As job market improves substantially along with technological advancements, it becomes essential to keep up the pace with ever-changing economy.

The 48-year-old cut a casual figure in a grey tassel dress as she visited the newsagents near her home in Hampstead, north London.

Inter Milan new boy Christian Eriksen has revealed that the coronavirus pandemic has caused him a personal nightmare since his move from Tottenham in January.

Sri Lanka has gradually begun relaxing curfew as the coronavirus outbreak is now “under control to a certain degree”, Prime Minister Mahinda Rajapaksa

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Santiago, Chile by So Cal Metro on Flickr.

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When a famed Egyptian actor revealed his daughter had transitioned, the reaction was unconventional.

Fear is ripe soil for the unscrupulous. With so much uncertainty and concern over our health and the broader world economy, cybercriminals have been playing on that fear to steal a few extra dollars out of the most scared and vulnerable. The U.S. Secret Service warned that phishing attacks were up significantly and scams over fake COVID-19 treatments have led to seizures and arrests.

From companies and organizations to individuals, it’s never been more important for everyone to have their cybersecurity measures on high alert. And whether you’re looking to protect your own assets or you’ve been tasked with safeguarding a company and all its workers, the vital work of white hat hackers is absolutely essential these days.

The training in The Ultimate 2020 White Hat Hacker Certification Bundle can put you in a position to understand all aspects of maintaining cybersecurity for a communication system of virtually any size, a lucrative career that can earn you a six-figure income.

The four-part Complete Cyber Security Course (taught by cybersecurity expert and noted consultant Nathan House) is a 360-degree starting point for any cybersecurity career. Starting at the beginning, each part of this multi-pronged introduction will help guide you through vital knowledge, from network hacking techniques and vulnerability scanning to all the defense methods that assure every laptop, desktop, smartphone and tablet in your network remain secure.

The hacker training continues with the rest of the courses in the collection, including building security analysis tools using Python and learning how to analyze web app security vulnerabilities and solutions using frameworks like Ruby on Rails and PHP. Read the rest

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

As daunting as this COVID-19 pandemic has proven to be, and as devastating as its impact is on people both here at home and around the world, we must stand together, united. We must all act with purpose, resolve, love and compassion because when we...

Almost five years ago, lawmakers on a bipartisan committee of Parliament agreed unanimously to amend the law to give the Independent Commission of Investigations (INDECOM) the power to arrest and prosecute cops. That proposed amendment, which was...

....GOING TO DO WHEN THEY BELIEVE THEY APPLY TO THEM BUT THEY HAVEN'T BEEN HOLY SPIRIT BAPTIZED? TODAY'S CHRISTIANS HAVEN'T BEEN "QUICKENED BACK TO LIFE" (EPHESIANS 2:1)  BY HIS "POWER THAT CAME UPON THEM" (ACTS 1:8) WITH HOLY SPIRIT BAPTISM (ACTS 1:5) AS THEY WERE "BORN AGAIN OF THE SPIRIT" (JOHN 3:5-7) FROM THEIR "DEAD SPIRITS" (ROMANS 5:12-14) AND WERE "RESURRECTED" (I COR 15) FROM THEIR GRAVES" (EZEKIEL 37:12-14). WHAT ARE THESE "DEAD SPIRITS" GOING TO DO? 

A study at Columbia University Mailman School of Public Health found that black subjects who were exposed to highly segregated neighborhoods in young adulthood exhibited worse performance in cognitive skills in mid-life.

In the ongoing struggle to address health care disparities in rural communities across the U.S., a recent Oregon State University study found that the perfect partner may be hiding in plain sight.

(May 1, 2020) On April 24, 2020, Singapore’s chief justice announced an extension to June 1, 2020, of the period during which the courts of Singapore would hear only essential and urgent matters in order to slow local transmission of COVID-19. On the same day, the Supreme Court, state courts, and family justice courts each […]

(May 5, 2020) On April 14, 2020, the Tribunal Judiciaire (Trial Court) of Nanterre ordered the French subsidiary of Amazon to limit the activities of its warehouses to processing only orders for items that were essential in coping with the COVID-19 pandemic. Essential items were defined as food, hygiene, and medical products. The court gave […]

OM Russia’s Student Christian Centre, in partnership with the local Evangelical Church, reaches universities in Novosibirsk. The project leader shares about plans for this year.

In the 1960s, when OM accepted untrained people for short-term campaigns, it was unheard of. Today, it has become a gateway into missions.

The varied teaching styles at Teenstreet Malaysia 2016 helped teens to connect with the theme of discovering their identity.

Tabitha Initiative in Kabwe, Zambia, gives business training and small loans to vulnerable women, empowering them to start sustainable businesses in their communities.

Royal Enfield has assured in a press statement that there will be complete compliance to norms of social distancing and workplace sanitization.

With the majority of the population asked to stay indoor, power demand across the country tanked over 8% in March and was expected to fall another 32% in April.

Consumer demand for non-essential products with e-commerce firms has increased manifold after the government last Friday lifted the ban on sale of such products by e-tailers.

The bright spot in the Indian real estate market viz leasing is likely to see an abrupt end to its rental uptick cycle.

Grofers said the company’s warehouses are operational with 60% staff and to meet the surge in demand, the firm is hiring an additional 2,000 temporary warehouse and delivery staff across the country.

E-commerce firms have been urging the government to allow sale of non-essentials like smartphones, electronic and stationary items on the premise that access to the items have become necessary as Corporate India shifted to work from home while students moved to online classes.

Its five-year mission: to explore strange new worlds, to seek out new life and new Kardashians, to boldly market...

Kerala will go into complete lockdown on Sunday, the state government said on Saturday. Nothing will be allowed to open except essential services, it said. "With a view to prevent the spread of...

The Department of Immigration has announced on September 22 that the nationals of the Republic of Yemen need to attain a visa to enter Hong Kong, including the transit passengers from September 29th.In the present scenario, the nationals of the Republic…

Hi sir
A married women known to me is having many extra marriage affairs and spoiling many people and their children. she even tried to seduce me and trying to spoil my life too. can we file a case on her for doing such type of bad.

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