y

[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




y

[ASAP] Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic <italic toggle="yes">Phaeosphaeria fuckelii</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00046




y

[ASAP] Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01022




y

[ASAP] Total Synthesis of Isohericenone J via a Stille Coupling Reaction

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01251




y

[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




y

[ASAP] Iheyamides A–C, Antitrypanosomal Linear Peptides Isolated from a Marine <italic toggle="yes">Dapis</italic> sp. Cyanobacterium

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00250




y

[ASAP] Cytotoxic Monoterpenoid Indole Alkaloids from <italic toggle="yes">Tabernaemontana corymbosa</italic> as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00856




y

[ASAP] Review of Progress in the Chemistry of Organic Natural Products<source>Progress in the Chemistry of Organic Natural Products</source>, Volume 108. Edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun’ichi Kobayashi, Yoshinori A

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00356




y

[ASAP] Cucurbitane-Type Triterpenoids from the Vines of <italic toggle="yes">Momordica charantia</italic> and Their Anti-inflammatory Activities

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00592




y

[ASAP] Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge <italic toggle="yes">Aplysina lacunosa</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01286




y

[ASAP] Bioactive Compounds from the Aerial Parts of <italic toggle="yes">Evolvulus linarioides</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01189




y

[ASAP] Constituents of Two <italic toggle="yes">Dioscorea</italic> Species That Potentiate Antibiotic Activity against MRSA

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01006




y

[ASAP] Effect of Temperature on <sup>1</sup>H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from <italic toggle="yes">Berberis brevissima</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00397




y

[ASAP] Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00014




y

[ASAP] <italic toggle="yes">Streptomyces albogriseolus</italic> SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian <italic toggle="yes">Muricella sibogae</italic>, the Bac

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00147




y

[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




y

[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




y

[ASAP] Advances in the Biosynthesis of Pyranocoumarins: Isolation and <sup>13</sup>C-Incorporation Analysis by High-Performance Liquid Chromatography–Ultraviolet–Solid-Phase Extraction–Nuclear Magnetic Resonance Data

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00607




y

[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




y

How tiny dependencies can topple the JavaScript Jenga tower

#486 — May 1, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

???? I18n Ally: An All-in-One i18n Extension for VS Code — Got some internationalization work to do? I18n Ally gives you inline annotations, automated translations via Google Translate (which you can review), progress indication, etc. Supports React, Angular, Vue and other frameworks.

Anthony Fu

How a Few Lines of Code Broke Lots of Packages — Just under a week ago, people were reporting that create-react-app was broken. The culprit? A tiny change in a tiny dependency: is-promise. Luckily a fix was out very quickly and the creator of is-promise reflects on what happened here. Liran Tal also has some analysis of the situation.

Forbes Lindesay

Identify Front-End Issues Like JavaScript or Network Errors Fast — Datadog’s algorithmic alerts will proactively alert on any client-side issues such as JavaScript and network errors. Optimize the load time of your front-end resources, and detect any UI issues that affect critical user journeys. Try it free with Datadog Synthetics.

Datadog sponsor

Q: A JavaScript 'Quantum Circuit' Simulator — Bring quantum computing to your browser with this JavaScript simulation. If you were never quite sure what your JavaScript code was going to do, now you can formally explore the concept ????

Stewart Smith

Quick bytes:

???? Jobs

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

Senior Full-Stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

???? Tutorials

A Guide to window.location — A breakdown that covers most of the methods and properties available on the DOM’s window.location object.

samantha ming

Implementing Dark Mode in React Apps Using styled-components

Blessing Krofegha

▶  Let's Build a Financial Dashboard App with React (Webinar On‑Demand) — Join TJ VanToll as he walks you through building a responsive Bootstrap-themed Stocks Portfolio app. Check it out today.

Progress KendoReact sponsor

Getting Started with NuxtJS — Learn how to create Vue.js-powered server-side rendered apps with NuxtJS including configuring an app and deploying it on Heroku.

