Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01381B, Paper

Minami Abe, Noriaki Seko, Hiroyuki Hoshina, Shigeki Wada, Shinya Yamasaki, Keisuke Sueki, Aya Sakaguchi
Amidoxime adsorbent was synthesised by graft polymerisation. The adsorbent was efficient for collection of U in seawater for both the adsorption and desorption steps, thus affording a new strategy for measurement of U isotopes.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02221H, Paper

Jianxia Gu, Yiqiong Jia, Zhanbin Jin, Tingting Wei, Yongxia Li
The Ce-MOF/g-C₃N₅ composite was first constructed using a simple reflux method in an oil bath, and the electrochemical sensor fabricated based on this composite shows excellent detection performance in nitrofurazone detection in practical samples.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00526K, Paper

Bin Liu, Yu Yin, qianwen Li, wanwan Li, Fubing Xiao, Jinquan Liu, Yan Tan, Shengyuan Yang
Herein, a novel sort of phosphorus and iron-doped carbon dots (P,Fe-CDs) with outstanding peroxidase activity and excellent fluorescence performance was hydrothermally synthesized to colorimetrically and fluorimetrically detect tannic acid (TA)....
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00187G, Minireview

Aleksandra Owczarzy, Karolina Kulig, Katarzyna Piordas, Patrycja Piśla, Patrycja Sarkowicz, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk
Traditional sample preparation techniques based on liquid-liquid extraction (LLE) or solid phase extraction (SPE) often suffer from a major error due to the matrix effects caused by significant co-extraction of...
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00422A, Paper

Pengrong An, Jincan Yang, Tianming Wang, Saiwen Lu, Dehao Wang, Zhuoyue Wang, Chun-Lin Sun, Chuanguang Qin, Jun Li
We report PA-γ-PGA-modified asymmetric nanochannels that enable ultra-sensitive detection of Ni²⁺ (limit of detection is 1 × 10⁻⁸ M).
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00333K, Paper

David Ulisses Tega, Luan Felipe Campos Oliveira, Patrick Cesar Ferreira, Bruna Beatriz Soldera, Heliara Dalva Lopes Nascimento, Marcos Nogueira Eberlin, Alessandra Sussulini
Optimization of a LC-V-EASI-MS system. Employment of LC-V-EASI-MS and online SPE to enhance analytical performance for caffeine determination reaching 90 s per sample.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00181H, Paper

Open Access

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Sofia K. Drakopoulou, Stefanos E. Kokolakis, Apostolos L. Karagiannidis, Marilena E. Dasenaki, Niki C. Maragou, Nikolaos S. Thomaidis
This study presents a robust and validated HRMS method for the determination of 771 pesticides in olive oil. LC-ESI/GC-APCI-QTOF MS was employed for the analysis.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper

Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02216A, Paper

Open Access

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David C. P. King, Michael J. Watts, Elliott M. Hamilton, Robert J. G. Mortimer, Mike Coffey, Odipo Osano, Maureene Auma Ondayo, Marcello Di Bonito
A method was developed for sampling and preserving total Hg from water samples, recovering >75% Hg over 4 weeks of storage. The method was assessed using water samples at artisanal gold mining sites in Kenya.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00605D, Paper

Omid Heydari Shayesteh, Katayoun Derakhshandeh, Akram Ranjbar, Reza Mahjub, Abbas Farmany
In this work, a sensitive colorimetric bioassay method based on poly (adenine) aptamer (polyA apt) and gold nanoparticles (AuNPs) was developed to the determination of aflatoxin B1 (AFB1). The polyA...
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Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper

Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
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Anal. Methods, 2024, 16,2311-2321
DOI: 10.1039/D3AY01831H, Paper

Kang Shen, Caili Bi, Haifan Yang, Miaowen Xu, Lili Huang, Youwei Wang
Based on the coordination principle of Lewis acids, a novel 4-MPBA-modified dumbbell-shaped Au–Ag nanorod (4-MPBA@DS Au–AgNR) SERS substrate was developed to realize the high sensitivity and specificity of SO₄²⁻ detection.
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Anal. Methods, 2024, 16,2198-2228
DOI: 10.1039/D3AY02321D, Critical Review

Arpna Tamrakar, Manzoor Ahmad Wani, Gargi Mishra, Ankur Srivastava, Rampal Pandey, Mrituanjay D. Pandey
The CN bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper

Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper

Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg²⁺ in actual surface water.
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Anal. Methods, 2024, 16,2349-2358
DOI: 10.1039/D3AY02202A, Paper

Varsha Raveendran P.T., Anjali C., Renuka Neeroli Kizhakayil
Luminescence quenching in carbon dots with an increase in Fe³⁺ concentration and the quantitative variation in luminescence intensity with added ferric ions.
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Anal. Methods, 2024, 16,2177-2197
DOI: 10.1039/D3AY01808C, Critical Review

Open Access

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Junhao Xie, Aoife Gowen, Wei Xu, Junli Xu
In this review, we discussed and compared the applications of Fourier transform infrared spectroscopy, quantum cascade laser infrared spectroscopy, atomic force microscopy-based infrared spectroscopy, and optical photothermal infrared spectroscopy in MNP research from multiple perspectives.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00279B, Paper

Shaoxin Ye, Zuoying Wen, Kai Xie, Xuejun Gu, Jian Wang, Xiaofeng Tang, Weijun Zhang
A new method for quantifying nicotine in e-cigarette aerosols within a few seconds using a homemade VUV-AMS.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper

Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper

Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00381K, Paper

Open Access

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Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios Economou
Carcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in...
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper

Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
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RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article

Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article

Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article

Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article

Open Access

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Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article

Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article

Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction

Open Access

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Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00742E, Research Article

Open Access

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Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek Wimmer
A series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article

Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article

Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article

Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article

Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article

Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article

Open Access

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Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article

Open Access

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Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article

Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article

Open Access

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Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article

Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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