want to miss for April 29:

1. Alameda County and five other Bay Area counties issued a revised shelter in place order on Wednesday that will allow for some outdoor activities to resume, such as, construction work, landscaping, gardening, golf and tennis, SFGate reports.…

There is no good reason to create unnecessary barriers for dental telehealth services As many Californians know from getting braces or filling cavities, dental care can be a huge investment. Cost concerns are at top of mind when considering visiting the dentist; one study found that it was the main barrier to dental care even for adults with private insurance.…

An employee at a Dunkin' (formerly Dunkin' Donuts) restaurant in Concord has inspired the company's brand-new DIY Dunkin' Donut Kits.

Norma Valkenaar asked the restaurant's franchisee, Matt Cobo, whether she could bring home some donuts, frosting, and sprinkles so that her young nephews could experiment with customizing their own treats.…

A combined collar stabilizer and button closure tool adds a utility that facilitates securing a button to an accessory that fits into the collar pocket of a shirt, and provides an aesthetically pleasing, straight, crisp, well-groomed appearance of the shirt collar. The combined collar stabilizer and button closure tool increases the efficiency and eases the process required to secure the button closure of a shirt for buttons with a range of diameters needed for buttons of various sizes. The combined tool is made of a substantial material without limiting pliability, is a single form, consists of two distinct ends, and is shaped to substantially fit within the collar stay pocket. One end of the tool is angular in shape and accommodates the angle of the collar pocket tip. The other end, proximate to the end of the collar pocket, is designed to facilitate the closure of a button closure system.

For computer game controller thumb protection, a sheath of resilient, breathable fabric is tailored to conform closely to the distal and proximal thumb phalanx profiles. Stitched to the sheath is a single, continuous strip of thin, elastomer permeated fabric as a taction pad. Taction pad stitching follows the pad edge perimeter. The taction pad covers the pad area of the distal phalanx with a dog-leg extension over the first interproximal joint and proximal phalanx. A hook and loop swatch at a loose distal end of the dog-leg secures the end of the extension to a corresponding swatch of hook and loop material secured to the sheath.

Summer’s now over, and sadly there’s little you can do to repair a holiday ruined by flight delay or cancellation (eg from a strike like Ryanair’s) but many are entitled to up to £550 per person compensation. In fact this applies even for delays as far back as 2012.

An outsole of a shoe includes: a plurality of ridges having a tread surface to be in contact with a road surface; and at least one longitudinal groove defined between the plurality of ridges. At least in a partial area of each of a forefoot portion and a rear foot portion on a medial side of a foot, the plurality of ridges and the longitudinal groove extend in a longitudinal direction or a diagonal longitudinal direction and are set so that an angle of the ridges and that of the longitudinal groove with respect to a long axis of the outsole are in a range of 0° to 35°. A ratio of a length of the tread surface of the ridges with respect to a width of the tread surface is set to be 1.8 to 200. The width of the tread surface of the ridges is set to be greater than a width of the longitudinal groove by a factor of 2 to 100.

The invention relates to a product for pilgrims performing the rites of Haj and Umrah. Used to reduce the crushes resulting from pilgrims colliding because, for example, pilgrims places their shoes close to the gate from which they entered thinking that it will be easy to return to the same place once they have performed the rites of circumambulation (tawaf) and running (sa'ay). However, in reality the pilgrims must walk against the flow, causing collisions and severe crushes, or he is forced to leave his shoes behind, which is a burden for cleaning staff, looks untidy and is a nuisance for pilgrims, the main figures for the inventions are FIG. 7 before wearing the shoes and FIGS. 8,9,10 and 11 after wearing it.

An article of apparel includes a base layer and an auxetic layer coupled to the base layer. The auxetic layer includes an auxetic structure defining a repeating pattern of shapes, with each of the shapes defined by perimeter walls and an interior recess. The auxetic layer includes a first region and a second region. Each interior recess in the first region provides a void exposing the base layer, and each interior recess in the second region is at least partially filled with a recess material.

An apparatus that assists foot movement includes a normally twisted plate configured to interact with the foot. The foot has a pronation axis, and the normally twisted plate is biased and configured to twist about a plate axis that substantially approximates the pronation axis in response to a load received from the foot during foot pronation. As the foot pronates, the plate twists to apply a non-linear force substantially about the plate axis.

POLICE are investigating a incident in which shots were fired outside one of Southampton's best-known pubs.

A SOUTHAMPTON home has been pelted with bricks in a series of targeted attacks.

POLICE have arrested a man for assaulting officers after he was told he was breaching the new coronavirus laws.

CIVIC chiefs are working with police and residents’ groups after an attempted murder in the city centre.