Timi Omoyeni

▶  Learn Svelte: A 16-Part Course on Learning the Popular UI Framework — The course centers around building a chatbot, which is a nice change from the todos and other overused tutorial examples.

noah kaufman

10 Practical JavaScript Tricks — These kinds of lists are usually pretty run of the mill, but this one actually contains some lesser-known quick tips that you may not have seen before.

zander shirley

Moving TinyMCE to Modern JavaScript — The creators of TinyMCE (a popular WYSIWYG HTML editor) have been refactoring its rather legacy JavaScript (the first version came out 17 years ago!) to modern practices.

Joakim Lindkvist

7 JavaScript Design Patterns Every Developer Should Know — This is sort of like a (very) mini version of Addy Osmani’s 2017 book on JS design patterns (which is referenced at the end of the post).

deven rathore

▶  An Introduction to State Machines Using XStateXState is a neat way to work with state machines in JavaScript, Kyle is a neat teacher, and Egghead is a neat platform for unlocking these videos for us too.

Kyle Shevlin

Ride Down Into JavaScript Dependency Hell

AppSignal sponsor

A Collection of Challenging TypeScript Exercises“The goal: Let everyone play with many different TypeScript features and get an overview of TypeScript capabilities and principles.”

Marat Dulin

A Visual Guide to React Mental Models — Different people learn in different ways but good mental models are always valuable and can be helpful if you need to juggle all of the pieces involved in a framework like React.

Obed Parlapiano

Turning Vue Components Into Reusable npm Packages — Outlines how you can reuse Vue components across your projects by automating your process to bundle, test, document, and publish your components.

Sjoerd de voorhoede

???? Code & Tools

jExcel v4: A Vanilla JS Interactive Table / Spreadsheet Control — 4.0 adds support for tabs/workbooks, updating a remote data source with JSON, formula support in a sheet footer, and more. There are lots of demos and examples on the official homepage.

Paul Hodel

Will It CORS? — A handy online tool/wizard for establishing how your (potential) use case will (or won’t!) operate alongside CORS (Cross-Origin Resource Sharing).

HTTP Toolkit

Get Great Visual Feedback & Bug Reports, Even from Non-Technical Folk — Simply click a page element to pin visual feedback with screenshots & metadata. BugHerd = fast and easy bug tracking.

BugHerd sponsor

utfu: Replace Busted Characters From Legacy Text with UTF-8 — Useful when old content contains characters like “— in place of a single quote, and similar legacy text issues.

Daniel Sieradski

Middy 1.0: A Node Middleware Framework for AWS Lambda — Middy’s aim is to make writing serverless functions (hosted on AWS Lambda) easier by providing a familiar middleware abstraction to Node developers.

Luciano Mammino

useWorker() 3.0: A React Hook for Blocking-Free Background Tasks — Makes it easier to throw tasks off to a Web Worker in React.

Alessio Koci

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JZZ: A MIDI Library for Node and the Browser — Send, receive and play MIDI messages from both Node and the browser on Linux, macOS and Windows.

Sema

MDX 1.6: Use JSX in Markdown Documents — This version introduces initial Vue support.

Compositor and Vercel

???? Upcoming Online Events

  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Raymond Camden, Christian Heilmann, and Aleksandra Sikora.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.




y

Long-term growth narrative has been set by Sitharaman: BofA's Kaku Nakhate

The government's decision of upholding power purchase agreements as well as the opening up of railways, city gas distribution, and electricity supply to the private sector, are welcome steps




y

Budget 2020: NRI tax to only impact India earnings, govt clarifies

The Union Budget had proposed on Saturday that NRIs have to pay up taxes on global earnings, if they're not paying in any other jurisdiction or country, generating much debate




y

From Nilesh Shah to Jyotivardhan Jaipuria, here're experts' views on Budget

'The disappointment is on the lack of bold, out of the box measures to tackle the current economic slowdown'




y

Decoding Budget 2020: Nirmala Sitharaman's fiscal maths gone awry

Slowdown in economic growth has taken a clear toll on revenue growth




y

LIC listing may take about a year, says Finance Secretary Rajiv Kumar

Kumar said the idea behind the listing of LIC was to "bring in more transparency and allow the company to share gains with its stakeholders"




y

Budget 2020: Selling pressure on stock market may continue, say experts

On Saturday, the benchmark indices closed near their day's lows, indicating further selling pressure on the following trading day




y

Budget stimulus unlikely to revive India's growth from slowdown: Experts

Economists and industry leaders said the budget proposals would provide some support to growth over the longer term but were insufficient to give it an immediate boost




y

Not all NRIs need to pay tax, here's what FM clarified post budget speech

Finance minister clarified that only Indian income of NRIs is proposed to be taxed under the new provision




y

Budget: No tax relief for home buyers stuck in stalled projects, says FPCE

Real estate developers' apex bodies CREDAI and Naredco have also expressed disappointment over the Budget as their demand of one-time restructuring of builders' loan was not met




y

Podcast: T N Ninan and A K Bhattacharya dissect Budget 2020

Has Finance Minister Nirmala Sitharaman delivered a fiscally prudent and growth-oriented Budget 2020? Business Standard Chairman T N Ninan and Editorial Director A K Bhattacharya discuss




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New tax structure will leave more cash in the hands of people: Revenue Secy

He said the Budget gives an option to individuals to migrate to a new regime by foregoing their existing exemptions and deductions for a lower tax rate




y

Govt very transparent in setting new fiscal deficit target: FM Sitharaman

She further said that many people have been speculating that the fiscal deficit would cross 4%




y

Power industry hails proposal for smart prepaid metering across the country

Power ministry has been planning it for two years, but with limited success




y

Govt not included AGR dues payment in Budget 2020-21: DEA Secretary

15 entities owe the government about Rs 1.47 trillion in past dues -- Rs 92,642 crore in unpaid licence fee and another Rs 55,054 crore in outstanding spectrum usage charges




y

Budget 2020 has not accounted for telcos' AGR dues: DEA secretary

But receipts from firms stand at a whopping Rs 1.33 trillion for FY21




y

Budget 2020: Rs 2,500 cr not enough for tourism promotion, says industry

Tourism bodies say Indians spending Rs 9,000 cr abroad abroad due to poor domestic infra, which cannot be improved with this allocation




y

LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




y

Budget proposes to shut thermal power plants of 166,000 mw, says group

National powermen body to stage protests against 'anti-people' proposals




y

Economy fundamentals strong; markets show faith in Budget 2020: Sitharaman

FM says country's macroeconomic parameters are sound




y

Yogi govt to table Budget 2020-21 on February 18; session starts Thursday

The size of the UP Annual Budget 2020-21 is expected to breach the historic mark of Rs 5 trillion




y

Open to tweaking Budget to address concerns of the industry, says FM

Finance ministry to come out with detailed rules on Vivad Se Vishwas Bill in a couple of days




y

Objective of kick-starting growth not addressed effectively in Budget: Garg

"All these expenditures are unlikely to be imparting any fresh growth stimulus to the Indian economy," he argued




y

No timeline to remove income tax exemptions, says Nirmala Sitharaman

"We have not made up our minds as yet (on the removal of all exemptions)... We are trying step by step, move forward and no particular timeline given," she said




y

Societal Perceptions of Physicians: Knights, Knaves, or Pawns?

Interview with Sachin H. Jain, MD, MBA and Christine K. Cassel, MD, authors of Societal Perceptions of Physicians: Knights, Knaves, or Pawns?




y

What If Physicians Actually Had to Control Medical Costs?

Interview with Robert H. Brook, MD, ScD, author of What If Physicians Actually Had to Control Medical Costs?




y

Putting the Public Back in Public Reporting of Health Care Quality

Interview with Tara Lagu, MD, MPH, author of Putting the Public Back in Public Reporting of Health Care Quality




y

Re"evolutionary" Regenerative Medicine

Interview with Helen M. Blau, PhD, author of Re"evolutionary" Regenerative Medicine




y

A Vision for Patient-Centered Health Information Systems

Interview with Alex H. Krist, MD, MPH, author of A Vision for Patient-Centered Health Information Systems




y

A Physician Management Infrastructure

Interview with Peter J. Pronovost, MD, PhD, author of A Physician Management Infrastructure




y

Damage Prevention and Control for Financial Incapacity

Interview with Charles Sabatino, JD, author of Damage Prevention and Control for Financial Incapacity